Brain Matters (Audio)

Exercise Improves Brain Health? Sep 09, 2024

What can you do today to improve or maintain your brain health? Join Sarah Banks, Ph.D., a leading expert in healthy aging, dementia, and Alzheimer's disease, as she discusses the latest research on the effects of exercise on brain health. Stay informed and proactive about maintaining cognitive function as you age with insights from cutting-edge research. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40062]

Risk Factors for Alzheimer's What You Can Change Aug 29, 2024

What can you do today to improve or maintain your brain health? Join Sarah Banks, Ph.D., a leading expert in healthy aging, dementia, and Alzheimer's disease, and discover actionable steps you can take to protect your brain health. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40061]

Diet's Effect On Cognitive Decline Vascular Risk Aug 21, 2024

What can you do today to improve or maintain your brain health? Join Sarah Banks, Ph.D., a leading expert in healthy aging, dementia, and Alzheimer's disease, as she discusses the latest research on diet and cognitive decline. Learn how diet, vascular health and inflammation contributes to cognitive function and discover actionable steps you can take to protect your brain health. Stay informed and proactive about maintaining cognitive function as you age with insights from cutting-edge research. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40063]

Delay Cognitive Decline with This Device Aug 15, 2024

What can you do today to improve or maintain your brain health? Sarah Banks, Ph.D., an expert in healthy aging, dementia, and Alzheimer's disease, explores risk factors and corrective tips associated with sleep apnea. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40042]

Can We Avoid Cognitive Decline with Age? May 30, 2024

What can you do today to improve or maintain your brain health? Join Sarah Banks, Ph.D., a leading expert in healthy aging, dementia, and Alzheimer's disease, for an in-depth exploration of the latest research on cognitive decline. This comprehensive program delves into the science behind brain health, covering key factors such as exercise, diet, sleep, social engagement, vascular health, hearing loss, and inflammation. Learn how each of these elements contributes to cognitive function and discover actionable steps you can take to protect your brain health. Stay informed and proactive about maintaining cognitive function as you age with insights from cutting-edge research. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 39387]

Cognitive Aging In The Oldest Old: Resilience And Risk Revealed Mar 29, 2024

Claudia H. Kawas, M.D., addresses Alzheimer's disease and related conditions in older adults, noting the challenge of accurate diagnosis and the resemblance of other brain conditions to Alzheimer's. She introduces "resistance" and "resilience," explaining how some individuals remain cognitively intact despite brain changes. Kawas suggests declining dementia risk due to improved vascular health management, emphasizing the complexity of cognitive decline and the need for further research. Series: "Brain Channel" [Health and Medicine] [Science] [Show ID: 39532]

Looking to a Future Without Alzheimer's Feb 11, 2023

Alzheimer’s disease is a major health crisis that is projected to become an even larger threat in the coming decades. According to the National Institute on Aging, the number of Americans 65 and older with Alzheimer’s could rise from 5.8 million in 2020 to 13.8 million by 2050. Given the severity of this health crisis and the toll it takes on patients, their families and society, we must be prepared today to address the needs of tomorrow. Dean Frank LaFerla of UC Irvine's School of Biological Sciences presents an overview of the state of Alzheimer’s disease research. Following his presentation, the panel discusses emerging trends in research, care and the upcoming challenges we will face and how we might mitigate them. [Health and Medicine] [Show ID: 38660]

Modeling Neurological Conditions Using Stem Cell-Derived Neurons: ApoE and APP in Alzheimer's Disease with Thomas C. Südhof - Sanford Stem Cell Symposium 2022 Nov 16, 2022

Thomas C. Südhof, M.D., Stanford University, discusses facets of the fundamental cell biology of ApoE and APP analyzed in stem cell-derived human neurons. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38405]

How Changes in Proteins Can Lead to Diseases Apr 13, 2022

Dr. Songi Han, professor in the Department of Chemistry, Biochemistry and Chemical Engineering at UC Santa Barbara, talks about her research into the function of proteins in the body and how changes like protein Tau tangles can lead to neurological diseases like Alzheimer's. Series: "GRIT Talks" [Health and Medicine] [Science] [Show ID: 37869]

Neurostimulation for Cognition in Alzheimer's Dementia and High Risk Populations with Tarek Rajji Nov 20, 2021

