The Stem Cell Podcast

Latest Episodes:

Ep. 20: SCNT Featuring Dr. Dieter Egli Jun 09, 2014

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Guest: Dr. Dieter Egli from the New York Stem Cell Foundation joins the hosts to talk about his work in using SCNT to derive new embryonic stem cell lines. They discuss his previous and current work, including his latest story published in Nature. Resources and Links Sensing of Amino Acids in a Dopaminergic Circuitry Promotes Rejection of an Incomplete Diet in Drosophila Histone Modifications Are Associated with Delta(9)-Tetrahydrocannabinol-Mediated Alterations in Antigen-Specific T Cell Responses Compound in Saliva Helps Protect Our Cells from Toxins in Coffee, Tea, Study Shows A Molecular Basis for Classic Blond Hair Color in Europeans Engineering a Memory with LTD and LTP Green Tea Component Upsets Cancer Cell Metabolism Photoactivation of Endogenous Latent Transforming Growth Factor–β1 Directs Dental Stem Cell Differentiation for Regeneration Targeting CXCL12 From FAP-Expressing Carcinoma-Associated Fibroblasts Synergizes with Anti–PD-L1 Immunotherapy in Pancreatic Cancer Fighting Back: Patient's Own Immune Cells Tackle Cervical Cancer A Draft Map of the Human Proteome Abnormal Neuronal Differentiation and Mitochondrial Dysfunction in Hair Follicle-Derived Induced Pluripotent Stem Cells of Schizophrenia Patients Role of the Primate Ventral Tegmental Area in Reinforcement and Motivation Tai Chi Intervention Increases Progenitor CD34+ Cells in Young Adults Unconditional Quantum Teleportation between Distant Solid-State Quantum Bits Remission of Disseminated Cancer after Systemic Oncolytic Virotherapy Less Pain (Receptors) Means a Longer Life Mice with Mohawks Reveal Two Biological Pathways Linked with Autism Behaviors CC Sabathia Ready to Throw for First Time since Stem-Cell Treatment for Knee New Record Highs In Moral Acceptability - Premarital Sex, Embryonic Stem Cell Research, Euthanasia Growing in Acceptance The Broad Foundation Advances Stem Cell Research at USC Obokata Agrees to STAP Experiment Inside a Corrupt Stem Cell Research Lab EU Commission Rejects Petition to Stop Funding Embryonic Stem Cell Research Blonde Is Just a Matter of a Tiny Stem Cell Molecule Tweak, Says New Research Modulating Innate Immunity Improves Hepatitis C Virus Infection and Replication in Stem Cell-Derived Hepatocytes The Age and Genomic Integrity of Neurons after Cortical Stroke in Humans Photo Reference: Courtesy of Dr. Dieter Egli Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Ep. 19: Saratoga Stem Cell Conference Review and 5 Interviews May 26, 2014

