American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM)

Paraproteinemic Neuropathies Oct 15, 2024

This podcast discusses paraproteinemic neuropathies, featuring experts Dr. Michelle Maruman and Dr. Eli Naddaf. They explore the definition and clinical significance of monoclonal proteins, the necessary tests for diagnosing these conditions, and the various types of paraproteinemic neuropathies. The discussion covers IgM-associated neuropathies, including DADS, CANOMAD, and Waldenstrom's acroglobulinemia-associated neuropathies, as well as non-IgM neuropathies such as POEMS syndrome and light chain amyloidosis. The experts detail the clinical features, diagnostic criteria, and management approaches for these conditions, emphasizing the importance of accurate diagnosis and appropriate treatment. They conclude by reminding clinicians that the co-occurrence of peripheral neuropathy and monoclonal gammopathy in aging populations is often coincidental, and a careful evaluation is necessary to establish a causal relationship.

Advances in the Therapeutic Landscape of Anti-MAG Neuropathy Sep 30, 2024

Despite its recognition for nearly 40 years, anti-MAG neuropathy continues to have limited therapeutic options. The emergence of bruton tyrosine kinase inhibition as a new therapeutic pathway appears promising. In this interview, Dr. Amro Stino interviews Dr. Chiara Briani on her 2023 paper exploring the prevalence of the MYD 88 mutation among patients with anti-MAG neuropathy. This is discussed within the broader context of disease presentation, current treatment landscape, and future drug development.

Clinical and Neurophysiological Recovery of Ulnar Nerve Conduction Block at the Elbow Sep 15, 2024

Dr. Andrés De León interviews Drs. Simon Podnar and Gregor Omejec about their research on recovery of ulnar nerve conduction block at the elbow.

Acquired Hyperexcitable Peripheral Nerve Disorders: Clinical and Laboratory Features, Therapeutic Responses, and Long-Term Follow-Up Aug 31, 2024

Dr. Chilvana Patel interviews Dr. Khadilkar on the article titled "Acquired Hyperexcitable Peripheral Nerve Disorders: Clinical and Laboratory Features, Therapeutic Responses, and Long-Term Follow-Up." This study examines the clinical and laboratory characteristics of acquired hyperexcitable peripheral nerve disorders, evaluates therapeutic responses, and provides insights from long-term follow-up observations.

Lessons From the Lab - LIVE 2 Webinar Recording (Aug. 2024) Aug 19, 2024

Did you miss Lessons From the Lab LIVE 2? Watch the recording now and see the fun you missed as Drs. Devon Rubin and Christopher Lamb present and discuss a unique case of a young rock climber with arm weakness.

AANEM EDX Lab Accreditation Aug 15, 2024

Carrie Ford, CNCT, RNSCT, REPT (Emeritus) interviews Peter Grant, MD who is a fraud and abuse expert for the FBI Office of Inspector General, US Attorney’s Office, private insurers, and state medical boards. During this podcast, Peter discusses AANEM lab accreditation—how and when it got started. Dr. Grant explains how to apply for lab accreditation, the benefits of being an accredited lab, exemplary accreditation status vs regular accreditation, and how the HB2639 will affect lab accreditation.

Promoting Quality EDX in Legislation Jul 31, 2024

Carrie Ford, CNCT, RNSCT, REPT (Emeritus) interviews Peter Grant, MD who is a fraud and abuse expert for the FBI, Office of Inspector General, US Attorney’s Office, private insurers, and state medical boards. In this podcast Dr. Grant discusses promoting quality electrodiagnostic medicine through legislation—HB2639 explaining the history and need for this legislation, as well as explaining EDX “fraudsters,” and roadblocks that have occurred with this legislation. Dr. Grant also discusses the AANEM’s state liaisons, lobbying in Washington, DC, and meetings with congressman Pete Sessions for support of HB2639.

Lessons From the Lab - Episode 14 - Approach to a Patient With Weakness Jul 18, 2024

Join this Lessons From the Lab as Dr. Devon Rubin picks the amazing brains of Drs. Donald Sanders and Janice Massey on the approach to a patient with weakness. Learn what it means when a patient walks into the office sucking on hard candy as well as what tools should be used to think about and assess for an uncommon neuromuscular disorder.

Fraud and Abuse Jul 15, 2024

Carrie Ford, CNCT, RNSCT, REPT (Emeritus), interviews Peter Grant, MD, for a podcast on electrodiagnostic (EDX) fraud and abuse. Dr. Grant is a fraud and abuse expert for the FBI, Office of Inspector General, US Attorney’s Office, private insurers, and state medical boards. In this podcast, Dr. Grant explains EDX fraud and how it adversely affects PM&R and neurology, which includes hand-held devices, billing unnecessary repeat studies, billing unnecessary multiple nerves with EMG, and mobile diagnostic labs.

Career Phenotypes Part 4 - Perspective from a Clinician in Private Practice Jun 30, 2024

Dr. Nadia Khalil interviews Dr. Collin Grant on his experience in private practice. He shares his take on the highlights, challenges, and keys for success.

Lessons From the Lab - Episode 13 - Clinical, EDX, and Practical Approaches for Progressive Weakness Jun 21, 2024

Have you ever encountered a patient with progressive patchy weakness in various muscles throughout the body? Have you ever performed an EMG in which the findings don’t always fit perfectly into what you were expecting? Have you ever wondered whether you even need to perform an EMG in a patient with weakness? Have you ever wondered how much fun it would be to listen to a new episode of Lessons From the Lab? Well, you have come to the right place to find some answers to these questions! Join Drs. Rubin and Narayanaswami as they ponder and discuss many clinical, electrodiagnostic, and practical approaches to an interesting patient with progressive weakness.

Career Phenotypes Part 3 - Perspectives from Neuromuscular Providers on Subspecialty Selection Jun 15, 2024

Dr. Nadia Khalil interviews Dr. Ileana Howard and Dr. Kelly Gwathmey on their careers in neuromuscular medicine. They define a neuromuscular practice and highlight how meaningful, challenging, and exciting this field of medicine is.

Career Phenotypes Part 2 - Perspective from a Clinician Researcher May 31, 2024

Dr. Nadia Khalil interviews Dr. Nicholas Johnson on a career in research. He describes what research in practice looks like, his inspiration, and pearls for success.

Career Phenotypes Part 1 - Perspectives from Clinician Educators in Academic Practice May 15, 2024

Dr. Nadia Khalil interviews Dr. Milind Kothari and Dr. Sandra Hearn on academic practice. They define what life as a clinician educator looks like and share pearls from their own journeys for success.

Lessons From the Lab - Episode 12 - Navigating EDX with Drs. Rubin and Cartwright May 09, 2024

If you had to evaluate a patient with hand numbness on a deserted island and could only take one EDX item with you, what would it be? Tune in to this episode to see what Drs. Devon Rubin and Michael Cartwright would choose! And learn many more tips of the trade as they discuss a common yet sometimes complicated problem in the EMG laboratory.

Comparison of Muscle Ultrasound and Needle Electromyography Findings in Neuromuscular Disorders Apr 30, 2024

Dr. Kelly Gwathmey interviews Dr. Juerd Wijntjes on the article titled "Comparison of muscle ultrasound and needle electromyography findings in neuromuscular disorders." This study explores the correlation of needle electromyography changes with both visual and quantitative muscle ultrasound results in patients with neurogenic and myopathic disorders.

The Role of AI in NM and EDX Medicine Apr 15, 2024

Drs. Mohamed Taha and John Morren speak with Andy Galbreath about their recent Muscle & Nerve paper on Artificial Intelligence in NM and EDX Medicine. The authors discuss concepts of machine learning, deep learning, and artificial neural networks as they relate to NM and EDX medicine. Limitations and regulatory challenges are also discussed. Muscle & Nerve. 2024;69:260-272.

Lessons From the Lab - Episode 11 - Peripheral Neuropathy Apr 04, 2024

Dr. Devon Rubin challenges the father-son combination of Drs. Peter Dyck and Jim Dyck with a case of peripheral neuropathy. Watch to find out whether the patient’s diabetes was the culprit or whether there was another cause. You will not be disappointed as you learn many pearls in the clinical and EDX evaluation of peripheral neuropathy. Visit our website for more information and educational materials ⁠education.aanem.org⁠.

Lessons From the Lab - LIVE Webinar Recording (March 2024) Mar 28, 2024

Did you miss the first-ever Lessons From the Lab LIVE? Listen and watch what fun you missed now! Hear Devon Rubin, MD, and Ruple Laughlin, MD, as they discuss a case on unilateral leg numbness.

A Discussion of Three Challenging Electrodiagnostic Cases Mar 18, 2024

This podcast is a discussion of three challenging electrodiagnostic cases. Teresa Spiegelberg, CNCT interviews three neuromuscular and electrodiagnostic experts: Dr. Ann Little, MD, Dr. Gary Gallagher, MD, and Dr. James Leonard, Jr. MD.

