This Week in Virology

Latest Episodes:

TWiV 1058: Clinical update with Dr. Daniel Griffin Nov 04, 2023

Show notes

In his weekly clinical update, Dr. Griffin discusses health worker–perceived working conditions and symptoms of poor mental health, Mpox neutralizing antibodies at 6 months from mpox infection or MVA-BN vaccination, newborn and early infant outcomes following maternal COVID-19 vaccination during pregnancy, duration of SARS-CoV-2 culturable virus shedding in children, prescribing outcomes in outpatients treated with nirmatrelvir–ritonavir for COVID-19 in an interdisciplinary community clinic, Nirmatrelvir and molnupiravir and post-COVID-19 condition in older patients, optimal duration of systemic corticosteroids in COVID-19 treatment, association between Guillain-Barré syndrome and COVID-19 infection and vaccination, SARS-CoV-2 infection correlates with male benign prostatic hyperplasia deterioration, Transplanting candidates with COVID-19, and favorable experience of transplant strategy including liver grafts from COVID-19 donors.

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Links for this episode

Routine vaccination coverage (CDC)
Outbreak of invasive Group A Streptococcusin children (PIDS)
Nirmatrelvir/ritonavir use in pregnant women with SARS-CoV-2 (Nature)
Outcomes of SARS-CoV-2 omicron variant infections compared with seasonal influenza and RSV infections in adults (CID)
Remdesivir is associated with reduced mortality in COVID-19 patients requiring oxygen (OFID)
Effectiveness of nirmatrelvir/ritonavir against the development of Post–COVID-19 conditions among U.S. veterans (AIM)
Contribute to our MicrobeTV fundraiser at PWB
Letters read on TWiV 1058
Dr. Griffin's COVID treatment summary (pdf)
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 1057: CMV-based HIV vaccine with Klaus Früh Oct 29, 2023

Show notes

Klaus Früh visits the Incubator to discuss his career and his work on cytomegalovirus-vectored vaccines which are unique in their ability to persistently maintain an immune shield of effector memory T cells, including highly unconventional MHC-II and MHC-E restricted CD8+ T cells.

Host: Vincent Racaniello, Rich Condit, and Brianne Barker

Guest: Klaus Früh

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Links for this episode

MicrobeTV Discord Server
MicrobeTV store at Cafepress
Spike shirts at vaccinated.us (promo code Microbetv)
Research assistant position in Rosenfeld Lab CBER/FDA (pdf)
HCMV-based attenuated vaccine platform (Sci Rep)
HLA-E-restricted, Gag-specific CD8+ T cells suppress HIV-1 infection (Sci Immunol)
RhCMV/SIV vaccine shows long-term efficacy against SIV challenge (Sci Transl Med)
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 1056: Clinical update with Dr. Daniel Griffin Oct 28, 2023

Show notes

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Links for this episode

Health worker–perceived working conditions and symptoms of poor mental health (CDC)
Neutralizing antibodies at 6 months from mpox infection or MVA-BN vaccination (The Lancet)
Newborn and early infant outcomes following maternal COVID-19 vaccination during pregnancy (JAMA)
Duration of SARS-CoV-2 culturable virus shedding in children (JAMA)
Prescribing outcomes in outpatients treated with PAXLOVID for COVID-19 (PLOS ONE)
Nirmatrelvir and molnupiravir and post–COVID-19 condition in older patients (JAMA)
Optimal duration of systemic corticosteroids in COVID-19 treatment (OFID)
Intravenous vitamin C for patients hospitalized with COVID-19 (JAMA)
Association between Guillain-Barré syndrome and COVID-19 infection and vaccination (NH)
SARS-CoV-2 infection correlates with male benign prostatic hyperplasia deterioration (JIM)
Transplanting candidates with COVID-19 (TID)
Favorable experience of transplant strategy including liver grafts from COVID-19 donors (TID)
Contribute to our Floating Doctors fundraiser at PWB
Letters read on TWiV 1056
Dr. Griffin's COVID treatment summary (pdf)
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 1055: Vermont viridae Oct 22, 2023

Show notes

Vincent travels to the University of Vermont to speak with Jason, Emily, Jessica, and Dimitry about their careers and their work on SARS-CoV-2, hantaviruses, poliovirus, influenza virus, and the involvement of viruses in the autoimmune disease multiple sclerosis.

