Real Science Exchange-Dairy

Latest Episodes:

The Future of Milk Protein as a Functional Food with Dr. John Lucey form the University of Wisconsin Sep 10, 2024

Show notes

This episode of the Real Science Exchange podcast was recorded during a webinar from Balchem’s Real Science Lecture Series.

Throughout the last 30 years, the dairy industry has moved to producing highly concentrated versions of milk proteins. In cows’ milk, about 80% of the protein is casein and 20% is in the serum or whey phase. These ratios vary by species. There are three major caseins in cows’ milk: alpha-S-casein, beta-casein, and kappa-casein. The first two are rich in phosphate for calcium binding. Kappa-casein is critical in a micellar structure that allows these structures to stay suspended in the milk. (1:21)

Whey proteins also differ by species. In cows’ milk, about 50% of the whey protein is beta-lactoglobulin. It’s rich in branched-chain amino acids, and it is not present in human milk so it is a focus of allergy research. Alpha-lactalbumin is found in all mammals and is a cofactor for lactose production. (10:34)

Caseins and whey proteins are different from one another and are in completely different classes of proteins. From structure, to size, to amino acid content, to solubility; these two types of proteins are yin and yang. (11:51)

When fluid milk or whey is concentrated by removing water, some sugars and other materials dissolve via evaporation or membrane filtration. It results in dried powders, milk protein concentrate, milk protein isolate, whey protein concentrate and whey protein isolates. Concentrates contain 80-85% protein and isolates contain more than 90% protein. (17:14)

What's driving the current and probably future popularity of these dairy proteins? One, is their versatility in many food applications, and the other is the superior nutritional quality of the proteins. Nearly half of the milk protein concentrate use is for mainstream nutrition and sports beverages. Similar trends have been observed for whey protein isolates. (20:05)

Dairy proteins are very rich in branched-chain amino acids (BCAA) like leucine. BCAAs help initiate protein synthesis, are important for muscle recovery, help with weight loss by maintaining blood glucose levels, are synergistic with exercise, and can promote healthy aging. Dr. Lucey gives several different examples of products utilizing dairy proteins. He predicts that the increased focus on nutrition products, interest in isolating individual proteins and improving export opportunities will continue to drive demand for dairy proteins in the future. (27:21)

All of the main milk proteins have genetic variants, which are minor amino acid differences in the same protein. Variants occur at different frequencies among breeds. Beta-casein has two variants, A1 and A2. There is one amino acid difference out of 209 total amino acids, located at position 67 where a histidine is found in variant A1 and a proline is found in variant A2. When histidine is present, the beta-casein is prone to cleavage at position 67, creating a fragment called beta-casomorphin-7 (BCM-7). When proline is present, it hinders the cleavage of casein at position 67. BCM-7 is an exogenous opioid peptide with the potential to elicit opioid activity on a range of tissues and organs. It’s known as a “bioactive peptide” and some others from milk and cheese have been implicated as anti-hypertensive. (35:26)

In the late 1990s, some researchers claimed that A1 milk was implicated in diabetes, coronary heart disease, autism, and schizophrenia. Subsequent reviews and investigations by significant international bodies found no evidence of these claims. (40:34)

In closing, Dr. Lucey answers questions from the webinar audience. He talks about the potential of breeding cows customized for the production of minor milk components, milk components as renewable bio-plastics, and the superiority of milk proteins compared to plant proteins. Watch the full webinar at balchem.com/realscience. (47:41)

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Turbocharge Your Fresh Cow Diets with Dr. Overton from Cornell University & Dr. Faldet with GPS Dairy Aug 27, 2024

Show notes

Dr. Overton presented on this topic in a Real Science Lecture series webinar on July 10, 2024. You can find it at www.balchem.com/realscience. This episode takes a deeper dive into the conversation.

