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    STEM-Talk

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    Copyright: © Florida Institute for Human and Machine Cognition

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    Latest Episodes:
    Episode 109: Robb Wolf discusses whether eating meat is bad for you and the environment … and his new book “Sacred Cow” Jul 14, 2020
    Show notes

    Today’s guest is Robb Wolf, who is making his third appearance on STEM-Talk. He has a new book, which is being released today, the same day as our interview with Robb goes live. His new book, “Sacred Cow: Why Well Raised Meat Is Good For You and Good For The Planet,” takes a critical look at the assumptions and also the misinformation about meat and provides contrarian views that are science-based showing that meat and animal fat are essential for our bodies.

    Robb is a former research biochemist who is also the author of two other New York Times bestsellers, “The Paleo Solution” and “Wired to Eat.” Robb’s career includes a stint as a review editor of the Journal of Nutrition and Metabolism, a consulting role for the Naval Special Warfare Resiliency Program, and membership on the board of directors and advisors for Specialty Health, Inc. He also is on the board of the Chickasaw Nation’s Unconquered Life Initiative and works with a number of innovative startups with the focus on health and sustainability.

    In today’s interview, Robb talks about his move from Reno, Nevada, to the hill country of Texas, the science that supports the importance of meat and fat in a healthy diet, his transition to a ketogenic diet, and how improving our metabolic health is one of the most important things we can do to protect ourselves against COVID-19.

    [00:03:52] Ken opens the interview mentioning that Robb is making his third appearance on STEM-Talk. He was a guest on episode 27 of STEM-Talk, and also helped Ken co-host an interview with Allan Savory, episode 40. Ken then asks Robb about his move from Reno to the hill country of Texas.

    [00:05:57] Dawn mentions that Robb has started a new podcast since his last appearance on STEM-Talk. The new podcast is The Healthy Rebellion Radio, and replaces the Paleo Solution. Dawn explains that this new show follows a Q&A format, and features Robb and his wife, Nicki Violetti, answering listener questions. Dawn asks what prompted Robb and Nicki and to start this new podcast.

    [00:08:12] Dawn asks for an update on a project Robb discussed on episode 27 called the Reno Risk Assessment project, which was a program of diet and lifestyle changes that he and Nicki developed to improve health and performance of police and fire departments.

    [00:14:07] Dawn asks about the motivations and origins of Robb’s work with the Chickasaw Nation and its “Unconquered Life” project.

    [00:18:31] Dawn asks Robb about his comments that improving metabolic health is one of the most important things a person can do to protect themselves during the COVID-19 pandemic.

    [00:20:52] Dawn mentions that researchers at the University of North Carolina published a paper last year that showed only 12% of Americans have optimal metabolic health. The report pointed out that those with poor metabolic health included many people of normal weight. Dawn follows up by asking Robb if he also has found this to be true in his work with people.

    [00:24:09] Ken asks for Robb’s take on BMI, which can often be misleading.

    [00:25:21] Dawn asks if Robb’s personal diet has evolved since his previous appearance on STEM-Talk.

    [00:33:16] Ken mention’s that Robb’s new book, which is scheduled to come out the same day as this episode goes live, is titled, “Sacred Cow.” Ken goes on to say that Robb and his co-author, dietician Diana Rogers, look at the quandaries we face in raising and eating animals. The book particularly focuses on cows, which Robb describes as not only the largest of our farmed animals, but also the most maligned. Ken begins the discussion of the book by asking Rob why he decided to take on the vegans and the topic of eating animals.

    [00:38:22] Dawn asks Robb for his take on one of the two major arguments against the consumption of animal products: that eating foods such as beef and chicken and cheese are bad for our health, and what the true science is behind these two claims.

    [00:42:58] Dawn asks what happens when people replace meat and dense protein sources with plant-based alternatives like grains, legumes, peas, nuts and the like.

    [00:45:33] Robb discusses the White Oak Pastures Life Cycle Analysis on the beef they raise and how it compares to the Beyond Burger, in terms of net carbon emissions, and other environmental factors.

    [00:49:56] Dawn mentions that an international team led by Bradley Johnston, an epidemiologist at Dalhousie University, conducted a systematic review and meta-analysis and found very weak evidence that eating red meat is a health risk. Dawn goes on to mention that these authors received significant backlash for their scientific findings as well as attacks that were both personal and political and motivated more by emotional entrenched beliefs than by science. Dawn asks Robb for his opinion on the study as well as the backlash the authors received.