The first case explores the challenges of routine electrodiagnostic testing in someone with a chronic, underlying brachial plexopathy. The second case discusses the expected electrophysiological changes in a patient with a presynaptic neuromuscular junction disorder. In the third case, electrophysiological features of a patient with Hirayama's Disease (i.e. monomelic amyotrophy) are discussed.

Lessons From the Lab - Episode 10 - Electrodiagnostic Assessment of Polyneuropathy Mar 01, 2024

Listen to this episode to see if Dr. Grant thinks that Dr. Rubin appropriately evaluated a patient with suspected polyneuropathy – is one NCS too few, are 22 NCS too many? Tune in to find out the answer, and much more!

Lessons From the Lab - Episode 9 - Subacute Lower Extremity Weakness Jan 16, 2024

Dr. Devon Rubin presents Dr. David Preston with a challenging case of a man with subacute lower extremity weakness. Enjoy the potpourri of information about anticoagulation, A waves, F waves, demyelination, ultrasound, Siri, and so much more! Visit our website for more information and educational materials ⁠education.aanem.org⁠.

Lessons From the Lab - Episode 8 - Evaluation of Patients With Suspected Motor Neuron Disease Jan 11, 2024

This episode of Lessons From the Lab should make you laugh, think, and maybe cry as Drs. Devon Rubin and Dianna Quan discuss various approaches to the evaluation of patients with suspected motor neuron disease. Visit our website for more information and educational materials education.aanem.org.

Diagnosis and Management of Metabolic Myopathies Jan 05, 2024

Chilvana Patel, Associate Professor and Neurology Residency Program Director at University of Texas Medical Branch Galveston, Texas, interviewing Dr. Bhai who is an Assistant Professor in the Department of Neurology at UT Southwestern Medical Center and the Director of the Neuromuscular Center in the Institute of Exercise and Environmental Medicine at Texas Health Presbyterian Hospital Dallas and Dr. Vissing who is a professor in Department of Neurology at university of Copenhagen, Denmark and Director of Copenhagen Neuromuscular Center at the National Hospital about their recently published articles in Muscle and Nerve in April 2023 on Diagnosis and management of metabolic myopathies.

The Treatment Landscape of Duchenne Muscular Dystrophy, Highlighting Elevidys, the Newly Approved Recombinant Gene Therapy Oct 09, 2023

Dr. Rothman interviews Drs. Stratton and Yang to discuss the treatment landscape of Duchenne Muscular Dystrophy, highlighting Elevidys, the newly approved recombinant gene therapy.

Lessons From the Lab - Episode 7 - EMG Discussion with Professor Erik Stalberg Sep 14, 2023

Join us in this episode as Devon Rubin, MD, challenges Professor Erik Stalberg with an unknown case and discusses various EMG approaches to a patient with suspected neuromuscular junction disease. Watch Professor Stalberg grade Dr. Rubin’s single fiber pairs and hearing about single fiber EMG on dogs will surely make you smile!

Respiratory Considerations in Patients With Neuromuscular Disorders Aug 30, 2023

Hear from Andrew D. Galbreath, DO, as he meets with Ileana Howard, MD, to discuss her recent paper: Respiratory Considerations in Patients With Neuromuscular Disorders.

Lessons From the Lab - Episode 6 - Scapular Winging Aug 02, 2023

In Episode 6 of Lessons From the Lab, we have a fun, educational discussion with Dr. Robert Irwin, current president of AANEM, about an interesting patient with scapular winging. Learn about clinical, electrodiagnostic, and neuromuscular ultrasound assessment of scapular winging, and approaches to managing these patients. Visit our website for more information and educational materials education.aanem.org.

ALS Treatment Landscape Jun 16, 2023

Elie Naddaf, MD, meets with Nicholas Maragakis, MD to discuss the ALS treatment landscape.

Lessons From the Lab - Episode 5 - A Patient With Bilateral Foot Numbness May 15, 2023

Devon Rubin, MD, is joined by John Kincaid, MD, to discuss which is the most important tool in the neurologist's bag, the largest wad of cotton, and interesting findings in a patient with foot numbness. Visit our website for more information and educational materials education.aanem.org.

Lessons From the Lab - Episode 4 - EDX & NMUS Approaches to a Patient With Dyspnea Apr 17, 2023

Devon Rubin, MD, is joined by Andrea Boon MD, to discuss EDX and NMUS approaches, intricacies, and difficulties of a patient who presented with respiratory weakness. Visit our website for more information and educational materials education.aanem.org.

Role of Electrodiagnosis in Nerve Transfers for Focal Neuropathies and Brachial Plexopathies Mar 30, 2023

Dr. Amro Stino interviews Dr. Larry Robinson about the role of electrodiagnosis in nerve transfers for focal neuropathies and brachial plexopathies.

Role of Electrodiagnosis in Nerve Transfers for Focal Neuropathies and Brachial Plexopathies Mar 30, 2023

Dr. Amro Stino interviews Dr. Larry Robinson about the role of electrodiagnosis in nerve transfers for focal neuropathies and brachial plexopathies.

Lessons From the Lab - Episode 3 - How to Approach Suspected Ulnar Neuropathy in the EMG Laboratory Mar 15, 2023

Devon Rubin, MD, is joined by Holli Horak, MD, to discuss the topic: How do we approach suspected ulnar neuropathy in the EMG laboratory?

Diagnosis and Treatment of Chronic Inflammatory Demyelinating Polyneuropathy Feb 21, 2023

Dr. Chilvana Patel interviews Dr. Jeffrey Allen about the diagnosis and treatment of chronic inflammatory demyelinating polyneuropathy (CIDP).

Lessons From the Lab - Episode 2 - EDX Approach to Radiculopathy Feb 15, 2023

Devon Rubin, MD, is joined by Michael Andary, MD, for a lively debate and discussion on EDX approach to radiculopathy. Visit our website for more information and educational materials education.aanem.org.

Lessons from the Lab - Episode 1 Jan 19, 2023

Devon Rubin, MD, leads an educational, informative, and humorous discussion with Dr. Litchy and Dr. Robinson, on their electrodiagnostic approaches to a patient with symptoms of possible mild carpal tunnel syndrome.

Complement and Neonatal Fc Receptor Inhibitors in Myasthenia Gravis, Highlighting CHAMPION MG (ravulizumab) and ADAPT (efgartigimod) Trials Dec 13, 2022

Dr. Elie Naddaf, MD interviews Dr. James Howard, MD about the use of complement and the neonatal Fc receptor inhibitors in myasthenia gravis, highlighting CHAMPION MG (ravulizumab) and ADAPT (efgartigimod) trials.

Complement and Neonatal Fc Receptor Inhibitors in Myasthenia Gravis (MG), Highlighting CHAMPION MG (ravulizumab) and ADAPT (efgartigimod) trials Dec 13, 2022

Elie Naddaf, MD, interviews James Howard, MD, about the use of complement and the neonatal Fc receptor inhibitors in myasthenia gravis (MG), highlighting CHAMPION MG (ravulizumab) and ADAPT (efgartigimod) trials.

Musculoskeletal Mimics of Cervical Radiculopathy Sep 08, 2022

Dr. Chilvana Patel interviews Dr. Faye Chiou Tan on Musculoskeletal Mimics of Cervical Radiculopathy

Musculoskeletal Mimics of Cervical Radiculopathy Sep 08, 2022

Dr. Chilvana Patel interviews Dr. Faye Chiou Tan on musculoskeletal mimics of cervical radiculopathy.

Spinal Muscular Atrophy (SMA) and its Management Jun 21, 2022

Dr. Beecher interviews Drs. Nassim Rad and Crystal Yeo on Spinal Muscular Atrophy (SMA) and its Management

Spinal Muscular Atrophy and its Management Jun 21, 2022

Dr. Beecher interviews Drs. Nassim Rad and Crystal Yeo on Spinal Muscular Atrophy (SMA) and its Management.

Diagnostic Utility of Gold Coast Criteria in Amyotrophic Lateral Sclerosis May 25, 2022

Dr. Naddaf interviews Dr. Vucic on Diagnostic Utility of Gold Coast Criteria in Amyotrophic Lateral Sclerosis

Diagnostic Utility of Gold Coast Criteria in Amyotrophic Lateral Sclerosis May 25, 2022

Dr. Naddaf interviews Dr. Vucic on diagnostic utility of gold coast criteria in amyotrophic lateral sclerosis (ALS).

European Academy of Neurology/Peripheral Nerve Society Guideline on Diagnosis and Treatment of Chronic Inflammatory Demyelinating Polyradiculoneuropathy: Report of a Joint Task Force—Second Revision Feb 26, 2022

Dr. Hearn interviews Dr. Van Den Bergh on European Academy of Neurology/Peripheral Nerve Society Guideline on Diagnosis and Treatment of Chronic Inflammatory Demyelinating Polyradiculoneuropathy: Report of a Joint Task Force—Second Revision. References: https://pubmed.ncbi.nlm.nih.gov/34327760/ and https://pubmed.ncbi.nlm.nih.gov/34085743/

European Academy of Neurology/Peripheral Nerve Society Guideline on Diagnosis and Treatment of Chronic Inflammatory Demyelinating Polyradiculoneuropathy: Report of a Joint Task Force Feb 26, 2022

Dr. Hearn interviews Dr. Van Den Bergh on European Academy of Neurology/Peripheral Nerve Society Guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): Report of a joint task force.