Host: Vincent Racaniello

Guests: Jason Botten, Emily Bruce, Jessica Crothers, and Dimitry Krementsov

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Links for this episode

MicrobeTV Discord Server
MicrobeTV store at Cafepress
Spike shirts at vaccinated.us (promo code Microbetv)
Research assistant position in Rosenfeld Lab CBER/FDA (pdf)
Lab worker contamination with SARS-CoV-2 plasmid DNA (J Clin Micro)
Fractional dose poliovirus vaccine (Vaccine)
No SARS-CoV-2 RNA in Vermont wildlife (Sci Rep)
Predicting SARS-CoV-2 infectivity from RT-PCR (EMBO Mol Med)
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 1054: Clinical update with Dr. Daniel Griffin Oct 21, 2023

Show notes

In his weekly clinical update, Dr. Griffin discusses high Influenza incidence and disease severity among children and adolescents aged

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Links for this episode

High Influenza incidence and disease severity among children and adolescents aged
Neurologic effects of SARS-CoV-2 transmitted among dogs (EID)
Effectiveness of mRNA vaccines against Omicron XBB infection in Singaporean children (JAMA)
Effectiveness of COVID-19 vaccine in the prevention of post-COVID conditions (ASHE)
Incidence and impact of acute pericarditis in hospitalized patients with COVID‐19 (JAHA)
Serotonin reduction in post-acute sequelae of viral infection (Cell)
Prevalence and risk factors for long COVID and post-COVID-19 in Africa (The Lancet)
Safety profile and clinical and virological outcomes of nirmatrelvir-ritonavir treatment in patients with kidney disease and COVID-19 (CID)
Antiviral efficacy of molnupiravir vs ritonavir-boosted nirmatrelvir in patients with early symptomatic COVID-19
Contribute to our Floating Doctors fundraiser at PWB
Letters read on TWiV 1054
Dr. Griffin's COVID treatment summary (pdf)
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 1053: Bird flu in Baltimore Oct 15, 2023

Show notes

From the Centers for Excellence in Influenza Research and Response meeting in Baltimore, Vincent speaks with Ron Fouchier, Rafael Medina, and Louse Moncla about recent changes in the epidemiology of avian H5N1 influenza virus and the threat to humans and other animals.

Host: Vincent Racaniello

Guests: Ron Fouchier, Rafael Medina, and Louise Moncla

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Links for this episode

MicrobeTV Discord Server
MicrobeTV store at Cafepress
Spike shirts at vaccinated.us (promo code Microbetv)
Research assistant position in Rosenfeld Lab CBER/FDA (pdf)
Centers for Influenza Research and Response Network
Transatlantic spread of avian H5N1 influenza virus (Sci Rep)
In-host diversity of influenza H5N1 virus (PLoS Path)
Influenza H5N1 virus and mass mortality in sea lions (Vet Q.)
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 1052: Clinical update with Dr. Daniel Griffin Oct 14, 2023

Show notes

In his weekly clinical update, Dr. Griffin discusses disease severity of RSV compared with COVID-19 and Influenza among hospitalized adults aged ≥60 years, antiviral efficacy of Molnupiravir versus ritonavir-boosted nirmatrelvir in patients with early symptomatic COVID-19, Nirmatrelvir-Ritonavir and COVID-19 mortality and hospitalization among patients with vulnerability to covid-19 complications, antibiotic use among hospitalized patients with COVID-19 in the United States, one week of oral Camostat vs Placebo in nonhospitalized adults with mild-to-moderate COVID-19, assessment of the available therapeutic approaches for severe COVID-19, optimal duration of systemic Corticosteroids in COVID-19 treatment, effect of monovalent COVID-19 vaccines on viral interference between SARS-CoV-2 and several DNA viruses in patients with long-COVID syndrome, local budesonide therapy in the management of persistent hyposmia in suspected non-severe COVID-19 patients, and the safety profile and clinical and virological outcomes of Nirmatrelvir-Ritonavir treatment in patients with advanced chronic Kidney disease and COVID-19.

