The Lead Podcast presented by Heart Rhythm Society

Latest Episodes:

The Lead Podcast - Episode 38 Nov 21, 2023

Show notes

Janice Y. Chyou, MD, FHRS, of Icahn School of Medicine at Mount Sinai is joined by guests Jonathan P. Piccini, Sr., MD, MHS, FHRS, of Duke University Medical Center, and Mintu P.Turakhia, MD, MS, of iRhythm Technologies and Stanford University to have A Discussion of Apixaban for Stroke Prevention in Subclinical Atrial Fibrillation. Subclinical atrial fibrillation is short-lasting and asymptomatic and can usually be detected only by long-term continuous monitoring with pacemakers or defibrillators. Subclinical atrial fibrillation is associated with an increased risk of stroke by a factor of 2.5; however, treatment with oral anticoagulation is of uncertain benefit. Among patients with subclinical atrial fibrillation, apixaban resulted in a lower risk of stroke or systemic embolism than aspirin but a higher risk of major bleeding.

https://www.hrsonline.org/education/TheLead

https://www.nejm.org/doi/full/10.1056/NEJMoa2310234

Host Disclosure(s):

J. Chyou: Honoraria/Speaking/Consulting Fee: McGraw-Hill, American Heart Association; Membership (Advisory Committee): American Heart Association

Contributor Disclosure(s):

J. Piccini: Honoraria/Speaking/Consulting Fee: Biotronik, AbbVie, LivaNova, Boston Scientific, Phillips, Medtronic, Electrophysiology Frontiers, Abbott, UpToDate, Inc., Sanofi, Milestone Pharmaceuticals, Bayer Healthcare Pharmaceuticals; Research (Contracted Grants for PIs Named Investigators Only): Boston Scientific, Bayer Healthcare Pharmaceuticals, AMA, Abbott, Phillips, Element Science, Inc., iRhythm Technologies, NIH

M. Turakhia: Research (Contracted Grants for PIs Named Investigators Only): Bristol-Myers Squibb, FDA Circulatory System Devices Panel, American Heart Association, Bayer Healthcare Pharmaceuticals, Sanofi; Stocks (Board Membership): 100Plus; Employment: iRhythm Technologies

The Lead Podcast - Episode 37 Nov 16, 2023

Show notes

Bruce A. Koplan, MD, MPH, FHRS, of Brigham and Women's Hospital is joined by guests Andres Alonso Enriquez, MD, and Andrés Felipe Miranda-Arboleda, MD, of Queens University to discuss Efficacy Of Early Catheter Ablation For Atrial Fibrillation After Admission For Heart Failure.

https://www.hrsonline.org/education/TheLead

https://www.jacc.org/doi/10.1016/j.jacep.2023.05.038

Host Disclosure(s):

B. Koplan: Honoraria/Speaking/Consulting Fee: GE Healthcare

Contributor Disclosure(s):

A. Enriquez: No relevant financial relationships with ineligible companies to disclose.

A. Miranda-Arboleda: No relevant financial relationships with ineligible companies to disclose.

The Lead Podcast - Episode 36 Nov 09, 2023

Show notes

William H. Sauer, MD, FHRS, CCDS, of Brigham and Women's Hospital is joined by guests Esseim Sharma, MD, of University Hospitals Cleveland, and Paul C Zei, MD, PhD, FHRS, of Brigham and Women's Hospital to discuss One-Year Outcomes Following Stereotactic Body Radiotherapy for Refractory Ventricular Tachycardia. Cardiac stereotactic body radiotherapy (SBRT) has emerged as a promising noninvasive treatment for refractory ventricular tachycardia (VT). The objective is to describe the safety and effectiveness of SBRT for VT in refractory to extensive ablation. For a select group of high-risk patients with VT refractory to standard therapy, SBRT is associated with a reduction of in VT and appropriate ICD therapies.

https://www.hrsonline.org/education/TheLead

https://www.heartrhythmjournal.com/article/S1547-5271(23)02782-0/fulltext

Host Disclosure(s):

W. Sauer: Honoraria/Speaking/Consulting Fee: Biotronik, Biosense Webster, Inc., Abbott, Boston Scientific; Research (Contracted Grants for PIs Named Investigators Only): Medtronic

Contributor Disclosure(s):

E. Sharma: No relevant financial relationships with ineligible companies to disclose.

P. Zei: Honoraria/Speaking/Consulting Fee: Varian Medical Systems, Biosense Webster, Inc., Abbott; Research (Contracted Grants for PIs Named Investigators Only): Biosense Webster, Inc.; Stocks (Publicly Traded): Affera, Inc.