References: https://pubmed.ncbi.nlm.nih.gov/34327760/ and https://pubmed.ncbi.nlm.nih.gov/34085743/

Diagnosis and Treatment of Chronic Inflammatory Demyelinating Polyneuropathy Feb 21, 2022

Dr. Chilvana Patel, MD interviews Dr. Jeffrey Allen, MD about the diagnosis and treatment of chronic inflammatory demyelinating polyneuropathy.

Neuromuscular Complications of Immune Checkpoint Inhibitors Jan 13, 2022

Dr. Patel interviews Dr. Dubey and Dr. Zekeridou on Neuromuscular complications of Immune Checkpoint Inhibitors.

Neuromuscular Complications of Immune Checkpoint Inhibitors Jan 13, 2022

Dr. Patel interviews Drs. Dubey and Zekeridou on neuromuscular complications of immune checkpoint inhibitors.

Evaluation of Persons With Suspected Lumbosacral and Cervical Radiculopathy Dec 16, 2021

Dr. Katarzyna Ibanez interviews Dr. Timothy Dillingham on Evaluation of Persons With Suspected Lumbosacral and Cervical Radiculopathy.

Evaluation of Persons With Suspected Lumbosacral and Cervical Radiculopathy Dec 16, 2021

Dr. Katarzyna Ibanez interviews Dr. Timothy Dillingham on evaluation of persons with suspected lumbosacral and cervical radiculopathy.

Clinical Features of LRP4/Agrin-Antibody–Positive Myasthenia Gravis Nov 03, 2021

Dr. Elahi Behzad interviews Dr. Michael H. Rivner on the clinical features of LRP4/agrin-antibody–positive Myasthenia Gravis.

Clinical Features of LRP4/agrin-antibody Positive Myasthenia Gravis Nov 03, 2021

Dr. Elahi Behzad interviews Dr. Michael H. Rivner on the clinical features of LRP4/agrin-antibody positive Myasthenia Gravis (MG).

COVID-19 and Neuromuscular Disorders Oct 26, 2021

Dr. Elie Naddaf interviews Dr. Amanda Guidon and Dr. Anthony Amato regarding coronavirus 19 (COVID19) and Neuromuscular disorders. This podcaste reviews the potential neuromuscular complications of COVID-19, impact of COVID-19 on patients with preexisting neuromuscular disease, and guidance for management of immunosuppressive and immunomodulatory therapies and timing vaccination. We also review the impact of COVID19 on training in neuromuscular and electrodiagnostic medicine.

Approach to Dysphagia With Focus on Neuromuscular Disorders Sep 10, 2021

Dr. Elie Naddaf interviews Dr. Georgia Malandraki and Dr. Kendrea Garand on the approach to dysphagia, with focus on neuromuscular disorders.

Approach to Dysphagia With Focus on Neuromuscular Disorders Sep 10, 2021

Dr. Elie Naddaf interviews Drs. Georgia Malandraki and Kendrea Garand on the approach to dysphagia, with focus on neuromuscular disorders.

Porphyric Neuropathy Part II Jul 23, 2021

Dr. Priya Dhawan interviews Drs. Mohamed Kazamel and Robert Desnick on their article, Porphyric Neuropathy Part II.

Porphyric Neuropathy Part I Jul 23, 2021

Dr. Priya Dhawan interviews Drs. Mohamed Kazamel and Robert Desnick on their article, Porphyric Neuropathy Part I.

Porphyric Neuropathy Part II Jul 23, 2021

Dr. Priya Dhawan interviews Drs. Mohamed Kazamel and Robert Desnick on their article, Porphyric Neuropathy Part II.

Porphyric Neuropathy Part I Jul 23, 2021

Dr. Priya Dhawan interviews Drs. Mohamed Kazamel and Robert Desnick on their article, Porphyric Neuropathy Part I.

COVID-19-Associated Guillain-Barre Syndrome: The Early Pandemic Experience Apr 21, 2021

Dr. Willer interviews Dr. Caress on his article, COVID-19-Associated Guillain-Barre Syndrome: The Early Pandemic Experience. Please review these papers that were mentioned in this podcast:

"Epidemiological and cohort study finds no association between COVID-19 and Guillain-Barre syndrome" "COVID-19 vaccine and Guillain-Barre ́syndrome: let's not leap to associations"

COVID-19-Associated Guillain-Barre Syndrome: The Early Pandemic Experience Apr 21, 2021

Dr. Willer interviews Dr. Caress on his article, COVID-19-associated Guillain-Barre syndrome: The early pandemic experience.

Please review these papers that were mentioned in this podcast:

"Epidemiological and Cohort Study Finds No Association Between COVID-19 and Guillain-Barre syndrome."
"COVID-19 Vaccine and Guillain-Barre syndrome: Let's Not Leap to Associations."

Autonomic Neuropathies Apr 15, 2021

Dr. Patel interviews Dr. Stino on his article, Autonomic Neuropathies.

Autonomic Neuropathies Apr 15, 2021

Dr. Patel interviews Dr. Stino on his article, Autonomic Neuropathies.

Guidelines on Clinical Presentation and Management of Nondystrophic Myotonias Mar 17, 2021

Dr. Waheed interviews Dr. LoRusso and Dr. Statland on thier article, Guidelines on clinical presentation and management of nondystrophic myotonias.

Guidelines on Clinical Presentation and Management of Nondystrophic Myotonias Mar 17, 2021

Dr. Waheed interviews Drs. LoRusso and Statland on their article, Guidelines on clinical presentation and management of nondystrophic myotonias.

COVID-19 and Neuromuscular Disorders Feb 26, 2021

Dr. Elie Naddaf interviews Drs. Amanda Guidon and Anthony Amato regarding COVID-19 and neuromuscular disorders. This podcast reviews the potential neuromuscular complications of COVID-19, impact of COVID-19 on patients with preexisting neuromuscular disease, and guidance for management of immunosuppressive and immunomodulatory therapies and timing vaccination. We also review the impact of COVID-19 on training in neuromuscular and electrodiagnostic medicine.

Electrodiagnostic Approach to Patients Presenting With Respiratory Symptoms Oct 28, 2020

Dr. Elie Naddaf interviews Dr. Andrea Boon about the approach to patients presenting to the EMG laboratory with respiratory symptoms, to evaluate for underlying neuromuscular cause of these symptoms. Dr Boon describes the role of phrenic nerve conduction studies and needle electromyography of the diaphragm and the technical limitations of these studies. Dr Boon also details the role of diaphragm ultrasound to enhance the accuracy and safety of diaphragm electromyography, and improve the diagnostic yield of EDX testing, including an overview of the diaphragm ultrasound technique

Anterior Interosseous Nerve Syndrome Sep 30, 2020

Dr. Sandra Hearn interviews Dr. Dr. Darryl Sneag, Dr. Danielle Stoner, Dr. Scott Wolfe, Dr. Joseph Feinberg, Anterior interosseous nerve syndrome.

Rehabilitative Approach to ALS Patients highlighting Eye-Controlled, Power Wheelchair Performs Well for ALS Patients Sep 03, 2020

Dr. Ibanez interviewing Dr. Elliott on “Rehabilitative approach to ALS patients” while also highlighting his article “Eye-controlled, power wheelchair performs well for ALS patients.

Immunomodulatory and Immunosuppressive Therapy for Neuromuscular Disorders Part II. Jul 24, 2020

Dr. Justin Willer interviews Dr. Constantine Farmakidis on his article, Immunomodulatory and Immunosuppressive Therapy for Neuromuscular Disorders Part II.

Immunomodulatory and Immunosuppressive Therapy for Neuromuscular Disorders Part I Jul 24, 2020

Dr. Justin Willer interviews Dr. Constantine Farmakidis on his article, Immunomodulatory and Immunosuppressive Therapy for Neuromuscular Disorders Part I.

Nutritional Neuropathies May 26, 2020

Dr. Priya Dhawan interviews Dr. Kelly Gwathmey on her article, Nutritional Neuropathies.

Quality Improvement Projects in the EMG laboratory Apr 03, 2020

Dr. Elie Naddaf interviews Dr. Andrea Leep Hunderfund on her article, Quality Improvement Projects in the EMG laboratory.

Long-term Safety and Efficacy of Eculizumab in Generalized Myasthenia Gravis Dec 18, 2019

Dr. Elahi Behzad interviews Dr. Srikanth Muppidi on his article, Long-term Safety and Efficacy of Eculizumab in Generalized Myasthenia Gravis.

Ultrasound-Guided Treatment of Peripheral Entrapment Neuropathies Oct 30, 2019

Dr. Sandra Hearn interviews Dr. John Norbury on his article, Ultrasound-Guided Treatment of Peripheral Entrapment Neuropathies.

