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    Technology

    This Week in AI

    An experts-only AI podcast: Think the ‘All In’ podcast for AI. Jason + 3 CEO-level experts breaking down the news & trends.

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    Latest Episodes:
    Is Meta's Muse agent reading your iMessages, even after you decline access? | E33 Oct 01, 2026
    Show notes

    This Week In Startups is made possible by:PayPal: https://paypal.com/businessToday’s show:OpenAI is delaying GPT-6.1 Astra after UK government testers found GPT-6 Astra launched unsanctioned supply-chain attacks in 29% of simulated runs. Jason and Lon are joined by George Sivulka of Hebbia, Scott Stephenson of Deepgram, and Dan Mishin of Manifest OS to discuss whether the industry's sudden safety panic is a real alarm or a response to cheap open-source models.Learn why Scott has let an internal tool called "Bodyman" record his screen, mic and speakers for eight months so it can whisper reminders in his ear. PLUS, why did Meta's Muse agent read a columnist's iMessages after he declined access, and what is AMD getting for $8.2B with Fei-Fei Li's World Labs?Guests:George Sivulka on X: https://x.com/gsivulka?lang=en Hebbia: https://www.hebbia.com/Scott Stephenson on X: https://x.com/deepgramscott Deepgram: https://deepgram.com/Dan Mishin on X: https://x.com/mishindan1 Manifest OS: https://manifestos.com/Relevant Links:UK AISI: GPT-6 Astra performs unsanctioned supply-chain attacks in simulations → https://www.aisi.gov.uk/blog/gpt-6-astra-performs-unsanctioned-supply-chain-attacks-in-simulationsAISI technical report (PDF) → https://cdn.prod.website-files.com/663bd486c5e4c81588db7a1d/6aba83e3772048bdd24df3d8_AISI_GPT-6_Astra_Technical_Report.pdfJ.P. Morgan: Dan's story of the first electrified house in New York → https://en.wikipedia.org/wiki/J._P._MorganILOVEYOU virus: the script-kiddie era Jason referenced → https://en.wikipedia.org/wiki/ILOVEYOUAMD acquires World Labs in an $8.2B all-stock deal (Quartz) → https://qz.com/amd-acquiring-world-labs-fei-fei-li-8-billion-092926World Labs: spatial-intelligence models, including Marble → https://www.worldlabs.ai/Instinct raises $1B Series C at a $10B valuation (PYMNTS) → https://www.pymnts.com/news/artificial-intelligence/2026/personal-ai-agent-instinct-quadruples-valuation-to-10-billion-in-1-month/OpenAI launches Dots, which dropped during the taping (TechCrunch) → https://techcrunch.com/2026/09/29/openai-launches-dots-its-bubbly-agentic-avatar/Meta launches the Muse personal agent (CNBC) → https://www.cnbc.com/2026/09/08/meta-personal-ai-agents-public-reckoning-privacy-safety.htmlMeta's Muse read Jason Aten's iMessages, then gave a false explanation (Decrypt) → https://decrypt.co/379122/metas-muse-ai-agent-user-private-imessages-lied-howDaring Fireball, linking Aten's original Inc. column → https://daringfireball.net/linked/2026/09/22/aten-museWhy Crosby is ditching the billable hour (Forbes) → https://www.forbes.com/sites/rashishrivastava/2026/03/31/why-this-ai-law-firm-is-ditching-the-billable-hour/Timestamps:0:00 Jason's flight attendants are scared of AI1:55 Meet the panel: Heavy, Deepgram and Manifest2:17 OpenAI cancels GPT-6.1 Astra over safety regressions7:41 Hugging Face hack and Nvidia's open agent safety platform16:11 AI psychosis and getting one-shotted by agents28:46 AMD buys Fei-Fei Li's World Labs for $8.2B32:08 Will open source commoditize world models too?34:34 Is the AI buildout bigger than the railroads?36:59 Around the horn: which AI agent are you using?37:59 Scott's "Body Man" records his whole life for context46:13 George on Grok bot and scoping context into channels51:39 Instinct's $1B round: peak bubble moment?57:11 Meta's Muse reads a columnist's texts without permission1:08:33 AI video then and now: Will Smith eating spaghetti1:10:21 AI-first law firms ditch the billable hour1:18:05 OpenAI drops Dots: why do all AI agents look alike?Subscribe to our newsletters on Substack:TWiST: https://twistartups.substack.com/TWiAI: https://www.thisweekinai.ai/TWiVC: https://thisweekinvc.substack.com/Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcpCheck out all our partner offers: https://partners.launch.co/


    Why OpenAI Should Buy Off the World’s Top Mathematicians | E32 Sep 24, 2026
    Show notes

    This Week In Startups is made possible by:

    PayPal - Pay zero processing fees on your first $100K in eligible PayPal payment volume. Learn more at https://paypal.launch.co


    Today’s show:

    OpenAI is claiming to have solved more than 100 math problems on top of Navier-Stokes, and guest Richard Socher thinks it's absurd for mathematicians to push back on AI solving their problems too quickly. Jason and Lon are also joined by Guy Podjarny of Tessl and Jake Loosararian of Gecko Robotics to argue over who wins when AI agents start collaborating with, and potentially replacing, academics and scholars.

