This Week in Virology

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TWiV 951: Clinical update with Dr. Daniel Griffin Nov 05, 2022

Show notes

In his weekly clinical update Dr. Griffin discusses Influenza incidence and vaccine effectiveness during the southern hemisphere influenza season in Chile, Nirsevimab for prevention of RSV infection in healthy late-preterm and term infants, severe Monkeypox in hospitalized patients, reinfections with different SARS-CoV-2 Omicron subvariants, impact of community masking on COVID-19 in Bangladesh, unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses, antibody responses to Omicron BA.4/BA.5 bivalent mRNA vaccine booster shot, immunogenicity of bivalent mRNA vaccine boosters, long-term gastrointestinal sequelae following COVID-19, evaluation of an automated text message–based program to reduce use of acute health care resources after hospital discharge, and how in adults with COVID-19, melatonin was assessed for effects on inflammatory markers, clinical signs and symptoms, and mortality.

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Links for this episode

Influenza incidence and vaccine effectiveness (CDC)
Nirsevimab for prevention of RSV (NEJM)
Severe Monkeypox in hospitalized patients (CDC)
Reinfections with different SARS-CoV-2 Omicron subvariants (CDC)
Impact of community masking on COVID-19 (Science)
Vaccine elicits protective immunity against sarbecoviruses (Science)
Antibody responses to bivalent mRNA vaccine booster shot (Biorxiv)
Immunogenicity of bivalent mRNA vaccine boosters (Biorxiv)
Long-term gastrointestinal sequelae following COVID-19 (CGH)
Remdesivir fact sheet for providers (Veklury)
Bebtelovimab fact sheet for providers (FDA)
Evaluation of an automated text message–based program (JAMA)
Melatonin assessed for effects on inflammatory markers in COVID patients (Heliyon)
PAXLOVID patient eligibility screening checklist (FDA)
Contribute to our MicrobeTV fundraiser at PWB
Dr. Griffin's treatment guide (pdf)
Letters read on TWiV 951
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 950: Prion diseases with Richard Knight Oct 30, 2022

Show notes

From the European Society for Clinical Virology 2022 Conference in Manchester UK, Vincent speaks with Richard Knight about prion diseases and the outbreak of bovine spongiform encephalitis that led to cases of variant Creutzfeldt-Jakob disease in humans.

Host: Vincent Racaniello

Guest: Richard Knight

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Links for this episode

National CJD Research and Surveillance Unit
Clinical diagnosis of human prion disease (Prog Mol Biol Trans Sci)
Variant Creutzfeldt-Jakob disease (Handbook Clin Viral)
Creutzfeldt-Jakob disease (Adv Exp Med Biol)
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV 949: Clinical update with Dr. Daniel Griffin Oct 29, 2022

Show notes

In his weekly clinical update Dr. Griffin discusses progress toward poliomyelitis eradication in Pakistan, polio by the numbers , influenza and COVID-19 vaccination coverage among health care personnel, phase 1/2a safety and immunogenicity of an adenovirus 26 vector RSV vaccine encoding prefusion F in adults 18–50 years and RSV seropositive children 12–24 months, receipt of first and second doses of JYNNEOS vaccine for prevention of Monkeypox, distinguishing SARS-CoV-2 persistence and reinfection, Novavax NVX-COV2373 triggers potent neutralization of Omicron sub-lineages, association between regular physical activity and the protective effect of vaccination against SARS-CoV-2 in a South African case, COVID-19 outcomes in solid organ transplant recipients who received Tixagevimab-cilgavimab Prophylaxis and/or Bebtelovimab treatment, Omicron sublineage BA.2.75.2 exhibits extensive escape from neutralizing antibodies, and Tocilizumab versus Baricitinib in hospitalized patients with severe COVID-19.

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Links for this episode

Progress toward Poliomyelitis eradication (CDC)
Polio by the numbers (JID)
Influenza & COVID-19 vaccination coverage among health care personnel (CDC)
Phase 1/2a Safety & Immunogenicity of an adenovirus RSV Vaccine (JID)
Receipt of first & second doses of JYNNEOS vaccine (CDC)
Distinguishing SARS-CoV-2 persistence and reinfection (CID)
Remdesivir fact sheet for providers (Veklury)
Bebtelovimab fact sheet for providers (FDA)
Novavax triggers potent neutralization of Omicron sub-lineages (bioRxiV)
Association between physical activity & vaccination protective effect (BMJ)
PAXLOVID patient eligibility screening checklist (FDA)
COVID-19 outcomes in solid organ transplant recipients who received monoclonal antibodies (Transplantation)
Omicron BA.2.75.2 exhibits escape from neutralizing antibodies (bioRxiV)
Tocilizumab vs. Baricitinib in hospitalized patients with severe COVID-19 (CMI)
Dr. Griffin's treatment guide (pdf)
Contribute to Floating Doctors fundraiser at PWB
Letters read on TWiV 949
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 948: Breathless with David Quammen Oct 23, 2022