Tarek Rajji, MD, shares research from current trials combining brain stimulation with interventions including cognitive remediation. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 37598]

Alzheimer's Disease - The Language Syndrome Aug 30, 2021

Dr. Georges Naasan discusses communication difficulties associated with the language syndrome of Alzheimer's Disease. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 37334]

Alzheimer's Disease - The Frontal/Executive Syndrome Aug 27, 2021

Dr. Georges Naasan describes the symptoms seen in the frontal/executive syndrome of Alzheimer's disease. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 37335]

The Role of Music in Dementia Caregiving Relationships Jul 09, 2021

Research suggests that listening to or singing songs can provide emotional and behavioral benefits for people with Alzheimer's disease. Dr. Theresa Allison provides an overview of music in the context of dementia and caregiving relationships. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 37150]

A Closer Look At...Alzheimer's Disease Mar 04, 2021

Stem cell research is changing the way Alzheimer's disease is diagnosed and treated. Larry Goldstein, PhD and Doug Galasko, MD join Alysson Muotri, PhD to share the latest findings and what the future may hold. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36805]

Using Human Stem Cells to Probe Mechanisms of Neuronal Changes in Alzheimer’s Disease - Larry Goldstein Oct 10, 2020

Lawrence S.B. Goldstein, PhD discusses his career in science and his work to understand the molecular basis of neuronal defects in Alzheimer's Disease. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36338]

Stem Cells and Disease Modeling in a Dish Autism Research via Brain Organoids Aug 28, 2020

Researcher Alysson Muotri is using stem cells to study everything from autism to the Zika virus. In this excerpt Muotri discusses stem cell and brain organoid research for possible applications to human diseases. Series: "Health Matters" [Health and Medicine] [Show ID: 36301]

Little-Known Jobs of the Immune System (They Are a Big Deal) Jul 31, 2020

Interactive immune systems are at the center of cancer and other diseases. Dr. Matthew Krummel explores some lesser-known functions of the immune system related to memory making, arteriosclerosis, and gut health. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 36205]

Is Cognitive Decline Inevitable? Jul 11, 2020

Dr. Aimee Kao discusses key behaviors known to protect brain health. Dr. Kao looks at population trends and wonders if they tell a complete story. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 36154]

Staying Sharp: Current and Future Approaches to Brain Health and Alzheimer’s Therapeutics Dec 07, 2019

Dr. Aimee Kao looks at recent news in Alzheimer's Disease therapeutics including drugs in development and the potential of stem cells and genome editing. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 35238]

APOE TREM and Microglia in the Pathogenesis of Tau-mediated Neurodegeneration with David Holtzman MD - Shiley Endowed Lecture Oct 08, 2019

David M. Holtzman, MD of the Washington University School of Medicine discusses the mechanisms underlying neurodegeneration and how microglia and specific microglial genes such as TREM2 influence neurodegeneration in the setting of Aβ and tau pathology. Learn how this line of study may lead to new therapeutics and diagnostic testing for Alzheimer's disease. Series: "Brain Channel" [Health and Medicine] [Education] [Professional Medical Education] [Show ID: 35262]

The Burden of Alzheimer’s Disease and Related Diseases in Vulnerable Populations Aug 30, 2019

Worldwide 50 million people live with dementia. By 2040 over 70% of them will be living in the developing world. Dr. Shamiel McFarlane explores the social and economic cost of dementia around the world. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 34779]

Brain Health Promotion Strategies: Separating Reality-Based Hope From Hopeless Pseudo-Medicine Aug 27, 2019

There are modifiable behaviors that may reduce the risk factor of Alzheimer's: vascular disease, sedentary lifestyle, depression/stress, diet factors and alcohol. Kaitlin Casaletto talks about the benefits of an active lifestyle and proper nutrition. Then Dr. Joanna Hellmuth looks at how to decode direct-to-consumer interventions - dietary supplements - and the rise of pseudo-medicine for dementia. She explains that supplements may or may not be safe and that manufacturers can make broad claims without supporting evidence. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 35136]

Treatment and Management of Patients with Neurodegenerative Disease: Current State of Science Aug 16, 2019