Show notes

The Stem Cell Podcast HostsDr. Fasano and Dr. Ganat On this episode we review the Next Gen Stem Cell Conference from earlier in the month. During the conference we interviewed 5 stem cell scientists live and put them all together for this show. In addition to these great guests, we review the literature as always. Topics include the biggest sperm ever, C-kit+ stem cells don't make heart, heart on a chip technology, a new element on the periodic table, and iPSCs from schizophrenia patients. After that, we end with a rant about bathroom air fresheners! Resources, Links and Research Papers Mentioned In This Session Include: World's Oldest Sperm Discovered: 17-Million-Year-Old Cell Is Longer Than Its Creator Researchers Identify Link Between Colon Cancer And Metabolism In Vivo Modulation Of Hypoxia-Inducible Signaling By Topographical Helix Mimetics. Heart Cells Have 'Preteen' Growth Spurt An Antidepressant Decreases CSF Aβ Production in Healthy Individuals and in Transgenic AD Mice New Super-Heavy Element 117 Confirmed By Scientists Autism-Related Protein Shown to Play Vital Role in Addiction Chd5 Orchestrates Chromatin Remodelling During Sperm Development ‘Heart Disease-On-A-Chip’ Syphilis Made A Big Comeback In 2013, CDC Warns Life Extension Factor Klotho Enhances Cognition Meet HD 162826, The Sister Star Of Our Sun Novel Antioxidant Makes Old Arteries Seem Young Again, Study Shows Scripps Research Institute Scientists Create First Living Organism that Transmits Added Letters in DNA 'Alphabet' Model Universe Recreates Evolution Of The Cosmos Long-Snouted Tyrannosaur Unearthed Vampire's Delight? Young Blood Recharges Brains of Old Fate of iPSCs Derived from Azoospermic and Fertile Men following Xenotransplantation to Murine Seminiferous Tubules Hope For Aging Brains, Skeletal Muscle Stem Cell Therapy Saves Eyesight Of Fountain Valley Mother c-kit+ Cells Minimally Contribute Cardiomyocytes To The Heart Study Questions Use Of Stem Cells To Repair Heart Modeling The Mitochondrial Cardiomyopathy Of Barth Syndrome With Induced Pluripotent Stem Cell And Heart-On-Chip Technologies Phenotypic Differences In Hipsc Npcs Derived From Patients With Schizophrenia. Recombinase-Mediated Reprogramming and Dystrophin Gene Addition in mdx Mouse Induced Pluripotent Stem Cells U.S. Biomedical Research 'Unsustainable,' Prominent Researchers Warn Rescuing US Biomedical Research From Its Systemic Flaws We are working on a way to categorize all of the research papers we mention on the show and provide, possibly even provide audio summaries. Enter in your name and e-mail address below, and we will notify you of when this feature is available. [widgets_on_pages id="Opt-In"] Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Ep. 18: Lou Gehrig’s Update Featuring Dr. Kevin Eggan May 13, 2014

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Guest: Dr. Kevin Eggan from Harvard University joins the show to talk about his latest work using stem cells to cure ALS/Lou Gehrig’s disease. Resources and Links Fate of iPSCs Derived from Azoospermic and Fertile Men following Xenotransplantation to Murine Seminiferous Tubules Hope for Aging Brains, Skeletal Muscle Pain Curbs Sex Drive in Female Mice, but Not in Males New Virus Related To Smallpox Is Found in Republic Of Georgia Male Researchers Stress Out Rodents Scripps Florida Scientists Find Connection Between Gene Mutation, Key Symptoms of Autism Soy-Dairy Protein Blend and Whey Protein Ingestion After Resistance Exercise Increases Amino Acid Transport and Transporter Expression in Human Skeletal Muscle Push Comes to Shove: Gilead's $1,000 Pill Could Hurt Insurer Earnings Death Rates From Pancreatic Cancer Predicted to Rise in Europe in 2014 Human CLP1 Mutations Alter tRNA Biogenesis, Affecting Both Peripheral and Central Nervous System Function Y chromosome is Not Disappearing, Researchers Say Loss Of Memory Reversed in Alzheimer's Mice Models MRSA Spreads in Households REDD1 is Essential for Stress-Induced Synaptic Loss and Depressive Behavior Amyloid Precursor Protein Regulates Neurogenesis by Antagonizing Mir-574-5p in the Developing Cerebral Cortex Japanese Nobel Winner Latest to Apologize Over Stem-Cell Research RIKEN to Check 20,000 Papers for Doctored Images and Plagiarism Stem Cells and the "Staircase of Shame" Stem Cells May Be Key to Long Life: Research on Body of 115-Year-Old Woman How Silly Putty May Advance Stem Cell Research First Stem Cells Cloned From Diabetes Patient, Thanks to Egg Donors Human Oocytes Reprogram Adult Somatic Nuclei of a Type 1 Diabetic to Diploid Pluripotent Stem Cells Human Embryonic-Stem-Cell-Derived Cardiomyocytes Regenerate Non-Human Primate Hearts Infertility: Stem Cell-Based Sperm Created From Infertile Mens Skin Reprogramming Committed Murine Blood Cells to Induced Hematopoietic Stem Cells with Defined Factors A 3D Sphere Culture System Containing Functional Polymers for Large-Scale Human Pluripotent Stem Cell Production 3D In Vitro Model of a Functional Epidermal Permeability Barrier from Human Embryonic Stem Cells and Induced Pluripotent Stem Cells Photo Reference: Courtesy of Dr. Kevin Eggan Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Ep. 17: Naked Stem Cells Featuring Dr. Chris Smith of The Naked Scientists Apr 22, 2014

