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    Science

    Age of Aging

    Welcome to the Age of Aging, a podcast about living well with an aging brain. The Age of Aging is a podcast released every other Tuesday, covering a wide range of stories in aging research. Co-hosted by Jake Johnson and Terrence Casey from the Penn Memory Center communications team, each episode they will explore what it means to age with independence and dignity in the modern world.

    The Age of Aging is recorded and produced at the Michael Naidoff Communications Hub at the Penn Memory Center.

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    Latest Episodes:
    Making Art, Creating Mind Oct 28, 2025
    Show notes

    Although the Age of Aging often focuses on science, art has been a recurring theme. In Season 2, Episode 2, “Diet, Exercise, and... Doodling?”, we explored how creativity can support longevity. However, beyond art’s apparent health benefits, making and consuming art can also help us better understand the experience of aging. In many ways, the change and loss associated with aging are best understood through art.

    Today’s episode of theAge of Aging looks once again at art creation in aging through the stories and work of three artists living with brain disease.

    Joe Vanek, a stage designer for more than 40 years, experienced a stroke that changed how he viewed time and creativity.
    Scott LaMascus left graduate school in poetry to care for his father with ALS, finding meaning through writing and reflection.
    Neesa Becker-Procaccino, a professional illustrator, stopped working after an Alzheimer’s diagnosis but returned to art as a way to heal and connect.

    Each artist faced disruption. Yet through art, each found a way to continue creating and redefining identity in the face of illness.

    Resources available on the episode webpage linked below

    • Watch the full video featuring Neesa Becker-Procaccino

    • Learn more about Joe Vanek

    • Read more of Joe Vanek’s story

    • Read “Dispatches from the Dark Side of the Moon” and “Hesitant Light”

    • Check out more of Joe Vanek’s illustrations

      • Saint Patrick

      • The Queen of Hearts

      • Our Lady Guadalupe

      • The Child of Prague

      • Nutcracker

      • The Snow Queen

    • Follow Joe Vanek on Instagram

    • Learn more about Scott LaMascus

    • Read The Edited Tongue: A Family’s Year with ALS

    • Follow Scott Lamascus on Instagram

    • Visti The Center for Emerging Visual Artists’ website

    Special thanks to Joe Vanek, Scott LaMascus, PhD, and Neesa Becker-Procaccino for being a part of this episode.

    The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and Penn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Jason Karlawish, Emily Largent, and Meaghan Sharp.

    The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub fund and our sponsor, the TIAA Institute. The TIAA Institute is a think tank committed to building knowledge that advances lifelong financial security and well-being while considering the intersections of health and wealth. Their cutting-edge research provides actionable financial and longevity insights that help individuals and employers navigate the complex journey of aging.


    What is it Like to be Dan? Oct 14, 2025
    Show notes

    Over the past year, the Age of Aging has spoken with expert clinicians who study the brain, as well as individuals living with neurodegenerative diseases like Alzheimer’s. We believe that these two perspectives are essential for fully understanding dementia in 2025.

    In today’s episode, we hear from someone who can speak to both perspectives.

    Dr. Daniel Gibbs is a retired neurologist and author currently living with Alzheimer’s disease. Joined by his wife and caregiver, Lois Seed, he sat down with Age of Aging Executive Producer Dr. Jason Karlawish to discuss Dan’s experience. While the two physicians have had repeated conversations over the years concerning Dan’s diagnosis, Lois’ presence highlights how the disease has progressed and how their relationship has taken on new caregiving dynamics.

    What you will hear is an authentic depiction of living with Alzheimer’s disease, along with insights on how a partner begins to care for that person’s changing mind.

    Resources available on the episode webpage linked below

    • Read A Tattoo on My Brain: A Neurologists Personal Battle with Alzheimer’s Disease.
    • Watch the documentary, A Tattoo on My Brain
    • Learn more about Dan and Lois’ story (American Heart Association)
    • Read Dr. Daniel Gibbs’ blog

    Special thanks to Daniel Gibbs, MD, PhD, and Lois Seed for being a part of this episode.

    The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and Penn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Jason Karlawish, Emily Largent, and Meaghan Sharpe.

    The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub fund and our sponsor, the TIAA Institute. The TIAA Institute is a think tank committed to building knowledge that advances lifelong financial security and well-being while considering the intersections of health and wealth. Their cutting-edge research provides actionable financial and longevity insights that help individuals and employers navigate the complex journey of aging.