    [00:54:45] Ken mentions that the way the authors of this study have been savaged for publishing their findings reminds him of John Ioannidis, who was the guest on episode 77 of STEM-Talk. Ken mentions that Ioannidis argued that evidence-based medicine has been hijacked by researchers with vested interests and personal bias. Ken asks for Robb’s advice for people who are looking for the best information on what is right for their bodies, and how to avoid this sort of biased research.

    [00:58:21] Ken asks Robb to explain how he addresses the argument that beef supposedly is the most environmentally destructive food, and a serious threat to the environment, in his book.

    [01:05:42] Ken asks Robb about his analysis of Allan Savory’s work, who appeared on STEM-Talk, episode 40, who argued that increasing the number of livestock on grasslands, rather than fencing them off, is a way to stop desertification.

    [01:07:53] Dawn asks Robb about the argument that cattle husbandry is extremely water intensive. Robb discusses a study out of the Netherlands which shows that raising beef requires less water per pound than raising avocadoes or walnuts.

    [01:09:48] Ken mentions that the New York Times recently published an opinion piece titled, “The End of Meat is Here,” with the subtitle, “If you care about the working poor, about racial justice, and about climate change, you have to stop eating animals.” Robb gives a counterview on those claims.

    [01:12:57] Dawn mentions that Bill Gates, on his website, has a review he wrote of Vaclav Smils’ book, “Should We Eat Meat.” Gates writes that there are indeed environmental issues that need addressing in terms of raising livestock. Gates’ review, however, goes on to explain the many benefits to the poor and developing countries in regards to the introduction of meat into their diets. Robb gives his take on the constant drumbeat in the media for the elimination of meat from our diet despite data such as what is discussed in Gates’ review.

    [01:16:59] Ken asks Robb about his take on the PRIME Act, or the Processing Revival and Intrastate Meat Exemption Act. Ken explains that the current law requires processing of all beef, pork and lamb to be slaughtered and processed in USDA inspected facilities or state facilities, which are often hundreds of miles away from small farms and ranches. Whereas the PRIME Act would give ranchers and farmers another more local-based option for processing and marketing their meat, and also give local restaurants, grocery stores and other food-service establishments the ability to more affordably source local meat.

    [01:22:53] Dawn mentions that Robb is part of a team that has put together a Sacred Cow website. The website focuses on the moral, environmental and nutritional issues we face in raising and eating animals, particularly the cow. Robb discusses the website and how people can order his book.

    [01:25:18] Dawn asks about the film Robb and his co-author, Diana, are working on, which is designed to be complimentary to the book.

    [01:26:05] Dawn asks how Robb and Diana met and what lead them to start working together.

    [01:29:08] Dawn asks Robb for his advice for people who decline eating meat for religious or other reasons that have nothing to do with the environment. She asks Robb to talk abou optimizing and maintaining metabolic health if you’re a person who doesn’t eat meat.

    [01:30:59] Robb explains the 30-day challenge he gives readers in “Sacred Cow,” which helps people transition to a healthful and conscientious diet, as well as a way to support sustainable farms.

    [01:34:14] Ken asks if Robb senses that the mainstream medical community is opening up to the idea of ketosis and fasting as tools to help people lose weight and improve their health.

    [01:38:26] Dawn mentions that Robb and Nicki co-founded one of the first CrossFit affiliates in the country in 2004, where they worked a lot with people on their diet and exercise regimens. Dawn asks Robb to give an update on the gym.

    [01:39:13] Ken asks what Robb’s training looks like since many gyms are closed due to COVID-19.

    [01:42:51] Dawn closes the interview asking Robb if it’s true that he and Ken are working on a book together.


    Episode 108: Ken and Dawn tackle questions ranging from AI to amino acids to methylene blue to ketosis to COVID-19 Jun 23, 2020
    Show notes

    Because of the number of questions that keep pouring in, today we have another Ask Me Anything episode. We also have been receiving requests to do more of these shows, so we plan to record more frequent AMA episodes in the future. If you have questions for Ken and Dawn, email them to STEM-Talk producer Randy Hammer at rhammer@ihmc.us.

    In today’s episode we touch a little bit on COVID-19, but most questions revolve around diet and sleep and brain health. Ken also explains the meaning behind IHMC’s name and Dawn shares why she tweaked her vegetarian lifestyle to now include fish in her diet. Plus, Ken weighs in on the dangers of AI, real and imagined. It’s a fun, wide-ranging episode. Enjoy!

