This Week in Virology

Latest Episodes:

TWiV 270: Homeland virology Feb 02, 2014

Show notes

Hosts: Vincent Racaniello and Rich Condit

Guests: Dennis Hruby and Yoshihiro Kawaoka

Vincent and Rich discuss avian influenza virus and an antiviral drug against smallpox with Dennis and Yoshi at the ASM Biodefense and Emerging Diseases Research Meeting in Washington, DC.

Links for this episode

ASM Biodefense Meeting
Influenza H5N1 transmission (Virus Res)
Aerosol transmission of H5N1 virus in ferrets (Nature)
Characterization of H7N9 virus from humans (Nature)
ST-246 efficacy in primates (AAC)
Antiviral options for biodefense (Curr Op Virol)
ST-246 safety in humans (Antimicrob Agents Chemother)
Gain-of-function experiments (Science)
Letters read on TWiV 270
Video of this episode - view at Vimeo

Weekly Science Picks

Vincent - Quanta MagazineRich - Colour is in the eye of the beholder

Listener Pick of the Week

Kehau - Beautiful but deadly viruses

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 269: Herpesvirus stops a nuclear attack Jan 26, 2014

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

The complete TWiV team reviews evidence for sensing of herpesviral DNA in the nucleus by the cell protein IFI16.

Links for this episode

IFI16 is a nuclear pathogen sensor (Cell Host Micr)
Nuclear IFI16 sensing of and antagonism by herpesvirus (PNAS)
Acetylation regulates IFI16 location (PNAS)
Letters read on TWiV 269

Weekly Science Picks

Kathy - Female conveners and speakersAlan - SandgrainsRich - 2013 Lamborghini Aventador Vincent - Happy Birthday Mac and 128K Mac teardownDickson - Farmdominion

Listener Pick of the Week

Peter - The Microscope and The Next Global Killer Richard - Glass viruses

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 268: Transmission is inevitable Jan 19, 2014

Show notes

Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Ashlee Bennett

Vincent, Alan, Kathy, and Ashlee discuss fomites in physicians offices, plant virus factories involved in aphid transmission, and clues from the bat genome about flight and immunity.

Links for this episode

How viruses cause disease (Coursera)
How clean is your iPad (Which?)
Meeting announcement: From emerging to pandemic viruses
CaMV virus factories involved in aphid transmission (J Virol)
Caulimovirus (ViralZone)
CaMV responds instantly to vector (eLIFE)
Aphid acquiring CaMV (J Virol)
Bat genomes, flight, and immunity (Science)
Letters read on TWiV 268

Weekly Science Picks

Kathy - Jean-Luc Doumont (slides, communicating science, website, Scitable )Alan - Wireless thermometer Vincent - LORiOLA viral necklaces

Listener Pick of the Week

Jessica - Knit icosahedronRobert - Practical computing for biologists by Haddock and DunnStephen - Fourteen years of US weather (YouTube)

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TWiV 267: Snow in the headlights Jan 12, 2014

Show notes

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Vincent, Alan, Rich and Kathy review a protease essential for influenza pathogenesis in mice, and directionality of rhinovirus RNA exit from the capsid.

Links for this episode

Protease essential for influenza pathogenesis in mice (PLoS Path)
Rhinovirus uncoating is directional (PLoS Path)
Fluorescence correlation spectroscopy
Capillary electrophoresis (Wiki)
Letters read on TWiV 267

Weekly Science Picks

Kathy - Amazing maps Alan - Florida to NJ in 156 seconds (YouTube)Rich - Whiteout over Great Lakes from Space Vincent - LORiOLA viral necklaces

Listener Pick of the Week

Carol - Knit picornavirusRobert - RNA: Life's Indispensible Molecule by James Darnell,and Biochemical Pathways by Michal and Schomburg

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TWiV 266: A pathogenic vicious cycle Jan 05, 2014

Show notes

Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler

Vincent, Alan, and Kathy discuss finding viruses in outer space, varying results obtained from personal genetic testing, and depletion of CD4 cells during HIV infection by pyroptosis.

