The Peter Attia Drive

Latest Episodes:

92 - AMA #12: Strategies for longevity (which don't require a doctor) Feb 10, 2020

Show notes

In this "Ask Me Anything" (AMA) episode, Peter explains the various levers one can pull to affect longevity with a specific focus on the strategies and tactics one can implement that do not require the help of a physician. Once again, Bob Kaplan, Peter's head of research, will be asking the questions. If you're not a subscriber and listening on a podcast player, you'll only be able to hear a preview of the AMA. If you're a subscriber, you can now listen to this full episode on your private RSS feed or on our website at the AMA #12 show notes page.

We discuss:

The five levers you can pull to affect longevity [1:15];
Nutritional biochemistry: Framework, 3 nutritional interventions, and how to approach your goals, and what you should be tracking [4:30];
Exercise for brain health, and the 4 components of exercise [20:45];
Exercise component—Stability [24:30];
Exercise component—Strength [29:00];
What is Peter optimizing for with his exercise? [30:30];
Exercise components—Zone 2 and zone 5 training [33:15];
More about DNS, and why we need to be careful with rushing kids through neuromuscular development stages [45:00];
Sleep: How to improve quantity and quality [48:15]; and
More.

Learn more: https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/AMA12 Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

Qualy #106 - Does LDL cause heart disease? Feb 05, 2020

Show notes

Today's episode of The Qualys is from podcast #03 – Ron Krauss, M.D.: a deep dive into heart disease.

The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.

Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.

Learn more: https://peterattiamd.com/podcast/qualys/

Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/

Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD

#91 – Eric Topol, M.D.: Can AI empower physicians and revolutionize patient care? Feb 03, 2020

Show notes

In this episode, Dr. Eric Topol, founder and director of the Scripps Research Translational Institute, shares how artificial intelligence and deep learning is currently impacting medicine and how it could transform the healthcare industry, not only in terms of the technological advancements, but also in restoring the patient-doctor relationship for better patient outcomes and experiences. We also discuss Eric's rich and fascinating career in cardiology as well as his involvement as one of the first outspoken researchers to question the cardiovascular safety of Vioxx.

We discuss:

Eric's background and his source of interest in cardiology [3:15];
The US medical field's resistance to technological change and learning from other healthcare models [11:15];
Eric's mission at the Cleveland Clinic [20:15];
How Eric helped to elucidate the issues with Vioxx (and why he came to regret it) [29:45];
How Eric came to found one of the most influential research centers in the world [47:30];
How AI and deep learning is currently impacting medicine, and the future possibilities [56:30];
Gut microbiome—Its role in health, impact on glycemic response and fuel partitioning, and how deep learning could improve our research and treatment [1:17:45];
Why machines combined with human doctors is superior to one without the other [1:32:00];
How AI and machines can reinstate medicine as an attractive career (and alleviate physician burnout) [1:36:45];
Eric's dream experiment [1:47:15] and;
More.

Learn more: https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/erictopol Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

Qualy #102 - Is the food industry still saying that all calories contribute equally to adiposity and insulin resistance? Jan 29, 2020

Show notes

Today's episode of The Qualys is from podcast #14 – Robert Lustig, M.D., M.S.L.: fructose, processed food, NAFLD, and changing the food system.

Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.

Learn more: https://peterattiamd.com/podcast/qualys/

Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/

Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD

#90 - Ryan Holiday: Stillness, stoicism, and suffering less Jan 27, 2020

Show notes

In this episode, Ryan Holiday, author of Stillness is the Key, shares the profound impact that stoic philosophy has had on his personal life and his career as a successful writer. Ryan stresses the importance of stillness in a modern world set up to encourage the opposite and lays out the best strategies to develop stillness in your life. He also explains the destructive nature of being driven by ego, as well as the perils of jealousy and anger, and provides practical steps you can take to avoid those harmful states.

We discuss:

Has a more connected world improved or worsened our lives? [2:15];
Consequences of an overly secure life, living in the present, & the misconception of unlimited time [5:45];
Stoicism 101: The definition and origins of stoic philosophy [15:45];
Ryan's career transition into writing, and his take on what makes a book or business successful [26:45];
Storytelling—The upside and downside of telling stories and self-narrative [36:15];
Does achieving success have to come from a place of craving and proving others wrong? And what are the costs of building a legacy? [38:45];
Ego—confusing ego with confidence, signs your ego is showing, & antidotes to the negative effects of ego [52:45];
Ryan's advice to Peter about writing (and finishing) his book [1:06:30];
Stillness—what it is, how it compares to meditation, & the obstacles to achieving stillness [1:10:30];
Ryan's morning routine, relationship with his smartphone, and how he avoids falling victim to the trappings of technology and a hyperconnected world [1:17:40];
The perils of jealousy and envy [1:24:15];
How to live in the moment in a modern world not designed for stillness [1:32:15];
How the idea of "dying well" can help you live better [1:36:00];
How has fatherhood impacted Ryan's philosophies on stillness and living in the moment? [1:39:45];
How to make your favorite day your every day [1:42:00];
The most reliable strategies for developing stillness [1:47:30];
Anger—what the stoics say about anger, outrage in politics, & why more anger isn't the solution [2:02:00];
How to follow Ryan's work [2:12:00]; and
More.