Dr. Overton begins by reminding listeners of the vast number of changes occurring in the fresh cow during the first two to three weeks after calving. Body fat and protein mobilization, some systemic inflammation, the potential for elevated NEFAs and ketones, and calcium dynamics all play a role in how the fresh cow starts her lactation period. (7:31)

When consulting with clients, Dr. Faldet uses research to guide his decisions. He likes to implement a 14-day pen for fresh cows, ranging from 10-17 days. He evaluates things like stocking rates, lockup times, and cow comfort, along with fine-tuning a diet for each individual farm setting. (9:14)

The panel discusses the importance of increasing effective fiber along with starch in fresh cow diets. Without adequate effective fiber in the diet, the risk of acidosis increases, resulting in cows going off feed. There is no silver bullet; each farm’s fresh cow diet is going to be different due to different forage bases and timing in the fresh cow group. (13:02)

Both Dr. Faldet and Dr. Overton stressed the diet is only one component of a successful fresh cow program. Other critical pieces include stocking rate, availability of feed, water quantity and quality, and cow comfort. Dr. Faldet suggests that if you do all these non-diet factors right, you could probably maneuver closeup and fresh pens a little differently and make the diet work with the ingredients you have. Dr. Overton’s group is conducting survey work evaluating the variability in particle size in closeup diets. A pilot study showed that as particle size variability increased, so did fresh cow health issues and poor postpartum metabolic status. (19:10)

Protein requirements of the fresh cow were another topic of Dr. Overton’s webinar. He described a recent experiment evaluating standard and high metabolizable protein concentrations in the diet for closeup and fresh cows. The postpartum MP gave a big milk response, around 15-16 pounds per day for the first 21 days after calving, with a carryover effect of 11-12 pounds of milk for the next 20 days after all cows went back on the same diet. It’s important to note that lysine and methionine were fixed regardless of treatment, so it seems that other amino acids are probably involved in the mechanism of action. (23:06)

Dr. Overton described an experiment designed to evaluate starch and fiber in fresh cow diets where higher fiber digestibility and increased corn in silage resulted in less fiber and more starch than anticipated in the diet. Fresh cows were a bit of a trainwreck, but the problem was resolved once another couple of pounds of straw were added to the diet. On the other hand, you can go too far with increased fiber in fresh cow diets, which results in ketosis, lower intakes, and less milk production. (35:19)

The panel then discusses far-off programs, fat supplementation in fresh cow diets, and vitamin and mineral concentrations for fresh cows. (42:37)

In summary, each panelist shares their takeaways. Dr. Elliott reminds listeners that we should think about starch, fat, fiber, and protein together and how they influence each other rather than considering them individually. Dr. Faldet’s take-home message is to know what your targets and bookends are and really hone in and implement your fresh cow diets accordingly. Dr. Overton suggests that the industry will shift to evaluating fresh cow diets as their own thing rather than trying to tweak a few things from your high cow diet. Implementing fresh cow diets consistently and well is going to be important. (53:30)

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Are Probiotics Just Magic Foo Foo Dust? With Dr. Callaway from the University of Georgia & Dr. Steele from the University of Guelph Aug 20, 2024

Show notes

Dr. Callaway presented on this topic in a Real Science Lecture series webinar on June 4, 2024. You can find it at www.balchem.com/realscience. The following podcast takes a deeper dive into the conversation.

For years, probiotics were known as direct-fed microbials (DFMs) in livestock and probiotics in humans. Terminology has been updated to reflect different modes of action and composition. (9:07)

A probiotic is defined as a living microorganism that will be beneficial to the health and/or performance of the host. Prebiotics are fermentable substrates that the host can’t use, but the microbes can. Dr. Steele agrees that terminology and definitions keep evolving; he uses “microbial-based solutions” rather than DFM. He believes that the ever-evolving terminology and definitions have led to some of the skepticism about these products in the industry. He recommends to farmers and nutritionists that a product should have a bare minimum of three publications in high-quality peer-reviewed journals showing efficacy before using them on-farm. (10:13)

Every farm is going to have a different set of challenges and goals that will play a role in determining the right choice of microbial-based solution. Weather and climate, water quality, pathogen challenges, ration grind size, and ration ingredients will all factor into the decision. (17:39)

Both guests agree that we don't know enough about the microbiome in cattle to define what a good versus a bad microbiome looks like. Dr. Steele suggests the next steps in research should look more deeply at the host’s physiological mechanisms in how they’re responding to a probiotic to truly understand when it’s going to work and when it’s not. (21:19)

Dr. Ordway asks how much microbial products could improve the absorption of nutrients. Dr. Steele responds that much of the research so far has focused on digestion and absorption has not been studied much. Some studies in calves fed microbials have shown changes in gut structure and the development of villi, and even papillae in the rumen. That gives us some high-level information about absorption, but we are not close to understanding the nitty gritty of the microbial mechanisms at play in absorption. Dr. Callaway adds that hindgut absorption in ruminants is more important than we have previously thought. Dr. Steele suggests the small and large intestines are equally as important as the forestomach, but they are not as well understood as they’re harder to study in ruminants. The conversation goes on to discuss possible modes of action behind increased liver abscesses observed in beef on dairy operations. (30:12)