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Links for this episode

Disease severity of RSV compared with COVID-19 and Influenza among hospitalized adults
Antiviral efficacy of molnupiravir vs ritonavir-nirmatrelvir in patients with symptomatic COVID-19 (The Lancet)
Nirmatrelvir-Ritonavir and COVID-19 mortality and hospitalization among patients with vulnerability to complications (JAMA)
Antibiotic use among hospitalized patients with COVID-19 (OFID)
One week of oral Camostat vs placebo in non-hospitalized adults with COVID-19
Assessment of the available therapeutic approaches for severe COVID-19 (Nature)
Optimal duration of systemic Corticosteroids in COVID-19 treatment (OFID)
Effect of monovalent COVID-19 vaccines on viral interference between SARS-CoV-2 and in patients with long-COVID syndrome (Nature)
Local budesonide therapy in the management of persistent hyposmia in suspected COVID-19 patients (JID)
Safety profile and clinical and virological outcomes of Nirmatrelvir-Ritonavir treatment in patients with Kidney disease and COVID-19
Contribute to our Floating Doctors fundraiser at PWB
Letters read on TWiV 1052
Dr. Griffin's COVID treatment summary (pdf)
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 1051: Like SARS-CoV-2 in the headlights Oct 08, 2023

Show notes

TWiV reviews the 2023 Nobel Prize in Physiology or Medicine awarded to Katalin Karikó and Drew Weissman for their identification nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19, and accelerated mutation of SARS-CoV-2 in white-tailed deer.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Angela Mingarelli

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

MicrobeTV Discord Server
MicrobeTV store at Cafepress
Spike shirts at vaccinated.us (promo code Microbetv)
Research assistant position in Rosenfeld Lab CBER/FDA (pdf)
2023 Nobel Prize Physiology or Medicine (Nobelprize.org)
Evading a toll on the road to mRNA vaccines (TWiV 860)
Katalin Karikó's overlooked work (Wired)
Accelerated mutation of SARS-CoV-2 in deer (Nat Comm)
Letters read on TWiV 1051
Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – The New City. How to Build Our Sustainable Urban Future Angela – 2023 Nobel Peace Prize Alan – The Ruin of All Witches, by Malcolm Gaskill Vincent – France kicks off bird flu vaccination despite trade backlash risk

Listener Pick

Charles – David Brooks and the $78 airport meal the internet is talking about John – Periodic Table of the Elements: Origins of the Elements AZ – Bronze statue of laboratory mouse knitting DNA in Russia

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 1050: Clinical update with Dr. Daniel Griffin Oct 07, 2023

Show notes

In his weekly clinical update, Dr. Griffin discusses the effectiveness of maternal mRNA COVID-19 vaccination during pregnancy against COVID-19–associated hospitalizations in infants aged

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Links for this episode

Effectiveness of maternal mRNA COVID-19 vaccination during pregnancy against COVID-19–associated hospitalizations in infants (CDC)
COVID-19 vaccination recommendations and practices for women of reproductive age (CDC)
Molnupiravir for intra-household prevention of COVID-19 (JOI)
Delayed peak SARS-CoV-2 viral loads relative to symptom onset and implications for COVID-19 testing programs
Viral kinetics of sequential SARS-CoV-2 infections (Nature)
FDA authorizes updated Novavax COVID-19 vaccine (FDA)
Antiviral efficacy of molnupiravir vs ritonavir/nirmatrelvir in patients with COVID-19 (The Lancet)
Long-term cardiovascular, cerebrovascular, and other thrombotic complications in COVID-19 survivors (CID)
SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in coronary vessels (NCR)
Efficacy of gabapentin For Post–COVID-19
Contribute to our Floating Doctors fundraiser at PWB
Letters read on TWiV 1050
Dr. Griffin's COVID treatment summary (pdf)
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 1049: Long COVID's book of homeostatic cats Oct 01, 2023

Show notes

TWiV explains how immune profiling was used to identify distinguishing features of Long COVID, and how a co-opted feline endogenous retroviral envelope promotes cell survival by controlling copper transport and homeostasis in cats.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker

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Become a patron of TWiV!

Links for this episode