Effect of Shoulder and Elbow Position on Ulnar Nerve Conduction Sep 24, 2019

Dr. Elie Naddaf interviews Lawrence R. Robinson MD on his article, Effect of shoulder and elbow position on ulnar nerve conduction.

Thymectomy may not be Associated With Clinical Improvement in MuSK Myasthenia Gravis Jul 07, 2019

Dr. Justin Willer interviews Dr. Michael Hehir on his article, Thymectomy may not be associated with clinical improvement in MuSK myasthenia gravis.

Satisfactory Response With Achieving Maintenance Low-Dose Prednisone in Generalized Myasthenia Gravis Jul 03, 2019

Dr. Elie Naddaf interviews Dr. Mazen Dimachkie on his article, Satisfactory Response With Achieving Maintenance Low-Dose Prednisone in Generalized Myasthenia Gravis. To estimate the satisfactory response rate (SR%) with achieving maintenance, low-dose prednisone in acetylcholine receptor antibody-positive generalized myasthenia gravis. In this retrospective study, we estimate the SR% as defined by (remission/minimal manifestations status for at least 6 months using 7.5 mg or less of prednisone daily, for maintenance treatment at 2, 4, and 6 years after symptoms onset) for patients who were not taking steroid-sparing immunosuppressant (SSI) as a primary outcome and for patients taking an SSI as a secondary outcome. Forty-five patients were not taking an SSI at 2 years, 34 patients at 4 years, and 17 patients at 6 years; SR% was 44.4%, 64.7%, and 58.8%, respectively. Thirty-six patients were taking an SSI at 2 years, 22 patients at 4 years, and 15 patients at 6 years; the SR% was 50.0%, 45.4%, and 66.7%, respectively. Nearly half of the generalized myasthenia gravis patients who were not taking an SSI achieved an SR.

Clinical and Electrodiagnostic Features Of Nontraumatic Sciatic Neuropathy Jun 06, 2019

Dr. Justin Willer interviews Dr. Yuebing Li about his article, Clinical and Electrodiagnostic Features Of Nontraumatic Sciatic Neuropathy. This study sought to characterize etiologies and features of sciatic neuropathy unrelated to penetrating nerve trauma. Methods: This investigation was a retrospective review of 109 patients with electrodiagnostically confirmed sciatic neuropathies. Results: Hip replacement surgery represented the most common (34.9%) etiology, whereas inflammatory sciatic neuropathy was seen in 7.3%. Electrodiagnostic testing revealed an axonal neuropathy in 95.4% and a demyelinating neuropathy in 4.6%. Predominant involvement of the peroneal division was seen in 39.4% and was tibial in 5.5%. Nine of 31 (29.0%) patients who had MRI or neuromuscular ultrasound study showed abnormalities within the sciatic nerve. At the final visit, 46.4% of patients required assistance for ambulation. Young age, lack of severe initial weakness, and presence of tibial compound muscle action potential or sural sensory nerve action potential were predictors of favorable outcome. Discussion: Sciatic neuropathies are usually axonal on electrodiagnostic testing, affect preferentially the peroneal division, and are commonly associated with incomplete recovery. Muscle Nerve 59:309–314, 2019.

Needle Electromyography and Histopathologic Correlation in Myopathies Apr 24, 2019

Dr. Behzad Elahi interviews Dr. Devin I. Rubin on his article, Needle Electromyography and Histopathologic Correlation in Myopathies. Fibrillation potentials and short-duration MUPs predict pathologic changes of muscle fiber necrosis, splitting, and/or vacuolar changes (as seen with inflammatory myopathies and muscular dystrophies). Absence of fibrillation potentials suggests other myopathologic changes (e.g., congenital myopathy). Muscle Nerve 59:315-320, 2019.

Muscle Biopsy EMG Correlation Feb 11, 2019

Dr. Scott Speelziek interviews Dr. Elie Naddaf on his article, Muscle Biopsy EMG Correlation. In myopathies, the correlation of individual electromyographic and histopathologic findings remains poorly explored, as most previous studies have focused on the ability of muscle biopsy and electromyography to distinguish the neuropathic vs. myopathic nature of the underlying neuromuscular disease. By demonstrating a clear correlation of various electromyographic and histopathologic findings, this study improves interpreting electrodiagnostic testing in myopathies, and serves as the basis to further assess the correlation between clinical, electromyographic, and histopathologic findings.

Long‐Term Neuromuscular Outcomes of West Nile Virus Infection A Clinical and Electromyographic Evaluation of Patients With a History of Infection Aug 31, 2018

Dr. Justin Willer interviews Dr. Athar Parveen on her article, Long‐term neuromuscular outcomes of west nile virus infection A clinical and electromyographic evaluation of patients with a history of infection. The study found that 33% of these patients (10 of 30) showed abnormalities on either nerve conduction or needle electromyography due to primary or secondary outcomes of WNV infection. Most common electrodiagnostic findings and causes of long-term disability were related to anterior horn cell poliomyelitis (WNV poliomyelitis). Electrical data on these patient populations were similar to those observed in chronic poliomyelitis. With more than 16,000 cases of WNV neuroinvasive disease reported across the USA since 1999, understanding clinical outcomes from infection will provide a resource for physicians managing long-term care of these patients. Muscle Nerve 57: 77-82, 2018.

Electrodiagnostic Errors Contribute to Chronic Inflammatory Demyelinating Polyneuropathy Misdiagnosis Jul 23, 2018

Dr. Justin Willer interviews Dr. Jeffrey Allen on his article, Electrodiagnostic Errors Contribute to Chronic Inflammatory Demyelinating Polyneuropathy Misdiagnosis.

Amyloid TTR Treatment Studies Jul 23, 2018

Dr. Ted Burns interviews Dr. William Litchy and Drs. Jim and Peter Dyck on their articles, Amyloid TTR treatment studies. The articles are Inotersen Treatment for Patients with Hereditary Transthyretin Amyloidosis (N Engl J Med. 2018 Jul 5;379(1):22-31. doi: 10.1056/NEJMoa1716793) and Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis (N Engl J Med. 2018 Jul 5;379(1):11-21. doi: 10.1056/NEJMoa1716153.)

Subcutaneous Versus Intravenous Immunoglobulin for Chronic Autoimmune Neuropathies - A Meta-Analysis Jun 27, 2018

Dr. Speelziek interviews Dr. Kurt Kimpinski and Dr. Luciano Sposato on their article, Subcutaneous versus intravenous immunoglobulin for chronic autoimmune neuropathies. A meta-analysis. High-dose intravenous immunoglobulin (IVIg) is an evidence-based treatment for multifocal motor neuropathy (MMN) and chronic inflammatory demyelinating polyneuropathy (CIDP). Recently, subcutaneous immunoglobulin (SC-Ig) has received increasing attention. The authors performed a meta-analysis of reports of efficacy and safety of SC-Ig versus IVIg for inflammatory demyelinating polyneuropathies.The efficacy of SC-Ig is similar to IVIg for CIDP and MMN and has a significant safety profile. Muscle Nerve 55: 802-809, 2017.

Complex and Simple Clinical Reaction Times Are Associated with Gait, Balance, and Major Fall Injury Mar 27, 2018

Dr. Sandra Hearn interviews Dr. James Richardson on his article, Complex and simple clinical reaction times are associated with gait, balance, and major fall injury in older subjects with diabetic peripheral neuropathy. In the diabetic peripheral neuropathy subjects, the ratio of complex RTclin accuracy to simple RTclin latency was strongly associated with longer UST, and decreased step width variability and range on an uneven surface. Additionally, the 2 DPN subjects sustaining major injuries had lower complex RTclin accuracy:simple RTclin latency than those without.The ratio of complex RTclin accuracy:simple RTclin latency is a potent predictor of UST and frontal plane gaitvariability in response to perturbations and may predict major fall injury in older subjects with DPN. These short latency neurocognitive measures may compensate for lower limb neuromuscular impairments and provide a more comprehensive understanding of balance and fall risk. Am J Phys Med Rehabil. 2017 Jan;96(1):8-16.

Acute Nutritional Axonal Neuropathy Mar 27, 2018

Dr. Willer interviews Dr. Johanna Hamel and Dr. Eric Logigian about their article Acute Nutritional Axonal Neuropathy. This study describes clinical, laboratory, and electrodiagnostic features of a severe acute axonal polyneuropathy common to patients with acute nutritional deficiency in the setting of alcoholism, bariatric surgery (BS), or anorexia. Thirteen patients were identified with a severe, painful, sensory or sensorimotor axonal polyneuropathy that developed over 2-12 weeks with sensory ataxia, areflexia, variable muscle weakness, poor nutritional status, and weight loss, often with prolonged vomiting and normal cerebrospinal fluid protein. Vitamin B6 was low in half and thiamine was low in all patients when obtained before supplementation. Patients improved with weight gain and vitamin supplementation, with motor greater than sensory recovery. The authors suggest that acute or subacute axonal neuropathy in patients with weight loss or vomiting associated with alcohol abuse, BS, or dietary deficiency is one syndrome, caused by micronutrient deficiencies. Muscle Nerve 57: 33-39, 2018.