Both guests share their thoughts regarding working together across disciplines, especially agronomy researchers since the feed base has such an impact on-farm. They discuss soil microbes, forge inoculants, and silage microbes. (43:23)

Dr. Ordway’s take-home message for nutritionists is to not forget to have conversations with your partners - the producer, the end user, the veterinarian, the crop team and the management team on the farm. Coordinated biology is not just within the animal, it’s all the factors coming into play that have been discussed in this episode. (58:32)

Dr. Steele reiterates his earlier advice to only use microbial-based solutions that have a bare minimum of three publications showing efficacy in a high-ranking journal. He also recommends you choose your metric of measurement properly. Focusing on cattle that are experiencing some stress or metabolic or infectious issues may allow you to truly evaluate the return on investment. There are great microbial solutions out there but you need to use a proven solution from a company that’s research-based. (59:48)

Dr. Callaway echoes Dr. Steele’s recommendation to be slightly cynical about companies that come in to sell you things. Ask how their product works, and ask to see the research. A company that tells you when its product works and when it doesn’t might be more trustworthy than one that says their product always works. Lastly, what does success look like for you as a farmer? Have a measurable, bite-size metric for determining if these products impact your bottom line. (1:01:28)

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Why Cows Become Hypocalcemic and Steps to Reduce Impact with Dr. Goff- ISU Aug 13, 2024

Show notes

This episode of the Real Science Exchange podcast was recorded during a webinar from Balchem’s Real Science Lecture Series.

Dr. Goff sees three main challenges for transition cows: negative energy and protein balance, immune suppression, and hypocalcemia. About half of all older cows experience hypocalcemia, and around 3% will experience milk fever. Cows develop hypocalcemia if they are unable to replace the calcium lost in milk from either their bone or diet. Compared to the day before calving, a cow needs around 32 extra grams of protein the day of calving to meet her increased requirements. (2:00)

Dr. Goff reviews the pathways of calcium homeostasis and the actions of parathyroid hormone (PTH). Aged cows may have a harder time maintaining calcium homeostasis due to the loss of vitamin D receptors in the intestine with age and fewer sites of active bone resorption capable of responding quickly to PTH once they have finished growing. Blood pH plays a role in calcium homeostasis: when blood pH becomes alkaline, animals become less responsive to PTH. Dr. Goff reviews the impacts of high vs low DCAD diets and reviews the amount of time it takes for the kidney and bone to respond to PTH. (4:20)

There are several strategies to reduce the risk of hypocalcemia. One is to reduce dietary potassium so the cow is not as alkaline. Using forages from fields that have not had manure applied to them is one way to accomplish this. In addition, warm-season grasses (corn) accumulate less potassium than cool-season grasses, and all grasses contain less potassium as they mature (straw). A second strategy is to add anions such as chloride or sulfate to the diet to acidify the blood to improve bone and kidney response to PTH. Research has shown that sulfate salts acidify about 60% as well as chloride salts. The palatability of anionic diets has led to commercial products such as Soychlor. (13:06)

Dr. Goff then discusses the over- and under-acidification of diets and gives his opinion on the appropriate range of urine pH for proper DCAD diet management, including a new proposed DCAD equation to account for alkalizing and acidifying components of the diet. He also gives some options for pH test strips to use for urine pH data collection. (18:30)

Dr. Goff’s lab has found that as prepartum urine pH increases, the calcium nadir decreases. The inflection point is right around pH 7.5, where above 7.5 indicates a higher risk of hypocalcemia. Data from other researchers suggests that urine pH lower than 6.0 may result in lower blood calcium, indicating an overall curvilinear response. Low urine pH (under 6.0) has also been associated with a higher incidence of left-displaced abomasum. (29:02)

Moving on to other minerals, Dr. Goff discusses phosphate homeostasis and how that interacts with calcium in the close-up cow. Feeding too much phosphorus can decrease calcium absorption and feeding low phosphorus diets before calving can improve blood levels of calcium. He recommends less than 0.35% phosphorus in close-up cow diets. For magnesium,he recommends 0.4% prepartum and immediately postpartum to take advantage of passive absorption across the rumen wall. (31:08)