    Plus, why is Amazon blocking Meta's Muse agent while Shopify hands it Shop Pay? Should we trust Anthropic’s new wet lab? And what’s so exciting about Typesafe’s new text-less model Jev?

    Guests:

    Guy Podjarny on X: https://x.com/guypod Tessl: https://tessl.io/

    Richard Socher on X: https://x.com/RichardSocher?lang=en You.com: https://you.com/

    Jake Loosararian on X: https://x.com/jakeloosy Gecko Robotics: https://www.geckorobotics.com/


    Relevant Links:

    The Eureka Machine by Richard Socher → https://shop.hachettebookgroup.com/products/the-eureka-machine-9781541705708

    Shopify and Meta partner so Muse can buy through Shop Pay (Quartz) → https://qz.com/shopify-meta-muse-ai-agent-shop-pay-checkout-092226

    Meta’s standoff with Amazon over Muse — https://www.cnbc.com/2026/09/23/metas-standoff-with-amazon-over-muse-comes-ahead-of-meta-connect.html

    OpenAI says its internal model solved 100+ math problems on top of Navier-Stokes (The Decoder) → https://the-decoder.com/openai-says-its-internal-model-solved-over-100-long-standing-math-problems-after-just-a-month-of-training/

    OpenAI's IAS-hosted advisory group, with Timothy Gowers and Edward Witten (Business Standard) → https://www.business-standard.com/technology/tech-news/openai-s-model-solves-100-maths-problems-company-forms-advisory-group-126092200561_1.html




    Timestamps:

    0:00 OpenAI claims 100+ solved math problems after Navier-Stokes

    0:41 Welcome back to This Week in AI

    1:04 Meet the guests: Guy Pigeon, Richard Socher, and Jake Lucier

    2:54 Shopify and Meta team up so Muse can check out with Shop Pay

    6:19 Why Amazon blocked Muse: ads, habit, and owning the front door

    15:13 Do coupons and ads survive one-shot agent shopping?

    18:04 OpenAI's internal model resolves 100+ longstanding math problems

    26:07 Jason's pitch: pay the top 50 mathematicians $100M each

    34:29 Why scientists should be as famous as NBA players

    37:41 Anthropic's biology wet lab: can we trust it?

    40:59 Why biology is the field AI will transform most

    54:22 AI's trust problem and the wealth gap

    57:29 The AI Tax and Work Protection Act

    1:01:29 Will AI unemployment show up in the data?

    1:11:47 TypeSafe AI's Jev: fast, calibrated decisions for software

    Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com

    Check out the TWIST500: https://www.twist500.com

    Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp

    Follow Lon:

    X: https://x.com/lons

    Follow Jason:

    X: https://twitter.com/Jason

    LinkedIn: https://www.linkedin.com/in/jasoncalacanis


    Check out all our partner offers: https://partners.launch.co/

    Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland

    Subscribe to our Substack Newsletters!

    TWiST: https://twistartups.substack.com/

    TWiAI: https://www.thisweekinai.ai/

    TWiVC: https://thisweekinvc.substack.com/

    Follow TWiST:

    Twitter: https://twitter.com/TWiStartups

    YouTube: https://www.youtube.com/thisweekin

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    TikTok: https://www.tiktok.com/@thisweekinstartups

    Substack: https://twistartups.substack.com



    The biggest AI threat still comes from humans | E31 Sep 17, 2026
    Show notes

    This Week In Startups is made possible by:

    PayPal: paypal.launch.co

    Today’s show:

    Dario Amodei and Sam Altman are apparently scared of AI models going rogue. Swarms of agents spontaneously deciding to copy themselves over to thousands of computer systems and plot world domination.

    Our panelists this week — Kevin Mandia (Armadin) and Soups Ranjan (Sardine AI) — investigate real AI-based attacks every single day, and they suggest we’re hyping the wrong concerns. The actual danger isn’t coming from an AI system that turns hostile. It’s human beings, like criminals, using AI to drain your bank account.

    Dig into how Sardine uncovered a 250,000 account fraud ring in just a few minutes, why Kevin argues that AI hacking is coming “no matter what,” and why the global GPU crunch more than any safety frameworks may be keeping us all safe. For now.