The Value Transformation of Health Care: Impact on Neuromuscular and Electrodiagnostic Medicine Jan 25, 2018

Dr. Scott Speelziek interviews Dr. Pushpa Narayanaswami and Dr. Lyell K Jones about the article, The Value Transformation of Heath Care: Impact on Neuromuscular and Electrodiagnostic Medicine. Beginning in 2017, most physicians who participate in Medicare are subject to the Medicare Access and CHIP Reauthorization Act (MACRA), the milestone legislation that signals the US health care system's transition from volume-based to value-based care. Here we review emerging trends in development of value-based healthcare systems in the US. MACRA and the resulting Quality Payment Program create 2 participation pathways, the Merit-based Incentive Payment System (MIPS) and the Advanced Alternative Payment Model (AAPM) pathway. Although there are several program incentives for AAPM participation, to date there have been few AAPM options for specialists. MIPS and its widening bonus and penalty window will likely be the primary participation pathway in the early years of the program. Value-based payment has the potential to reshape health care delivery in the United States, with implications for neuromuscular and electrodiagnostic (EDX) specialists. Meaningful quality measures are required for neuromuscular and EDX specialists. Muscle Nerve 56: 679-683, 2017.

Hereditary Myopathies With Early Respiratory Insufficiency in Adults Jan 19, 2018

Dr. Ted Burns interviews Dr. Elie Naddaf and Dr. Margherita Milone about the article Hereditary Myopathies With Early Respiratory Insufficiency in Adults. Hereditary myopathies with early respiratory insufficiency as a predominant feature of the clinical phenotype are uncommon and underestimated in adults. The authors highlighted the most common hereditary myopathies associated with early respiratory insufficiency as the predominant clinical feature, and underscored the importance of a timely diagnosis for patient care. Muscle Nerve 56: 881-886, 2017.

Thoracic Outlet Syndrome Part 1 and Part 2 Oct 26, 2017

Thoracic Outlet Syndrome Part 1 and Part 2

Evaluation of Patients With Refractory Chronic Inflammatory Demyelinating Polyneuropathy Jun 29, 2017

Evaluation of Patients With Refractory Chronic Inflammatory Demyelinating Polyneuropathy

International Consensus Guidance for Management of Myasthenia Gravis: Executive Summary Jun 27, 2017

International Consensus Guidance for Management of Myasthenia Gravis: Executive Summary

Optimizing Muscle Selection for Electromyography in Amyotrophic Lateral Sclerosis Jun 22, 2017

Optimizing Muscle Selection for Electromyography in Amyotrophic Lateral Sclerosis

Association of Inclusion Body Myositis With T Cell Large Granular Lymphocytic Leukaemia Jan 24, 2017

Association of Inclusion Body Myositis With T Cell Large Granular Lymphocytic Leukaemia

Transthyretin Amyloid Neuropathy has Earlier Neural Involvement but Better Prognosis than Primary Jan 17, 2017

Transthyretin Amyloid Neuropathy has Earlier Neural Involvement but Better Prognosis than Primary

POEMS vs CIDP Dec 21, 2016

POEMS vs CIDP

Gene Editing in Monogenic Diseases With CRISPR Dec 08, 2016

Gene Editing in Monogenic Diseases With CRISPR by Eric Olson, PhD

Presymptomatic ALS Genetic Counseling and Testing: Experience and Recommendations Nov 28, 2016

Presymptomatic ALS Genetic Counseling and Testing: Experience and Recommendations

Randomized Trial of Thymectomy in Myasthenia Gravis Nov 02, 2016

Randomized Trial of Thymectomy in Myasthenia Gravis by Dr. Gil Wolfe

Normative Data Task Force: Establishing High-Quality Reference Values for NCS Oct 10, 2016

Dr. Ted Burns interviews Dr. Timothy Dillingham about the Normative Data Taskforce (NDTF) report on establishing high quality reference values for nerve conduction studies (NCS). Because there are not uniform standards for NCS in the United States, the NDTF developed consensus-based methodological criteria for examining NCS and applied this quality criteria to a systematic review of the published literature. The NDTF has done the difficult work of scouring the literature and identifying high quality articles for our members. Nerve conduction testing techniques and normative reference values from these studies that met a high quality standard are now presented for our membership to use in an easy to follow tabular format. Two reports on the work of the NDTF were published in the September issue of Muscle and Nerve: Muscle Nerve. 2016 Sep;54(3):366-70. doi: 10.1002/mus.25204 and Muscle Nerve. 2016 Sep;54(3):371-7.

Rapid Screening for Inflammatory Neuropathies by Standardized Clinical Criteria Sep 23, 2016

Rapid Screening for Inflammatory Neuropathies by Standardized Clinical Criteria

Sensory Neuronopathies Aug 31, 2016

Dr. Justin Willer interviews Dr. Kelly Gwathmey about her article, Sensory Neuronopathies. The sensory neuronopathies (or ganglionopathies) are a small subcategory of neuropathies characterized by primary degeneration of the dorsal root ganglia and trigeminal ganglion sensory neurons, resulting in a distinctive clinical presentation. Patients typically have subacute onset of asymmetric, non–length-dependent sensory impairment and early ataxia. The etiologies of acquired sensory neuronopathies are rather limited. Early identification is imperative, as they may herald an underlying malignancy or an autoimmune condition such as Sjögren syndrome. This podcast reviews the Muscle and Nerve article on this subject. Muscle Nerve 53: 8–19, 2016.

Mutations in SEPT9 Cause Heredic Neuralgic Amyotrophy Mar 25, 2016

Mutations in SEPT9 Cause Heredic Neuralgic Amyotrophy by Phillip Chance, MD and Mark Hannibal, MD

Critically re-evaluating a common technique: Accuracy, reliability, and confirmation bias of EMG Mar 24, 2016

Dr. Stephen Goutman interviews Drs. Pushpa Narayanaswami and Seward Rutkove about their article Critically re-evaluating a common technique: Accuracy, reliability, and confirmation bias of EMG. This study supports that in evaluations of radiculopathy (1) serial EMG studies should be performed by the same electromyographer since intrarater reliability is better than interrater reliability; (2) knowledge of clinical information does not bias EMG interpretation substantially, (3) EMG has moderate diagnostic accuracy for radiculopathy with modest specificity and electromyographers should exercise caution interpreting mild abnormalities. Neurology. 2016 Jan 19:86(3):218-23.

Can Mycophenolate Mofetil be Tapered Safely in MG. A Retrospective, Multicenter Analysis Feb 24, 2016

Dr. Justin Willer interviews Dr. Lisa Hobson Webb about her Muscle and Nerve article on safely tapering mycophenolate mofetil in myasthenia gravis patients. MMF is frequently used to treat patients with MG but there is little information to guide clinicians on the safety of reducing the dose in well-controlled patients. Discussion includes standard dosages, determining clinical response to MMF and suggested goals in tapering MMF. Muscle Nerve. 2015 Aug;52:211-5. doi: 10.1002 mus.24694. Epub 2015 Jun 18.

Paraproteinemic Neuropathies Feb 05, 2016

Paraproteinemic Neuropathies

Inherited Etiologies of Rhabdomyolysis Oct 16, 2015

In this second part of the Clinical Presentation and Acquired Causes of Rhabdomyolysis podcast, Dr. Ted Burns interviews Drs. Jessica Nance and Andrew Mammen about their paper Diagnostic evaluation of rhabdomyolysis from the June 2015 issue of Muscle and Nerve. Rhabdomyolysis is characterized by severe acute muscle injury resulting in muscle pain, weakness, and/or swelling with release of myofiber contents into the bloodstream. Symptoms develop over hours to days after an inciting factor and may be associated with dark pigmentation of the urine. This podcast focuses on the inherited etiologies. For the article in Muscle and Nerve refer to Muscle Nerve 51: 793-810, 2015.

Pharmacotherapy for Neuropathic Pain in Adults: A Systematic Review and Meta-Analysis Sep 21, 2015

Dr. Stephen Goutman interviews Dr. Nadine Attal about the article she coauthored in Lancet Neurology on pharmacotherapy for neuropathic pain in adults. Drs. Goutman and Attal discuss the evidence and limitations supporting each class of medication aimed at the treatment of neuropathic pain and how these recommendations can be incorporated into clinical practice. Lancet Neurol. 2015 Feb;14:162-173.

Clinical Presentation and Acquired Causes of Rhabdomyolysis Sep 02, 2015

Dr. Ted Burns interviews Drs. Jessica Nance and Andrew Mammen about their paper Diagnostic evaluation of rhabdomyolysis from the June 2015 issue of Muscle and Nerve. This podcast focuses on the clinical presentation and acquired causes which can include substance abuse, medication or toxic exposures, electrolyte abnormalities, endocrine disturbances, and autoimmune myopathies. For the article in Muscle and Nerve refer to Muscle Nerve 51: 793-810, 2015.