Another strategy to reduce milk fever risk is to reduce dietary calcium prior to calving to stimulate parathyroid hormone release well before calving. A zeolite product that binds calcium is now available and may make this much easier to achieve. (42:59)

In closing, Dr. Goff reminds the audience that some level of hypocalcemia post-calving is normal and in fact, is associated with higher milk production. The key is making sure that the cow’s blood calcium levels can bounce back to normal by day two after calving. (51:23)

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Lessons Learned in Research on Nutritional Management of Robot Milked Cows with Dr. DeVries- U of G, Dr. Penner- USask, & Todd Ward-Direct Dairy Nutrition Aug 06, 2024

Show notes

Dr. DeVries presented a Real Science Lecture webinar on May 8, 2024, titled “Lessons Learned in Research on Nutritional Management of Robot Milked Cows.” You can find the webinar recording at balchem.com/realscience.

Dr. DeVries begins with an overview of how his robotic milking research has evolved. In Canada, around 20%-plus of farms are using robotic milkers. He describes survey research in the US and Canada as to why producers choose to implement robotic milkers. (9:19)

In Trevor’s webinar, he discussed the large amount of variation in nutritional management of robot-milked cows across Canada. Some of his research with Dr. Penner has looked at the interaction between feed consumed at the feed bunk and feed consumed at the robot. Ideally, you wish to be able to accurately predict intake because that is a primary driver of milk production. Because cows can be supplemented individually at the robot, there is opportunity to better feed cows to match their individual needs. (13:50)

Trevor and Greg describe their respective university’s robot milking research facilities. The panel discusses additional technologies that would be useful for all robotic milkers, like load cells to measure feed delivery and disappearance. Cows typically consume around 250-300 grams of concentrate per minute, and that can vary by feed type (pellet vs mash, for example.) The panel also ponders whether the design of the feed bunk in the robots has an impact on intake rate. (17:35)

As a consulting nutritionist, Todd prefers to feed as little as possible in the robot and have a more consistent mix in the PMR. The level of milk production of the cows can have a large influence on how much pellet is fed at the robot versus the feed bunk. Todd goes on to describe his strategy for creating proportions of PMR and robot intakes for different scenarios. (26:06)

Clay asks the panel what the maximum amount of concentrate should be fed at the robot. They discuss factors that can influence concentration including individual cow variation, length of time in the robot per milking, and the number of visits to the robot per day. Clay goes on to ask how fast fresh cows can be stepped up in their robot feedings. The group has a lively discussion about all the different factors that play a role in that decision. Greg reminds the audience not to get so caught up with programming the robot that we lose sight of the fact we’re still feeding cows and good dairy management still applies. (31:29)

Todd describes some of the biggest challenges he observes as a consultant in robotic dairies, primarily centered around understanding cow behavior. Trevor underlines the importance of cow comfort and other non-nutritional factors in regard to their influence on the success of the nutrition program.(41:29)

Scott asks the panel what they think robotic milkers might look like in 2050 and what problems will have been solved by then. Greg’s wish list includes knowing PMR intake to better manage robot feedings and having cow body weights on every dairy. Trevor thinks we will have a much better understanding of how genetics influence cow performance in a robotic system and how we can raise cows to adapt to the technology to be better robot cows. Todd agrees that body weights are critical and also envisions more individualized milkings depending on each cow’s preferences. On his wish list is a drone that could be used to fetch cows to the robot who have not gone to be milked. (46:51)

Trevor and Greg discuss what’s next in their upcoming research projects, and Todd gives some wishlist ideas for future research. (54:18)

In summary, each guest gives their take home messages. Clay is intrigued by the precision feeding aspects of robotic milking systems. Todd encourages dairy producers not to be scared of robotic milking systems. Greg looks forward to research in the next 5-10 years to support or refute the preconceived notions we have about robotic systems. Trevor reminds listeners that cows must consume a certain amount of nutrients in order to produce milk. In the robotic system, those nutrients are delivered via two different components and research continues to understand the interplay between them. Lastly, animal behavior is a critical component of the success of robotic systems and our management approach should reflect that. (1:02:46)

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Balancing Diets of Highly Productive Sheep & Goats: Combining Performance and Health with Dr. Cannas from the University of Italy & Dr. Teixeira from the University of Idaho Jul 23, 2024

Show notes

Dr. Cannas presented a Real Science Lecture webinar on October 17, 2023, titled “Diets of Productive Sheep & Goats: Performance & Health.” You can find the webinar recording at balchem.com/realscience.