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Guest: In this episode we talk with the creator and host of The Naked Scientists; a website and podcast dedicated to all things science. We talk with Chris about his shows, and get his take on the stem cell field. Resources and Links House Windows That Double As Solar Panels? Shiny Quantum Dots Brighten Future of Solar Cells Is Parkinson's an Autoimmune Disease? KOI-3278: A Self-Lensing Binary Star System Scientists Spot a Planet That Looks Like 'Earth's Cousin' Female ‘Penis’ Found on Brazilian Cave Insects Oh Baby: Scientists Find Protein That Lets Egg and Sperm Hook Up Is 'Sluggish Cognitive Tempo' a New Disorder or an Extension of ADHD? Artificial Blood on an Industrial Scale Mapping Gene Expression in the Fetal Brain Gene Variant Puts Women at Higher Risk of Alzheimer’s Than It Does Men, Study Finds Traces of Trauma in Sperm RNA Lab-Grown Private Parts: Vagina Implants Cure Rare Disorder Gut-Eating Amoeba Caught on Film Gene Therapy Successfully Regenerates an Old Organ Inside a Living Animal Bees Exposed to Fungicide More Vulnerable to Nosema Parasite Obokata Mentor, Co-Author: STAP Cells Just A ‘Hypothesis’ In Stem-Cell Research, Health Benefits Outweigh the Risks Of Copying Humans Human Somatic Cell Nuclear Transfer Using Adult Cells Conversion of Quiescent Niche Cells to Somatic Stem Cells Causes Ectopic Niche Formation in the Drosophila Testis Auxetic Nuclei in Embryonic Stem Cells Exiting Pluripotency Pathways Disrupted in Human ALS Motor Neurons Identified through Genetic Correction of Mutant SOD1 Multifaceted Regulation of Somatic Cell Reprogramming by mRNA Translational Control Two miRNA Clusters Reveal Alternative Paths in Late-Stage Reprogramming Photo Reference: Courtesy of Dr. Chris Smith - The Naked Scientists Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Ep. 16: Stem Cell Scientist in Washington? Apr 08, 2014