Patterns of Clinical and Electrodiagnostic Abnormalities in Early Amyotrophic Lateral Sclerosis Jul 27, 2015

Patterns of Clinical and Electrodiagnostic Abnormalities in Early Amyotrophic Lateral Sclerosis by Drs. Neil Simon and Noah Kolb

NCS technique for ulnar neuropathy Jul 08, 2015

Mary E. Franklin, CNCT, R. EEGT. interviews William W. Campbell, MD on NCS technique for ulnar neuropathy

NCS Technique for Ulnar Neuropathy Jun 17, 2015

NCS Technique for Ulnar Neuropathy

Neuralgic Amyotrophy (Parsonage-Turner): Etiology, Treatment, Natural History May 07, 2015

Neuralgic Amyotrophy (Parsonage-Turner): Etiology, Treatment, Natural History by Nens Van Alfen

Neuralgic Amyotrophy (Parsonage-Turner): Presentation & Diagnosis Apr 30, 2015

Neuralgic Amyotrophy (Parsonage-Turner): Presentation & Diagnosis by Nens Van Alfen

Whole Exome Sequencing Apr 16, 2015

Whole Exome Sequencing by Dr. Daniel MacArthur

Next Generation Sequencing and its Impact on Neuromuscular Medicine Apr 13, 2015

Next Generation Sequencing and its Impact on Neuromuscular Medicine by Dr. Daniel MacArthur

ALS Onset is Influenced by the Burden of Rare Variants in Known ALS Genes Mar 27, 2015

ALS Onset is Influenced by the Burden of Rare Variants in Known ALS Genes by Drs. Baloh and Harms

Muscle Intrusion as a Potential Cause of Carpal Tunnel Syndrome Jan 21, 2015

Muscle Intrusion as a Potential Cause of Carpal Tunnel Syndrome by Dr. Michael Cartwright

Dermatomyositis and Autoantibodies by Dr. Andrew L. Mammen Dec 18, 2014

Dermatomyositis and Autoantibodies by Dr. Andrew L. Mammen. This is part three of a three part series on immune-mediated myopathies and autoantibodies.

Necrotizing Myopathies by Dr. Andrew L. Mammen Dec 11, 2014

Necrotizing Myopathies by Dr. Andrew L. Mammen. This is part one of a three part series on immune-mediated myopathies and autoantibodies.

Antisynthetase syndrome and myositis by Dr. Andrew L. Mammen Dec 04, 2014

Antisynthetase syndrome and myositis by Dr. Andrew L. Mammen. This is part one of a three part series on immune-mediated myopathies and autoantibodies.

Pathokinesiology of Duchenne Muscular Dystrophy Nov 21, 2014

Pathokinesiology of Duchenne Muscular Dystrophy by Ernest W. Johnson, MD

Clinical Value of Motor Nerve Conduction Velocity Determination Nov 20, 2014

Clinical Value of Motor Nerve Conduction Velocity Determination by Ernest W. Johnson, MD

Diagnosis and Treatment of Limb Girdle and Distal Dystrophies, Evidence-Based Guideline Nov 12, 2014

The guideline, entitled, Evidence-based Guideline Summary: Diagnosis and Treatment of Limb-Girdle and Distal Dystrophies. A Report of the Guideline Development Subcommittee of the American Academy of Neurology and the Practice Issues Review Panel of the American Association of Neuromuscular and Electrodiagnostic Medicine, was published in the October 13, 2014, online issue of Neurology®, AAN’s medical journal and makes recommendations about treating and managing complications, which may include muscle symptoms, hearth problems, and breathing problems.

Electrodiagnosis of Ulnar Neuropathy at the Elbow (Une): a Bayesian Approach. Nov 11, 2014

This podcast, Electrodiagnosis of ulnar neuropathy at the elbow (Une): a Bayesian approach, is based on an article in Muscle Nerve. 2014 Mar;49(3):337-44. doi: 10.1002/mus.23913.

Myotonic Dystrophy Health Index: Initial Evaluation of a Disease-Specific Outcome Measure Aug 29, 2014

Myotonic Dystrophy Health Index: Initial Evaluation of a Disease-Specific Outcome Measure

Vasculitic Neuropathies Jul 30, 2014

Vasculitic Neuropathies by Drs. Kelly Gwathmey and P. James B. Dyck interviewed by Dr. Ted

Improving Referring Physicians' Understanding of EMG Reports When Qualifying Radiculopathies Apr 10, 2014

Improving Referring Physicians' Understanding of EMG Reports When Qualifying Radiculopathies

Exome Sequencing by Michael Shy, MD and Stephan Zuchner, MD Mar 10, 2014

Exome sequencing discussion by Michael Shy, MD and Stephan Zuchner, MD, and interviewed by Ted Burns, MD

Spinal muscular atrophy: Development and Implementation of Potential Treatments Dec 19, 2013

Spinal muscular atrophy: Development and Implementation of Potential Treatments

Amyotrophic lateral sclerosis and palliative care: Where we are, and the road ahead by Dr. Blackhall Nov 21, 2013

Amyotrophic lateral sclerosis and palliative care: Where we are, and the road ahead by Dr. Leslie J. Blackhall, interviewed by Dr. Michael K. Hehir. Patients with amyotrophic lateral sclerosis (ALS) have high symptom burdens, including pain, fatigue, dyspnea, and sialorrhea, and they must make difficult decisions about the use of life-prolonging therapies, such as long-term mechanical ventilation. The impact of ALS is also felt by family caregivers who often struggle to meet the heavy physical, financial, and emotional demands associated with the illness. Expert multidisciplinary care may improve both quality and length of life of patients with ALS. However, although advances have been made in the treatment of some symptoms, others, including pain management, remain poorly studied. Involvement of palliative care specialists as part of the ALS multidisciplinary team is recommended, as we continue to work toward improving the quality of life for patients and their families. Muscle Nerve, 2012. The ideas and opinions expressed are solely those of the specific authors and do not necessarily represent those of AANEM.

Myasthenia Gravis and the use of IVIg and Therapeutic Plasma Exchange by Dr. Vern Juel Aug 30, 2013

Myasthenia Gravis and the use of IVIg and Therapeutic Plasma Exchange by Dr. Vern Juel interviewed by Dr. Elliot Dimberg.

Inherited Neuropathies: Clinical Overview and Update by Drs. Christopher Klein and Michael Shy Jul 30, 2013

Inherited Neuropathies: Clinical Overview and Update by Drs. Christopher Klein and Michael Shy interviewed by Dr. Laurie Gutmann. Muscle Nerve. 2013 Jan 30. doi: 10.1002/mus.23775

Electrodiagnosis of ulnar neuropathy at the elbow (Une): A bayesian approach Jun 26, 2013

Justic Willer, MD interviews Eric Loggigian, MD on electrodiagnosis of ulnar neuropathy at the elbow (Une): A bayesian approach.

Cytosolic 5'-nucleotidase 1A autoimmunity in sporadic inclusion body myositis by Dr.Steven Greenberg Jun 05, 2013

Cytosolic 5'-nucleotidase 1A autoimmunity in sporadic inclusion body myositis by Dr. Steven A. Greenberg interviewed by Dr. Ted Burns. Ann Neurol. 2013 Mar;73(3):408-18. doi: 10.1002/ana.23840.

Diagnostic Ultrasound of the Fibular (Peroneal) Nerve by Drs. Francis Walker and Michael Cartwright May 08, 2013

Diagnostic Ultrasound of the Fibular (Peroneal) Nerve by Drs. Francis Walker and Michael Cartwright interviewed by Dr. Ted Burns.

Diagnostic Ultrasound of the Ulnar Nerve and Ulnar Neuropathy at the Elbow by Drs. Francis Walker and Michael Cartwright Apr 19, 2013

Diagnostic Ultrasound of the Ulnar Nerve and Ulnar Neuropathy at the Elbow by Drs. Francis Walker and Michael Cartwright interviewed by Dr. Ted Burns.

Diagnostic Ultrasound of the Median Nerve and Median Neuropathy at the Wrist by Drs. Francis Walker and Michael Cartwright Mar 27, 2013

Diagnostic Ultrasound of the Median Nerve and Median Neuropathy at the Wrist by Drs. Francis Walker and Michael Cartwright interviewed by Dr. Ted Burns.

Paraneoplastic Neuromuscular Disorders Dec 28, 2012

Paraneoplastic Neuromuscular Disorders by Drs. Lydia Sharp and Steven Vernino

Diabetic cervical radiculoplexus neuropathy: a distinct syndrome expanding the spectrum of diabetic radiculoplexus neuropathies Nov 29, 2012

Diabetic cervical radiculoplexus neuropathy: a distinct syndrome expanding the spectrum of diabetic radiculoplexus neuropathies by Drs. P. J. Dyck and R. Massie, interviewed by Dr. Ted Burns. Brain. 2012 Oct;135(Pt 10):3074-88. doi: 10.1093/brain/aws244.

Chronic pain as a manifestation of potassium channel-complex autoimmunity by Dr. Christopher Klein Oct 23, 2012

Chronic pain as a manifestation of potassium channel-complex autoimmunity by Dr. Christopher Klein, interviewed by Dr. Ted Burns. Neurology. 2012;79:1136-44. Epub 2012 Aug 15.

