This Week in Virology

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TWiV 664: TWiV is for the dogs Sep 17, 2020

Show notes

On this mid-week edition, does it matter that SARS-CoV-2 is mutating, seasonal coronavirus immunity is short-lived, another bogus claim that the virus was produced in a laboratory (it came from Nature), and answers to listener questions.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker

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Links for this episode

Coronavirus is mutating (Nature)
Seasonal CoV immunity is short (Nat Med)
Sorry, no link to the fake science document!
Letters read on TWiV 664
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV 663: The joy of vax Sep 13, 2020

Show notes

Daniel Griffin provides a clinical report on COVID-19, including vaccines, Alan summarizes a vaccine webinar on the most advanced US trials, a nidovirus from snapping turtles, longevity of memory B cells in recovered patients, and listener email.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Daniel Griffin

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Links for this episode

Young adults with COVID-19 (JAMA)
Letter from Stanford professors on Atlas (pdf)
National Adult and Influenza Immunization Summit
Bugger, even the snapping turtles! (PLoS One)
Memory B cell longevity in COVID-19 (medRxiv)
Letters read on TWiV 663
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 662: Principals of Principles, Fifth Edition Sep 11, 2020

Show notes

The authors of the textbook Principles of Virology gather to reveal new additions to the fifth edition, including a new author, study questions, and a chapter on therapeutic viruses.

Host: Vincent Racaniello

Guests: Jane Flint, Anna Marie Skalka, Glenn F. Rall, and Theodora Hatziioannou

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Links for this episode

Purchase PoV 5e Volumes 1 + 2 (link)
Purchase PoV 5e Volume 1 (link)
Purchase PoV 5e Volume 2 (link)

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 661: SWAG with Ralph Baric Sep 10, 2020

Show notes

Ralph Baric returns to TWiV to provide an update on the COVID-19 resurgence in the US, monoclonal antibodies, antiviral drugs, vaccines, immunity and reinfection, reopening schools, and what will happen this fall.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker

Guest: Ralph Baric

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Broadly neutralizing sarbecovirus mAbs (bioRxiv)
Evaluation of mRNA-1273 in nonhuman primates (NEJM)
Bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 (bioRxiv)
Mouse-adapted SARS-CoV-2 (bioRxiv)
READDI
Das Coronavirus summaries in English
ChAdOx1 vaccine trial halted (NY Times)
Impact of high frequency screening (medRxiv)
Letters read on TWiV 661
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 660: In case of emergency finish the trial Sep 06, 2020

Show notes

Daniel Griffin provides a clinical report on COVID-19, then we discuss decline of virus-specific bone marrow B cells within a year after influenza vaccination, the push to release SARS-CoV-2 vaccines before completion of phase 3 trials, and absence of evidence for infectious virus in aerosols.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Daniel Griffin

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Links for this episode

Convalescent plasma RCT (medRxiv)
Multicenter RCTs on corticosteroids for COVID-19 (JAMA)
Decline of influenza B cells a year after vaccine (Science)
Be ready to distribute vaccines 1 Nov (WPRI and NYTimes)
EUA during COVID-19: lessons (JAMA)
Not evidence for aerosol transmission (one and two)
Letters read on TWiV 660
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 659: Sloppy coronavirus immunity with Christian Drosten Sep 03, 2020

Show notes

Christian Drosten returns to TWiV to provide an update on the COVID-19 situation in Germany, and general thoughts on testing, immunity, vaccines, therapeutics, epidemiology, reopening schools, and what will happen this fall.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

Guest: Christian Drosten

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Links for this episode

Christian previously on TWiV 601
Plague percolation phenomenon (Nature)
TMPRSS2 inhibitor for SARS-CoV-2 (Cell)
Repeated infections with endemic CoV (J Inf Dis)
Koch Institute SARS-CoV-2 reports
Letters read on TWiV 659
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV 658: Everyone needs a H.E.A.R.T. Aug 30, 2020

Show notes

Daniel Griffin provides a clinical report on COVID-19, then we discuss CDC softening testing guidelines, Moderna vaccine phase I results in older people, Abbott's $5 rapid antigen test, and reinfection with a distinct SARS-CoV-2 isolate, followed by listener email.

Hosts: Vincent Racaniello, Alan Dove, Dickson Despommier, and Rich Condit

Guest: Daniel Griffin

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Links for this episode

CDC told to soften SARS-CoV-2 testing guidelines (NYTimes)
Moderna investor presentation on mRNA-1273 vaccine (link)
SARS-CoV-2 reinfection (Clin Inf Dis)
Dr. Fauci talks with just about anyone (NYTimes)
Letters read on TWiV 658
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 657: Shane Crotty on SARS-CoV-2 immunity Aug 27, 2020

Show notes

Immunologist Shane Crotty joins TWiV to discuss the antibody and T cell responses to infection with SARS-CoV-2, followed by answers to listener questions.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Shane Crotty

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Links for this episode

Ahead of the Curve by Shane Crotty
SARS-CoV-2 T cell epitopes (Cell)
Cross-reactive CoV T cell epitopes (Science)
Knowns and unknowns about SARS-CoV-2 immunity (Nat Rev Imm)
Letters read on TWiV 657
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV 656: See, it can be done! Aug 23, 2020

Show notes

Daniel Griffin provides a clinical report on COVID-19, surgeons Lisa Smith and David Bruce detail how they have helped their Chattanooga community during the pandemic, then we discuss racial and ethnic disparities among COVID-19 cases, no more premarket review of laboratory developed tests by FDA; and emergency use authorization of convalescent plasma is on hold.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

Guests: Daniel Griffin, Lisa A. Smith, and W. David Bruce

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Links for this episode

Racial and ethnic disparities in workplace COVID-19 (CDC)
Rescission of guidances on laboratory tests (FDA)
EUA on convalescent plasma on hold (NY Times)
Letters read on TWiV 656
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV 655: Minority health with Robert Fullilove Aug 20, 2020

Show notes

Sociomedical scientist Robert Fullilove joins TWiV to discuss disparities in minority health; FDA announces an EUA on Yale's SalivaDirect, protection of the upper and respiratory tract of mice after intranasal inoculation with an adenovirus-vectored SARS-CoV-2 spike gene, and listener questions.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Robert Fullilove

Click arrow to play Download TWiV 652 (69 MB .mp3, 114 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV!

Links for this episode

Health of racial and ethnic minority groups (CDC)
COVID-19 death/hospitalization by race/ethnicity (CDC)
Racial and ethnic disparities in workplace COVID-19 (CDC)
SalivaDirect EUA (FDA)
Adenovirus vectored SARS-CoV-2 experimental vaccine protects mice (Nat Comm)
Letters read on TWiV 655
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

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