Dr. Cannas outlines the topics he covered in his webinar, including nutritional requirement differences between small and large ruminants, particularly in late gestation. Small ruminants have a shorter gestation and are more prolific than cattle, for example, and this means they have more nutritional challenges in late gestation. Dr. Cannas covered supplementation, basal diet quality, and sorting ewes or does by number of fetuses. He also discussed how high milk-producing sheep and goats partition nutrients. (10:36)

Many people treat sheep and goats like smaller, low-producing cattle. Dr. Cannas considers this approach a big mistake. During pregnancy and lactation, sheep and goats are highly-producing animals that garner the same attention given to high-producing dairy and beef cattle. Dr. Texeira agrees and reminds the audience that just because sheep and goats are very adaptable animals doesn’t mean you should feed them low-quality diets. Jessica mentions that providing poor-quality feed may not allow the ewe or doe to meet her genetic potential. (21:51)

The panel discusses the importance of record keeping and data to evaluate management changes. (27:31)

Jessica asks about how Antonello fed rumen-protected choline in his experiments. They fed individually to ensure each animal received the correct dose but recommended to mix it into a TMR or mineral supplement for on-farm feeding. (33:12)

Izabelle asks how many groups most farms sort ewes or does into before lambing or kidding in Sardinia. Antonello says it depends on the individual farm because they are so diverse, but at least two groups, singles and twins. They may also sort based on the number of days pregnant as well. He describes some experimental results from feeding rumen-protected choline to ewes carrying singles versus twins. (35:35)

Dr. Teixeira describes some of the challenges sheep and goat producers face in her native Brazil due to heat stress. Jessica gives examples of management strategies to help manage heat stress based on her work at Cornell. (41:14)

The panel discussed challenges with body condition scoring goats using a sheep scale since goats store more fat internally or in other locations like the tail. They also discuss recommendations for target body condition scores at different stages of the production cycle. (48:00)

In summary, Jessica recommends that sheep and goat producers focus on what they do well, make small changes to improve their operation, and collect data to see what is working and what is not working. Izabelle encourages producers to understand what is happening physiologically in each stage of production to best manage nutritional challenges. Antonello reiterates that sheep and goats should be given the same attention and care as high-producing dairy cows. It is a complex business and there is much room for improvement in the management of small ruminants. (57:27)

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Real Science Exchange: Not All Encaps Are Created Equal with Dr. Zimmerman, Kari Estes & Dr. Hanigan Jul 09, 2024

Show notes

Dr. Zimmerman presented a Real Science Lecture webinar on December 12th, 2023, titled “Not All Rumen-Protected Products Are Created Equal.” You can find the webinar recording at balchem.com/realscience.

Clay outlines four attributes of a good rumen-encapsulated product. They are feed and TMR stable, ruminal stable, nutrient bioavailability, and good efficacy biologically in the animal. (6:21)

Kari describes a TMR stability test that Balchem has been perfecting based on a paper published in 2016. One to two grams of a rumen-protected product (based on the nutrient composition) is mixed with a half pound of TMR in a Ziploc bag, then the mixture incubates for 0, 6, 12 or 24 hours (based on feeding 1x, 2x, or 3x per day). Once a sample is finished incubating, it’s placed in a strainer bag in one liter of distilled water for one minute. Then, the amount of nutrient that was leached into the distilled water is measured. She describes some of the observations and trends they’ve seen from using this technique on different products. (8:24)

Mark asks about the impact of abrasion during the mixing process on encap stability. Kari describes a mineral mix technique using a small ribbon and paddle mixer. In this case, 5-10 pounds of encap product are mixed with 90-95 pounds of a mineral mix for three minutes. Then a sample is analyzed for damage to the encap. Clay does not recommend pelleting any encapsulated product because that will only reduce efficacy. It may not be 100% damage, but it will be significant. (12:41)

Scott asks about the freeze-thaw stability of encapsulates. Clay mentions that all of Balchem’s encapsulated products are freeze-thaw stable. If a product is not, there will be cracks in the coating and some ruminal stability will be lost. (19:34)