    Guests:

    Soups Ranjan on X: https://x.com/soupsranjan Sardine AI: https://www.sardine.ai/

    Kevin Mandia on LinkedIn: https://www.linkedin.com/in/kevin-mandia-0a07173/ Armadin: https://www.armadin.com/

    Relevant Links:

    "We Must Pace the Frontier" — Dario Amodei's Sept 12 essay

    Axios: Anthropic and OpenAI CEOs call for a slowdown

    Trump and the White House push back

    Forbes: what the essay actually proposes

    2026 OpenAI agent cyberattacks

    GLM-5.3 — Z.ai's open-weight model

    Hermes Agent — the agent framework Ranjan runs in a local harness

    Timestamps:


    0:00 Dario Amodei's "We Must Pace the Frontier" essay

    1:51 Kevin Mandia: how scared should we be of agentic attack swarms?

    6:53 Rogue agents vs. humans pointing AI at a target

    9:52 250,000 fraudulent account signups in two days

    16:59 Sam Altman's two ways AI fails

    19:41 Open-weight models are catching up

    21:39 Why proprietary data is the new moat

    27:51 Mixing frontier models with open models

    35:37 Bloomberg: Chinese hackers lean on DeepSeek because it's cheap

    37:05 How much in-house expertise it takes to use AI well

    42:56 Armadin's Palo Alto office and the Palantir playbook

    1:02:54 AI and jobs: normal churn or something bigger?

    1:07:19 What founders are actually saying in the group chats

    1:08:49 Every meeting recorded, every meeting summarized

    Subscribe to TWiAI on Substack: https://thisweekinai.ai

    Follow Lon:

    X: https://x.com/lons

    Follow Jason:

    X: https://twitter.com/Jason

    LinkedIn: https://www.linkedin.com/in/jasoncalacanis

    Thank you to our partners:

    Check out all our partner offers: https://partners.launch.co/

    Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland

    Check out Jason’s suite of newsletters: https://substack.com/@calacanis

    Follow TWiST:

    Twitter: https://twitter.com/TWiStartups

    YouTube: https://www.youtube.com/thisweekin

    Instagram: https://www.instagram.com/thisweekinstartups

    TikTok: https://www.tiktok.com/@thisweekinstartups

    Substack: https://twistartups.substack.com



    OpenAI's chief scientist wants to slow down | E30 Sep 10, 2026
    Show notes

    This Week In Startups is made possible by:

    PayPal - Pay zero processing fees on your first $100K in eligible PayPal payment volume. Learn more at paypal.launch.co

    Today’s show:

    OpenAI's chief scientist wrote a lengthy manifesto arguing that no lab has solved alignment, mere days after GPT-6 Astra shipped. Jason and Lon are joined by Tudor Achim of Harmonic, Alex Elias of Qloo, and Ahmed Ahres of Reactor to figure out if that's genuine alarm being expressed or just another pre-IPO sales pitch and play for regulatory capture.

    Plus news broke while we were recording! OpenAI is claiming to have solved a second Millennium Prize problem, after a 25-year-plus weight. AND, who is paying influencers to tell you AI is wonderful/harmful? And why?

    Guests:

    Tudor Achim on X: https://x.com/tachim

    Harmonic: https://harmonic.fun/

    Alex Elias on X: https://x.com/ape

    Qloo: https://www.qloo.com/

    Ahmed Ahres on X: https://x.com/Boudatw

    Reactor: https://reactor.inc/

    Relevant Links:

    Jakub Pachocki, "An Alien Mind" — https://openai.com/index/an-alien-mind/

    GPT-6 Astra — https://fortune.com/2026/09/03/openai-debuts-gpt-6-astra-computer-use-greg-brockman-says-start-of-agi/

    OpenAI: "On the Navier–Stokes Millennium Prize Problem" — https://openai.com/index/navier-stokes-solution/

    ControlAI — the nonprofit that sponsored the SciShow episode — https://controlai.org/

    New York Times (Eli Tan), "Corporate America Is Getting Hooked on Open-Source A.I." — https://www.nytimes.com/2026/09/04/technology/open-source-ai-companies.html

    Artificial trailer and the cast → https://variety.com/2026/film/news/artificial-trailer-andrew-garfield-openai-biopic-1236802616/

    Timestamps:

    0:00 "An Alien Mind"

    3:08 AI psychosis, marketing, or half a mile ahead on the racetrack?

    12:52 The Manhattan Project analogy

    15:20 Tudor: if it's really that dangerous, the answer is nationalization

    17:02 Regulatory capture: Bill Gurley at All-In, Sacks, and who can afford to be regulated

    20:37 The influencer propaganda tape

    23:22 BREAKING: OpenAI solves the Navier-Stokes Millennium Prize problem

    28:53 The Hank Green / SciShow video sponsored by ControlAI

    32:11 Fogging and flooding

    46:47 UBS will require AI skills from its 2027 graduate

    56:41 How LAUNCH hired its associates-in-training

    57:18 NYT: Corporate America is getting hooked on open-source AI

    1:04:16 Alex on Qloo's shift from NYT film critics on payroll to small specialized models

