Show notes
This isn’t an anti-GLP-1 episode. It’s an anti-“here’s your injection, see you in six months” episode.
In this episode of Root Cause Radio, we break down how GLP-1 medications work, including semaglutide, the dual GLP-1/GIP agonist tirzepatide, and the investigational triple agonist retatrutide. We explain how these medications truly work (and how some may work better than others), and how they influence appetite, fullness, blood sugar, gastric emptying, fat metabolism, and energy expenditure.
We also explore the parts of GLP-1 use that are too often ignored:
• Undereating, nutrient deficiencies, and inadequate protein intake
• Muscle loss and changes in body composition
• Nausea, constipation, reflux, bloating, and impaired gut motility
• Potential consequences for women’s hormones, menstrual cycles, and fertility
• Gallbladder, pancreatic, kidney, and dehydration concerns
• Reduced pleasure, motivation, and possible anhedonia
• Metabolic adaptation and weight regain after stopping
• The emerging conversation around low-dose or “microdosed” GLP-1 use for conditions such as endometriosis, MCAS, and autoimmune disease
Most importantly, we discuss what responsible GLP-1 care should actually look like: adequate calories and protein, resistance training, micronutrient monitoring, proactive GI support, individualized dosing, body-composition assessment, and a transition plan that begins before the medication is stopped.
GLP-1 medications can be valuable tools- let's know what they really do, how they work, and how do use them responsibly.
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