Dr. Julio Rojas-Martinez discusses the pharmacological treatment of Alzheimer’s disease now and what is in development. Current approaches pursue early intervention in the dementia phase. Novel emerging strategies will likely accompany anti-amyloid and anti-tau approaches in the future. Then Sarah Dulaney, RN, describe dementia education, support, and non-pharmacological treatment strategies. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 34777]

Looking Beyond Alzheimer’s Disease: An Overview of Other Major Forms of Neurodegenerative Disease Aug 05, 2019

Alzheimer’s disease is the most common but not the only cause of dementia throughout the lifespan. Dr.Salvatore Spina discusses frontotemporal dementias and how they differ. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 34776]

Diagnosing Alzheimer’s Disease: From Genetics Neuropathology to Common and Rare Clinical Manifestations of the Disease Jul 27, 2019

Dr. Georges Naasan explores the principal clinical syndromes of Alzheimer's Disease: memory, visual, language and frontal/executive. He also discusses neuropathology, genetic factors and modern biomarkers with colleagues from the UCSF Memory and Aging Center. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 34775]

A Brief Overview of the Neurodegenerative Diseases of the Brain Jul 23, 2019

Neurologist Dr. Serggio Lanata explores the neurodegenerative disease of the brain, what they have in common and how they differ. alzheimer's is the most common neurodegenerative disease but there are several others including Parkinson's, Huntington Disease and others. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 34774]

Young Latino Scientists Working on Alzheimer's Jan 31, 2019

More than 5 million Americans are currently diagnosed with Alzheimer’s disease, and that number is expected to triple by 2050, without prevention or cure. By 2060, the number of Latinos in the United States living with Alzheimer’s disease is projected to increase 832 percent — from 379,000 in 2012, to more than 3.5 million. Find out what UC San Diego is doing to both serve this community and catalyze the research careers of investigators from underrepresented groups. Series: "Brain Channel" [Health and Medicine] [Show ID: 34417]

Investigation About Alzheimer's Disease in the Latino Community (English Subtitles) Jan 24, 2019

Alex Figueroa and Dr. Jose Soria-Lopez discuss clinical symptoms of Alzheimer's Disease and the need to include the Latino community in clinical research. Series: "Brain Channel" [Health and Medicine] [Science] [Show ID: 34416]

A Flaw in Modern-Day Alzheimer's Treatment Nov 13, 2018

Rudolph Tanzi, PhD, of the Harvard Medical School describes a fundamental problem with modern-day treatment of Alzheimer's disease. Series: "Wellbeing " [Health and Medicine] [Show ID: 34243]

Metabolic Health Alzheimer's Dementogens Exposome: The Hidden Epidemic Oct 10, 2018

Dale Bredesen, MD, UCSF and UCLA, discusses how environmental toxins may lead to Alzheimers disease. Series: "UCSF Consortium for Obesity Assessment, Study and Treatment" [Health and Medicine] [Education] [Professional Medical Education] [Show ID: 34090]

What Role Do Genetics Play in Alzheimer’s? - On Our Mind Oct 05, 2018

There are different types of genetic influences on people's risk of developing Alzheimer's disease. Douglas Galasko, MD, of the UCSD Shiley-Marcos Alzheimer’s Disease Research Center joins William Mobley, MD, PhD to discuss these genes, how they are being studied, and what being a carrier of Alzheimer's associated genes means. Learn more about penetrance and expressivity, genome-wide association studies, and more. Series: "Brain Channel" [Health and Medicine] [Show ID: 33725]

Studying the Progression of Alzheimer's Disease with Bradley Hyman MD PhD - Shiley Endowed Lecture Aug 24, 2018

How do you model a disease process that stretches out over 20 years in a way that helps you intervene in that process? In the inaugural Shiley Endowed Lecture, Bradley Hyman, MD, PhD shares his research on the progression of Alzheimer's disease. Series: "Brain Channel" [Health and Medicine] [Science] [Show ID: 33992]

Adapting to Alzheimer's: Understanding Dementia in Individuals with Intellectual and Developmental Disabilities Jun 12, 2018

Jennifer A. Dresen, MSW, MPH. Chief of Health and Housing Services, The Arc San Francisco Series: "Developmental Disabilities Update" [Health and Medicine] [Education] [Professional Medical Education] [Show ID: 33522]