Show notes

David Quammen returns to TWiV to discuss how he wrote his new book 'Breathless', a story about the science and the scientists behind the race to understand the pandemic coronavirus SARS-CoV-2.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: David Quammen

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Links for this episode

Boston Quammens (TWiV 408)
Breathless by David Quammen
Spillover by David Quammen
Song of the Dodo by David Quammen
Timestamps by Jolene. Thanks!

Weekly Picks

David – Shepherd Brianne – Adventure Aquarium Kathy – DART results (Narrative, images) Rich – "Elementary" TV series Vincent – Stop passing the buck on intro science

Listener Pick

Rich – Consensus

Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV 947: Clinical update with Dr. Daniel Griffin Oct 22, 2022

Show notes

In his weekly clinical update Dr. Griffin discusses the prediction of upcoming global infection burden of influenza seasons after relaxation of public health and social measures during the COVID-19 pandemic, severe COVID-19 outcomes after full vaccination of primary schedule and initial boosters, and how successful immunomodulators for treatment of COVID-19 have opened the pathway for comparative trials.

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Links for this episode

Support MicrobeTV with a Spike t-shirt at Vaccinated.US
Prediction of upcoming global infection burden of Influenza (The LANCET)
Severe COVID-19 outcomes after full vaccination (The LANCET)
Successful immunomodulators for treatment of COVID-19 (CMI)
Remdesivir fact sheet for providers (Veklury)
Bebtelovimab fact sheet for providers (FDA)
PAXLOVID patient eligibility screening checklist (FDA)
Dr. Griffin's treatment guide (pdf)
Contribute to Floating Doctors fundraiser at PWB
Letters read on TWiV 947
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 946: Poo versus flu Oct 16, 2022

Show notes

Angela Mingarelli joins TWiV to discuss whether the gut microbiota of bats confers tolerance to influenza virus infection in mice, and primate hemorrhagic fever-causing arteriviruses that can reproduce in human cells and might be capable of infecting humans.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Angela Mingarelli

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Links for this episode

Research assistant position at FDA (pdf)
Support MicrobeTV with a Spike t-shirt (Vaccinated.us)
Bat gut microbiota and flu infection in mice (Transbound Emerg Dis)
Primate hemorrhagic fever-causing arteriviruses (Cell)
Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Jazz pics: #5. Small group. Art Blakey and the Jazz Messenger: Art Blakey, Drums; Lee Morgan, Trumpet; Benny Golson, Tenor saxophone; Bobby Timmons, Piano; Jymie Merrit, Bass (1958-1964). Signature album: Art Blakey And The Jazz Messengers: Blues March: Signature song: Blues March Brianne – Why Chimps and Gorillas Form Rainforest Friendships Rich – Fly Water – FPV to New Depths Alan – The Seven Words You Can't Say on Television, by George Carlin, and its repercussions Angela – Nature's Inspiring Women in Science Award Vincent – Mysteries of Nevada Barr and her protagonist Anna Pigeon

Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV 945: Clinical update with Dr. Daniel Griffin Oct 15, 2022

Show notes

In his weekly clinical update Dr. Griffin discusses a healthcare-associated infection with Monkeypox virus, air and surface sampling for monkeypox virus in a UK hospital, misrepresentation and nonadherence regarding COVID19 public health measures, tolerability and immunogenicity of an intranasally-administered adenovirus-vectored COVID-19 vaccine, clinical, virologic, and immunologic evaluation of symptomatic rebound following Nirmatrelvir/Ritonavir treatment, early outpatient treatment with Eemdesivir in patients at high risk for severe COVID-19, Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes, and outcomes among confirmed cases and a matched comparison group in the long-COVID in Scotland.