    Canine Care Sep 30, 2025
    Show notes

    At the Penn Memory Center, we often recommend exercise, social engagement, and a solid support system to help people age well. Owning a dog is not on that list, but maybe it should be. For many older adults, dogs are more than companions. They’re motivators to stay active, reasons to connect with neighbors, and steady sources of comfort through life’s challenges. Emerging research suggests that that this age-old bond between humans and dogs may be one of our healthiest friendships. On this episode of The Age of Aging, we celebrate dogs, and how they might help us live long, healthy lives.

    First, we hear from caregivers and dog owners about how their dogs help them care for their loved ones with dementia. Then, Professor Philip Tedeschi explains how humans’ co-evolution with dogs has made us perfect support system for one another. Lynn Cronomiz recounts how a powerful moment between a therapy dog and her mother with Alzheimer’s helped her process her mother’s passing. Finally, we explore humans’ inseparable connection with nature through the biophilia hypothesis.

    Resources available on the episode webpage linked below

    • Dog ownership in the U.S. statistics – American Veterinary Medical Association
    • “2025 Alzheimer’s Facts and Figures” – Alzheimer’s Association
    • Listen to Season 1 Episode 4, “Diagnosing Dementia,” featuring Lynn Cronomiz
    • Learn more about the Insitute for Human-Animal Connection
    • Visit KPETS, which Lynn Cronomiz does her therapy dog work with
    • Learn more about the “biophilia hypothesis”
    • Petfinder to adopt a pet near you
    • Visit the American Kennel Club website for more information on dog breeds

    Special thanks to Tom Casey, Miguel Centeno, Kathy Oldfield, Philip Tedeschi LCSW, MSSW, Lynn Cronomiz, and Carlo Siracusa DVM, PhD, DACVB, DECAWBM

    The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and Penn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Jason Karlawish, Emily Largent, and Meaghan Sharp.

    The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub fund and our sponsor, the TIAA Institute. The TIAA Institute is a think tank committed to building knowledge that advances lifelong financial security and well-being while considering the intersections of health and wealth. Their cutting-edge research provides actionable financial and longevity insights that help individuals and employers navigate the complex journey of aging.


    Just Aging Sep 16, 2025
    Show notes

    When we think about justice, older adults aren’t always top of mind. Yet in the United States, seniors often face stigma, exploitation, and insufficient social support, all while navigating cognitive and physical decline. As lifespans continue to grow globally, aging is a future we all hope to reach. So how do we ensure that future is just? And what does justice for older adults truly look like?

    Welcome to Season 4 of The Age of Aging! We’re kicking off with a vital and multifaceted topic: elder justice. Joining us are three leading voices who help unpack the legal, cultural, and systemic challenges facing older adults — and what can be done to address them.

    • MT Connolly, author and elder justice advocate, explores the deep-rooted cultural and structural issues that shape aging in America, and offers ideas for meaningful reform.
    • Charlie Sabatino, former director of the American Bar Association’s Commission on Law and Aging, explains how working with an elder law attorney can help preserve autonomy and dignity throughout the aging process.
    • Judge Lois Murphy shares insights from the courtroom, including a real-life guardianship case that illustrates the complexities and consequences of our legal system’s approach to elder care.

    If you enjoy the episode, please leave us a review and share it with a friend. Got a story idea for Season 4 or beyond? Reach out to us at ageofaging@pennmedicine.upenn.edu.

    Resources

    • Listen to Season 1 Episode 2, “Living Well with Purpose,” about supported decision-making.
    • Read The Measure of Our Age: Navigating Care, Safety, Money, and Meaning Later in Life by MT Connolly.
    • Learn more about MT Connolly.
    • More information on the RISE model
    • CDC Mortality Trend Graph
    • 2023 CDC Life Expectancy
    • Learn more about Charlie Sabatino
    • More information on guardianship in Pennsylvania
    • Learn more about Judge Murphy

    Special thanks to Charlie Sabatino JD, MT Connolly JD, and Judge Lois Murphy.

    The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and UPenn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Jason Karlawish, Emily Largent, and Meaghan Sharp.

    The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub fund and our sponsor, the TIAA Institute. The TIAA Institute is a think tank committed to building knowledge that advances lifelong financial security and well-being while considering the intersections of health and wealth. Their cutting-edge research provides actionable financial and longevity insights that help individuals and employers navigate the complex journey of aging.