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Guest: In this episode we bring on Dr. Raja Kittappa, a stem cell scientist who has recently decided to leave science and run for congress. Resources and Links Brain Activation during Human Male Ejaculation Experimental Cancer Drug Reverses Schizophrenia in Adolescent Mice First Synthetic Yeast Chromosome Revealed Party Drug Ketamine Could Help People with Severe Depression Experimental Compound FRAX486 Reverses Signs of Fragile X In Mice Researchers Identify Good Bacteria That Protects against HIV MIT Researchers Develop Living Material Using E. coli Disorganized Cortical Patches Suggest Prenatal Origin of Autism Blood Test of 4 Biomarkers Predicts Death within 5 Years Gene Family Linked To Brain Evolution Implicated in Severity of Autism Symptoms HPV-Linked Throat Cancer May Have Telltale First Symptoms Mugshots Built from DNA Data Genetic Factor Contributes to Forgetfulness Study: Climate Change Accelerates Greenland Ice Loss Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV Human Nose Can Detect More Than 1 Trillion Smells, Scientists Discover Scientists Find Gene Which Is Linked to Exceptionally Low IQ in Children Stem Cell Scientist Guilty of Falsifying Data Ancient Virus DNA Gives Stem Cells the Power to Transform Modeling ALS with iPSCs Reveals that Mutant SOD1 Misregulates Neurofilament Balance in Motor Neurons Intrinsic Membrane Hyperexcitability of Amyotrophic Lateral Sclerosis Patient-Derived Motor Neurons Telomerase Protects Werner Syndrome Lineage-Specific Stem Cells from Premature Aging Mouse SCNT ESCs Have Lower Somatic Mutation Load Than Syngeneic iPSCs Dynamics of HSPC Repopulation in Nonhuman Primates Revealed by a Decade-Long Clonal-Tracking Study Combined Hydrogels That Switch Human Pluripotent Stem Cells From Self-Renewal to Differentiation Mutations in USP9X Are Associated with X-Linked Intellectual Disability and Disrupt Neuronal Cell Migration and Growth Photo Reference: Courtesy of Dr. Raja Kittappa Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Ep.15: Melanoma and Zebrafish Featuring Dr. Leonard Zon Mar 21, 2014

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Guest: In this episode, we bring on an internationally recognized stem cell and cancer researcher Dr. Leonard Zon from Harvard Medical School and Boston Children's Hosital. Dr. Zon talks to us about his work using zebrafish as a model to study cancer and melanoma and tells some really funny stories on his experiences with these fish. Resources and Links Trends In Atmospheric Carbon Dioxide In Mauna Loa, Hawaii Gel Protects Monkeys from H.I.V. after Sex, Study Finds Genetic Modification and Screening in Rat Using Haploid Embryonic Stem Cells Telescope Captures View of Gravitational Waves Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation Environmental and State-Level Regulatory Factors Affect the Incidence of Autism and Intellectual Disability Respiratory Failure, Cleft Palate and Epilepsy in the Mouse Model of Human Xq22.1 Deletion Syndrome CDC Warns Untreatable Gonorrhea Could Spread Like Wildfire In Rare Case, Woman with H.I.V. Infects Female Sex Partner, C.D.C. Says Obesity-Associated Variants within FTO Form Long-Range Functional Connections with IRX3 Hydrous Mantle Transition Zone Indicated By Ringwoodite Included within Diamond Human C-Tactile Afferents Are Tuned to the Temperature of a Skin-Stroking Caress Shorter Telomeres with High Telomerase Activity are Associated with Raised Allostatic Load and Impoverished Psychosocial Resources Biomarkers Could Predict Alzheimer's Before It Starts Confusions About Totipotency: Stem Cells Are Not Embryos Mechanical Memory and Dosing Influence Stem Cell Fate Cell-Autonomous Correction of Ring Chromosomes in Human Induced Pluripotent Stem Cells C9orf72 Nucleotide Repeat Structures Initiate Molecular Cascades of Disease Haematopoietic Stem Cells Require a Highly Regulated Protein Synthesis Rate High-Efficiency Motor Neuron Differentiation from Human Pluripotent Stem Cells and the Function Ofislet-1 Photo Reference: Courtesy of Dr. Leonard Zon Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Ep.14: Direct Reprogramming Featuring Dr. Justin Ichida Mar 10, 2014