    Show notes:

    [00:02:28] Dawn opens the AMA with a listener question for Ken about his thoughts on social distancing.

    [00:03:19] A listener asks Dawn about the long-term pulmonary effects for survivors of COVID-19, and how this will impact divers.

    [00:04:49] Dawn reads a listener question for Ken about the U.S. relationship with China in regards to drug manufacturing: “During your interview with Katherine Eban, you made a comment about how current events related to COVID-19 truly highlight the fault in our dependency on Chinese manufacturing for our pharmaceuticals. That was just a few months ago…Where do you see our relationship with China heading with respect to drug manufacturing in the future?”

    {00:06:54] Ken talks about the need for each individual to take responsibility for the pharmaceuticals they ingest and recommends listening to Katherine’s Eban’s STEM-Talk interview and checking out her website, which has a wealth of information about generic drugs.

    [00:07:19] A listener asks Dawn about her shift from strict vegetarianism to occasionally adding fish into her diet. The listener wonders if this came about as a result of some of the discussions on STEM-Talk, or if her decision was inspired by something else?

    [00:09:07] A listener asks Ken if he uses branch chain amino acids, and if so how?

    [00:11:52] Ken talks about how combining essential amino-acid supplementation with mechanical loading via resistance training is a powerful strategy to combat the age-related loss of muscle function and mass that often leads to sarcopenia in the older population.

    [00:14:45] Dawn poses a listener’s question to Ken about why nutritionists seem to almost unanimously tolerate intermittent fasting or time-restricted eating, but oppose the ketogenic diet. The listener goes on to ask if there is any difference between getting into ketosis through diet versus fasting.

    [00:17:30] A listener asks Ken, who was an early adopter of a low-carb ketogenic diet, how his understanding of low-carb and healthy diets has changed as research has progressed.

    [00:19:25] A listener talks about how their adoption of time-restricted eating has led to late-night binge eating. The listener asks if it is true that skipping breakfast makes it harder to suppress ghrelin, sometimes referred to as “the hunger hormone.” The listener is curious about this because so many STEM-Talk guests talk about how they skip breakfast.

    [00:22:45] A listener asks Dawn: “In your podcast with Francisco Gonzalez-Lima, you talked about the potential role of methylene blue in protecting individuals exposed to environmental hypoxia. Do you know of any studies that have looked at this potential application of methylene blue?”

    [00:26:05] A listener asks Ken about adding legumes back into one’s diet after losing weight through the ketogenic diet, and if the weight will return if legumes are reintroduced.

    [00:29:20] A listener asks how Ken came up with the name “Institute for Human and Machine Cognition,” and what all the name entails?

    [00:30:51] A listener asks Dawn about the replication of extreme environments in a lab setting when studying human performance in various extreme environments.

    [00:34:56] A listener asks Ken: “There was some recent news coverage about how tanks are being driven by artificial intelligence and how machine guns are being equipped with facial recognition software…As I listened to the interview that Dawn did with you a while back, you said you didn’t agree with Elon Musk’s rather dark vision of rogue robots going around killing people…I’m curious if your thoughts about weaponized robots and the dangers of AI have changed over the past couple of years. And what do you see as the future?”

    [00:37:14] In responding to a listener’s question about the best ways to improve a person’s mental health, Ken recommends throwing away your TV, limiting your time on social media, taking walks in forests, get better sleep, have more sex, and listen to STEM-Talk. He goes on to expand on some of these ideas.

    [00:38:27] A listener asks if Ken has ever used the Ooler sleep device, and if so, what does he think of it?

    [00:39:32] Dawn answers a listener’s question about what her research into the brain’s lymphatic system in extreme environments is yielding.

    [00:41:54] A listener asks Ken to elaborate on a speech he gave in which he said people should strive to be better animals. Ken explains what he meant and adds that people should also recognize and embrace that we are all part of the animal kingdom.

    [00:42:56] A listener mentions that there are several activity and sleep-tracking devices in the form of a ring, and that during the Peter Attia episode, Ken and Peter discussed the Oura ring and another ring that Ken said he was evaluating. The listener asks about the results of that evaluation.

    [00:46:59] Ken asks Dawn if it’s true that you have better glymphatic function when you sleep on your side?

    [00:47:52] A listener asks how the collection of health-related data via smartphones and wearables will impact the diving community. The listener goes on to ask if Dawn sees the diving community moving toward collecting such physiological parameters to define such things as decompression.