    1:09:35 First look: the "Artificial" teaser trailer

    1:14:34 Sam Altman's bunker, Peter Thiel, and casting rundown


    Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com

    Check out the TWIST500: https://www.twist500.com

    Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp

    Follow Lon:

    X: https://x.com/lons

    Follow Jason:

    X: https://twitter.com/Jason

    LinkedIn: https://www.linkedin.com/in/jasoncalacanis

    Check out all our partner offers: https://partners.launch.co/

    Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland

    Check out Jason’s suite of newsletters: https://substack.com/@calacanis

    Follow TWiST:

    Twitter: https://twitter.com/TWiStartups

    YouTube: https://www.youtube.com/thisweekin

    Instagram: https://www.instagram.com/thisweekinstartups

    TikTok: https://www.tiktok.com/@thisweekinstartups

    Substack: https://twistartups.substack.com



    The real danger is the gap BETWEEN two robots | E29 Sep 03, 2026
    Show notes

    This Week In Startups is made possible by:

    Paypal


    Today’s show:

    Anthropic gave AI agents hands, allowing them to control real-world equipment like robots and microscopes… but is it safe to give autonomous agents their own lasers? Gatik’s Gautam Narang says the real danger isn’t one machine like this going rogue, it’s the exploit surface hiding in the gaps between the machines.

    Plus, in a huge week for AI news… OpenClaw shipped its biggest release ever. AND the entire industry debated whether or not agents are forming “civilizations.”

    On TWiAI Ep 29, our expert panel — including Gautam (Gatik), Russ d’Sa (LiveKit), and Billy Kraft (Path) — explores the world of “multiplayer agents,” and Jason suggests the one killer feature that would make any new agentic app the market leader. PLUS Perplexity’s new “Hybrid Compute” just for Macs, some advice for Apple’s new CEO John Ternus, the value of “AI Detectors” like Pangram, and Jason’s complete guide to tipping and over-tipping.


    Guests:

    Gautam Narang on X: https://x.com/gautam_narang?lang=en

    Gatik: https://www.gatik.ai/

    Russ d’Sa on X: https://x.com/dsa

    LiveKit: https://livekit.com/

    Billy Kraft on X: https://x.com/billykraft

    Path: https://path.dev/


    Relevant Links:

    OpenClaw 2.0 - https://openclaw.ai/blog/openclaw-2-accidentally

    Grok Bot — https://grok.com

    Buzz — https://buzz.build

    Perplexity Hybrid Compute — https://www.perplexity.ai/hub/blog/introducing-hybrid-compute-on-mac

    John Ternus — https://www.apple.com/leadership/john-ternus/

    OpenAI's Mac mini / Mac Studio buying spree https://the-decoder.com/openai-and-rival-ai-labs-are-buying-tens-of-thousands-of-mac-minis-to-train-computer-use-agents/

    Waymo hits a child — https://www.cnbc.com/2026/01/29/waymo-nhtsa-crash-child-school.html


    Timestamps:


    2:58 OpenClaw 2.0

    5:11 "Agents ARE AI"

    7:27 Billy: OpenClaw is still too technical for business users

    9:00 Slack Code, and collaborative prompting

    10:40 Multi-agent orchestration and Stripe's "minions"

    14:13 Slack's moat, switching costs, and the Salesforce rebound

    15:11 Jason's "Oracle": a heads-up display for the whole company

    18:42 The Hugging Face breach: who's responsible when agents go rogue?

    19:42 Perplexity launches Hybrid Compute — local models on your Mac

    21:39 Why unmetered local tokens change corporate behavior

    26:57 Gatik's Autonomous Vehicle AI Stack

    32:22 Jason's Tesla FSD stories

    34:05 Are AV companies being pushed to move too fast?

    41:38 Trucking is a "have to have," robotaxis are a "nice to have"

    42:36 Jason's fix: a safety driver for the first million rides

    46:50 Why physical AI's adoption curve runs in decades

    52:21 Anthropic's Model Hardware Standard (MHS), explained

    1:06:27 How Jason got onion rings on the menu at Buck's of Woodside

    1:09:05 AI detectors under fire: Pangram, MIT, and the handwritten diary

    1:15:20 Why AI is "very mid" at writing (it learned from the average)

    1:17:11 The Orin Kerr test: Pangram catches Claude writing as Kerr

    1:28:35 Micro Duck and designing robots with Claude

    1:29:42 Phil Kaplan's $14 custom circuit boards



    Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com

    Check out the TWIST500: https://www.twist500.com

    Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp

    Follow Lon:

    X: https://x.com/lons

    Follow Jason:

    X: https://twitter.com/Jason

    LinkedIn: https://www.linkedin.com/in/jasoncalacanis

    Check out all our partner offers: https://partners.launch.co/

    Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland

    Check out Jason’s suite of newsletters: https://substack.com/@calacanis

    Follow TWiST:

