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    Life Sciences

    Razib Khan’s Unsupervised Learning

    Razib Khan engages a diverse array of thinkers on all topics under the sun. Genetics, history, and politics. See: http://razib.substack.com/

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    Latest Episodes:
    Lost civilizations and the promise of new knowledge May 31, 2024
    Show notes

    On this episode of Unsupervised Learning Razib discusses the idea of "lost civilizations," the possibility that there were complex societies during the Pleistocene Ice Age. This topic recently rose to salience after a dialogue between writer Graham Hancock and archaeologist Flint Dibble on Joe Rogan's podcast. Hancock is a longtime guest on Rogan's show and he promotes a theory that an advanced "lost civilization" during the Ice Age left remnants of its culture across the world, for example the pyramids of both Egypt and the New World. In the exchange, Dibble, a vigorous online critic of pseudo-archaeology came back with scientific orthodoxy; civilization emerged after the end of the Ice Age, and there is no evidence for anything during the Pleistocene.

    Razib explains why evidence from biology makes it clear that Hancock is almost certainly wrong. No massively advanced global civilization during the Ice Age left its imprint across the world. Though the archaeological evidence is strong, the data from DNA is even more unambiguously robust and informative. But then Razib steps back and asks what "civilization" is, and presents the possibility that stillborn cultures might have existed during the Ice Age. Civilizations that left no descendants and barely any archaeological footprint. He also argues that the modern conception of civilization starting in Sumer and Egypt 5,000 years ago is simplistic, and American ideas about an arrow of history ascending onward and upward tend to be misleading as a guide to the past. Though the orthodox view is mostly right, there are always gaps in our knowledge and surprises around the corner. Graham Hancock's enthusiasm for what we can know is commendable, his conclusions long ago outpaced his evidence. In the future, understanding the past will be done with even more powerful tools, but we must proceed with humility upon the foundations of all we know while acknowledging what we don't.

    Related: Why Civilization Is Older Than We Thought and Paradise Lost.

    If you have a sibling with autism, your future child's risk for an autism diagnosis is increased by a factor of 2 to 3.5×. Orchid's whole genome embryo reports can help mitigate your child's risk by screening for over 200 genetic variants definitively linked to autism and other neurodevelopmental disorders. Discuss your situation with a genetics expert.


    Akshar Patel: Modi's India in the 21st century May 23, 2024
    Show notes

    On this episode of Unsupervised Learning Razib talks to Akshar Patel of The Emissary about his recent sojourn in India. Patel began The Emissary because he felt there were many gaps in the media representation of India. Razib asks whether The New York Times' claim that Modi is a strongman is correct, and whether India is an illiberal democracy. Patel notes that despite a Westernized super-elite embedded in global Left politics, India is fundamentally a conservative society where communal identity and background reign supreme. He observes that this collectivism is recognized in laws and social norms, though urbanized contexts are breaking down traditional barriers.

    Perhaps the most notable aspect of modern India is its macroeconomic dynamism; today India is the world's fifth largest economy, surpassing the United Kingdom. Patel saw widespread optimism about the nation's economy and citizens' own futures, bolstering Modi's broad popularity. Nevertheless, media claims that the Muslim minority is being marginalized does seem to be broadly correct as Indian reaffirms its Hindu identity. Equally as important as religion in India is caste. Though Patel believes that dating apps and day to day interaction are breaking down caste, he observed on the ground the institution's day to day utility as a way to obtain jobs or foster social welfare. Overall he sees a future India that is economically and geopolitically relevant, but also very distinctive and civilizationally assertive.

    10% of pediatric cancer is linked to a single-gene variation. These variants can be detected in embryos before pregnancy begins. Orchid's whole genome embryo reports can help mitigate your child's risk for cancer by screening for 90+ genetic variants linked to pediatric cancer. Discuss embryo screening and IVF with a genetics expert.


    Jeremy Carl: The Unprotected Class - How Anti-White Racism Is Tearing America Apart May 20, 2024
    Show notes

    On this episode of Unsupervised Learning Razib talks to Jeremy Carl, Senior Fellow at the Claremont Institute, where he focuses on immigration, multiculturalism, and nationalism in America. Previously, Carl was a Research Fellow at Stanford's Hoover Institute where he analyzed and wrote about energy policy. He has BA with distinction from Yale University and an MPA from the Kennedy School of Government at Harvard University.