The Lead Podcast - Episode 35 Nov 02, 2023

Show notes

Jason T. Jacobson, MD, FHRS, of Westchester Med Center-New York Med College discusses A Novel ECG-Based Deep Learning Algorithm to Predict Cardiomyopathy in Patients With Premature Ventricular Complexes with Daniel Frenkel, MD, FHRS, of Westchester Medical Center, and Jagmeet P. Singh, MD, PhD, FHRS, of Massachusetts General Hospital. This study utilized a machine learning algoritihm to predict the devlopment of cardiomyopathy in patients with PVCs based on the baseline ECG.

https://www.hrsonline.org/education/TheLead

https://www.jacc.org/doi/10.1016/j.jacep.2023.05.025

Host Disclosure(s):

J. Jacobson: Honoraria/Speaking/Consulting Fee: American College of Cardiology, Zoll Medical Corporation; Research (Contracted Grants for PIs Named Investigators Only): Abbott, Phillips; Stocks (Privately Held): Atlas 5D

Contributor Disclosure(s):

D. Frenkel: Ownership/Partnership/Principal: Summit Health

J. Singh: Honoraria/Speaking/Consulting Fee: Medtronic, EBR Systems, Boston Scientific, Biotronik, Abbot, MicroPort Scientific Corporation, Cardiologs, Sanofi, CVRx Inc., Impulse Dynamics, USA, Implicity, Orchestra Biomed, Rhythm Management Group Corp, Medscape, Biosense Webster Inc., Notal Vision, iRhythm Technologies, Philips

The Lead Podcast - Episode 34 Oct 31, 2023

Show notes

William H. Sauer, MD, FHRS, CCDS, of Brigham and Women's Hospital is joined by guests Sunil Kapur, MD, of Brigham and Women's Hospital, and Joshua M. Cooper, MD, FHRS, of Temple University Health System to discuss Intra-Pocket Ultrasound-Guided Axillary Vein Puncture vs. Cephalic Vein Cutdown for Cardiac Electronic Device Implantation: The ACCESS Trial. Intra-pocket ultrasound-guided axillary vein puncture (IPUS-AVP) for venous access in implantation of transvenous cardiac implantable electronic devices (CIED) is uncommon due to the lack of clinical evidence supporting this technique. This study investigated the efficacy and early complications of IPUS-AVP compared to the standard method using cephalic vein cutdown (CVC) for CIED implantation. IPUS-AVP is superior to CVC in terms of success rate, time to venous access, procedure duration, and radiation exposure. Complication rates were similar between the two groups. Intra-pocket ultrasound-guided axillary vein puncture should be a recommended venous access technique for CIED implantation.

https://www.hrsonline.org/education/TheLead

https://pubmed.ncbi.nlm.nih.gov/37832512/

https://pubmed.ncbi.nlm.nih.gov/37378419/

Host Disclosure(s):

W. Sauer: Honoraria/Speaking/Consulting Fee: Biotronik, Biosense Webster, Inc., Abbott, Boston Scientific; Research (Contracted Grants for PIs Named Investigators Only): Medtronic

Contributor Disclosure(s):

S. Kapur: Honoraria/Speaking/Consulting Fee: Medtronic, Novartis, Abbott, Biotronik

J. Cooper: Honoraria/Speaking/Consulting Fee: Medtronic, Biosense Webster, Inc., Abbott, Boston Scientific, Medical Device Business Services, Zoll Medical Company

The Lead Podcast - Episode 33 Oct 26, 2023

Show notes

Michael S. Lloyd, MD, FHRS, of Emory University is joined by guests T. Jared Bunch, MD, FHRS, of University of Utah School of Medicine, and Amit Shah MD, MSCR, of Emory University to discuss Atrial Fibrillation Catheter Ablation vs Medical Therapy and Psychological Distress - A Randomized Clinical Trial.

https://www.hrsonline.org/education/TheLead

https://jamanetwork.com/journals/jama/article-abstract/2809419

Host Disclosure(s):

M. Lloyd: Honoraria/Speaking/Consulting Fee: Medtronic, Baylis Medical Company, Boston Scientific

Contributor Disclosure(s):

T. Bunch: Honoraria/Speaking/Consulting Fee: Pfizer, Inc., Heart Rhythm Society; Research (Contracted Grants for PIs and Named Investigators Only): Boehringer Ingelheim, Altathera, Abbott; Other Financial Relationships: Biosense Webster, Inc.

