This Week in Virology

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TWiV 172: Two can be as bad as one Feb 27, 2012

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Hosts: Vincent Racaniello and Kathy Spindler

Vincent and Kathy discuss how a virus may cause disease distant from its replication site, then review a day in the life of a senior microbiology professor.

Links for this episode:

Celsius vs Centigrade
Neuropathogenesis during polymicrobial infection (PLoS Pathogens)
Tetramer staining (pdf)
One
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Letters read on TWiV 172

TWiV 171: One is the loneliest number Feb 19, 2012

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Matt joins the TWiVarians to review virus production in single cells and single virion genomics.

Links for this episode:

H5N1 results will be published (NY Times)
Virus production in single cells then and now
Single virion genomics (PLoS One)
Multiple displacement amplification (Wikipedia)
Ranavirus killing turtles, tadpoles in Maryland (Washington Post)
Three Dog Night
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Letters read on TWiV 171

TWiV 170: From variolous effluvia to VLPs Feb 12, 2012

Show notes

Alan, Rich, and Dickson discuss Edward Jenner's paper on cowpox vaccine, then move 200 years later to modern vaccines against norovirus, influenza H5N1, and more.

Links for this episode:

Norton Zinder, 83 (Reuters)
Jenner's cowpox vaccine paper (Bartleby, Gutenberg)
Norovirus VLP vaccine (NEJM)
Plant-grown H5N1 VLP vaccine (Reuters, PLoS One)
Plant-grown norovirus VLP
Hexavalent pediatric vaccine
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Letters read on TWiV 170

TWiV 169: Epidemiology causes conclusions (p<0.05) Feb 05, 2012

Show notes

Michael and the TWiV team review epidemiology basics, including fatality ratios.

Links for this episode:

Michael's blog and podcast
Epidemiology literature critique (PowerPoint)
Seven mistakes in epidemiology (ETE)
Snow cholera map
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Letters read on TWiV 169

TWiV 168: Super CalTech prophylaxis and ferret runny noses Jan 29, 2012

Show notes

Welkin joins the TWiV team for a discussion of HIV prophlaxis using vectored antibodies, and the influenza H5N1 virus studies in ferrets that were not redacted.

Links for this episode:

Vectored HIV immunoprophylaxis (Nature)
Vectored immunoprophylaxis - the Movie (YouTube)
Adeno-associated virus (Wikipedia)
In vitro evolution of H5N1 towards human receptor specificity (Virology)
Endogenous viral genes non-essential in chicken (Nature)
Rates of HIV transmission per coital act (J Inf Dis)
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Letters read on TWiV 168

TWiV 167: It starts with a cough Jan 22, 2012

Show notes

The complete TWiVome deconstructs the movie Contagion.

TWiV 166: Breaking and entering Jan 15, 2012

Show notes

Vincent, Dickson, Rich, and Alan review cell proteins essential for entry of hepatitis C, Ebola, and measles viruses.

Links for this episode:

Niemann-Pick C1 is entry factor for HCV (Nature Med)
Ebola virus entry requires Niemann-Pick C1 (Nature one, two)
Nectin-4 is measles virus epithelial receptor (Nature, PLoS Pathogens)
An exit strategy for measles virus (Science)
On this day in history
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Letters read on TWiV 166

TWiV 165: The email zone Jan 08, 2012

Show notes

Vincent, Dickson, Rich, and Alan answer listener questions about XMRV, cytomegalovirus, latency, shingles vaccine, myxomavirus and rabbits, and more.

TWiV 164: Six steps forward, four steps back Jan 01, 2012

Show notes

Vincent, Alan, and Rich review ten compelling virology stories of 2011.

TWiV 163: What Rous wrought Dec 25, 2011

Show notes

Vincent, Dickson, Rich, and Alan review the 100 year old finding by Peyton Rous of a transmissible sarcoma of chickens, a discovery that ushered in the era of tumor virology.

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