    This Moment in Alzheimer's: Taking Stock and Look Forward Aug 26, 2025
    Show notes

    Welcome to a mid-year bonus episode of The Age of Aging! While the podcast takes a short break between seasons, we wanted to bring you a special update on the state of Alzheimer’s today. Penn Memory Center Co-Directors Dr. Jason Karlawish and Dr. David Wolk sat down with Terrence Casey to share their reflections from this year’s Alzheimer’s Association International Conference (AAIC), which they attended earlier this summer. They discuss their biggest takeaways, including the impact of NIH funding cuts, the rapid innovations that continue to shape the field, and what they’re keeping their eye on for next year’s conference in London.

    We hope you enjoy and stay tuned for season 4 of The Age of Aging this fall! If you enjoy the show, leave us a review and share this episode with a friend. If you have any story suggestions for Season 4 and beyond, contact us at ageofaging@pennmedicine.upenn.edu.

    Resources

    • Learn more about the Alzheimer’s Association and AAIC

    Special thanks to Jason Karlawish, MD and David Wolk, MD.

    The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and UPenn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Jason Karlawish, Emily Largent, and Meaghan Sharp.


    Season 3 Finale: Neither Superheroes, Nor Angels Jul 22, 2025
    Show notes

    When we talk about dementia on this podcast, we are often talking about its most common cause: Alzheimer's disease. However, dementia has many causes, and among the most prevalent after Alzheimer’s is Lewy Body Disease. Though it can share similarities with Alzheimer’s, Lewy Body Dementia (LBD) has distinct symptoms and challenges that can complicate diagnosis, treatment, and caregiving.

    On the season 3 finale of the Age of Aging, we explore Lewy Body Disease and its impact on caregivers and families.

    We begin with a clip from the documentary Facing the Wind, which follows two caregivers as they navigate caring for their husbands with Lewy Body Disease. Then, Co-Host Terrence Casey shares his reflections on a live Q&A following a screening of the film in Philadelphia. Finally, Dr. Jason Karlawish provides a deeper insight into Lewy Body Disease, its significance in the world of aging research, and what it reveals about caregiving today.

    Resources

    • Find an upcoming screening of Facing the Wind
    • Learn more about Lewy Body Dementia
    • National Institute of Health booklet on Lewy Body Dementia
    • More resources on Lewy Body Dementia Association website

    Special thanks to Tony Heriza, Deirdra Fishel, and Linda Szypula for sharing their film with us and being a part of this episode. Special thanks as well to ARTZ Philidelphia for presenting the screening and Q&A.

    The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and UPenn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Jason Karlawish, Emily Largent, and Meaghan Sharp.


    Okay, Let's Talk About Sex and Dementia Jul 08, 2025
    Show notes

    Sex and intimacy can be difficult topics to navigate, especially for caregivers and their partners facing the challenges of a dementia diagnosis. These conversations are often avoided, yet the emotional toll of intimacy-related struggles can be profound, bringing feelings of grief, confusion, and isolation. The stigma surrounding sex and dementia only deepens this silence, making open dialogue all the more essential.

    On this episode of The Age of Aging, we explore one caregiver’s deeply personal journey through love, loss, and change. Alison Lynn, Director of Social Work at the Penn Memory Center, speaks with author and advocate Lisa Marshall about her book Oh, Hello Alzheimer’s: A Caregiver’s Journey of Love.

    Lisa shares the story of her husband Peter’s Alzheimer’s diagnosis and the emotional complexities that followed — including her decision to end their sexual relationship. With honesty and vulnerability, she reflects on the grief, guilt, and growth that came with that choice, offering insight and solidarity to others navigating similar paths.

    Resources

    • This week’s Beautiful Question: What is a place with special meaning to you? Leave us a message at (571) 449-6474.
    • Read Lisa Marshall’s book, Oh, Hello Alzheimer's: A Caregiver's Journey of Love
    • Visit Lisa’s website

    Special thanks to Lisa Marshall and Alison Lynn, MSW, LCSW for being a part of this episode.

    The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and UPenn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Jason Karlawish, Emily Largent, and Meaghan Sharp.


    Transforming a System of Care Jun 24, 2025
    Show notes

    The U.S. healthcare system is changing—especially when it comes to caring for older adults. The COVID-19 pandemic revealed how vulnerable our aging population is, and how unprepared many parts of the system remain. Overstressed nursing homes, overworked primary care physicians, and a lack of accessible resources for dementia care remain persistent challenges.

