The Stem Cell Podcast

Latest Episodes:

Ep. 278: “Stembryo Engineering” Featuring Dr. Alfonso Martinez Arias Oct 15, 2024

Show notes

Dr. Alfonso Martinez Arias is the CREA Research Professor in the Department of Systems Bioengineering of the Universitat Pompeu Fabra in Barcelona. He talks about his path to developmental biology research and developing gastruloids to model human development. He also discusses standards for embryo models and his recent research on hematopoiesis.

Ep. 277: “Lung Development” Featuring Dr. Behzad Yeganeh Oct 01, 2024

Show notes

Dr. Behzad Yeganeh is an Associate Scientist at the Children's Hospital of Eastern Ontario Research Institute and the University of Ottawa. His work focuses on lung development and injury. He talks about neonatal lung diseases and the mechanisms that regulate autophagy and apoptosis.

Ep. 276: “Musculoskeletal Disorders” Featuring Dr. Dmitriy Sheyn Sep 17, 2024

Show notes

Dr. Dmitriy Sheyn is an Associate Professor in the Department of Orthopedics and Regenerative Medicine Institute at Cedars-Sinai Medical Center. His lab focuses on the development of stem cell therapies for multiple musculoskeletal disorders caused by acute injuries and aging. He talks about ways to model disc degeneration and tendon injuries. He also discuses his lab's work on tendon differentiation and the mechanisms of low back pain.

Ep. 275: “Liver Organogenesis” Featuring Dr. Ludovic Vallier Sep 03, 2024

Show notes

Dr. Ludovic Vallier is the W3 Einstein Strategic Professor for Stem Cells in Regenerative Therapies at the Berlin Institute of Health and a Max Planck Fellow at the Max Planck Institute for Molecular Genetics. His lab uses stem cells to model embryonic development in vitro and to produce liver cells with an interest for cell therapy. He talks about modeling non-alcoholic fatty liver disease and his lab's pivot to SARS-CoV-2 research early in the pandemic. He also discusses how iPSCs could be used to regenerate the liver after injury.

Ep. 274: “Brain Organoids” Featuring Dr. Ziyuan Guo Aug 20, 2024

Show notes

Dr. Ziyuan Guo is an Assistant Professor of Pediatrics at the Center for Stem Cell & Organoid Medicine at Cincinnati Children's Hospital. He talks about in vivo reprogramming and cell and gene therapy in neurodevelopmental and neurodegenerative disorders. He also discusses assembloids to model the blood-brain barrier and strategies for organoid vascularization.

Ep. 273: “Hematopoiesis and Cancer” Featuring Dr. Irving Weissman Aug 06, 2024

Show notes

Dr. Irving Weissman is the Virginia and Daniel Ludwig Professor of Clinical Cancer Research and Professor of Pathology and Developmental Biology at Stanford University. Dr. Weissman was the first scientist to identify and isolate mammalian blood-forming stem cells in mice, and his work has contributed to the understanding of how a single hematopoietic stem cell can give rise to specialized blood cells. He talks about developing new treatments for metastatic breast cancer and severe combined immunodeficiency. He also discusses myeloid bias in aging and strategies for commercializing new therapies.

Ep. 272: “Live at ISSCR 2024: Stem Cell Research in Space” Featuring Drs. Davide Marotta and Catriona Jamieson Jul 23, 2024

Show notes

Dr. Davide Marotta is the Program Director for In-Space Biomanufacturing at the International Space Station National Laboratory. Dr. Catriona Jamieson is the Director of the Sanford Stem Cell Institute at the University of California, San Diego. In this special episode recorded in front of a live audience at ISSCR 2024 in Hamburg, Germany, they talk about the opportunities and challenges of working with stem cells in a microgravity environment, and what this could mean for the future of stem cell-based therapies. They discuss the challenges of culturing cells in space, the need for risk reduction and collaboration, and how microgravity affects stem cell growth and aging. They also discuss the opportunities that come with the growing popularity of private spaceflight.

Ep. 271: “Skin Regeneration” Featuring Dr. Valentina Greco Jul 09, 2024

Show notes

Dr. Valentina Greco is the Carolyn Walch Slayman Professor of Genetics and Co-Chair of the Committee on the Status of Women in Medicine at Yale University. Her research focuses on tissue homeostasis in the face of continuous cellular turnover, frequent injuries, and spontaneous mutations. She talks about her research on skin and hair follicle stem cells, the role of imaging techniques, and bridging science and art. She also discusses disease modeling and building an inclusive lab culture.

Ep. 270: “Microvascular Regeneration” Featuring Dr. Sara Vasconcelos Jun 25, 2024

Show notes

Dr. Sara Vasconcelos is a Senior Scientist and the John Kitson McIvor Endowed Chair in Diabetes Research at University Health Network. She is also an Associate Professor at the Institute of Biomedical Engineering at the University of Toronto. Her lab studies microvascular regeneration in cardiovascular diseases and diabetes, and are working to develop personalized patient-derived organ-chip models for drug screening and other applications. In this episode, she talks about modeling cardiac fibrosis and studying pancreatic islet vasculature. She also discusses working with microchips and with large animal models.

Ep. 269: “iPSC Technology” Featuring Dr. Sebastian Diecke Jun 11, 2024

Show notes

Dr. Sebastian Diecke is a Group Leader and Stem Cell Core Director at the Max Delbrück Center, where his research focuses on iPSCs and organoid models. He talks about the early days of iPSC research, developing organoids from endangered rhinoceros, and modeling Huntington's and other diseases.

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