    Twitter: https://twitter.com/TWiStartups

    YouTube: https://www.youtube.com/thisweekin

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    TikTok: https://www.tiktok.com/@thisweekinstartups

    Substack: https://twistartups.substack.com


    XBOW Founder: “Your Infrastructure is Not Safe” | EP 28 Aug 27, 2026
    Show notes

    This Week In Startups is made possible by:PaypalToday’s show:XBOW’s AI has held the top rank on the HackerOne leaderboard for more than a year. On TWiAI, founder Oege de Moor (who also built GitHub Copilot) tells us that no one’s infrastructure is truly safe anymore, now that open-weight models are trailing the American frontier by only a couple of months. Staging a serious cyberattack is now cheap and accessible, with attackers able to get dangerously solid results quickly from relatively cheap, open-source options from China.Guests:Runbin Dong on LinkedIn: linkedin.com/in/runbindongScale Social: https://scalesocial.ai/Oege de Moor on X: https://x.com/oegerikusXBOW: https://xbow.com/Relevant LinksWSJ: Nvidia-Poolside deal: https://www.wsj.com/tech/ai/nvidia-is-spending-6-billion-to-build-a-powerful-u-s-alternative-to-chinese-ai-c51c38ccPoolside: https://poolside.ai/Silicon Angle: Nvidia in talks to invest in Perplexity: https://siliconangle.com/2026/08/24/nvidia-reportedly-eyes-another-investment-in-perplexity-ai-at-a-30b-valuation/Perplexity: https://www.perplexity.ai/Bloomberg: Chinese hackers using DeepSeek: https://www.bloomberg.com/news/articles/2026-08-24/chinese-hackers-use-deepseek-to-boost-attacks-researchers-say-mt7o4205Nvidia: Groq 3 LPX enters full production: https://nvidianews.nvidia.com/news/nvidia-groq-3-lpx-now-in-full-production-with-world-class-speed-for-agentic-aiCNBC: Groq-Nvidia acqui-hire deal: https://www.cnbc.com/2025/12/24/nvidia-buying-ai-chip-startup-groq-for-about-20-billion-biggest-deal.htmlOpenAI on early Jalapeño results: https://openai.com/index/jalapeno-first-results/Stanley Druckenmiller WSJ op-ed: https://www.wsj.com/opinion/let-the-bond-market-speak-81529d74Druckenmiller confirms op-ed was authored with AI: https://www.notus.org/media/stanley-druckenmillers-wsj-op-ed-bessent-aiPangram: https://www.pangram.com/Alabama AG: OpenAI subpoena announcement: https://www.alabamaag.gov/attorney-general-marshall-launches-investigation-into-openai-and-sam-altman-for-massive-artificial-intelligence-data-breach/Ox Alpha on OpenRouter: https://openrouter.ai/stealth/ox-alphaApple: M6 and M5 Ultra press release: https://www.apple.com/newsroom/2026/08/apple-introduces-m6-and-m5-ultra-for-a-big-leap-in-performance-and-ai-compute/9 to 5 Mac: M5 Mac Studio launch: https://9to5mac.com/2026/08/25/apple-unveils-next-generation-mac-studio-with-m5-max-and-m5-ultra/DHH on X: Ubiquity comments: https://x.com/dhh/status/2087272392557007042Shane Parrish on X: Ubiquiti Wi-Fi set-up: https://x.com/shaneparrish/status/2088672566558761065Timestamps:0:00 Today's guests: Runbin Dong (Scale Social) and Oege de Moor (XBOW)2:12 Open-weight models are right behind the frontier8:22 Your infrastructure is not ready for what's coming13:07 Nvidia's Perplexity announcement16:43 Spending $2K/month on AI tools per employee21:59 Why security teams have to lean on AI25:19 The Great Chip Land Grab32:02 Jason's multi-agent restaurant-style workflow34:54 AI ghostwriting is lip syncing45:18 Are rogue AI agents breaking the law?52:38 The dangers of using a stealth model58:57 Apple's new M5 Mac Studio1:06:43 Everyone's fav AI tool of the momentSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason’s suite of newsletters: https://substack.com/@calacanis


    Anthropic is training to destroy your company | EP 27 Aug 20, 2026
    Show notes

    This Week In AI is made possible by:

    PayPal - Pay zero processing fees on your first $100K in eligible PayPal payment volume. Learn more at paypal.launch.co

    Today’s show:

    *On “All In,” Gavin Baker said that Anthropic leadership privately believes that it could one day become “the only private company in the world.” The ensuing street fight on X turned into a referendum on doomerism, the nature of regulatory capture, and why the public hates AI so darn much.

    Jason’s take: If a frontier lab really believes they’re destined to be the world’s only company, they’re studying your data and planning to steal your business.