Links for this episode

We should hunt for viruses in space (New Scientist)
I had my DNA picture taken (NY Times)
CD4 cell death by pyroptosis (Nature)
Abortive HIV infection in lymphoid tissue (Cell)
IFI16 sensor required for HIV mediated cell death (Science)
PubMed Commons
Preferential CTL targeting of Gag (Cell Rep)
Exonic transcription protein binding (Science)
Letters read on TWiV 266
Video of this episode - view at YouTube

Weekly Science Picks

Kathy - 17 mundane things, mind blowing views Alan - Snowovel Vincent - Public's views on human evolution

Listener Pick of the Week

Emily - Dengue pillow

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 265: This year in virology Dec 29, 2013

Show notes

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

In their final episode of the year, the TWiV team reviews ten compelling virology stories from 2013.

Links for this episode

Antiviral RNAi (TWiV 255, 256, 263)
MERS-CoV (TWiV 215, 223, 224, 233, 239, 247, 251, 258)
Placental trophoblasts confer viral resistance (TWiV 241)
Origin of REV (TWiV 248)
Phage T7 gets a cat scan (TWiV 220)
It's a cGAS! (TWiV 222)
Dual virus-host arms race (TWiV 242)
Pandoraviruses (TWiV 246, 261)
CMV based SIV vaccine (TWiV 254)
Threading the NEIDL
Letters read on TWiV 265
Video of this episode - view at YouTube

Weekly Science Picks

Kathy - Women in Science Alan - ContagiumRich - RC helicopter (demo)Vincent - The athletic power of quadcopters

Listener Pick of the Week

Lindsay - Alcohol consumption and vaccines (Vaccine)Johnye - The Singing Microbiologist

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 264: We should do an all-email show some day Dec 22, 2013

Show notes

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

The TWiVites read listener questions and comments about public engagement in science, vaccines, RNAi, reprogramming CD8 cells to treat cancer, rabies, and much more.

Links for this episode

Viral gifts
Controlling plant viruses by vector control (Ann Rev Phyto)
Flavivirus RNAi suppressor (J Virol)
Entre probetas podcast (iTunes)
Hedgehog central
Reprogramming T cells for leukemia therapy (NEJM)
Petri Dish podcast
On Your Mind podcast
Letters read on TWiV 264

Weekly Science Picks

Kathy - Sorting algorithms visualized Alan - StratodeanRich - Art in Science by Polyxeni PotterVincent - Pixel Genes

Listener Pick of the Week

Judi - Olympus BioScapes Winner

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 263: Game of clones Dec 15, 2013

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Ben tenOever

Ben joins the TWiV team to reveal the winner of his contest in which influenza viruses carrying different interferon-stimulated genes vie against one another in mice.

Links for this episode

Virusninja
Game of clones (Vax Rep)
Game of clones bracket
Letters read on TWiV 263

Weekly Science Picks

Kathy - The Brain Scoop, esp. Where My Ladies AtAlan - Say 'hi' to a spaceship (YouTube)Rich - Garmin BlueChart Mobile and Active CaptainVincent - Journal boycott (one, two)Dickson - Futurescape TV show

Listener Pick of the Week

Luis - Spillover by David QuammenKen - Gravity

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 262: Wrong form, right professor Dec 09, 2013

Show notes

Host: Vincent Racaniello

Guest: Ann Palmenberg

Vincent returns to the University of Wisconsin - Madison to speak with Ann Palmenberg about her career in virology.

Links for this episode

Palmenberg lab website - great resources
Genome sequences of all rhinoviruses (J All Clin Imm)
Cardioviral poly(C) tracts (Arch Virol Supp)
EMCV disruption of nuclear transport (PNAS)
Picornavirus protease in replicase gene (J Virol)
Bacteriophage Qbeta replicase (J Virol)
Thanks to Jordan for the episode title!
Video of this episode - view at YouTube

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

TWiV 261: Giants among viruses Dec 01, 2013

Show notes

Hosts: Vincent Racaniello and James Van Etten

Guests: Chantal Abergel and Jean-Michel Claverie

Vincent meets up with Chantal and Jean-Michel at the first International Symposium on Giant Virus Biology in Tegernsee, Germany, to discuss their work on Mimivirus, Megavirus, and Pandoravirus.

Links for this episode

Unanswered giant virus questions (Adv Virus Res)
Fourth domain of life (Commun Integr Biol)
Pandoraviruses (Science)
Phaeocystis globosa virus (PNAS)
Cafeteria roenbergensis virus (PNAS)
Symposium group photo (jpg)
Video of this episode - view at YouTube

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

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