Down Syndrome Neurobiology: Developmental and Age-Related Disorders Apr 13, 2018

William Mobley, MD, PhD shares the latest research on preventing Alzheimer's disease in people with Down syndrome. He looks at the genetics and progression of both conditions and shares potential therapies to reduce APP expression that leads to dementia. Series: "Alzheimer’s Disease" [Health and Medicine] [Science] [Show ID: 33600]

Karen Gaffney: We Need Medical Research that Improves Our Lives Apr 13, 2018

Karen Gaffney, advocate and disability champion, discusses her life with Down syndrome. She also talks about the impact that pre natal testing is having on the Down syndrome community and advocates for medical research to focus on the immediate needs such as Alzheimer's disease prevention. Series: "Brain Channel" [Health and Medicine] [Science] [Show ID: 33602]

Neurological Issues in Down Syndrome and Aging Apr 13, 2018

Michael Rafii, MD, PhD describes the conditions that affect people with Down syndrome including vision issues, hearing issues, hormonal issue, spinal cord issues, sleep apnea, and Alzheimer's disease. He stresses the need for routine medical follow ups with primary care physicians and specialty clinics to make sure all changes in health are addressed. Series: "Brain Channel" [Health and Medicine] [Science] [Show ID: 33603]

Models Of / Models For Integrative and Whole Systems Research -- Part 2 Dec 22, 2017

Can (Martin) Zhang of Harvard Medical School leads off the panel with a detailed discussion of factors leading to Alzheimer’s disease and the potential benefits of curcumin in treatment. He is followed by Rinchen Dhondrup of Qinghai University, who presents on treating chronic atrophic gastritis and Chenchen Wang of Tufts University who explains her work using Tibetan medicines and Tai Chi to treat rheumatoid arthritis, fibromyalgia and other chronic diseases as part of the Tibetan Medicine Conference on Mind-Body Health held at Harvard in October, 2017. Series: "Wellbeing " [Health and Medicine] [Show ID: 33048]

The Potential for Natural Products in Treating Alzheimer's Disease and Other Keynotes from 2017 Tibetan Medicine Conference on Mind-Body Health Dec 08, 2017

Keynote talks at the 2017 Tibetan Medicine Conference on Mind-Body Health are presented here, including Rudolph Tanzi, PhD, of the Harvard Medical School who describes his research with natural products to prevent and treat Alzheimer's; Yumba of Lhasa on the Great Treasury of Tibetan Medical and Astronomical Texts; and Janet Gyatso of the Harvard Divinity School on the Challenges for the Study of Tibetan Medicine. Series: "Wellbeing " [Health and Medicine] [Show ID: 33044]

Designer DNA Drugs with Don Cleveland - On Our Mind Nov 01, 2017

Can we turn off the genes responsible for neurodegenerative diseases? Designer DNA drugs are making this possible. By identifying and targeting the genes that drive disease, scientists are moving closer to treatments for ALS, Huntington's disease, and more. Don W. Cleveland, PhD, Department of Cellular and Molecular Medicine, UC San Diego joins William Mobley, MD, PhD to talk about how these drugs work and how they will impact patient care. Series: "Brain Channel" [Health and Medicine] [Science] [Show ID: 32505]

The Intersection of Behavior and Mental Health Through the Lens of Inflammation HIV Alzheimer's Disease and More with Igor Grant - On Our Mind May 09, 2017

Igor Grant, MD, FRCP(C) pursues research that addresses real world behavioral problems. Studying the intersection of drugs of abuse (primarily methamphetamine) and infection, his work sheds light on the basic mechanisms of injury for people with HIV. He examines inflammation in the context of neurological disorders and measures the impact of chronic stress on Alzheimer's disease caregivers. Dr. Grant joins William Mobley, MD, PhD to discuss his life in science and his fascinating work. Series: "Brain Channel" [Health and Medicine] [Show ID: 32221]

Making an Old Brain Young? From Developmental Critical Periods to Alzheimer's Disease Apr 24, 2017

2016 Kavli Prize recipient Carla Shatz from Stanford University presents a lively exploration of how understanding early stages of neural development may be leading to a pathway for developing treatments for Alzheimer's Disease. Series: "Alzheimer’s Disease" [Health and Medicine] [Science] [Show ID: 31763]

The Quest for Treatments for Alzheimer's Disease with Eric Siemers - On Our Mind Apr 10, 2017