    [00:50:14] Ken asks Dawn about underwater eye-tracking studies.

    [00:51:32] Dawn closes the AMA with a listener’s question about natural sleep aids to maintain healthy sleep during the COVID-19 crisis and the disruption of sleep schedules that many people are experiencing in quarantine.

    Learn more about IHMC

    STEM-Talk homepage

    Ken Ford bio

    Dawn Kernagis bio


    Episode 107: Francisco Gonzalez-Lima discusses methylene blue and near-infrared light as therapies for cognitive disorders May 26, 2020
    Show notes

    Today we have part two of our interview with Dr. Francisco Gonzalez-Lima, a behavioral neuroscientist at The University of Texas at Austin.

    Francisco and his colleagues at the Gonzalez-Lima Lab are recognized as world leaders for their research on the relationship between brain energy metabolism, memory and neurobehavioral disorders.

    Today’s interview focuses on two interventions Francisco has explored with the aim of protecting people against neurodegeneration: low-dose methylene blue and the application of near-infrared light. Part one of our interview, episode 106, touched on Francisco’s youth and training as well as his early research into Alzheimer’s disease and brain-metabolic mapping.

    Over the years, much of Francisco’s brain research has focused on transcranial lasers, memory enhancement, neuroprotection, neurocognitive disorders. Current research in the Gonzalez-Lima Lab focuses on the beneficial neurocognitive and emotional effects of noninvasive human brain stimulation in healthy, aging and mentally ill populations. This research primarily uses transcranial infrared laser stimulation and multimodal imaging.

    Show notes:

    Today we have part two of our interview with Dr. Francisco Gonzalez-Lima, a behavioral neuroscientist at The University of Texas at Austin.

    Francisco and his colleagues at the Gonzalez-Lima Lab are recognized as world leaders for their research on the relationship between brain energy metabolism, memory and neurobehavioral disorders.

    Today’s interview focuses on two interventions Francisco has explored with the aim of protecting people against neurodegeneration: low-dose methylene blue and the application of near-infrared light. Part one of our interview, episode 106, touched on Francisco’s youth and training as well as his early research into Alzheimer’s disease and brain-metabolic mapping.

    Over the years, much of Francisco’s brain research has focused on transcranial lasers, memory enhancement, neuroprotection, neurocognitive disorders. Current research in the Gonzalez-Lima Lab focuses on the beneficial neurocognitive and emotional effects of noninvasive human brain stimulation in healthy, aging and mentally ill populations. This research primarily uses transcranial infrared laser stimulation and multimodal imaging.

    [00:04:15] Ken begins part two of our interview mentioning he would like to talk about low-dose methylene blue and the application of near-infrared light. Ken explains that Both of these interventions act by a similar cellular mechanism that targets mitochondrial respiration via the electron transport chain. Ken asks Francisco to describe for listeners what the electron transport chain is and why it is important to the function of the mitochondria.

    [00:08:22] Dawn asks what the clinical signs and symptoms of unhealthy mitochondrial function are, and what are markers of good mitochondrial health.

    [00:11:41] Francisco gives an overview of the drug methylene blue, and its mechanism of action.

    [00:15:02] Ken asks about the origin and history of methylene blue.

    [00:17:19] Dawn asks about the potential use of methylene blue as treatment for traumatic brain injury.

    [00:21:10] Ken asks how methylene blue might stimulate neurogenesis.

    [00:22:42] Dawn mentions that acute brain injury such as stroke and traumatic brain injury involves the upregulation of multiple stress-related responses, she asks how the addition of a hermetic stressor such as methylene blue alters this process. She goes on to ask if there would be an optimal window of time to administer this drug relative to the injury for optimal recovery of function.

    [00:23:48] Ken asks if methylene blue could be used by an individual before they engage in something that is likely to lead to brain damage, such as boxing, sports, or military operations.

    [00:26:32] Ken asks about the future of methylene blue in the treatment and prevention of neurodegeneration.

    [00:29:37] Ken asks if compounding pharmacies are producing oral forms of methylene blue.

    [00:32:17] Francisco addresses the issue of oral versus intravenous administration of methylene blue, and if there is an optimal mode of administration for brain targeted therapy.

    [00:36:15] Dawn asks about the potential use of methylene blue to protect against radiation poisoning.

    [00:38:32] Francisco explains how the beneficial effects of transcranial lasers were discovered.

