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    Software How-To

    Talk Python To Me

    Talk Python to Me is a weekly podcast for Python developers, data scientists, and AI builders,
    hosted by developer and entrepreneur Michael Kennedy. We dive deep into the packages, tools, and people
    shaping Python, from web development and data science to AI and LLMs. If you’re new to Python, you’ll
    quickly learn the ins and outs of the community by hearing from its leaders. And if you’ve been Pythoning
    for years, you’ll hear about your favorite packages and the hot new ones coming out of open source.

    Advertise

    Copyright: © Copyright 2015-2024

    • Apple Podcasts
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    Latest Episodes:
    #546: Self hosting apps for Python people Apr 27, 2026
    Show notes

    The cloud is convenient until it isn't. You upload your photos, sync your contacts, click through the cookie banners. Then prices go up again or you read about a family that lost their entire Google account over a medical photo sent to a doctor. At some point, the question shifts from "why would I run this myself?" to "why aren't I?"
    My guest this week is Alex Kretzschmar, head of DevRel at Tailscale, longtime host of the Self-Hosted podcast, and co-founder of Linuxserver.io. We cover what self-hosting really means in 2026, the apps worth running yourself like Immich and Home Assistant, why Docker Compose ties it all together, and how Tailscale lets you reach any of it from anywhere, without opening a single port. If you've been thinking about pulling your digital life back behind your own walls, this is your roadmap.
    Episode sponsors
    Temporal
    Talk Python Courses

    Links from the show

    Guest
    Alex Kretzschmar: alex.ktz.me
    Bitflip podcast: bitflip.show
    Self-Hosted podcast (Alex's previous show): selfhosted.show
    Perfect Media Server: perfectmediaserver.com
    KTZ Systems on YouTube: youtube.com/@ktzsystems
    Linuxserver.io (co-founded by Alex): linuxserver.io
    "How Tailscale Works" blog post: tailscale.com/blog/how-tailscale-works
    https://tailscale.com/: tailscale.com
    Self-hosted apps discussed
    Awesome Self-Hosted (GitHub list): github.com
    Immich (Google Photos alternative): immich.app
    Home Assistant: home-assistant.io
    Open Home Foundation: openhomefoundation.org
    Plausible Analytics: plausible.io
    Umami Analytics: umami.is
    Python integration for umami: pypi.org
    Pi-hole: pi-hole.net
    AdGuard Home: adguard.com
    NextDNS: nextdns.io
    Coolify: coolify.io
    Docker + ufw: docs.docker.com
    Storage, backup & filesystem
    OpenZFS: openzfs.org
    ZFS.rent (offsite ZFS replication): zfs.rent
    Backblaze: backblaze.com
    Hetzner Storage Box: hetzner.com
    DigitalOcean: digitalocean.com
    Secrets management mentioned
    OpenBao (open-source Vault fork): openbao.org
    HashiCorp Vault: hashicorp.com
    Bitwarden: bitwarden.com
    1Password: 1password.com
    Hardware mentioned
    Proxmox VE: proxmox.com
    Minisforum MS01: minisforum.com
    Zima Board / Zima OS: zimaspace.com
    Other references
    Cory Doctorow on "enshittification" (Cory's blog where he coined the term): pluralistic.net
    Linus Tech Tips' WAN Show (Linus mentioned NAS-building going mainstream): linustechtips.com
    Watch this episode on YouTube: youtube.com
    Episode #546 deep-dive: talkpython.fm/546
    Episode transcripts: talkpython.fm
    Theme Song: Developer Rap
    🥁 Served in a Flask 🎸: talkpython.fm/flasksong
    ---== Don't be a stranger ==---
    YouTube: youtube.com/@talkpython
    Bluesky: @talkpython.fm
    Mastodon: @talkpython@fosstodon.org
    X.com: @talkpython
    Michael on Bluesky: @mkennedy.codes
    Michael on Mastodon: @mkennedy@fosstodon.org
    Michael on X.com: @mkennedy
    #545: OWASP Top 10 (2025 List) for Python Devs Apr 16, 2026
    Show notes

    See the full show notes for this episode on the website at talkpython.fm/545

    #544: Wheel Next + Packaging PEPs Apr 10, 2026
    Show notes

    See the full show notes for this episode on the website at talkpython.fm/544

    #543: Deep Agents: LangChain's SDK for Agents That Plan and Delegate Apr 01, 2026
    Show notes

    See the full show notes for this episode on the website at talkpython.fm/543

    #542: Zensical - a modern static site generator Mar 25, 2026
    Show notes

    See the full show notes for this episode on the website at talkpython.fm/542

    #541: Monty - Python in Rust for AI Mar 19, 2026
    Show notes

    See the full show notes for this episode on the website at talkpython.fm/541

    #540: Modern Python monorepo with uv and prek Mar 13, 2026
    Show notes

    See the full show notes for this episode on the website at talkpython.fm/540

    #539: Catching up with the Python Typing Council Mar 06, 2026
    Show notes

    See the full show notes for this episode on the website at talkpython.fm/539

    #538: Python in Digital Humanities Feb 28, 2026
    Show notes

    See the full show notes for this episode on the website at talkpython.fm/538

    #537: Datastar: Modern web dev, simplified Feb 21, 2026
    Show notes

    See the full show notes for this episode on the website at talkpython.fm/537

    Previous 1 2 3 4 5 57 Next

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