This Week in Virology

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TWiV 1137: Dengue is not BANAL Aug 04, 2024

Show notes

TWiV discusses a twice-yearly antiviral for prevention of AIDS, the WHO pandemic plan, West Nile resurgence in the US, the BANAL SARS-CoV-2 related viruses reproduce in human cells but do not transmit among animal hosts, and an amino acid change in dengue virus that enhances midgut replication in mosquitoes but reduces pathogenicity in humans.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

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Links for this episode

MicrobeTV Discord Server
PrEP with HIV-1 capsid inhibitor (NEJM)
WHO pandemic plan (pdf)
West Nile virus resurgence in US (NY Times)
Properties of BANAL SARS-CoV-2 like viruses (Nat Micro)
BANAL viruses on TWiV 809
Different effect of dengue virus amino acid change in humans and mosquitoes (Sci Transl Med)
Eng Ong Ooi on TWiV 633
Letters read on TWiV 1137
Timestamps by Jolene. Thanks!

Weekly Picks

Kathy – Using big data to improve traffic light timing Rich – Dillo Dirt Alan – Dueling Banjos on banjo and kora Vincent – The world's most expensive dinosaur and more

Listener Pick

Mike – Science through a glass darkly Lisa – On A Mission" Season Four

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

TWiV 1136: Clinical update with Dr. Daniel Griffin Aug 03, 2024

Show notes

In his weekly clinical update, Dr. Griffin discusses how the pandemic may have effected our trust in physicians and hospitals and if waiting longer to make strain selection for the seasonal influenza vaccine would be advantageous before reviewing the recent statistics on SARS-CoV-2 infection, how different CVODI-19 vaccines effect the cardiovascular system, if the a third of either COVID-19 mRNA vaccine is effective, where to find PEMGARDA, if convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, and the long term consequences of a SARS-CoV-2 infection on human health including incidences of diabetes, respiratory problems, hearing loss and maternal-fetal health.

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Links for this episode

In physicians and hospitals, we trust (JAMA Network)
Are there benefits for delaying seasonal influenza vaccine selections (JID)
Personal protective effect for wearing surgical face masks in public spaces (the BMJ)
COVID-19 national trend (CDC)
COVID-19 deaths (CDC)
Cardiovascular safety of different COVID-19 vaccination(Nature Comm)
Effectiveness of a third dose of mRNA-1273 versus BNT162b2 among older adults (Vaccine)
Where to get pemgarda (Pemgarda)
CDC Quarantine guidelines (CDC)
Early phase of SARs-CoV-2 infection (COVID.gov)
NIH COVID-19 treatment guidelines (NIH)
Infectious Disease Society guidelines for treatment and management (ID Society)
Drug interaction checker (University of Liverpool)
Molnupiravir safety and efficacy (JMV)
Convalescent plasma recommendation for immunocompromised (ID Society)
Managing healthcare staffing shortages (CDC)
Steroids,dexamethasone at the right time (OFID)
Anticoagulation guidelines (hematology.org)
Incidence of diabetes after SARS-CoV-2 infection (The Lancet Diabetes & Endocrinology)
Post-COVID-19 respiratory sequelae two years after hospitalization (The Lancet Regional Health)
Incidence of hearing loss following COVID-19 among young adults (eClinical Medicine)
The effect of long-term COVID-19 infection on maternal and fetal complications (Scientific Reports)
Contribute to our Floating Doctors fundraiser
Letters read on TWiV 1136
Dr. Griffin's COVID treatment summary (pdf)
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 1135: Resistance is not always futile Jul 28, 2024

Show notes

TWiV reviews whats going on with measles and its global resurgence, poliovirus found in Gaza, vaccine hesitancy in a community, 14 year old dies of Nipah, selection of SARS-CoV-2 viruses resistant to nirmatrelvir, and protective but non-neutralizing antibodies from survivors of Crimean-Congo hemorrhagic fever virus.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Brianne Barker, and Angela Mingarelli

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Links for this episode

MicrobeTV Discord Server
What's going on with measles? (J Virol)
Poliovirus in Gaza (Science)
Sanitation concerns in Gaza (AP)
Community vaccine beliefs (PLoS One)
14 year old dies of Nipah in India (Hindustan Times)
Selection of nirmatrelvir resistance mutants (Sci Adv)
CCHFV monoclonal antibodies (Cell Rep)
CCHFV vaccine (TWiV 565)
Prometheus Project (TWiV 578)
TWiV at USAMRIID (TWiV 1015)
Letters read on TWiV 1135
Timestamps by Jolene. Thanks!