    PLUS why AI agents don’t understand it’s wrong to cheat (and how we can teach them), why Grok Bot may be AI’s “iPhone moment,” and the panel reacts to Amazon feeding rare books into a dino-themed shredding machine.

    Guests

    Galina Antova on X: https://x.com/GalinaAntova

    Kai: https://www.kai.security/

    Eric Ho on X: https://x.com/eric_ho

    Goodfire: https://www.goodfire.com/

    Silico: https://www.goodfire.com/silico

    Relevant Links

    All-In Podcast: Gavin Baker on Anthropic: https://x.com/theallinpod/status/2088367978270142811

    Sholto Douglas response: https://x.com/_sholtodouglas/status/2088463770318516734

    Gavin Baker response: https://x.com/GavinSBaker/status/2088611616577253502

    Dario Amodei response: https://x.com/DarioAmodei/status/2088758816376807762

    Zuckerberg AI manifesto: https://www.meta.com/thefutureisforeveryone/

    Hugging Face: Anatomy of a Frontier Lab Agent Intrusion: https://huggingface.co/blog/agent-intrusion-technical-timeline

    Simon Willison: OpenAI’s accidental cyberattack on Hugging Face: https://simonwillison.net/2026/Jul/22/openai-cyberattack/

    SWE-bench Leaderboards: https://www.swebench.com/

    xAI: Introducing Grok Bot: https://x.ai/news/introducing-grok-bot

    Peter Yang praises Grok Bot: https://x.com/petergyang/status/2089401696946634801?s=20

    Wispr Flow: https://wisprflow.ai/

    @Aaronp613 on X: AirPods with Cameras in action: https://x.com/aaronp613/status/2089522745184760112?s=20

    9to5 Mac: AirPods with cameras get their clearest leak yet: https://9to5mac.com/2026/08/17/airpods-with-camera-get-their-clearest-leak-yet/

    Toms Hardware: Google Buys Spirit Airlines Data for AI Training: https://www.tomshardware.com/tech-industry/artificial-intelligence/google-buys-spirit-airlines-data-for-ai-training-for-just-usd10-million-purchase-includes-hundreds-of-millions-of-emails-microsoft-teams-chats-billions-of-flight-pricing-records-and-anonymized-passenger-records


    Micro1: https://www.micro1.ai/


    Timestamps:

    0:00 Why is everyone mad at Dario Amodei?

    1:47 Is Anthropic training to kill your company?

    10:10 How to talk to the public about cyber risk

    15:33 Reward hacking and sycophancy

    21:55 Why do models care about rewards?

    28:55 Is Grok Bot an iPhone Moment?

    38:26 First look at AirPods with Cameras

    42:16 Why Google bought Spirit Airlines' data

    48:52 Amazon is scanning and shredding rare books

    59:06 Can we build a "moral layer" on top of models?

    1:01:14 Your LLM could catch a mind virus

    1:10:55 Are we already in the AGI Era?

    1:14:17 Silicon Valley's lost hippie vibes

    Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com

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    Follow Jason:

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    LinkedIn: https://www.linkedin.com/in/jasoncalacanis

    Check out all our partner offers: https://partners.launch.co/

    Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland

    Check out Jason’s suite of newsletters: https://substack.com/@calacanis

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    Substack: https://twistartups.substack.com


    Why Anthropic is watermarking every word Claude writes | E26 Aug 13, 2026
    Show notes

    This Week In AI is made possible by:

    Paypal Open


    Today’s show:

    Anthropic’s new Claude watermark travels around any and all copy-and-pasted text. Is this a logical response to AI slop, or more overreach from those regulation-loving Europeans? The panel agrees that identifying AI outputs has a place, but divides on how the world should get there.

    PLUS everyone’s favorite section of Mark Zuckerberg’s 6500-word techno-optimist AI manifesto, exploring the frontier labs’ blatant hypocrisy around distillation, and why Texas is hitting the pause button on 474 GW of proposed data centers.


    Guests:

    Will Bryk: https://x.com/WilliamBryk

    Exa: https://exa.ai/

    Josh Sirota: https://x.com/joshua_sirota

    Eragon: https://www.eragon.ai/

    Kashif “Kash” Ali: https://x.com/ChKashifAli

    TaxGPT: https://www.taxgpt.com/


    Relevant Links:

    Anthropic: How Claude marks AI-generated content: https://support.claude.com/en/articles/16266773-how-claude-marks-ai-generated-content

    Coalition for Content Provenance and Authenticity (C2PA): https://c2pa.org/

    EU AI Act: Article 50 transparency obligations: https://artificialintelligenceact.eu/article/50/

    TechCrunch: Pangram Raises $9M: https://techcrunch.com/2026/07/29/as-ai-content-floods-the-internet-pangram-raises-9m-to-detect-it/

    TechCrunch: Anthropic’s landmark copyright settlement is approved: https://techcrunch.com/2026/07/20/anthropics-landmark-1-5b-copyright-settlement-is-approved/

