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    Life Sciences

    Tiny Matters

    Science shapes every facet of our lives, but so much of its influence is overlooked or buried in the past. Tiny Matters is an award-winning science podcast about the small science of big things. From the microbes behind deadly diseases to the molecules informing our search for extraterrestrial life, hosts and former scientists Sam Jones and Deboki Chakravarti embrace the awe and messiness of science and its significance both today and in the past, asking questions like, “how was IVF invented?,” “what do glaciers tell us about Earth’s ancient past?,” and “why is smallpox the only human infectious disease we’ve eradicated?”

    Tiny Matters is created by the American Chemical Society, a non-profit scientific organization based in Washington, D.C., and is produced by Multitude. New episodes every Wednesday, wherever you listen to podcasts.

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    Copyright: © 2025 American Chemical Society

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    Latest Episodes:
    Vaping vs. smoking: What does decades of research tell us? Oct 02, 2024
    Show notes

    E-cigarettes, commonly referred to as “vapes,” were invented in the early 2000s with the explicit goal of helping people quit smoking by transitioning them to something safer. But there are many people, particularly in the United States, who start vaping without ever having smoked a cigarette, leading to fears that vaping will be an on-ramp to smoking — a “gateway drug.” In fact, in the U.S. alone, nearly half a million middle school students vape. And in 2019, the CDC started receiving reports of severe and acute lung injury in people who vaped. By February of 2020, almost 3,000 people had been hospitalized and 68 people had died.
    We know that smoking is deadly (in fact, it’s estimated to take about 10 years off your life), but of course vaping isn’t risk free. In this episode of Tiny Matters, we’ll dive into the science behind both to answer, “What’s more dangerous, smoking or vaping?” “And does vaping actually help people quit smoking cigarettes?” We’ll also get to the bottom of why so many people got sick or died from vaping back in 2019 and 2020, yet we haven’t seen injuries like that since.
    Send us your science stories/factoids/news for a chance to be featured on an upcoming Tiny Show and Tell Us episode and to be entered to win a Tiny Matters coffee mug! And, while you're at it, subscribe to our newsletter at bit.ly/tinymattersnewsletter.
    Link to the Tiny Show & Tell story is here. All Tiny Matters transcripts and references are available here.

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.


    [BONUS] How the moon causes tides and ancient viruses lurking in your DNA: Tiny Show and Tell Us #7 Sep 25, 2024
    Show notes

    In this episode of Tiny Show and Tell Us, we break down the complicated science of tides and why some places have massive tidal swings while others do not. We also cover the role of ancient viral DNA in our genomes, and how it seems to be making us less responsive to cancer treatments like chemotherapy.
    We need your stories — they're what make these bonus episodes possible! Write in to tinymatters@acs.org *or fill out this form* with your favorite science fact or science news story for a chance to be featured in a future episode and win a Tiny Matters mug!
    Here's the tides video George mentioned. The rest of the references and transcript for this episode can be found at acs.org/tinymatters.

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.


    Extinction: Rethinking the dodo's demise, and could a supervolcano threaten humanity's future? Sep 18, 2024
    Show notes

    Around 8 million years ago, an underwater volcano just to the east of Madagascar formed the island of Mauritius. Pigeons on nearby islands set flight and settled on that island. There they continued to evolve, and the dodo bird eventually emerged as its own species: Raphus cucullatus. And tiny Mauritius, with an area of just 720 square miles, was the only place in the entire world where the dodo lived. And it lived a good life, among bats and tortoises and other birds, safe from the predators its ancestors left back on land millions of years before. But in 1598, when sailors from the Netherlands arrived, the dodo’s luck ran out.
    On today's Tiny Matters we dive into the history of the bird that everyone loves to make fun of: the dodo. And we’re going to explore some of the work investigating why this bird went extinct and what it was like when it was alive. Then we’ll shift gears and talk about what some people worry will cause a massive extinction in the future — one that might include us: supervolcanoes. These are volcanoes capable of eruptions thousands of times larger than the volcanic eruptions we are most familiar with today. The recent volcanic eruptions in Iceland or the deadly Mount St. Helens eruption in 1980 pale in comparison. These are volcanoes bigger than anything we've experienced as human beings in our recorded history. So are we ready if one comes our way?
    Send us your science stories/factoids/news for a chance to be featured on an upcoming Tiny Show and Tell Us episode and to be entered to win a Tiny Matters coffee mug! And, while you're at it, subscribe to our newsletter at bit.ly/tinymattersnewsletter.
    Links to the Tiny Show & Tell stories are here and here. Check out the Headline Science video series here.
    All Tiny Matters transcripts and references are available here.