Weekly Picks

Angela – Animal research is not always king Brianne – Why the US has more tornadoes than any other country Dickson – Earth's core has slowed so much it's moving backward Alan – Article about the Smithsonian's forensic ornithology lab, led by Carla Dove Vincent – Seventh patient 'cured' of HIV: why scientists are excited

Listener Pick

Charles – An Inquiry into Morals by Robert M. Pirsig and My Beloved Monster by Caleb Carr

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

TWiV 1134: Clinical update with Dr. Daniel Griffin Jul 27, 2024

Show notes

In his weekly clinical update, Dr. Griffin discusses Merck's RSV preventative monoclonal antibody Clesrovimab before reviewing the recent statistics on SARS-CoV-2 infection, if previous SARS-COV-2 infections predict the outcome of subsequent infections, if using COVID rapid diagnostic tests is cost effective, if the protein based vaccine NVX-CoV2327 elicits a durable immune response, if combination treatment of vaccine and antiviral drugs effectively protect against hospitalization, where to find PEMGARDA, what do when healthcare workers succumb to SARS-CoV-2 infection, and how COVID-19 may alter the cognitive trajectories of older patients.

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Links for this episode

Clesrovimab, RSV preventative monoclonal antibody for infants (Merck)
COVID-19 national trend (CDC)
COVID-19 deaths (CDC)
Characterizing SARS-CoV-2 reinfections and long COVID (Communications Medicine)
Cost-effectiveness of COVID rapid diagnostic tests (PLoS Medicine)
NVX-CoV2373 against pre-Delta and Delta strains of COVID-19 little evidence of waning immune response (CID)
Combined Protection of Vaccination and Nirmatrelvir-Ritonavir Against Hospitalization(CID)
Pemgarda infusion center locator (Pemgarda)
Respiratory virus guidance (CDC)
Early phase of SARS-CoV-2 infection (COVID.gov)
NIH COVID-19 treatment guidelines (NIH)
Infectious Disease Society guidelines for treatment and management (ID Society)
Drug interaction checker (University of Liverpool)
Molnupiravir safety and efficacy (JMV)
Convalescent plasma recommendation for immunocompromised (ID Society)
What do when your heathcare provider is infected with SARS-CoV-2 (CDC)
Managing healthcare staffing shortages (CDC)
Steroids,dexamethasone at the right time (OFID)
Anticoagulation guidelines (hematology.org)
Cognitive trajectories in older survivors of COVID-19 up to 2.5 years post-infection(Nature Aging)
Contribute to our Floating Doctors fundraiser
Letters read on TWiV 1134
Dr. Griffin's COVID treatment summary (pdf)
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 1133: Gain of function makes us safer Jul 21, 2024

Show notes

TWiV reviews cases of measles in Brooklyn NY and Washington DC, stalling of global childhood vaccination, licenses H5N1 vaccines protect against circulating strains, viruses traveling without passports. OC43 SARS-CoV- 2 spike replacement virus as an improved BSL-2 proxy virus for SARS-CoV-2 neutralization assays, and deep mutational scanning reveals functional constraints and antibody-escape potential of Lassa virus glycoprotein complex.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

MicrobeTV Discord Server
Measles in Brooklyn NY (ABC)
Measles in Washington DC (DC Health)
Global childhood immunization stalls (WHO)
Licensed H5N1 vaccines protect against circulating strains (Nat Med)
Viruses moving without passports (European CDC)
OC42-SARS-CoV-2 replacement spike virus (PNAS)
Deep mutational scanning of Lassa virus glycoprotein (Immunity)
Letters read on TWiV 1133
Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Elemental sulfur found on Mars Kathy – Lennette Lectures at ASV, including Gail Wertz, ASV 2024 Rich – Electricity maps (Opinions: Nuclear Waste Is Misunderstood; Should We Be Worried About Nuclear Waste?) Alan – Nature sent an investigative reporter to a predatory conference Vincent – Coal-filled trains are likely sending people to the hospital

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

TWiV 1132: Clinical update with Dr. Daniel Griffin Jul 20, 2024

Show notes

In his weekly clinical update, Dr, Daniel Griffin reviews President Biden's case of COVID, reviews recent statistics on SARS-CoV-2 infection, discusses post-acute sequelae after infection during pregnancy, the use of nirmatrelvir-ritonavir for post-exposure prophylaxis, where to find Pemgarda, effectiveness of combined nirmatrelvir-ritonavir-molnupiravir treatment, effectiveness of Ensitrelvir in reducing severe outcomes in outpatients at high risk for COVID-19, effectiveness of combined nirmatrelvir-ritonavir-molnupiravir treatment in patients hospitalized with COVID-19, CDC update of Long COVID Basics page, postacute sequelae of SARS-CoV-2 infection in the pre-delta, delta, and omicron eras, Long COVID risk has dropped over time but remains substantial, efficacy of antivirals, corticosteroids, and mAbs as acute COVID treatments in reducing the incidence of long COVID, and the interplay between diet and the gut microbiome: implications for health and disease.