Diagnosis of the Limb-girdle Muscular Dystrophies by Dr. Kate Bushby Aug 29, 2012

An interview with Dr. Kate Busby about diagnosis of the limb-girdle muscular dystrophies. Interviewed by Dr. Elliot Dimberg.

The Thoracic Outlet Syndromes Jul 17, 2012

The Thoracic Outlet Syndromes by Dr. Mark A. Ferrante

The Role of Exercise in Amyotrophic Lateral Sclerosis Apr 30, 2012

The Role of Exercise in Amyotrophic Lateral Sclerosis by Dr. Amy Chen

The Distal Hereditary Motor Neuropathies by Dr. Mary Reilly Mar 27, 2012

An interview with Dr. Mary Reilly about the article The distal hereditary motor neuropathies in J Neurol Neurosurg Psychiatry. 2012 83:6-14. Interviewed by Dr. Ted Burns.

Myokymic and Neuromyotonic Discharges by Drs. Ludwig Gutmann, Jasper Daube, and Devon Rubin Feb 23, 2012

Drs. Ted Burns, Ludwig Gutmann, Jasper Daube, and Devon Rubin discuss myokymic and neuromyotonic discharges.

Evidence Based Guideline on Treatment of Painful Diabetic Neuropathy by Vera Bril, MD Dec 30, 2011

Drs. Ted Burns and Vera Bril discuss the article Evidence Based Guidelines on Painful Diabetic Neuropathy. Muscle Nerve. 2011;43:910-7.

Cardiomyopathies in Muscular Dystrophies by Christopher Spurney, MD Oct 26, 2011

Drs. Ted Burns and Christopher Spurney discuss the article Cardiomyopathy of Duchenne muscular dystrophy: current understanding and future directions in Muscle Nerve 2011;44:8-19.

Treatment-induced Diabetic Neuropathy: A Reversible Painful Autonomic Neuropathy Oct 07, 2011

Treatment-induced Diabetic Neuropathy: A Reversible Painful Autonomic Neuropathy by Christopher H. Gibbons, MD

ALS may be caused by impaired protein recycling and degradation by Teepu Siddique, MD Aug 26, 2011

Drs Ted Burns and Teepu Siddique discuss the article Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia, Nature. 2011 Aug 21. doi: 10.1038/nature10353

Good Nutritional Control May Prevent Polyneuropathy After Bariatric Surgery by Pariwat Thaisetthawatkul, MD and P. James Dyck, MD Jul 21, 2011

Drs. Ted Burns, Pariwat Thaisetthawatkul, and P. James Dyck discuss the article Good Nutrional Control May Prevent Polyneuropathy After Bariatric Surgery Muscle Nerve. 2010 Nov;42(5):709-14.

Charcot-Marie-Tooth Disease Subtypes and Genetic Testing Strategies by Michael Shy, MD Jun 16, 2011

An interview by Dr. Ted Burns with Dr. Michael Shy about the article Charcot-Marie-Tooth disease subtypes and genetic testing strategies in Ann Neurol. 2011 Jan;69(1):22-33. doi: 10.1002/ana.22166.

Evaluation and management of foot drop by John D. Stewart, MBBS,MRCP(UK),FRCP Apr 15, 2011

Dr. Ted Burns and John Stewart discuss the evaluation and management of patients with foot drop, peroneal neuropathies, as well as L5 radiculopathies, lumbosacral plexopathies and proximal sciatic neuropathies.

A randomized study of alglucosidase alfa in late-onset Pompe's disease by Robert Leshner, MD, and Paula Clemens, MD Mar 10, 2011

An interview with Drs. Robert Leshner and Paula Clemens about the article A randomized study of alglucosidase alfa in late-onset Pompe's disease in N Engl J Med. 2010 Apr 15;362(15):1396-406.

Post-surgical Inflammatory Neuropathy by P. James B. Dyck, MD and Nathan Staff, MD Jan 10, 2011

An interview with Drs. P. James B. Dyck and Nathan Staff about the article Post-surgical Inflammatory Neuropathy in Brain. 2010 Oct;133(10):2866-80. Epub 2010 Sep 15.

Treatment of Chronic Inflammatory Demyelinating Polyneuropathy Oct 29, 2010

Treatment of Chronic Inflammatory Demyelinating Polyneuropathy by P. James B. Dyck, MD and Jennifer A. Tracy, MD

A Novel Autoantibody in Patients with Necrotizing Myopathy by Andrew L. Mammen, MD, PhD Aug 25, 2010

An interview with Dr. Andrew Mammen about A novel autoantibody recognizing 200 and 100 kDa proteins is associated with an immune-mediated necrotizing myopathy, Arthritis Rheum. 2010 May 23.

Pharmacokinetics of IVIg and Outcome in GBS by Krista Kuitwaard, MD Aug 05, 2010

An interview with Dr. Krista Kuitwaard about Pharmacokinetics of IVIg and outcome in GBS. Annals Neurol 2009;66:597-603.

A Practical Approach to the Metabolic Myopathies; Diagnosis and treatment: Glycogen Storage Myopathy Jul 08, 2010

A Practical Approach to the Metabolic Myopathies; Diagnosis and treatment: Glycogen Storage Myopathy by Mark A. Tarnopolsky, MD, PhD

Practical Approach to the Metabolic Myopathies: Diagnosis and Treatment-FAOD and Mitochondrial Myopathies by Mark A. Tarnopolsky, MD, PhD Jun 30, 2010

An interview with Mark A. Tarnopolsky, MD, PhD, about Metabolic myopathies: Update 2009. J Clin Neuromusc Disease 2009;10:97-121. Interviewed by Ted Burns, MD.

Genetics, Pathology, and Treatment of Nondystrophic Myotonias by Michael G. Hanna, MD, and Richard J. Barohn, MD Jun 23, 2010

An interview with Michael G. Hanna, MD, and Richard J. Barohn, MD, about genetics, pathophysiology, and treatment of nondystrophic myotonias. Interviewed by Ted Burns, MD.

Nondystrophic Myotonias by Michael G. Hanna, MD, and Richard J. Barohn, MD Apr 27, 2010

An interview with Michael G. Hanna, MD, and Richard J. Barohn, MD, about nondystrophic myotonias. Interviewed by Ted Burns, MD.

Pulsed High-dose Dexamethasone Versus Standard Prednisolone Treatment for CIDP (PREDICT study): a double-blind, randomized, controlled trial by Ivo N. van Schaik, MD, PhD Mar 25, 2010

An interview with Ivo N. van Schaik, MD, PhD, about pulsed high-dose dexamethasone versus standard prednisolone treatment for chronic inflammatory demyelinating polyradiculoneuropathy (PREDICT study): a double-blind, randomized, controlled trial. Interviewed by Ted Burns, MD and Robert Pascuzzi, MD.

Influenza Vaccination Safety for Patients with Myasthenia Gravis Jan 15, 2010

Influenza Vaccination Safety for Patients with Myasthenia Gravis by Lorne H. Zinman, MD, MSc, and David N. Juurlink, BPhm, MD, PhD

Inclusion Body Myositis Jan 06, 2010

Inclusion Body Myositis by Anthony A. Amato, MD, and Richard J. Barohn, MD

Evaluation and Treatment of the Inflammatory Myopathies Dec 24, 2009

Evaluation and Treatment of the Inflammatory Myopathies by Anthony A. Amato, MD, and Richard J. Barohn, MD

Toxic, Including Statin, Myopathies Oct 22, 2009

Toxic, Including Statin, Myopathies by Marinos Dalakas, MD

Is There an Increased Risk of GBS Following Influenza Vaccines or Other Vaccines? Oct 05, 2009

Is There an Increased Risk of GBS Following Influenza Vaccines or Other Vaccines? by Richard AC Hughes, MD

A Discussion about the Distal Symmetric Polyneuropathy Practice Guidelines by John D. England, MD Aug 20, 2009

An interview with John D. England, MD, about the practice parameters about distal symmetrical polyneuropathy. Interviewed by Elliot L. Dimberg, MD, and Robert M. Pascuzzi, MD.

Ascorbic Acid for Charcot–Marie–Tooth Disease by Joshua Burns, PhD Jul 21, 2009

An interview with Joshua Burns, PhD, about the paper, Ascorbic acid for Charcotâ€“Marieâ€“Tooth disease type 1A in children: a randomized, double-blind, placebo-controlled, safety and efficacy trial in Lancet Neurol. 2009 Jun;8(6):537-44. Interviewed by Ted Burns, MD.