    [00:42:11] Ken mentions that transcranial absorption of photon energy up-regulates cortical cytochrome oxidase and enhances oxidative phosphorylation. Low level near-infrared light improves prefrontal cortex-related cognitive functions, such as sustained attention, extinction memory, working memory, and affective state. Ken asks Francisco to talk about the use of near infrared light as a targeted treatment for cognitive decline and neurodegenerative disorders.

    [00:45:37] Dawn mentions that Francisco’s work and that of others suggests that low-level laser therapy stimulates the production of mitochondrial matrix water, which is depleted in deuterium. Dawn asks if this deuterium depletion could result in enhanced genomic stability and epigenetic effects.

    [00:48:00] Ken asks about the use of methylene blue and ketone esters for performance in elite warfighters.

    [00:49:08] Dawn brings up the Neurotherapy Effectiveness and Safety Trial (NEST), a clinical trial which successfully used laser therapy to treat acute stroke patients. She goes on to mention that the phase III of the trial was suspended at the half-way point due to lack of significance. Francisco talks about these trials and why they didn’t end up being successful.

    [00:51:22] Ken asks Francisco how quickly transcranial laser therapy can alter mood or cognition.

    [00:51:47] Ken asks what Francisco’s thoughts are on whole-body low-level laser therapy, such as Erchonia’s system, for musculoskeletal pain or the NovoTHOR pod.

    [00:52:29] Ken asks how does one develop a dosing protocol for near-infrared light, and if overuse of commercially available low-level laser therapy units lead to side effects or unfavorable responses.

    [00:53:31] Dawn asks if there are nutritional, medicinal, or other strategies that could be synergistic with either near infrared light or methylene blue.

    [00:54:38] Dawn mentions that both methylene blue and various cranial laser therapy devices are available commercially online. She asks if these are comparable with what has been used for research and if these procedures are ready for at-home use by the general public.

    [00:56:14] Francisco closes the interview explaining why he describes himself as a survivor and someone who is a testament to the American dream.

    Links:

    Francisco Gonzalez-Lima bio

    Gonzalez-Lima Lab

    Learn more about IHMC

    STEM-Talk homepage

    Ken Ford bio

    Dawn Kernagis bio


    Episode 106: Francisco Gonzalez-Lima talks about brain metabolic mapping and Alzheimer’s Apr 29, 2020
    Show notes

    Our guest today is Dr. Francisco Gonzalez-Lima, a professor in the department of psychology, pharmacology and toxicology and the department of psychiatry at The University of Texas at Austin. He also is a professor at the university’s Institute for Neuroscience.

    We covered so much ground in our discussion with Francisco that we have split his interview into two parts. Today’s interview focuses on Francisco’s fascinating background as a youth and Cuban expatriate as well as his early research into Alzheimer’s Disease and brain metabolic mapping. The second part of our interview, which follows in a few weeks, covers two interventions Francisco has been exploring with the aim of protecting people against neurodegeneration: low-dose methylene blue and the application of near-infrared light.

    Francisco describes himself as a behavioral neuroscientist. He and his colleagues at the Gonzalez-Lima Lab are recognized as world leaders for their research on the relationship between brain energy metabolism, memory and neurobehavioral disorders.

    Although he has spent most of his academic career at the University of Texas, Francisco has been a visiting neuroscientist in Germany, England, Canada and Spain, and has delivered more than 120 lectures around the world about his brain research. He also has contributed work to more than 300 scientific publications.

    Over the years, Francisco’s brain research has focused on transcranial lasers, memory enhancement, neuroprotection and neurocognitive disorders. Current research in the Gonzalez-Lima laboratory focuses on the beneficial neurocognitive and emotional effects of noninvasive human brain stimulation in healthy, aging and mentally ill populations. This research primarily uses transcranial infrared laser stimulation and multimodal imaging.

    Show notes:

    [00:03:23] Dawn opens the interview mentioning that Francisco was born in Cuba where his father worked as a veterinarian. Dawn asks how Francisco’s family ended up leaving Cuba for Costa Rica when he was only ten years old.

    [00:04:25] Ken asks if it is true that Francisco got into a lot of fights as a child.

    [00:05:19] Francisco talks about his time as a child accompanying his veterinarian father to take care of cattle.

    [00:06:46] Dawn asks about Francisco’s time in college, two years of which he spent in Venezuela, and how he became known as an anti-communist student leader on campus.

    [00:08:18] Francisco tells the story of how he ended up going to school at Tulane University.

    [00:09:13] Dawn mentions that because Francisco’s father was a veterinarian, Francisco went to Tulane with the intent of working with animals. But after watching a professor dissect a human brain in class one day, Francisco changed his major.