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

President Biden has COVID (CNN, USA Today)
COVID-19 national trend (CDC)
COVID-19 deaths (CDC)
Post–acute sequelae of COVID after infection during pregnancy (OB & Gyn)
Oral nirmatrelvir–ritonavir as postexposure prophylaxis for Covid-19 (NEJM)
Pemgarda infusion center locator (Pemgarda)
Unable to access pemgarda, gotta call Daniel (microbeTV)
CDC Quarantine guidelines (CDC)
Early phase of SARs-CoV-2 infection (COVID.gov)
NIH COVID-19 treatment guidelines (NIH)
Infectious Disease Society guidelines for treatment and management (ID Society)
Drug interaction checker (University of Liverpool)
Combined treatment of COVID reduces molnupiravir-induced mutagenicity (J Inf Dis)
Effectiveness of ensitrelvir in reducing severe outcomes in outpatients at high risk for COVID-19 (Inf Dis Therapy)
Comparative effectiveness of combination therapy with nirmatrelvir–ritonavir and remdesivir versus monotherapy (Lancet)
Molnupiravir safety and efficacy (JMV)
Convalescent plasma recommendation for immunocompromised (ID Society)
Isolation guidance (CDC)
Managing healthcare staffing shortages (CDC)
Steroids, dexamethasone at the right time (OFID)
Anticoagulation guidelines (hematology.org)
Long COVID is defined (National Academies)
Long COVID: the ANSWERS! (longcovidtheanswers.com)
The FACTS: post COVID-19=long COVID? (WHO)
The BASICS of long COVID-19 (CDC)
Postacute sequelae of SARS-CoV-2 infection in the pre-delta, delta, and omicron eras (NEJM)
Long Covid risk has dropped over time but remains substantial (CNN)
Efficacy of antivirals, corticosteroids, and mAbs as acute COVID treatments in reducing the incidence of long COVID (Clin Micro Inf)
Diet and the gut microbiome: implications for health and disease (Nat Rev Micro)
Contribute to our Floating Doctors fundraiser
Letters read on TWiV 1132
Dr. Griffin's COVID treatment summary (pdf)
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 1131: Mootant influenza H5N1 virus Jul 14, 2024

Show notes

TWiV reviews the potential impact on science of the Supreme Court ruling in the Chevron decision, measles in New Hampshire and Vermont, new who proposed terminology for respiratory pathogen transmission, and pathogenicity and transmission of bovine H5N1 influenza virus.

Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

MicrobeTV Discord Server
Articles on Chevron decision (one, two, three)
Measles in New Hampshire and Vermont (NH DHHS)
Pathogenicity and transmission of bovine H5N1 virus (Nature)
Letters read on TWiV 1131
Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Stockholm Wood City Rich – "The Wide Wide Sea" by Hampton Sides Vincent – Tour de France stage 12

Listener Picks

Amy – Earth Forced from the Protective Heliosphere: What Do We know?

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

TWiV 1130: Clinical update with Dr. Daniel Griffin Jul 13, 2024

Show notes

In his weekly clinical update, Dr. Griffin discusses H5N1 influenza in the bird and cow communities of Colorado and Michigan and dengue in New York and the US before reviewing the recent statistics on SARS-CoV-2 infection, the absence of association with proton pump inhibitors and COVID-19 severity in children, where to find PEMGARDA, the effectiveness of molnupiravir and dexamethasone, convalescent plasma, what to do when healthcare workers succumb to SARS-CoV-2 infection, a resource of long COVID answers, how the WHO and CDC define long COVID and how it compares to ME/CSF.