    Today Carl talks about his new book, The Unprotected Class: How Anti-White Racism Is Tearing America Apart. Though it is in vogue to talk about white supremacy and systemic privilege today, it is notable that in 2024, only 32% of Harvard's student body is white. Largely due to the opioid crisis there has been a decline in life expectancy among whites, disproportionately shouldered by those without college degrees. In The Unprotected Class Carl narrates how in the 60 years since the Civil Rights revolution of the 1960's, the movement has mutated into a war on the soon-to-be-erstwhile white majority, with anti-white sentiment openly and proudly expressed by cultural elites. He argues that this descent into identitarianism undermines the fabric of American society, and divides our society rather than uniting us. Razib and Carl discuss how racialized insults and attacks on whites, seen by many as innocuous due to the power and privilege of the white majority, actually degrade the public discourse and deplete the common cultural capital of Americans to coexist despite their diversity. They also discuss anti-white racism's erasure of class differences among white Americans, and the social and economic pathologies afflicting regions like Appalachia. Ultimately, The Unprotected Class shows how denigrating and attacking one group of Americans leaves us all with less dignity and rights.

    10% of pediatric cancer is linked to a single-gene variation. These variants can be detected in embryos before pregnancy begins. Orchid's whole genome embryo reports can help mitigate your child's risk for cancer by screening for 90+ genetic variants linked to pediatric cancer. Discuss embryo screening and IVF with a genetics expert.


    The Genetic Origin of the Indo-Europeans May 14, 2024
    Show notes

    On this episode of Unsupervised Learning Razib talks about the April 2024 preprint The Genetic Origin of the Indo-Europeans. This blockbuster publication introduces nearly 300 new ancient DNA samples, uncovers the origins of the Yamnaya, and delves into how they transformed the genetic and cultural landscape of Eurasia ~5,000 years ago.

    Razib addresses:

    • The now-identified ancestors of the Yamnaya

    • The genetic landscape between the Dnieper, Volga and Caucasus before the Yamnaya and that region's numerous distinct populations

    • When the Yamnaya came into being as a distinct genetic-cultural cluster (after 4000 BC)

    • The relationship of the Yamnaya to the Anatolian Hittites and the newly refined idea of an Indo-Anatolian (as opposed to Indo-European) language family

    • The region where proto-Indo-Anatolian languages likely flourished, and why they disappeared

    • The population-genetic landscape of clines vs. clusters in human genetic structure over historical time

    10% of pediatric cancer is linked to a single-gene variation. These variants can be detected in embryos before pregnancy begins. Orchid's whole genome embryo reports can help mitigate your child's risk for cancer by screening for 90+ genetic variants linked to pediatric cancer. Discuss embryo screening and IVF with a genetics expert.


    John Massey: Chinese dreams through Western eyes May 13, 2024
    Show notes

    On this unusual "from the vault" episode of Unsupervised Learning, Razib talks to John Massey, a retired Australian engineer who has been a long-time correspondent. Massey and Razib recorded this podcast in the spring of 2021, at the height of the COVID-19 pandemic. At that time, Australia and China were enacting strict lockdowns to halt the spread of the virus, while the US and Europe were already taking a more relaxed approach. Though the conversation is a bit of a temporal rewind, back to a time when Americans were more worried about infection than inflation, the overarching theme is the role of China in the world and its possible future history.

    Massey, though an Australian, has married into an ethnic Chinese family, and some of his grandchildren live in China. The current great power tension of the 21st century is clearly China vs. the US, and in this battle Massey takes a broadly pro-Chinese stance. This is obviously a minority view for Westerners, but it is not entirely unheard of, with even voices as prominent as Thomas Friedman, columnist at The New York Times, waxing poetic about Chinese technocratic efficiency. Prior to its recent economic doldrums and fertility problems, the narrative of China ascendant was dominant and overpowering, and Massey reflects a faction of the West that still believes that Asian power's preeminence is inevitable, given the forces of history. For them, the fundamental question is simply how we in the West will adapt to it.

    For the first time ever, parents going through IVF can use whole genome sequencing to screen their embryos for hundreds of conditions. Harness the power of genetics to keep your family safe, with Orchid. Check them out at orchidhealth.com.