    [00:10:17] Ken asks Francisco what lead him to decide to get a bachelor’s degree in biology and psychology.

    [00:11:49] Dawn asks about Francisco’s work with Nobel Prize winner Dr. Andrew Schalley during Francisco’s last summer at Tulane.

    [00:12:56] Francisco explains how he ended up of the University of Puerto Rico getting his doctorate in anatomy and neurobiology.

    [00:14:28] Dawn asks Francisco how learning about electrophysiology in his doctoral studies had an impact on him.

    [00:15:22] Francisco tells an interesting story of his doctoral dissertation.

    [00:16:21] Dawn asks about Francisco’s work with Dr. Walter Stiehl and the papers the two of them published in the European Journal of Pharmacology.

    [00:17:19] Dawn mentions that in 1981 Francisco met Henning Scheich, a German professor who had done a study involving the newly developed 2-deoxyglucose autoradiographic method. Francisco talks about why this neuroimaging approach to brain research fascinated him and led him to propose an ambitious collaborative research project with Dr. Scheich.

    [00:18:27] Dawn asks Francisco to talk about the work he did with Dr. Scheich to develop the human FDG (fluorodeoxyglucose) neuroimaging method, the first functional brain imaging technique to be used in humans.

    [00:19:58] Ken asks Francisco to explain the difference between functional studies and imaging studies.

    [00:21:18] Dawn asks about how Francisco met a group of Texas professors at a conference in Madrid, which lead him to join the new College of Medicine at Texas A&M.

    [00:22:35] Dawn mentions that in 1991, the University of Texas at Austin recruited Francisco to join its new Institute for Neuroscience and the Department of Psychology.

    [00:23:32] Dawn asks about the research Francisco and his colleagues are doing in the Gonzalez-Lima lab.

    [00:24:11] Ken asks what Francisco means when he describes himself as a behavioral neuroscientist.

    [00:25:13] Dawn asks about Francisco’s work on the neuroimaging effects of Pavlovian conditioning.

    [00:27:45] Dawn asks about the work Francisco did on habituation and sensitization.

    [00:29:57] Ken mentions that the brain is designed to handle large amounts of communication and computation. He asks if Francisco can elaborate on this concept.

    [00:31:10] Ken asks Francisco to describe the redundant structures of the brain.

    [00:33:35] Dawn turns the discussion to Alzheimer’s Disease, mentioning we still don’t fully grasp how the brain works.

    [00:35:12] Dawn mentions that in 2001 Francisco published a paper titled “Energy Hypometabolism in Posterior Cingulate Cortex of Alzheimer’s Patients: Superficial Laminar Cytochrome Oxidase Associated with Disease Duration.” The main histochemical finding of this study was that the decreased ration or the gravity of Alzheimer’s Disease was not related to any of the other things that were commonly mentioned like amyloid or tau proteins. Francisco gives an overview of this study and its significance.

    [00:39:32] Ken asks if ketone uptake in the brain diminishes some cases of Alzheimer’s or TBI.

    [00:41:18] Ken mentions Steven Cunane’s STEM-Talk interview and the work he has done work using neuroimaging to see if it’s possible to replace the energy lost from the glucose deficit with exogenous ketones.

    [00:42:11] Ken asks about the early signs of Alzheimer’s Disease.

    [00:45:27] Ken asks about the vascular hypothesis of Alzheimer’s Disease.

    [00:48:16] Dawn mentions that in the past few years, there has been a lot of coverage in the media about Early Onset Alzheimer’s Disease. She goes on to say that Francisco has pointed out in past interviews that EOAD is a rare genetic disease that is causally different than the most common geriatric dementia that is mistakenly called Alzheimer’s or late onset AD. Francisco discusses how this confusion has been an obstacle in advancing research.

    [00:52:24] Dawn gives a preview of part two of our interview with Francisco, which will upload in a few weeks.

    Links:

    Francisco Gonzalez-Lima bio

    Gonzalez-Lima Lab

    Learn more about IHMC

    STEM-Talk homepage

    Ken Ford bio

    Dawn Kernagis bio


    Episode 105: Art De Vany talks about healthspan, lifespan and healing the wounds of aging Apr 07, 2020
    Show notes

    Our guest today is Dr. Arthur De Vany, who we interviewed three years ago on episode 30 of STEM-Talk. Art, who is perhaps best known as one of the founders of the Paleo movement, is the author of “The New Evolution Diet: What Our Paleolithic Ancestors Can Teach Us About Weight Loss, Fitness and Aging.”