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Links for this episode

Research assistant position with Amy Rosenfeld (pdf)
Support MicrobeTV with a Spike t-shirt at Vaccinated.US
A healthcare-associated infection with monkeypox virus (OFID)
Air and surface sampling for monkeypox virus (The Lancet)
Misrepresentation & nonadherence in COVID-19 public health measures (JAMA)
Tolerability and immunogenicity of a COVID-19 vaccine (The Lancet)
PAXLOVID patient eligibility screening checklist (FDA)
Evaluation of symptomatic disease rebound following PAXLOVID (CID)
Outpatient treatment with Remdesivir in patients at high risk (OFID)
Remdesivir fact sheet for providers (Veklury)
Bebtelovimab fact sheet for providers (FDA)
Molnupiravir as early treatment for adults with COVID-19 (SSRN)
Outcomes among confirmed cases and matched comparison group in long-COVID (Nature)
Dr. Griffin's treatment guide (pdf)
Contribute to Floating Doctors fundraiser at PWB
Letters read on TWiV 945
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 944: Hacking through Borneo with Kathryn Hanley Oct 09, 2022

Show notes

Kathryn Hanley joins TWiV to discuss her career and the research in her laboratory on the molecular biology, evolution and ecology of emerging RNA viruses and their insect vectors.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

Guest: Kathryn Hanley

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Links for this episode

Research assistant position at FDA (pdf)
Support MicrobeTV with a Spike t-shirt (Vaccinated.us)
One bite is all it takes (TWiV 587)
CREATE-NEO
Shifts in Borneo mosquito diversity (Ecosphere)
VSV surveillance along Rio Grande (PLoS Path)
Virulence a trade-off between transmission and clearance (Viruses)
West Nile virus disease indicators (Viruses)
Identify mosquito meals by barcoding (Trop Med Inf Dis)
SkitoSnack (Sci Rep)
Neal Nathanson dies (Baltimore Sun)
VRR interview with Neal Nathanson (YouTube)
Letters read on TWiV 944
Timestamps by Jolene. Thanks!

Weekly Picks

Kathy – Car Talk Puzzler Archive Rich – The Molecular Biologist Who Exposed the Soviet Union" by Sean B. Carroll Vincent – NYU Chemistry prof fired because his course was too difficult

Listener Pick

Jack – The Everything Virus

Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV 943: Clinical update with Dr. Daniel Griffin Oct 08, 2022

Show notes

In his weekly clinical update Dr. Griffin discusses high points of the multi-national monkeypox outbreaks, monkeypox virus genome mutations, possible occupational infection of healthcare workers with monkeypox virus, rates of monkeypox cases by vaccination status, protection of SARS-CoV-2 infection against reinfection, Paxlovid significantly reduces COVID-19 hospitalizations and deaths, and rebound in COVID19 with and without Paxlovid treatment.

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Links for this episode

Research assistant position with Amy Rosenfeld (pdf)
Support MicrobeTV with a Spike t-shirt at Vaccinated.US
Multi-National Monkeypox outbreak (CDC)
Mutation of the Monkeypox Virus (Nature)
Occupational infection of Healthcare workers with Monkeypox (CDC)
Rates of Monkeypox cases by vaccination status (CDC)
Protection of SARS-CoV-2 natural infection against reinfection (CMI)
PAXLOVID patient eligibility screening checklist (FDA)
Paxlovid reduces COVID19 hospitalizations & deaths (EPIC)
Paxlovid rebound in COVID19 (NEJM)
Remdesivir fact sheet for providers (Veklury)
Bebtelovimab fact sheet for providers (FDA)
Dr. Griffin's treatment guide (pdf)
Contribute to Floating Doctors fundraiser at PWB
Letters read on TWiV 943
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

Public Health with Laurie Garrett: Wastewater Testing Oct 04, 2022

Show notes

Laurie Garrett discusses the role of wastewater testing in public health and her idea of a device that could be used by anyone to analyze water samples.

This podcast is not an episode of TWiV, but I thought it would be of interest to listeners.

Laurie Garrett and Vincent Racaniello

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Links for this episode

Support MicrobeTV with a Spike t-shirt (Vaccinated.us)
Coliform testing of water in Florida (YouTube)
Declining cost of genome sequencing (Illumina)
National wastewater surveillance system (CDC)
Advances in detection of viruses in wastewater (Med Express)
Wastewater monitoring comes of age (Nature)
Monitoring monkeypox virus in wastewater (Med Express)
Poliovirus wastewater surveillance in NY (Dept of Health)
Wastewater surveillance in NYS (Dept of Health)
Estimating norovirus infections through wastewater (Water Res)
Estimating antimicrobial resistant bacteria through latrine water (Antimicro Res Inf Control)

Intro music is by Ronald Jenkees Send your questions and comments to twiv@microbe.tv

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