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.


    [BONUS] We think your dog loves you and an intriguing molecule hitches a ride on space dust: Tiny Show and Tell Us #6 Sep 11, 2024
    Show notes

    In this episode of Tiny Show and Tell Us, we cover work scientists have done to understand what’s going on in dog brains and how attached to us they really are. We also discuss a polymer called hemoglycin that hitches a ride on literal tons of space dust and may have played a big role in how life on Earth got started.

    We need your stories — they're what make these bonus episodes possible! Write in to tinymatters@acs.org *or fill out this form* with your favorite science fact or science news story for a chance to be featured in a future episode and win a Tiny Matters mug!

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.


    CTE: From ‘punch drunk’ to today, how this devastating disease is finally being taken seriously Sep 04, 2024
    Show notes

    *A disclaimer that there will be discussions of self harm in this episode* In 2003, Chris Nowinski found himself in a WWE wrestling ring, concussed and not remembering where he was or how he was supposed to finish the match. This would be a pivotal moment not just in his life but for an entire field of research on a neurodegenerative disease long known to exist but poorly defined and even censored: chronic traumatic encephalopathy or CTE.

    There’s evidence that people knew about CTE — which went by names like “punch drunk” — starting in the 1920s, but it wasn’t until the 2000s, when American football players began being diagnosed with CTE post-mortem, that the disease started gaining public traction. Many of those football players, including Andre Waters, had died by suicide. Chris, now a behavioral neuroscientist and the co-founder and CEO of the Concussion Legacy Foundation, pushed to get the brains of Waters and other athletes tested, and began spreading awareness and putting pressure on organizations like the NFL to acknowledge the devastation this disease can bring to athletes and their families. Today on the show we will cover what’s known about CTE and how to prevent it, and how researchers are trying to find ways of diagnosing it in people who are still alive and working to find treatments.

    Here are some good CTE resources:

    https://concussionfoundation.org/CTE-resources/support

    https://www.bu.edu/cte/resources/resources-for-families/

    Send us your science stories/factoids/news for a chance to be featured on an upcoming Tiny Show and Tell Us episode and to be entered to win a Tiny Matters coffee mug! And, while you're at it, subscribe to our newsletter at bit.ly/tinymattersnewsletter. Links to the Tiny Show & Tell stories are here and here. All Tiny Matters transcripts and references are available here.

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.


    [BONUS] Cleaning up brain junk while you sleep and new neurons from exercise: Tiny Show and Tell Us #5 Aug 28, 2024
    Show notes

    In this episode of Tiny Show and Tell Us, we cover neurogenesis in adulthood (yes! your brain can make new neurons even as you age), the link between exercise and increased neurogenesis in the hippocampus, and the implications that could have for neurodegenerative diseases like Alzheimer's. We continue on our brain-focused episode with the role cerebrospinal fluid plays in cleaning out your brain while you sleep and how its movement is in fact influenced by your brain waves. We need your stories — they're what make these bonus episodes possible! Write in to tinymatters@acs.org *or fill out this form* with your favorite science fact or science news story for a chance to be featured in a future episode and win a Tiny Matters mug!

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.