    Art is a professor emeritus of economics at the University of California, Irvine. In our first interview, we talked to Art about his early research into the economics of the movie business and how he created mathematical and statistical models to precisely describe the motion-picture market.

    In today’s interview, Art talks to us about the new book he’s working on that’s tentatively titled, “The Youthful Brain—A Revolutionary Program to protect the Brain, Extend Youthfulness and Prevent Alzheimer’s Disease.”

    The book is a continuation of Art’s ongoing study of the human body and brain and offers his strategies for preventing brain deterioration and maintaining a healthy, lean body.

    Show notes:

    [00:03:13] Dawn opens the interview mentioning that it has been three years since Art’s first appearance on the podcast. She asks Art what it is about the modern Western lifestyle that sends so many people to an early grave.

    [00:05:42] Dawn asks about Art’s discovery that the world’s healthiest, long-living individuals typically have low insulin.

    [00:07:44] Ken mentions that Art is working on a new book that will look at brain-body signaling and provide strategies for preventing brain deterioration and maintaining a healthy lean body. Art talks about how we originally planned to write about aging, but that most aging research is bull and that nobody really understands what it is. He explains that in his mind aging is basically a directed random walk into entropy.

    [00:10:11] Ken asks about one of Art’s key points, that Alzheimer’s disease and many other diseases of neural degeneration and cognitive decline are largely metabolic diseases compounded by loss of muscle mass and stem-cell exhaustion.

    [00:13:09] Dawn asks about the evolution of the human brain, and how the most recent additions to the brain are the most dependent on glucose metabolism.

    [00:14:22] Dawn mentions that synapses are essential to neuronal function, as they are the means by which neurons communicate signals. She asks Art to expand on the comment he made in his recent lecture at IHMC stating that “synapses are forever young but in ever need of support and protection.”

    [00:16:29] Ken asks about the lactate shuttle hypothesis, which is based on the observation that lactate is formed and utilized continuously in diverse cells under both anaerobic and aerobic conditions.

    [00:18:51] Dawn mentions the role of mitochondria, and how when they are not working the way they should that cells and tissues of our body become starved for energy, forcing us to rely on anaerobic metabolism. This results in a number of issues. She asks Art what we can do to maintain healthy mitochondria over our lifespan.

    [00:21:25] Art gives advice for reprograming the metabolism of the aging brain.

    [00:22:35] Ken asks about mTOR from an evolutionary perspective and why people have so many concerns regarding its role in cancer and degenerative disease.

    [00:24:35] Art explains his view of aging as the “failure of a renewal program,” and why aging is not programmed.

    [00:26:35] Dawn mentions that she has heard that Art eats just two meals a day, an early breakfast and dinner, to create a long interval between meals so his body can maintain low-insulin signaling. She asks how this brings on the defensive and repair pathways.

    [00:28:52] Ken asks about Art’s exercise routine and why he prefers fasted exercise.

    [00:30:46] Dawn asks about the importance of sleep, if Art still takes melatonin to help with his sleep, and what advice he has for people in terms of getting good sleep.

    [00:32:56] Dawn mentions that Art has commented that physically and genetically we are built to run fast and climb trees, but given the state of the modern world she asks what is the best way to stay physically fit if we are not allowed to regularly do those things that we evolved to do.

    [00:35:47] Ken asks for Art’s thoughts on why we have seen the loss of mass in the human brain, particularly in the hippocampus.

    [00:41:44] Ken asks about the role of oxytocin in preserving brain mass.

    [00:43:02] Dawn points out that Art is 82 years old. If aging is indeed a random walk into entropy, she asks Art what he considers a reasonable expectation is in terms of human lifespan.

    [00:43:50] Dawn mentions that Art has in the past said that he was 78 years old when he first started thinking about aging. Given that most people start having those thoughts in their 60s, she asks why it took him so long.

    [00:44:55] Ken closes the interview asking Art what advice he would give to his younger self.