    Colin Wright: In the trenches of the gender wars May 07, 2024
    Show notes

    On this episode of Unsupervised Learning Razib talks to Colin Wright, a returning guest, host of the Reality's Last Stand Substack and a fellow at the Manhattan Institute. Before digging deep into the biology of sex and the cultural politics of gender ideology, Razib and Wright touch on what's been happening to Jonathan Pruitt, Wright's erstwhile advisor. He was accused of academic fraud in 2019, and dozens of papers where Pruitt was the primary contributor of data had to be retracted. Notably, papers where his mentees collected the data did not suffer from the same problems. Evidence quickly mounted that Pruitt's whole career productivity was built on fraudulent data. As of 2024, Pruitt's university, McMaster, where he had an endowed chair, found him to be guilty of fraud, while his doctoral dissertation from University of Tennessee was withdrawn. He resigned from his university in 2022, and embarked on a fantasy writing career. Today he is the author of the dark fantasy, The Amber Menhir.

    Then Razib and Wright talk about the current state of gender ideology, and the conflicts around trans rights in the US and abroad. Wright, who is working on a book on sex and gender, believes we may have seen the high tide of gender ideology, with the retreat occuring earlier abroad in places like Britain, where youth medical gender transition has been severely curtailed. He also reviews the major terms and concepts, like the difference between sex and gender, and also what exactly is meant by binary sex and why it is so important in our ability to understand biology generally and patterns in human society specifically. Finally, Razib asks Wright to expound on the different factions in the "gender wars," from gender critical TERFs to social conservatives and queer theorists.

    https://razib.substack.com This is where you will find all the podcasts from Razib Khan's Substack and original video content.

    For the first time ever, parents going through IVF can use whole genome sequencing to screen their embryos for hundreds of conditions. Harness the power of genetics to keep your family safe, with Orchid. Check them out at https://orchidhealth.com.


    Eric Cline: After 1177 B.C. Apr 24, 2024
    Show notes

    On this episode of Unsupervised Learning Razib talks to George Washington University archaeologist Eric Cline. The author of 1177 B.C. - The Year Civilization Collapsed, Cline has a new book out, After 1177 B.C. - The Survival of Civilizations. While 1177 B.C. closed with the end of the first global civilization, that of the Eastern Mediterranean at the end of the Bronze Age, After 1177 B.C. tells the story of those who picked up the pieces. But first Cline and Razib talk about the popular appetite for ancient history, and how 1177 B.C. became a surprise bestseller. Cline's training is in archaeology and they discuss how new technologies like ancient DNA and isotope analysis are now contributing to transforming our understanding of the past.

    Then they turn to he organization of After 1177 B.C., how Cline decided to build on regional geographically focused histories rather than constructing a tightly integrated single narrative thread. This gets to the reality that the period covered in After 1177 B.C. is one of disintegration and isolation, as the networks binding together ancient Near Eastern kingdoms collapsed, with some states like that of the Hittites disappearing, and others like Egypt re-emerging sharply restructured.

    Cline and Razib also discuss the lacunae in our understanding of the past, and the possibility that civilization may have gone through more cycles than we yet understand, with perhaps some social and technological complexity in the Pleistocene that we had not previously anticipated. Cline points out that Göbekli Tepe certainly must have had precursors in the Pleistocene, as local people could not have constructed such a site without skill and know-how accumulated over generations.

    If you have a sibling with autism, your future child's risk for an autism diagnosis is increased by 2 - 3.5x. Orchid's whole genome embryo reports can help mitigate your child's risk by screening for 200+ genetic variants definitively linked to autism and other neurodevelopmental disorders. Discuss your situation with a genetics expert.

    Special note: I've partnered with Roundtable to create a unique space dedicated to genetics and history enthusiasts. Our exclusive space is going to be organized into small, intimate roundtables of 4-6 people to ensure deep discussions and personal engagement. Every week, I'll provide an agenda for these discussions, and twice a month, I host an AMA for all members. If this opportunity excites you, apply here.


    Kristian Kristiansen: DNA and European prehistory Apr 16, 2024
    Show notes

    On this episode of Unsupervised Learning Razib talks to Kristian Kristiansen, an archaeologist at the University of Gothenburg and affiliate professor at the Lundbech Center for Geogenetics, Copenhagen University. A past guest on this podcast, Kristiansen has recently contributed to an astonishing lineup of landmark papers published in Nature just in the last few months, Population genomics of post-glacial western Eurasia, Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations, 100 ancient genomes show repeated population turnovers in Neolithic Denmark and The selection landscape and genetic legacy of ancient Eurasians. They also discuss his chapter in the 2023 book The Indo-European Puzzle Revisited: Integrating Archaeology, Genetics, and Linguistics.