    World ID iris scanning orb: https://world.org/world-id

    Time: Sam Altman voices concern about “Dead Internet Theory”: https://time.com/7316046/sam-altman-dead-internet-theory/

    Meta: The Future is for Everyone: https://about.fb.com/news/2026/08/the-future-is-for-everyone/

    Meta: Introducing Muse Glimmer: https://research.meta.ai/blog/introducing-muse-glimmer-open-agentic-model

    Texas: Gov. Abbott directs comprehensive data center audit: https://gov.texas.gov/news/post/governor-abbott-directs-comprehensive-data-center-audit

    Texas Tribune: New data center projects frozen: https://www.texastribune.org/2026/08/03/texas-data-center-project-audit-greg-abbott/

    ERCOT: https://www.ercot.com/

    Public Utility Commission of Texas: https://www.puc.texas.gov/

    TechCrunch on Sirota’s “software is dead” thesis: https://techcrunch.com/2026/03/18/this-startup-wants-to-make-enterprise-software-look-more-like-a-prompt/

    River AI: https://river.ai/

    Thinking Machines Lab: https://thinkingmachines.ai/


    Timestamps:


    0:00 Guest Intros

    3:30 Anthropic to watermark Claude text

    5:50 Cracking down on AI Slop

    10:45 Will slop-trackers push users to open source

    16:21 Jason's "No Clankers" proposal

    23:01 Parsing Zuckerberg's techno-utopian manifesto

    39:27 The distillation double standard

    44:28 "When you're behind, go open…"

    51:17 Texas freezes new data centers

    1:04:12 Is software dead?

    1:05:39 Software managing, not engineering

    1:10:24 Everyone is vibecoding

    Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com

    Check out the TWIST500: https://www.twist500.com

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    X: https://twitter.com/Jason

    LinkedIn: https://www.linkedin.com/in/jasoncalacanis

    Follow Lon:

    X: https://x.com/lons

    Check out all our partner offers: https://partners.launch.co/

    Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland

    Check out Jason’s suite of newsletters: https://substack.com/@calacanis

    Follow TWiST:

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    Substack: https://twistartups.substack.com



    Is open source AI really ahead of the frontier? 3 builders weigh in. | E25 Aug 06, 2026
    Show notes

    This Week In Startups is made possible by:


    PAYPAL OPEN


    Today’s show:

    China’s Alibaba just dropped a 2.4 trillion parameter open weight model that the company claims only trails Anthropic’s flagship among the major frontier rivals. Of course, this happened the very same week that the US government appears to have backed off from banning these models stateside entirely.

    Are these models anywhere close to actually catching up to the latest and greatest releases from US labs like Anthropic and OpenAI? Really seems to depend on who you ask. (Even long time friends JCal and Elon Musk can’t see eye to eye on it.)

    So on TWiAI Ep 25, we welcomed on Poolside AI CTO Eiso Kant, EXO Labs co-founder Alex Cheema, and Qloo founder Alex Elias to break down just how close Chinese labs are to catching up with the biggest and best models… and how long it will take US open weight builders to catch up.

    PLUS we explore the cutting edge of AI-powered baby sleep monitors, consider Hank Green’s public AI apology, and dig into sci-fi author Ursula K. LeGuin’s “hand-mind” thesis.


    Guests:


    Eiso Kant on X: https://x.com/eisokant

    Poolside: https://poolside.ai/

    Alex Elias on X: https://x.com/ape

    Qloo: https://www.qloo.com/

    Alex Cheema on X: https://x.com/alexocheema

    EXO Labs: https://exolabs.net/

    Local AI benchmark platform: https://local.ai/

    Relevant Links

    Qwen3.8-Max launch announcement: https://qwen.ai/blog?id=qwen3.8

    Bloomberg on Qwen3.8-Max launch: https://www.bloomberg.com/news/articles/2026-08-03/alibaba-drops-another-china-ai-model-with-breakthrough-performance

    NYT: “White House Whipsaws Silicon Valley Over AI Rules”: https://www.nytimes.com/2026/08/04/technology/ai-washington-regulation-whiplash.html

    Nvidia: “Open Weights and American AI Leadership”: https://images.nvidia.com/pdf/Open-Weights-and-American-AI-Leadership.pdf

    World Bank: World Development Report 2026: https://thedocs.worldbank.org/en/doc/1e4e52502104a331fb42cba0d4afa995-0050062026/original/WDR2026-Concept-Note.pdf

    Hank Green apology on Reddit: https://www.reddit.com/r/nerdfighters/comments/1vbmoj5/comment/p0vzmog/

    Taylor Lorenz responds to Hank Green on X: https://x.com/TaylorLorenz/status/2083272682188206564

    TechCrunch: Substack partners with Pangram: https://techcrunch.com/2026/07/22/substacks-new-tool-tells-you-whos-been-writing-their-newsletters-with-ai/

    Amazon: Ursula K. Le Guin’s “Always Coming Home” expanded edition: https://www.amazon.com/Ursula-K-Guin-Authors-Expanded/dp/1598536036




    Timestamps:

    0:00 Guest intros and open

    10:03 Why Poolside thinks coding is the path to AGI

    12:55 A first look at EXO's local.ai

    16:24 The White House's open source pivot

    20:21 Margins, compute, and "dirt to intelligence"

    36:02 Jason's self-driving auction pitch

    37:58 Hank Green's AI apology

    38:45 Is AI addictive?