    Links:

    Art De Vany Amazon page

    Learn more about IHMC

    STEM-Talk homepage

    Ken Ford bio

    Dawn Kernagis bio


    Episode 104:  Katherine Eban talks about the dangers associated with relying on generic drugs manufactured overseas Mar 10, 2020
    Show notes

    Today’s interview is with Katherine Eban, an investigative journalist who uncovered the widespread fraud that goes on overseas in the manufacturing of U.S. generic drugs. With the outbreak of the deadly coronavirus, which originated in China but is now spreading across the globe and United States, today’s interview is especially timely. Katherine’s recent book, “Bottle of Lies,” reveals that nearly 80 percent of the active ingredients of all brand-name and generic drugs as well as almost all of our antibiotics in the U.S. are made outside of the country, mostly in China and India. Today’s interview highlights the dangers Americans face in outsourcing the quality and safety of its brand-name and generic drugs to overseas manufacturers. Katherine is an investigative journalist who has written award-winning stories that range from pharmaceutical counterfeiting to gun trafficking to even coercive interrogations by the CIA. Her first book, “Dangerous Doses: A True Story of Cops, Counterfeiters and the Contamination of America’s Drug Supply,” was named one of the Best Books of 2005 by Kirkus Reviews. “Bottle of Lies: The Inside Story of the Generic Drug Boom” is a New York Times bestseller that came out in 2019 and was named one of the top 100 notable books of 2019 by the Times.


    Episode 103: Abe Morgentaler talks about men’s health, sex drive and the benefits of testosterone therapy Feb 19, 2020
    Show notes

    Today’s interview is with Dr. Abraham Morgentaler, an internationally known pioneer in men’s sexuality and the founder of the first comprehensive center in the U.S. specializing in men’s health. Abe’s research has upended longstanding concepts regarding testosterone therapy, prostrate cancer and male sexuality. He is particularly credited with research that has contradicted the established view that testosterone injections led to elevated risks for prostate cancer. In today’s interview, we talk to Abe about testosterone deficiency and its effects on men’s health and sex drive; the biological functions of testosterone; and Abe’s work treating metastatic prostrate cancer. Abe is the director of Men’s Health Boston and an associate clinical professor of Urology at Harvard Medical School. He is the author of “Why Men Fake It: The Totally Unexpected Truth About Men and Sex,” which was retitled “The Truth About Men and Sex” for the paperback edition. He also is the author of “Testosterone for Life: Recharge Your Vitality, Sex Drive, Muscle Mass and Overall Health.”


    Episode 102: Adam Konopka talks about metformin’s effects on healthspan and lifespan Jan 28, 2020
    Show notes

    Our guest today is Dr. Adam Konopka, an assistant professor in the Department of Kinesiology and Community Health at the University of Illinois Urbana Champaign, who believes that aging is the greatest risk factor for just about every single chronic disease that exists. Adam’s lab, called the Musculoskeletal Aging and Metabolism Lab, is focused on aging-related research. In addition to doing research that looks at different ways to delay the onset of age-related diseases and functional decline, Adam also has done a lot of research related to the interaction of exercise with metformin. Adam and his colleagues had a paper in Aging Cell that suggested metformin may blunt the health benefits of exercise in healthy older adults, a study that attracted a lot of attention and was highlighted in a story in The New York Times back in June.


    Episode 101: Rachel Yehuda talks about epigenetic inheritance, PTSD and the potential of MDMA therapies Jan 07, 2020
    Show notes

    Today we talk with Dr. Rachel Yehuda whose pioneering research on cortisol and brain function has revolutionized worldwide our understanding and treatment of post-traumatic stress disorder. Rachel is also well-known for her studies on the intergenerational transmission of trauma and PTSD. This novel research has shown that the children of traumatized parents are at risk of similar problems due to epigenetic changes that are transmitted from the parents to their offspring. She has worked with war veterans, Holocaust survivors and other victims of trauma to detail the biological roots of PTSD. She is a professor of psychiatry and neuroscience and the director of the Traumatic Stress Studies Division at the Mount Sinai School of Medicine in New York City. She also is the director of the Mental Health Patient Care Center at the James J. Peters VA Medical Center.


    Episode 100: Peter Attia gives an update on his views regarding longevity and health span Dec 17, 2019
    Show notes

    Today’s episode marks the 100th episode of STEM-Talk and the return of guest Peter Attia, who Ken and Dawn interviewed for episode one of STEM-Talk back in 2016. Peter is the founder of Attia Medical, a medical practice with offices in San Diego and New York City that focuses on the applied science of longevity. Peter emphasizes nutritional biochemistry, exercise physiology, sleep physiology, lipidology, pharmacology and four-system endocrinology to help people increase their lifespan and health span. Peter is the host of the podcast The Drive. He earned his M.D. from Stanford University and holds a B.S. in mechanical engineering and applied mathematics.


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