Abnormal EMG Findings During Muscle Activation Jul 16, 2009

Abnormal EMG Findings During Muscle Activation by Jasper R. Daube, MD and Devon I Rubin, MD

Abnormal Needle EMG Findings with the Muscle at Rest Jun 29, 2009

Abnormal Needle EMG Findings with the Muscle at Rest by Jasper R. Daube, MD and Devon I Rubin, MD

Needle Electromygraphy Apr 17, 2009

Needle Electromygraphy by Jasper R. Daube, MD and Devon I Rubin, MD

Needlestick Injuries Among Electromyographers Jan 27, 2009

Needlestick Injuries Among Electromyographers by Farrah Mateen, MD

Risk of Hematoma Following Needle EMG Study in Anticoagulated Patients and Patients on Antiplatelet Therapy Jan 09, 2009

Risk of Hematoma Following Needle EMG Study in Anticoagulated Patients and Patients on Antiplatelet Therapy by Andrea Boon, MD

Stem Cell Replacement Research for ALS Dec 04, 2008

Stem Cell Replacement Research for ALS by Nick Maragakis, MD

Pediatric Electromyography Nov 04, 2008

Pediatric Electromyography by H. Royden Jones, MD

Myofibrillar Myopathies Oct 29, 2008

Myofibrillar Myopathies by Duygu Selcen, MD

Lessons Learned in Single Fiber EMG Aug 21, 2008

Lessons Learned in Single Fiber EMG by Erik Stalberg, MD, PhD and Donald Sanders, MD

Early Days of Single Fiber EMG Aug 01, 2008

Early Days of Single Fiber EMG by Erik Stalberg, MD, PhD and Donald Sanders, MD

IgG1 Antibodies to Acetylcholine Receptors in ‘Seronegative’ MG Jul 28, 2008

IgG1 Antibodies to Acetylcholine Receptors in ‘Seronegative’ MG by Angela Vincent, MD

Limb Girdle Muscular Dystrophy Jul 01, 2008

Limb Girdle Muscular Dystrophy by Kathryn N. North, MD

Histopathology of Neuropathy May 08, 2008

Histopathology of Neuropathy by Peter J. Dyck, MD

Lifetime Course in Myasthenia Gravis Apr 21, 2008

Lifetime Course in Myasthenia Gravis by Mikhail Charny, MD and Murali Pagala, MD

Critical Illness Polyneuropathy and Myopathy Mar 31, 2008

Critical Illness Polyneuropathy and Myopathy by Charles Bolton, MD

Sacral Plexopathies Feb 15, 2008

Sacral Plexopathies by Jinny Tavee, MD

Identifying Lumbosacral Radiculopathies Jan 30, 2008

Identifying Lumbosacral Radiculopathies by Timothy Dillingham, MD, MS

Pathokinesiology of Duchenne Muscular Dystrophy Jan 21, 2008

Pathokinesiology of Duchenne Muscular Dystrophy by Ernest W. Johnson, MD

Autosomal-Recessive and X-linked Forms of Hereditary Motor and Sensory Neuropathy in Childhood Dec 11, 2007

Autosomal-Recessive and X-linked Forms of Hereditary Motor and Sensory Neuropathy in Childhood by Monique Ryan, M Med, BS, FRACP and Robert Ouvrier, MD, BS, BSc

Immunotherapy in Guillain-Barre Syndrome Nov 20, 2007

Immunotherapy in Guillain-Barre Syndrome by Richard AC Hughes, MD

The Therapy of Congenital Myasthenic Syndromes Nov 05, 2007

The Therapy of Congenital Myasthenic Syndromes by Andrew G. Engel, MD

Safety of Nerve Conduction Studies in Patients with Implanted Cardiac Devices Aug 28, 2007

Safety of Nerve Conduction Studies in Patients with Implanted Cardiac Devices by Michelle Mellion, MD

Chronic Inflammatory Polyradiculoneuropathy Aug 15, 2007

Chronic Inflammatory Polyradiculoneuropathy by Peter J. Dyck, MD

Electromyographic and Magnetic Resonance Imaging to Predict Lumbar Stenosis, Low-back Pain, and No Back Symptoms by Andrew J. Haig, MD Jul 23, 2007

An Interview with Andrew J. Haig, MD, author of Haig AJ, et al. Electromyographic and magnetic resonance imaging to predict lumbar stenosis, low-back pain, and no back symptoms. J Bone and Joint Suregy 2007;89:358-366. Haig AJ, et al. Spinal stenosis, back pain, or no symptoms at all? A masked study comparing radiologic and electrodiagnostic diagnoses to the clinical impression. Arch Phys Med Rehabil 2006;87:897-903. Haig AJ, et al. The sensitivity and specificity of electrodiagnostic testing for the clinical syndrome of lumbar spinal stenosis. Spine 2005;30:2667-2676.0. Interviewed by Ted Burns, MD and Gregory T. Carter, MD, MS The participants in this Podcast had nothing to disclose.

Accuracy of Repetitive Nerve Stimulation for Diagnosis of Cramp-Fasciculation Syndrome Jul 10, 2007

Accuracy of Repetitive Nerve Stimulation for Diagnosis of Cramp-Fasciculation Syndrome by Taylor B. Harrison, MD and Michael Benatar, MBChB, DPhi

An Unusual Variant of Acute Idiopathic Polyneuritis Jun 21, 2007

An Unusual Variant of Acute Idiopathic Polyneuritis by C. Miller Fisher, MD

The Influence of the Reference Electrode on CMAP Configuration May 31, 2007

The Influence of the Reference Electrode on CMAP Configuration by John Kincaid, MD

Uremic Neuropathy: Clinical Features and New Pathophysiologic Insights May 09, 2007

Uremic Neuropathy: Clinical Features and New Pathophysiologic Insights by Matthew Kiernan, MD

Experimental Allergic Neuritis Apr 13, 2007

Experimental Allergic Neuritis by Raymond Adams, MD

Sporadic Onset of Erythermalgia Mar 30, 2007

Sporadic Onset of Erythermalgia by Stephen Waxman, MD

Peripheral Neuropathy in Krabbe Disease Mar 16, 2007

Peripheral Neuropathy in Krabbe Disease by Zaeem Siddiqi, MD

Radiculopathy and the Herniated Lumbar Disc Feb 27, 2007

Radiculopathy and the Herniated Lumbar Disc by Michael K. Schaufele, MD

Sural Neuropathy: Etiologies and Predisposing Factors Feb 16, 2007

Sural Neuropathy: Etiologies and Predisposing Factors by David Stickler, MD and Wayne Massey, MD

Is Exercise Necessary with Repetitive Nerve Stimulation in Evaluating Patients with Suspected Myasthenia Gravis Jan 31, 2007

Is Exercise Necessary with Repetitive Nerve Stimulation in Evaluating Patients with Suspected Myasthenia Gravis by Devon Rubin, MD

Myelin Protein Zero Mutation His39Pro Jan 08, 2007

Myelin Protein Zero Mutation His39Pro by Christopher J. Klein, MD

Interferon-Alpha Beta–Mediated Innate Immune Mechanisms in Dermatomyositis Dec 13, 2006

Interferon-Alpha Beta–Mediated Innate Immune Mechanisms in Dermatomyositis by Steven A. Greenberg, MD

Electrophysiological Findings in a Cohort of Old Polio Survivors Dec 04, 2006

Electrophysiological Findings in a Cohort of Old Polio Survivors by Eric J. Sorenson, MD

Clinical Value of Motor Nerve Conduction Velocity Determination Nov 16, 2006

Clinical Value of Motor Nerve Conduction Velocity Determination by Ernest W. Johnson, MD

Diabetic and Nondiabetic Lumbosacral Radiculoplexus Neuropathies by P. James B. Dyck, MD Nov 02, 2006

An Interview with P. James B. Dyck, MD author of "Diabetic and Nondiabetic Lumbosacral Radiculoplexus Neuropathies: New Insights into Pathophysiology and Treatment." an article appearing in Muscle & Nerve. 2002 Apr;25(4):477-91. Interviewed by Michelle Mauermann, MD and Jeremy Lanford, MD. The participants in this Podcast had nothing to disclose.

Rehabilitation Management of Peripheral Neuropathy Oct 20, 2006

Rehabilitation Management of Peripheral Neuropathy by Greg Carter, MD, MS

The Natural History of Primary Lateral Sclerosis Sep 28, 2006

The Natural History of Primary Lateral Sclerosis by Paul Gordon, MD

Facioscapulahumeral Muscular Dystrophy by Rabi Tawil, MD Sep 14, 2006

An Interview with Rabi Tawil, MD author of "Facioscapulahumeral Muscular Dystrophy" an article appearing in the July 2006 issue of Muscle & Nerve. Interviewed by Ted Burns, MD and Vern Juel, MD.

Mutations in SEPT9 Cause Heredic Neuralgic Amyotrophy by Phillip Chance, MD and Mark Hannibal, MD Aug 31, 2006

An Interview with Phillip Chance, MD and Mark Hannibal, MD authors of "Mutations in SEPT9 Cause Heredic Neuralgic Amyotrophy" an article appearing in Volume 30, Number 10, October 2005, Nature Genetics. Interviewed by Ted Burns, MD and Devon Rubin, MD.

Axillary Pain as a Heralding Sign of Neoplasm Involving the Upper Thoracic Root Jul 09, 2006

Axillary Pain as a Heralding Sign of Neoplasm Involving the Upper Thoracic Root by Devon Rubin, MD

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