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

H5N1: birds and cows oh, my…..Michigan and Colorado (CIDRAP)
Flu pandemic for the Colorado chicken (Colorado Sun)
It's a disaster: Avian flu in Weld county (Colorado.gov)
More 9.7 million dengue cases in US this year: CDC issues warning (Patch.com)
Long Island has DENGUE! (Long Island News12)
COVID-19 national trend (CDC)
COVID-19 deaths (CDC)
Association between proton pump inhibitors and COVID-19 susceptibility or severity in children? (Journal of Pediatrics)
Where to get pemgarda (Pemgarda)
Unable to access pemgarda, gottacall Daniel (microbeTV)
CDC Quarantine guidelines (CDC)
Early phase of SARs-CoV-2 infection (COVID.gov)
NIH COVID-19 treatment guidelines (NIH)
Infectious Disease Society guidelines for treatment and management (ID Society)
Drug interaction checker (University of Liverpool)
Molnupiravir safety and efficacy (JMV)
Convalescent plasma recommendation for immunocompromised (ID Society)
What do when your heathcare provider is infected with SARS-CoV-2 (CDC)
Managing healthcare staffing shortages (CDC)
Steroids,dexamethasone at the right time (OFID)
Benefits of desamethasone, reversal of monocyte dysfunction for severe COVID-19 (Cell)
Anticoagulation guidelines (hematology.org)
Long COVID: the ANSWERS! (longcovidtheanswers.com)
The FACTS: post COVID-19=long COVID? (WHO)
The BASICS of long COVID-19 (CDC)
Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness (CDC)
Contribute to our Floating Doctors fundraiser
Letters read on TWiV 1130
Dr. Griffin's COVID treatment summary (pdf)
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 1129: You never forget the first time you flu Jul 07, 2024

Show notes

TWiV reviews measles in Kenya, a trial for a intranasal COVID vaccine, dengue in the Florida Keys and in Central/South America, Spain connecting government with scientists, T cell activation and viral RNA fragments persist for up to 2 years after SARS-CoV-2 infection, and durable cross-reactive and protective antibodies against avian N2 neuraminidases elicited by A(H2N2) and A(H3N2) influenza pandemics.

Hosts: Vincent Racaniello and Alan Dove

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

MicrobeTV Discord Server
Measles in Kenya (WHO)
Intranasal COVID vaccine trial (NIH)
Dengue in Florida Keys (Florida Health)
Dengue rising in Central/South America (NPR)
Spain to connect scientists with government (Science)
Persistence of T cells and viral RNA after SARS-CoV-2 infection (Sci Transl Med)
Influenza pandemics induce cross-reactive antibodies against avian N2 (Nat Comm)
Letters read on TWiV 1129
Timestamps by Jolene. Thanks!

Weekly Picks

Alan – The first few minutes of this video by Roger Barnes Vincent – Billy & Molly: An Otter Love Story

Listener Picks

Fernando – A City on Mars

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 1128: Clinical update with Dr. Daniel Griffin Jul 06, 2024

Show notes

In his weekly clinical update, Dr. Griffin discusses the fourth US case of H5N1 human infection and reminds the audience of the definition of "pasteurization" before reviewing the recent statistics on SARS-CoV-2 infection, where to find PEMGARDA, the effectiveness of molnupiravir and dexamethasone, convalescent plasma, what to do when healthcare workers succumb to SARS-CoV-2 infection, how an EEG can be used to look for signatures of cognitive decline after SARS-CoV-2 infection and what we observed 2 years following SARS-CoV-2 infection for tissue-resident T cell and viral RNA persistence.

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

Fourth case human infection associated with an ongoing multistate outbreak of A(H5N1) (CDC)
Human H5N1 in Colorado and thedefinition of pasteurization (CIDRAP)
Is "raw" milk more risky than pasteurized (Annenberg Public Policy Center)
COVID-19 national trend (CDC)
COVID-19 deaths (CDC)
Winter, spring, summer and fall COVID-19 surges? (CDC)
Where to get pemgarda (Pemgarda)
Unable to access Pemgarda, gotta call Daniel (microbeTV)
CDC Quarantine guidelines (CDC)
Early phase of SARs-CoV-2 infection (COVID.gov)
NIH COVID-19 treatment guidelines (NIH)
Infectious Disease Society guidelines for treatment and management (ID Society)
Drug interaction checker (University of Liverpool)
Molnupiravir safety and efficacy (JMV)
Molunpiravir works: reduces hospitalizations and deaths due to COVID-19 and all-cause mortality (CID)
Convalescent plasma recommendation for immunocompromised (ID Society)
What do when your heathcare provider is infected with SARS-CoV-2 (CDC)
Managing healthcare staffing shortages (CDC)
Steroids,dexamethasone at the right time (OFID)
Benefits of dexamethasone, reversal of monocyte dysfunction for severe COVID-19 (Cell)
Anticoagulation guidelines (hematology.org)
EEG signatures for cognitive decline after SARS-CoV-2 infection (BMC Medicine)
Tissue resident T-cells and viral RNA 2 years after SARS-CoV-2 infection (Science Translational Medicine)
Contribute to our Floating Doctors fundraiser
Letters read on TWiV 1128
Dr. Griffin's COVID treatment summary (pdf)
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

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