    Razib and Kristiansen discuss the state of the emerging synthesis between archaeology, genetics and historical linguistics. Though himself an archaeologist, Kristiansen admits that in many ways historical linguists were correct, with models of mass migration now overturning those of cultural diffusion. He also gives a high-level summary of soon-to-be-published work on the spread of plague in Europe 5,000 years ago, and its role in the collapse of Neolithic civilization and the rise of steppe Indo-Europeans. Kristiansen gives a summary of recent developments in understanding the archaeology of Bronze Age Northern Europe, and in particular the expansion of the Corded Ware people. Razib and Kristiansen also discuss the role of distinct migration streams of the steppe people and their contribution to various Indo-European populations. Is it time to wonder if the Greeks descended from Corded Ware or Yamnaya?


    Samo Burja: Palladium Magazine, China, Russia and the future of Eurasia Apr 06, 2024
    Show notes

    Today on Unsupervised Learning, Razib talks to long-time podcast favorite Samo Burja. Burja is the founder of Bismarck Analysis and Bismarck Brief, a Research Fellow at the Long Now Foundation and The Foresight Institute. He is also now the chair of the editorial board of Palladium Magazine. Already a four-time guest on Unsupervised Learning (he has previously shared his views on China's future, Russia's present and archaeology's past, his role at Bismarck Analysis and geopolitical uncertainty, reflected on his piece in Palladium on Finding "lost civilizations" and covered his ideas on "social technology," China, and the foreign view of America), the Slovenian-born Burja is one of the most original and incisive public intellectuals writing in America today. His 2021 piece, Why Civilization is Older than We Thought, brings a level of depth and rigor to historical heterodoxy that you rarely find anymore. Burja has also forwarded the "great founder theory" of historical change and formulated the idea of "live players" in social analysis.

    In this episode, Razib asks Burja for his sense of the world landscape in early 2024, revisiting conversations that delve into logistical details of the Russian invasion of Ukraine and the future of Chinese power. Burja continues to be pessimistic about the long-term prospects of European and Ukrainian resistance to a Russian war-machine that is geared toward grinding its way through lengthy battles of attrition. He also asserts that the current bearish attitude toward Chinese power is short-sighted, arguing that Western media in particular understates the technological and economic achievements of the PRC over the last generation. Burja believes that even if the "China bulls" were overly optimistic, the "China bears" go to excess in the opposite direction. Finally, he touches upon his vision for Palladium Magazine, a publication he has long contributed to, and which he now helms.


    Steve Hsu: IQ, artificial intelligence and academia Mar 30, 2024
    Show notes

    On this episode of Unsupervised Learning Razib talks to Steve Hsu, physicist, entrepreneur and public intellectual. Hsu is an Iowan who earned his undergraduate degree from Caltech and his Ph.D. from Berkeley. Later he was a Harvard Junior Fellow, before moving on to professorships at Yale and the University of Oregon, and finally settling down at Michigan State University in 2012. Hsu is founder of Safeweb and Genomic Prediction, and his current focus is on a new AI startup. Between 2012 and 2020, he was vice president for research and graduate studies at Michigan State. Hsu also has a blog, Information Processing, and a podcast, Manifold.

    Razib asks Hsu about where cognitive and behavioral genomics are in 2024, and where they are going. They discuss the reality that while study of educational attainment (EDU) has proceeded relatively far, the study of intelligence itself has been neglected. Hsu outlines the case for why cognitive phenotypes should be studied, even if the topic remains controversial and fraught. They then address the current fad for artificial intelligence, and how emerging companies in the space are going to transform workplace productivity and culture. Hsu contrasts the rapid pace in the advancement in AI with the torpidity of behavioral genomics. Finally, Razib and Hsu discuss changes in academia in the wake of the "Great Awokening" that led to his ouster in 2020 from his role as vice president of research and graduate studies at Michigan State. Hsu talks about how his work in IQ and genetics became weaponized on social media by left-wing graduate students during the George Floyd protests.


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