    Pig hearts in people: Xenotransplantation's history, promise, and the ethical use of people who are brain-dead in research Aug 21, 2024
    Show notes

    In the early hours of January 7, 2022, David Bennett was out of options. At just 57 years old, he was bedridden, on life support, and in desperate need of a heart transplant for which he was ineligible. Yet Bennett would go on to live for two more months — not with a human heart, but with a heart from a pig. David Bennett was the first case of a pig heart being transplanted into a human, an example of xenotransplantation — when the cells, tissues or organs from one species are transplanted into another. In the United States, over 100,000 kids and adults are currently on the national transplant waiting list, and every day around 17 people on that list die while waiting.

    In today's episode, we cover the science and historical research that made Bennett’s transplant possible, and what doctors learned from him that helped the next heart xenotransplant recipient, Lawrence Faucette, live even longer. We also get into some of the ethics conversations surrounding xenotransplantation work — not just questions about the use of animals like pigs and baboons, but experiments with recently deceased, i.e. brain dead, people.

    Check out Jyoti Madhusoodanan's Undark story, "The Allure and Dangers of Experimenting With Brain-Dead Bodies" here. Her JAMA story we mention, also on xenotransplantion, is here. Send us your science stories/factoids/news for a chance to be featured on an upcoming Tiny Show and Tell Us episode and to be entered to win a Tiny Matters coffee mug! And, while you're at it, subscribe to our newsletter at bit.ly/tinymattersnewsletter. Links to the Tiny Show & Tell stories are here and here. Pick up a Tiny Matters mug here! All Tiny Matters transcripts are available here.

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.


    [BONUS] 1930s (inebriated) chemist poetry and a new organelle: Tiny Show and Tell Us #4 Aug 14, 2024
    Show notes

    In this episode of Tiny Show and Tell Us, we cover the recent discovery of a new (relatively speaking, more like 100 million year old) organelle called a nitroplast that could revolutionize agriculture. Then we embark on a highly entertaining journey of 1930s chemistry poetry, sometimes written by inebriated chemists, and track down a rare and stunning Chemical Map of North America. Check out the map in this YouTube short and this Instagram post.

    We need your stories — they're what make these episodes possible! Write in to tinymatters@acs.org *or fill out this form* with your favorite science fact or science news story you found captivating for a chance to be featured in a future episode!

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.


    Could most of our food, medication, and clothing come from...bacteria? Aug 07, 2024
    Show notes

    You might be familiar with plant-based alternatives to animal products — things like the Impossible Burger or Beyond Meat. And maybe you’ve heard of places trying to grow fish or meat cells in a dish to make sushi or steak without a fish or cow. But in today’s episode we’ll cover an old technology that’s bringing us some new foods: precision fermentation. With precision fermentation, many everyday products including dairy-free milk, insulin, and the collagen in lotions are now being made by microbes. How did we turn microbes into teeny tiny production factories for so many different products, and where’s the limit when it comes to what we can use them to create? In this episode we’ll demystify the science behind this technology and its history. We’ll also dive into how public perception influences the success of new food technologies and how framing can change minds and reduce both misinformation and skepticism.

    Send us your science stories/factoids/news here for a chance to be featured on an upcoming Tiny Show and Tell Us episode and to be entered to win a Tiny Matters coffee mug! Subscribe to our newsletter at bit.ly/tinymattersnewsletter. Links to the Tiny Show & Tell stories are here and here. Pick up a Tiny Matters mug here! All Tiny Matters transcripts are available here.

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.


    [BONUS] A dark energy discovery and a thirsty hydrangea mystery: Tiny Show and Tell Us #3 Jul 31, 2024
    Show notes

    Could dark energy be more dynamic than we thought? In this episode of Tiny Show and Tell Us, we cover a recent dark energy discovery that has us contemplating what the end of the universe might look like, and then we delve into if hydrangeas can actually absorb water through their petals (ahem, sepals).

    We need your stories — they're what make these episodes possible! Write in to tinymatters@acs.org *or fill out this form* with your favorite science fact or science news story you found captivating for a chance to be featured in a future episode!

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.


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