When it comes to ruminal stability, matrix encapsulates tend to have lower stability in the rumen, but it varies widely. Some have no ruminal stability; some lose less than 10% in the rumen. Encapsulation is a complex process and there are tradeoffs between some of the steps. For example, between TMR stability or rumen stability and bioavailability, the goal is to find the perfect mix of these to make a high-efficacy product on the farm. Kari describes a rumen stability test that can be conducted on-farm for protected choline and lysine products. Mark describes in situ experiments for rumen stability testing using small Dacron bags in rumen-cannulated animals. He mentions that creating an encap with high rumen stability and high intestinal digestibility is key. (19:58)

Bioavailability is key, but methodologies for assessing bioavailability are a limitation. Kari and Mark discuss the pros and cons of various in situ/in vivo techniques, including mobile bag, abomasal pulse dose, and stable isotope. (29:25)

Clay mentions that in vitro techniques are a key piece to product development and testing, but may give erroneous results compared to in vivo testing. Kari describes an experiment she conducted with Mark comparing in vivo and in vitro techniques. She suggests that there may be an argument for creating specific in vitro tests built for different types of protected products. For example, for a pH-sensitive product, a step mimicking abomasal enzymes would be important. For a fat-coated product, a step mimicking intestinal enzymes for fat breakdown would be important. Clay cautions that a product with only in vitro data should be regarded with skepticism. (44:25)

Biological response in the animal is the key final step. Ultimately, you want independent, peer-reviewed data to prove the efficacy of a product. Mark reminds the audience that even if animals don’t respond to a product, there are a host of different issues that could be causing that unrelated to the product being tested. Things like water quality, water quantity, stress, cow comfort - there’s a whole laundry list of things to consider. (50:39)

In closing, Kari recommends that when picking an encap product, ask for the research that hits the four pillars: TMR stability, rumen stability, bioavailability, and animal performance. Mark suggests that you can’t make a bad encap good, but you can make a good encap bad if you aren’t careful. Clay agrees that the more data, the better. Lastly, we need more work on the feed stability pillar which has been overlooked. It is a critical piece to encap products being effective in the field. (55:13)

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New developments in Transition Cow Nutrition in the UK Jun 25, 2024

Show notes

This episode comes to you from the “New Developments in Transition Cow Nutrition” seminar in Stoke-on-Trent, England. Dr. Santos, Dr. Reynolds and Dr. Zimmerman spoke at the seminar. Each speaker gives a brief overview of their seminar presentation, and then the panel takes questions from the audience.

In his presentation, Dr. Santos discussed some of the latest research using rumen-protected choline in transition cows. There is substantial evidence that choline plays an important role in transition cow nutrition, particularly because of its consistent positive effect on the yield of energy-corrected milk and benefits that extend beyond the supplementation period. (1:16)

Dr. Reynolds’s presentation focused on protein nutrition in very early lactation cows. Cows are in a substantial negative balance for metabolizable protein in the first week or two postpartum. Recent research, with abomasal infusions of casein, or the amino acids in casein, immediately after calving, has resulted in substantial increases in milk yield. In his lab, Dr. Reynolds has used rumen drenches to supplement cows immediately postpartum as palatability of supplements has been an issue. Providing essential amino acids and total protein to cows immediately after calving is a challenging problem. (2:10)

Dr. Zimmerman’s presentation discussed differences in rumen encapsulated products. There are four parts of a good ruminant encap: good ruminal stability, good intestinal digestibility, good feed mixing and TMR stability and biological response in the animal. (3:44)

Questions from speakers and attendees were as follows:

What is the optimum level of choline to feed to a transition cow? Given the close relationship between methionine and choline, is there a similar ratio between them like the 3:1 lysine:methionine ratio? (4:56)

Around 98-99% of dietary choline will be degraded in the rumen whereas, with lysine and methionine, we know there's an amount that escapes with the bypass protein fraction of the diets. Has the ruminant animal evolved not to require any bypass choline? (13:46)

Dr. Santos’s presentation focused on the benefits of choline supplementation to the transition cow. What are the benefits for the in-utero calf? (19:45)

What is the mechanism by which choline increases colostrum production? Is it just similar to the effect on milk yield generally? (28:21)

Does choline impact younger or older cows differently? (30:36)