A. Shah: No relevant financial relationships with ineligible companies to disclose.

The Lead Podcast - Episode 32 Oct 24, 2023

Show notes

Danesh Kella, MBBS, FHRS, and Christopher V. DeSimone, MD, PhD, FHRS, of Mayo Clinic are joined by guests Christopher J. McLeod, MBChB, PhD, FHRS, and Siva K. Mulpuru, MD, FHRS, of Mayo Clinic to discuss Chlorhexidine Gluconate Pocket Lavage to Prevent Cardiac Implantable Electronic Device Infection in High-Risk Procedures.

https://www.hrsonline.org/education/TheLead

https://www.heartrhythmjournal.com/article/S1547-5271(23)02585-7/fulltext

Host Disclosure(s):

D. Kella: Honoraria/Speaking/Consulting Fee: Zoll Medical Company

C. DeSimone: No relevant financial relationships with ineligible companies to disclose.

Contributor Disclosure(s):

C. McLeod: Honoraria/Speaking/Consulting Fee: BioSig Technologies

S. Mulpuru: No relevant financial relationships with ineligible companies to disclose.

The Lead Podcast - Episode 31 Oct 19, 2023

Show notes

William H. Sauer, MD, FHRS, CCDS, of Brigham and Women's Hospital is joined by guests Thomas Tadros, MD, and Ashraf Sabe, MD, of Brigham and Women's Hospital, to discuss efficacy and safety of hybrid epicardial and endocardial ablation versus endocardial ablation in patients with persistent and longstanding persistent atrial fibrillation. In this randomized trial, hybrid surgical and catheter ablation was more effective than catheter ablation alone in persistent atrial fibrillation without significant procedural risk increase.

https://www.hrsonline.org/education/TheLead

https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(23)00229-8/fulltext

Host Disclosure(s):

W. Sauer: Honoraria/Speaking/Consulting Fee: Biotronik, Biosense Webster, Inc., Abbott, Boston Scientific; Research (Contracted Grants for PIs Named Investigators Only): Medtronic

Contributor Disclosure(s):

T. Tadros: No relevant financial relationships with ineligible companies to disclose.

A. Sabe: No relevant financial relationships with ineligible companies to disclose.

The Lead Podcast - Episode 30 Oct 17, 2023

Show notes

Jason T. Jacobson, MD, FHRS, of Westchester Med Center-New York Med College discusses Return-to-Play for Elite Athletes With Genetic Heart Diseases Predisposing to Sudden Cardiac Death with Sei Iwai, MD, FHRS, of WMC Health Network, and Rachel Lampert, MD, FHRS, of Yale University School of Medicine. This study reports on cardiac events in elite athletes with genetic heart diseases associated with sudden cardiac death that, through a shared decision making process have returned to play. This was done under the care of expert sports and genetic cardiologists. The incidence of cardiac events was low and no fatalities occurred.

https://www.hrsonline.org/education/TheLead

https://www.jacc.org/doi/10.1016/j.jacc.2023.05.059

Host Disclosure(s):

Contributor Disclosure(s):

S. Iwai: No relevant financial relationships with ineligible companies to disclose.

R. Lampert: Honoraria/Speaking/Consulting Fee: Medtronic; Research (Contracted Grants for PIs Named Investigators Only): MediLynx, Medtronic, Boston Scientific, Medtronic Inc.

The Lead Podcast - Episode 29 Oct 12, 2023

Show notes

Christopher C. Cheung, MD, MPH, of Sunnybrook Health Sciences Centre, University of Toronto, is joined by guests Edward P. Gerstenfeld, MD, FHRS, of University of California, San Francisco, and Paul C. Zei, MD, PhD, FHRS, of Brigham and Women's Hospital to discuss the benefits and risks associated with pulsed field ablation and conventional thermal ablation in the content of paroxysmal atrial fibrillation.

https://www.hrsonline.org/education/TheLead

https://www.nejm.org/doi/full/10.1056/NEJMoa2307291

Host Disclosure(s):

C. Cheung: No relevant financial relationships with ineligible companies to disclose.

Contributor Disclosure(s):

E. Gerstenfeld: Honoraria/Speaking/Consulting Fee: Medtronic, Boston Scientific, Biosense Webster, Abbott, Thermedica; Other Non-Financial Relationships: Farapulse, Abbott Medical, Adaigo Medical, Boston Scientific

P. Zei: Honoraria/Speaking/Consulting Fee: Abbott, Biosense Webster Inc., Varian Medical Systems; Research (Contracted Grants for PIs Named Investigators Only): Daiichi, Biosense Webster Inc.; Stock Options (Publicly Traded): Affera, Inc.

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