    1:08:31 What does it mean for AI to be "privacy first"?

    1:10:29 Enterprise AI sovereignty and "colonization"


    Sign up for the TWiAI newsletter!

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    LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm

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    LinkedIn: https://www.linkedin.com/in/jasoncalacanis

    Check out all our partner offers: https://partners.launch.co/

    Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland

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    Substack: https://twistartups.substack.com



    Are we already in the Singularity? | E24 Jul 30, 2026
    Show notes

    This Week In Startups is made possible by:

    Paypal Open


    Today’s show:

    On a podcast this week, Sam Altman made a bold declaration: “We are now, like, in the singularity.” A bold claim which Alex puts bluntly to this week’s panel. Grant Lee of Gamma and Philip Johnston of Starcloud sound off… Is this actually the Singularity, and if so, why do things still feel so normal?

    Plus the panel and guest host Alex Wilhelm discuss the infrastructure and economics that will make singularity-scale AI buildout possible… NVIDIA’s strongly worded letter about open-weight models… Moonshot’s new Kimi K3 twist on open-source licenses… Stripe’s reported $10B run at OpenRouter… and more.


    Guests


    Grant Lee on X: https://x.com/thisisgrantlee

    Gamma: https://gamma.app/

    Philip Johnston on X: https://x.com/PhilipJohnston

    Starcloud: https://www.starcloud.com/


    Relevant Links


    TechCrunch: Gamma hits $110M ARR: https://techcrunch.com/2025/11/10/ai-powerpoint-killer-gamma-hits-2-1b-valuation-100m-arr-founder-says/

    Nvidia: How Starcloud is Bringing Data Centers to Space: https://blogs.nvidia.com/blog/starcloud/

    Open Weights and American AI Leadership letter: https://www.microsoft.com/en-us/corporate-responsibility/wp-content/uploads/2026/07/open-weight-models-letter-1.pdf

    CNBC on Nvidia-OpenAI infrastructure plans: https://www.cnbc.com/2026/07/27/nvidia-and-openai-in-talks-for-up-to-250-billion-dollar-ai-backstop.html

    Kimi K3: https://www.kimi.com/en

    Crusoe announces strategic Starcloud partnership: https://www.crusoe.ai/resources/newsroom/crusoe-to-become-first-cloud-operator-in-space-through-partnership-with-starcloud

    Andrej Karpathy on YouTube: “Let’s Build GPT”: https://www.youtube.com/watch?v=kCc8FmEb1nY

    Demis Hassabis Starcloud post on X: https://x.com/demishassabis/status/1999296127276126417

    RAISE Summit: https://www.raisesummit.com/

    Lilian Weng exits Thinking Machines post: https://x.com/lilianweng/status/2081816923088814421

    Baseten: https://www.baseten.co/

    Fireworks AI: https://fireworks.ai/

    Legora: https://legora.com/

    OpenEvidence: https://www.openevidence.com/

    Yahoo: Stripe in talks to acquire OpenRouter: https://finance.yahoo.com/technology/ai/articles/stripe-talks-acquire-openrouter-potential-215104525.html

    Sam Altman on the Relentless podcast: https://www.youtube.com/watch?v=Vv3CEAS_w34

    TechCrunch: Cursor India-only pricing tier: https://techcrunch.com/2026/07/27/cursor-makes-its-biggest-india-push-yet-ahead-of-spacex-acquisition-with-localized-pricing/

    Gergely Orosz: The Pragmatic Engineer: https://www.pragmaticengineer.com/


    Timestamps:

    0:00 Guest intros: Grant Lee (Gamma) and Philip Johnston (Starcloud)

    1:22 Nvidia's open weight letter

    8:11 Starcloud's first H100 in space

    19:47 Series A extension economics

    20:39 How Gamma stayed lean and balanced work and fun

    30:40 Betting on a compute-constrained world

    35:48 Different approaches to pricing

    44:59 Where does the AI moat really live?

    57:41 Are we in the Singularity?

    1:04:42 Starcloud's mission to Alpha Centauri


    Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com

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    X: https://x.com/alex

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    X: https://twitter.com/Jason

    LinkedIn: https://www.linkedin.com/in/jasoncalacanis

    Check out all our partner offers: https://partners.launch.co/

    Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland

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