Given the increase in intestinal length and changes in the architecture in early lactation, does this result in suboptimal absorption and scouring? Could it be a nutrient deficiency problem as opposed to something like acidosis? Should we analyze fecal samples to assess this? (34:50)

Do you think fundamentally we are underestimating metabolizable protein requirements in very early lactation? Or are we just not managing that transition particularly well? And if so, what sort of safety factors should we evaluate regarding protein nutrition? (41:45)

In the early lactation studies where metabolizable protein is supplemented in high concentrations, we see big milk and energy-corrected milk responses, but no increase in dry matter intake. Why is that? (43:34)

Dr. Santos describes an experiment in beef cattle, evaluating the inflammation impacts of pneumonia on essential and nonessential amino acids in the gut. This model might be quite similar to that of a dairy cow with metritis. (50:24)

Do you have any recommendations for amino acid supply for cows on grass? Is there anything new coming in that regard? Are there any specific recommendations for synchrony and/or ratios of energy and amino acid supplies? (55:58)

When should amino acids be fed after calving? (1:01:13)

In closing, each panelist provides a take-home message. (1:06:00)

Dr. Santos: Consider choline a required nutrient.

Dr. Reynolds: Most of our cows have the genetic potential to produce a lot more milk than they are achieving in very early lactation. We need to look at that in terms of how we might be able to help them achieve that potential yield.

Dr. Zimmerman: Not all encaps are created equal. Make sure that you’re able to see published in-vivo research with these products, done by reputable institutions, to prove that these products are working in the animals.

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The dynamic world of feeding fat and where high oleic soybeans fit in, with Dr. Kevin Harvatine, Penn State University and Dr. Lynn Davis, Quality Roasting, Inc. Jun 18, 2024

Show notes

Dr. Harvatine gave a presentation on the Real Science Lecture series on April 2nd titled “High Oleic Soybeans, Where Do They Fit Into Dairy Diets?” Access the recording at balchem.com/real science.

As Dr. Harvatine thinks back over his 15 years at Penn State, he didn’t think he’d do much fat supplement work. But we keep getting new questions, new products, and new challenges. One of these is high oleic soybeans, which could be an opportunity to grow some of our own fat on the farm. (6:35)

High oleic soybeans have been around for about seven years or a little longer. They were developed for fry oil (french fries and potato chips), but dairy nutritionists were interested in the opportunity to use 18:1 fats because of their lower risk of milk fat depression. (7:36)

Dr. Davis indicates that high oleic soybeans are a growing piece of the soybeans planted yearly. Seedstock availability is limited, but many companies have it in their pipeline. Pest and weed control traits will eventually be baked into the seedstock, but growers are taking a risk by choosing to grow high oleic soybeans. Dr. Davis’s company offers a premium for high oleic soybeans at their plants to encourage growers to take those risks. (13:15)

What factors should a producer or a nutritionist consider when using high oleic soybeans? Dr. Harvatine sees a couple of different ways folks are feeding soybeans. One, is using expeller soybean meal or roasted soybeans as a RUP source while accounting for the additional fat that it provides, and the other would be pulling the dry fat supplement out of the ration and feeding high levels of roasted soybeans to replace it. He has some hesitations about the latter approach and reminds the audience that high oleic soybeans are not at zero risk for milk-fat depression. Dr. Davis adds that a major consideration is economics. The market has been extremely volatile lately, with very high oil prices, recently, followed by a decline over the last year. As renewable diesel becomes more common and more crush plants come online, we could see depressed meal prices as well. (16:14)

Do we know what amount of oleic acid to be feeding? Dr. Harvatine shares that Dr. Andres Contreras at the Michigan State Vet School has seen molecular changes in adipose tissue metabolism with 50 grams per day of abomasally infused oleic acid, so it seems to be bioactive at reasonably low levels. The challenge, however, is we’re not sure how much actually gets through the rumen from different feed sources. In addition, there may be some interaction between fatty acids and the type of fiber on NDF digestibility that needs to be investigated. (26:50)

A concern with roasted beans compared to extruded products is the potential for higher variability with roasted beans. Dr. Davis gives some examples of considerations dairy farmers need to consider when roasting beans on-farm. (37:16)

Dr. Harvatine and Dr. Davis discuss how dairy producers may be able to take advantage of market volatility and be opportunistic in different settings regarding growing and feeding high oleic soybeans. Both guests agree that soybeans should be used in diets for all their nutrients, protein, RUP, and fat. They caution against pulling it into diets just as a fat supplement and not assessing what it’s doing for the protein side. (43:30)