Learn more: https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/ryanholiday Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

Qualy #99 - The steroid controversy: Mark's use of them and Peter's perspective Jan 23, 2020

Show notes

Today's episode of The Qualys is from podcast #28 – Mark and Chris Bell: steroids, powerlifting, addiction, diet, training, helping others, documentaries, and living your best life.

Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.

Learn more: https://peterattiamd.com/podcast/qualys/

Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/

Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD

#89 - AMA #11: All things fasting Jan 20, 2020

Show notes

In this "Ask Me Anything" (AMA) episode, Peter answers a wide range of fasting-specific questions from subscribers. Peter starts by defining the various fasting protocols, details his own personal fasting regimen, explains his revised plan for 2020, and provides a ton of value to anyone interested in fasting. Once again, Bob Kaplan, Peter's head of research, will be asking the questions. If you're not a subscriber and listening on a podcast player, you'll only be able to hear a preview of the AMA. If you're a subscriber, you can now listen to this full episode on your private RSS feed or on our website at the AMA #11 show notes page. We discuss:

Defining the various fasting protocols [1:00];
Why Peter plans to switch to a 3-day fast once per month in 2020 [11:00];
How Peter uses his CGM to gain insights into the depth of fast [13:15];
Peter's supplement protocol during fasting, and why he eats a ketogenic diet leading up to a prolonged fast [17:00];
Peter's exercise regimen during a fast [23:30];
Peter's hunger levels during a typical 7-day fast [26:45];
Fasting observations—Core body temperature and thyroid hormone [30:30];
Fasting observations—Glucose, BHB, and hunger levels [33:15];
Peter's sleep protocol during a fast [40:15];
Does Peter observe any differences between men and women in their ability to fast? [47:00];
How Peter prefers to break a long fast [50:15];
Importance of community support while fasting, and is there a perfect fasting protocol? [52:00]; and
More.

Learn more: https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/ama11/ Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

Qualy #94 - Comparing the two broad types of meditation, and Peter's favorite meditation apps Jan 15, 2020

Show notes

Today's episode of The Qualys is from podcast #34 – Sam Harris, Ph.D.: The transformative power of mindfulness.

Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.

Learn more: https://peterattiamd.com/podcast/qualys/

Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/

Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD

Qualy #89 - Cortisol and healthy aging Jan 07, 2020

Show notes

Today's episode of The Qualys is from podcast #31 – Navdeep Chandel, Ph.D.: metabolism, mitochondria, and metformin in health and disease.

Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.

Learn more: https://peterattiamd.com/podcast/qualys/

Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/

Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD

#87 - Rick Johnson, M.D.: Fructose—The common link in high blood pressure, insulin resistance, T2D, & obesity? Jan 06, 2020

Show notes

In this episode, Rick Johnson, Professor of Nephrology at the University of Colorado, explains how his research into the causes of blood pressure resulted in a change of research direction to focus more on how fructose has such profound metabolic effects. Rick discusses the relationship between salt and high blood pressure, provides a masterclass into uric acid, and expertly reveals the mechanisms and pathways by which sugar (specifically fructose) can profoundly impact metabolic health. From there, he explains how he applies this information to real life patients, as well as touches on some of the most promising ideas around pharmacotherapy that are being developed in response to the epidemics of fatty liver, insulin resistance, diabetes, and obesity. Furthermore, Rick gives his take on artificial sweeteners compared to real sugar, discusses cancer's affinity for fructose, and much more.

We discuss:

The connection between blood pressure and fructose that shifted Rick's professional focus [4:00];
The relationship between salt and blood pressure (and the role of sugar) [5:45];
Defining fructose, glucose, and sugar [19:30];
An ancient mutation in apes that explains why humans turn fructose into fat so easily [23:00];
The problems with elevated uric acid levels, and what it tells us about how sugar causes disease [31:30];
How sugar causes obesity—explaining the difference in glucose vs. fructose metabolism and the critical pathway induced by fructose [40:00];
Why drinking sugar is worse than eating it [50:00];
Unique ability of sugar to drive oxidative stress to the mitochondria, insulin resistance, and diabetes [54:00];
Why cancer loves fructose [1:00:15];
The many areas of the body that can use fructose [1:05:00];
Fructokinase inhibitors—a potential blockbuster? [1:07:15];
Treating high uric acid levels—Rick's approach with patients [1:10:00];
Salt intake—what advice does Rick give his patients? [1:16:30];
How excess glucose (i.e., high carb diets) can cause problems even in the absence of fructose [1:21:00];
Artificial sweeteners vs. real sugar—which is better? [1:29:15];
Umami, MSG, alcohol, beer—do these have a role in metabolic illness? [1:33:45];
Fructose consumption—Is any amount acceptable? Is fruit okay? Where does Rick draw a hard line? [1:38:45]
How does Rick manage the sugar intake of his young kids? [1:43:00]; and
More.

Learn more: https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/rickjohnson Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

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