Eric Siemers, MD, Distinguished Medical Fellow at Eli Lilly and Company joins William Mobley, MD, PhD to discuss clinical trails for Alzheimer's disease. He explains the trial design, results, and future implications of the EXPEDITION3 trial for people with with mild dementia due to Alzheimer's disease. Learn more about potential treatments in the clinical trials pipeline that may impact both the symptoms and pathologies of Alzheimer's disease. Series: "Alzheimer’s Disease" [Health and Medicine] [Science] [Show ID: 31802]

The Oncoming Epidemic of Alzheimer's Disease with Maria Carrillo - On Our Mind Feb 23, 2017

As baby boomers age, an unprecedented number of people will be diagnosed with Alzheimer's disease. The economic and social impacts will be wide reaching from cost of treatment to the effect on caregivers. Maria Carrillo, PhD, Chief Science Officer, Alzheimer’s Association joins Willliam Mobley. MD, PhD to discuss what can be done and how government, industry and the Alzheimer's Association are working together on larger scale trials and innovative projects. Series: "Alzheimer’s Disease" [Health and Medicine] [Show ID: 31801]

Research Ethics and Advancing the Future of Alzheimer's Disease Research with Ara Khachaturian - On Our Mind Jan 19, 2017

Ara Khachaturian, PhD, chair and president of the National Biomedical Research Ethics Council joins WIilliam Mobley, MD, PhD to discuss the evolution of biomedical research in Alzheimer's disease and the ethical standards needed to maintain excellent patient care. From institutional review boards (IRB) to industry and academic partnerships, learn how we can support and maintain effective research infrastructure. Series: "Alzheimer’s Disease" [Health and Medicine] [Show ID: 31770]

Getting to 2025 for Alzheimer's Disease with Phyllis Ferrell - On Our Mind Jan 16, 2017

Phyllis Ferrell, Vice President and Global Development Leader for Alzheimer's Disease at Eli Lilly and Company joins William Mobley, MD, PhD to talk about the goal set forth in the National Plan to Address Alzheimer’s Disease to “prevent and effectively treat Alzheimer’s disease by 2025.” Ferrell's shares her work to make Alzheimer's dementia preventable by finding ways to slow disease progression and advocating for early diagnosis. Series: "Alzheimer’s Disease" [Health and Medicine] [Show ID: 31803]

Finding Effective Treatments and Prevention of Alzheimer’s Disease: The Time is Now - Research on Aging Dec 08, 2016

From neuropathology to molecular target to clinical treatments, where are we on the road to finding an effective treatment for Alzheimer's disease? Howard Feldman, MD, FRCP(C), a neurologist noted for his original research in geriatric cognitive disorders and expertise in large-scale clinical trials, walks through the latest research and shares some tips on brain health. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Science] [Show ID: 31035]

Stalking an Alzheimer Gene Mutation in the Far Mountains of Colombia Nov 10, 2016

For the past three decades the largest family in the world with a genetic form of Alzheimer’s disease has been tracked. This extended family of some 5,000 individuals live in Antioquia, Colombia among a people who call themselves Paisa. Passing relentlessly through the generations with 100% penetrance is a mutation that causes early onset Alzheimer’s disease in its carriers. Dr. Kenneth Kosik explains that the mutation in the Americas likely originated from a Spanish conquistador whose progeny are the members of the family we see today. Recently, interest in the family has grown because they are now participating in a clinical trial intended to delay the onset of the disease. Series: "Alzheimer’s Disease" [Health and Medicine] [Science] [Show ID: 31481]

Can Sleep Cycles Predict Dementia? Aug 26, 2016

Dr. Elissaios Karageorgio explains the link between broken sleep patterns that are characteristic of insomnia and dementia. Series: "Wellbeing " [Health and Medicine] [Show ID: 31201]

Sleep Brain Health and Alzheimer's Prevention - Super Brain Aug 26, 2016

What is the relationship between sleep, brain health, and Alzheimer's disease? Series: "Wellbeing " [Health and Medicine] [Show ID: 31286]

Brain Conscious Dieting Aug 12, 2016

Dr. Gary Small talks about how to reprogram brain chemistry through repetition, and highlights which foods the brain-conscious dieter eat. Series: "Wellbeing " [Health and Medicine] [Show ID: 31229]

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