We've seen a rapid increase in milk fat percentage in the US milk supply over the last few years. Why? Dr. Harvatine points out rapid genetic improvement, a better understanding of mitigating diet-induced milk fat depression, and better use of forages and fiber digestibility. Certainly, palm fat has helped, but it does not explain all of it. Dr. Davis adds that not only have genetics improved, but we have improved nutrition programs to support that genetic potential. (52:14)

In summary, Dr. Davis advises nutritionists and dairy producers to stay flexible as we’re still early on in the high oleic arena. Dr. Harvatine agrees there are great opportunities and lots of decisions to be made for each individual farm. Don’t forget the fundamentals of nutrition when considering this - view high oleic soybeans as a complete package, keeping in mind not only the protein, RUP, and fat but also quality control and roasting. (58:55)

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Assessing Transition Cow Health: Integrating Traditional and Novel Biomarkers with Dr. Andres Contreras, Michigan State University Jun 04, 2024

Show notes

This journal club episode comes to you from the 2024 Tri-State Dairy Nutrition Conference. The paper is “Assessing Transition Cow Health: Integrating Traditional and Novel Biomarkers” from the conference proceedings with Dr. Andres Contreras of Michigan State University.

What is a biomarker, and what makes a good biomarker? Dr. Contreras defines anything that can help assess a physiological response or pathological state. Two examples would be BHBA (beta-hydroxybutyrate) and NEFA (non-esterified fatty acids), both fat mobilization measures. (2:56)

Dr. Contreras structured the paper in three sections of biomarkers: (3:54)

Ones that can be measured by looking at cow records, like how many DAs or hypocalcemias occurred over a period of time.
Cow-side measurements like BHBA in urine or blood.
Samples must be sent to a lab to be measured. These generally cannot be used to make decisions immediately but can help assess how a transition program is working, for example.

How many samples should be taken, and what cows should be sampled in a commercial dairy setting? Dairy size, pen size, and pocketbook size will all play a role in this decision. Experts usually recommend at least 10 head, and those 10 must represent the cows' population in your pen. If you have the ability to take more samples, Dr. Contreras recommends 10-12% of the cows in question. He then describes ideal times before and after calving to sample BHBA and NEFA for the most predictive value. (5:31)

Setting a target that integrates BHBA and NEFA the first week after calving with measures like body condition score and/or body weight is ideal. Cows will mobilize fat post-calving no matter what, so the goal is to moderate the degree and intensity of fat mobilization. (11:38)

Rumination and activity monitors are great for measuring biomarkers in real-time and are excellent tools for diagnosing problem cows early. Dr. Contreras has researched ultrasounds to measure fat mobilization, but this may not be practical in a commercial setting. Urine pH after calving might start to be a significant predictor of clinical ketosis. Healthy cows will have a higher urine pH than sick cows. (14:44)

A transition cow experiences several types of adaptations: lipid mobilization to address negative energy balance, skeletal muscle mobilization to address negative protein/amino acid balance, calcium mobilization to compensate for calcium loss, and oxidative stress due to generating energy. The goal is to target biomarkers that reflect the intensity of those adaptive mechanisms. Many of these require sending samples to a lab. A dairy’s nutritionist, veterinarian, and farm manager work together to create a targeted suite of biomarkers to assess their cows and reach their goals. (21:11)

Inflammation is often at the core of transition cow maladies. Measuring a panel of acute phase proteins the first week after calving and comparing the dynamics of how they occur through the year could help identify issues in closeup cows if those proteins are spiking. (26:03)

The group discusses the importance of using individual herds’ baseline data for prediction and assessment and focusing on closeup cows when fresh cow problems arise. They also discuss biomarkers for excessive protein catabolism and a liver functionality index. This leads to a discussion of whether creating an index might be a better overall measure than making decisions on just one diagnostic value. What if someday there might be one perfect predictive biomarker, and what might that look like? (27:50)

In summary, you should not rely on a single biomarker and start measuring early. Ideally, this would be in the dry period. If that’s too challenging, it would be at least a few days after cows go to the closeup pen. Cow-side biomarkers like BHBA, body condition score, and body weight can tell you a lot about transition cow health. Use all the biomarkers and herd records available to design your approach to transition cow health. (43:10)

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