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Guest: Over the past few weeks some really exciting papers came out describing the reprogramming of one cell into another, a process called Direct Reprogramming. On this episode we talk to Dr. Justin Ichida from the University of Southern California who uses the latest reprogramming techniques in his lab to study neural disease. His current research is focused on using patient-specific disease models to define the mechanisms that lead to neuronal loss in ALS and frontotemporal dementia. Resources and Links University of Southern California - The Ichida Lab – Board California Institute for Regenerative Medicine (CIRM) Center for Regenerative Medicine and Stem Cell Research Early Treatment Is Found to Clear H.I.V. in a Second Baby Why Can You Remember Your Dreams? Researchers Uncover Why Only Some People Can Recall Them in the Morning Acetaminophen In Pregnancy Linked to ADHD in Kids, Study Finds Study Uncovers New Pathway of Melanoma Metastasis New Research Finds Direct Connection Between Acupuncture and Processes That Alleviate Sepsis 'Largest Ever' Trial of Adult Stem Cells in Heart Attack Patients Begins This Company Wants to Make In Vitro Meat From Celebrities’ Stem Cells USPTO Issues Patent For Fraudulent Stem Cell Procedure Isolation Of Human Induced Pluripotent Stem Cell-Derived Dopaminergic Progenitors By Cell Sorting For Successful Transplantation Coordination Of Engineered Factors With TET1/2 Promotes Early-Stage Epigenetic Modification during Somatic Cell Reprogramming Small Molecules Facilitate the Reprogramming of Mouse Fibroblasts into Pancreatic Lineages Direct Reprogramming of Human Fibroblasts to Functional and Expandable Hepatocytes Human Hepatocytes with Drug Metabolic Function Induced from Fibroblasts by Lineage Reprogramming Photo Reference: Courtesy of Dr. Justin Ichida Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Ep. 13: STAP Stem Cells and Blogging Featuring Dr. Paul Knoepfler Feb 23, 2014

Show notes

Guest: STAP stem cells were a new method of generating pluripotent stem cells published in a paper a few weeks ago. When it came out, scientists scratched their heads and wondered whether or not this new method could actually work and be reproducible. Well, while the jury is still out, it is not looking good and we bring on the show one of the most recognized voices of stem cell research, Dr. Paul Knoepfler to discuss the STAP stem cell theory. In addition to running a laboratory, Dr. Knoepfler maintains an amazingly active stem cell blog breaking all the latest stem cell news, and educating the public about stem cells. Resources and Links Knoepfler Lab Stem Cell Blog Stem Cells: An Insiders Guide by Paul Knoepfler Expandable Megakaryocyte Cell Lines Enable Clinically Applicable Generation of Platelets from Human Induced Pluripotent Stem Cells The Endocannabinoid System Controls Food Intake via Olfactory Processes Astrocyte-Derived Endothelin-1 Inhibits Remyelination through Notch Activation Rejuvenation of the Muscle Stem Cell Population Restores Strength to Injured Aged Muscles Nanog-Independent Reprogramming to iPSCs with Canonical Factors Nanog Is Dispensable for the Generation of Induced Pluripotent Stem Cells In Vivo Direct Reprogramming of Reactive Glial Cells into Functional Neurons after Brain Injury and in an Alzheimer’s Disease Model NPTX1 Regulates Neural Lineage Specification from Human Pluripotent Stem Cells Photo Reference: Courtesy of Dr. Paul Knoepfler Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Ep. 12: Cancer and Stem Cells Featuring Dr. Sean Morrison Feb 10, 2014

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Guest: In this episode, we interview another stem cell pioneer, Dr. Sean Morrison, who is internationally recognized for his work in understanding the mechanisms of stem cell regulatory mechanisms and how this is relevant in cancer. In the science roundup we cover zombie bees, stem cells for baldness, dipping cells in acid to make stem cells, and how to identify the difference between iPSCs and hESCs. Photo Reference: Courtesy of Dr. Chad Cowan Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Ep. 11: Stem Cell Core Facilities Featuring Dr. Mark Tomishima Jan 27, 2014

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Guest: Dr. Mark Tomishima, director of the SKI Stem Cell Research Facility located in New York City joins us for this episode. Dr. Tomishima tells us about what his and other core facilities do for stem cell researchers locally and abroad, as well as various projects his group is working on. We then go through the science roundup discussing everything from a new herpes drug, to heart cell propelled sperm looking bio-bots, to stem cell-derived 3D kidneys. Photo Reference: Courtesy of Dr. Mark Tomishima Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

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