    But there’s hope. New technologies, treatments, and care models are reshaping what aging and diagnosis can look like. The question now is: How do we deliver these advances to the people that need them most?

    In this episode of the Age of Aging, we explore the evolving landscape of elder care in the U.S.

    We start with Dr. PJ Brennan, the Chief Medical Officer of Penn Medicine who discusses the challenges the U.S. healthcare system is currently facing with its elder population. Then Dr. Kyra O’brien explains why the new anti-amyloid therapies, lecanemab and donanemab, might help more people get diagnosed and allow clinics like the Penn Memory Center to expand their resources. Finally, Dr. O’Brien dives into the new federal program “GUIDE,” which aims to reshape dementia care across the country.

    Resources

    • This week’s Beautiful Question: What is something that you could teach someone? Leave us a message at (571) 449-6474.
    • Listen to our episode on anti-amyloid therapies, “In Sickness and in Health”
    • Read more about anti-amyloid therapies
    • More information about GUIDE at Penn Medicine
    • Penn GUIDE interest form
    • General information on GUIDE (cms.gov)

    Special thanks to PJ Brennan, MD, and Kyra O’Brien, MD, for being a part of this episode.

    The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and UPenn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Jason Karlawish, Emily Largent, and Meaghan Sharp.


    Early Onset Caregiving Jun 10, 2025
    Show notes

    We often think of dementia as something that affects the oldest among us, and that’s often true; at the Penn Memory Center, the average age of diagnosis is between 70 and 75. In most of those cases, caregiving falls to a spouse, partner, or adult child. But what happens when dementia is diagnosed before the age of 65?

    In this episode of the Age of Aging, we explore early onset dementia and the young caregivers who step up when their lives are just beginning. The stories of teens and young adults reveal the unique challenges of caregiving and what they can teach us about care across all ages.

    We begin with a segment from a recent episode of Science Friday, where Executive Producer Dr. Jason Karlawish discussed the FDA’s recent approval of new diagnostic blood tests for Alzheimer’s disease. Then, Paige Censale shares the life-changing decision she faced: accept a full scholarship to college or stay home as the sole caregiver for her mother. We then learn about Lorenzo’s House, an organization dedicated to supporting young caregivers and families impacted by early onset dementia. Finally, we hear from Sierra, a 16-year-old from South Pasadena California who began caring for her father with early onset dementia when she was just 8 years old.

    Resources

    • This week’s Beautiful Question: What is something in your home that you treasure? Leave us a message at (571) 449-6474.
    • Thank you to Science Friday for letting us play part of their episode with Dr. Karlawish. You can listen to the full episode here.
    • Check out Paige Censale’s website
    • Learn more about early onset dementia (WebMD)
    • Learn more about Lorenzo’s House
    • Join Lorenzo’s House’s “Youth Summit” (June 20 – 21)

    Special thanks to the Science Friday team, Jason Karlawish, MD, Paige Censale, Diana Cose M. ED, Patti LaFleur M. ED, CPD, Sierra Mercer, and Alison Lynn, MSW, LCSW, for being a part of this episode.

    The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and UPenn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Jason Karlawish, Emily Largent, and Meaghan Sharp.


    From Surviving to Thriving After 50 May 27, 2025
    Show notes

    The world is getting older—and that reality is what inspired this podcast. Thanks to advances in medicine, healthier lifestyles, and improved living conditions, people are living longer than ever. That’s a good thing. However, longer lives will also require a lot of change from both individuals and society. We will have to prepare now for something earlier generations never considered possible: the second 50 years of our lives.

    In this episode of the Age of Aging, Executive Producer Jason Karlawish speaks with Debra Whitman, Chief Public Policy Officer at AARP, about her new book, The Second Fifty: Answers to the 7 Big Questions of Midlife and Beyond. Together, they explore what it means to plan not just for retirement, but for an entire second half of life—dispelling myths about aging and offering practical insights for the years ahead.

    Resources

    • This week’s Beautiful Question: What is something that makes you laugh? Leave us a message at (571) 449-6474.
    • Get your copy of The Second Fifty: Answers to the 7 Big Questions of Midlife and Beyond

    Special thanks to Debra Whitman and Jason Karlawish, MD, for being a part of this episode.

    The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and UPenn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Jason Karlawish, Emily Largent, and Meaghan Sharp.

    The Age of Aging is made possible by generous donors like you. To learn more visit www.pennmemorycenter.org/ageofaging


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