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Leveraging the Tumor Microenvironment for IO Therapy Mar 08, 2020

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First recorded at the 4th annual IO Combinations 360° conference, this talk provided by Dr Kenneth Hance, GSK addresses agonistic strategies, T and NK cell redirection and the use of genetic/phenotypic assocations to identify novel target space in IO. To learn more about the upcoming IO Combinations 360° conference please visit, www.iocombinations360.com

Updates on Bintrafusp alfa/M7824 Clinical Data Mar 07, 2020

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In this podcast, first recorded at the 4th annual IO Combinations 360° conference, Dr Laureen Ojalvo, EMD Serono provides an overview of the moleculte Bintrafusp alfa/M7824. This molecule is an innovative, first-in-class bifunctional fusion protein composed of an anti-PD-L1 mAb fused with 2 extracellular domains of TGF-βRII (a TGF-β “trap”). The mechanism of action, pre-clinical and phase 1 studies of this molecule is discussed as well as an overview of the next wave of clinical development. To learn more about the upcoming IO Combinations 360° conference please visit, www.iocombinations360.com

NKTR-214: Harnessing the IL-2 Pathway in Combination Immunotherapies Mar 06, 2020

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In this podcast, first recorded at the 4th annual IO Combinations 360° conference, Dr Willem Overwijk, Nektar Therapeutics discusses Bempegaldesleukin (NKTR-214): harnessing the IL-2 pathway in combination immunotherapies. Topics include: Bempegaldesleukin: Structure and function of an engineered IL-2 cytokine prodrug providing sustained IL-2Rβγ-biased signalingPreclinical PK, PD, MOA and combination with PD-1 checkpoint inhibitionClinical PK, PD, clinical response data and biomarkers in patients with melanoma and bladder cancerCombinations under investigation To learn more about the upcoming IO Combinations 360° conference please visit, www.iocombinations360.com

Advancing Bispecifics for Combination Immunotherapy Mar 02, 2020

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First recorded at the fourth annual IO Combinations 360° conference, this panel moderated by Dr Daniel Chen, IGM Biosciences discusses advancing bispecifics for combination immunotherapy. This discussion covers the following topics: What are the types of bispecifics and what are the limitations?What are the toxicity related side effects?What are teh next steps/levels for bispecifics?What does the future hold for bispecifics? Panelists include: Julie Bailis, PhD, AmgenRajkumar Ganesan, PhD, Janssen Research & DevelopmentDavid Schaer, PhD, Pfizer To learn more about the 5th annual IO Combinations 360° conference please visit www.iocombinations360.com

How AI, Machine Learning and Big Data are Used to Inform Combinations Mar 01, 2020

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In this podcast, you will hear a panel discussion from the 2019 IO Combinations 360° conference regarding how AI, machine learning and big data are used to inform combinations. Moderated by Matthew Albert, MD, PhD, Insitro Panelists: Edward Bowen, GSK Ryan Fukushima, Tempus Renée Deehan-Kenney, PhD, QuartzBio, part of Precision for Medicine To learn more about the 2020 IO Combinations 360° conference please visit www.iocombinations360.com

Weighing Your Options in Considering Clinical Trials from a Patient Perspective Feb 20, 2020

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In this podcast, you will hear a panel discussion from the 2019 Clinical Research as a Care Option (CRAACO) conference with patients and advocates on weighing your care options and considering participation in a clinical trial. Some points include, Strategies and ideas to reduce the burden to patientsUnderstanding of clinical care with their physician?Communication, consent and data sharing Moderated by Cindy Geoghegan, Cancer Veteran, Patient Advocate Panelists: Allison Greiner Patient Advocate Sarah Larson, Director of Global Clinical Operations, Biogen and Cancer Veteran Kelly Piacsek, PhD, VP, Patient-Centered Research, Aurora Research Institute The 2020 CRAACO conference will take place on April 27-28 in Raleigh, NC. Learn more here.

Understanding the Goals of Care vs Research Feb 19, 2020

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In this podcast, you will hear a panel discussion from the 2019 Clinical Research as a Care Option (CRAACO) conference on Understanding the Goals of Care Vs Research. The panelists explore points including, Goals for care vs goals for researchOversight and governanceIs there an ethical burden of breaking down the line between research and care?What is the hesitation behind embracing the blurring of this boundary?In areas like precision medicine, this is already blurring, how to manage?Hurdles stopping large companies from thinking about this– Is it practical? Ethical? Moderated by Jennifer Byrne, CEO and Founder, Javara Panelists: Greg Burke, MD, MSc, Chief Science Officer, Senior Associate Dean for Research, Wake Forest School of Medicine Amy Nordo, Director eSource Implementation, Pfizer The 2020 CRAACO conference will take place on April 27-28 in Raleigh, NC. Learn more here.

6 Min Podcast on What to Expect at the 7th Annual Patients as Partners Feb 18, 2020

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This 6 minute podcast summarizes what you can expect during the virtual Patients as Partners conference. Key topic areas include: BioPharma Strategies on Applying Patient Engagement Initiatives and Demonstrating ImpactDirect-to-Patient Clinical Trials Next Milestones and Actions to Get ThereMeasuring the Impact of Patient Engagement and Patient Centricity in Clinical Research and DevelopmentCurrent Efforts for Educating and Enrolling Diverse Populations in Clinical TrialsProgress on Patient Data OwnershipCollaborating with Site Partners & CROs to Increase Efficiencies, Provide Greater Value to Patients and Clinical TrialsProgress on the National Health Council’s Patient Engagement Fair Market Value InitiativeFDA Reports on the Latest Guidance Updates and New Agency Efforts on Patient Engagement Keynotes include: Dr Dara Richardson-Heron, PfizerDr Joanne Waldstreicher, Johnson & JohnsonDr Darryl Sleep, AmgenBarry Greene, Alnylam PharmaceuticalsRonnie Sharpe, Cystic Fibrosis AdvocateKen Getz, Tufts CSDDJeff Borghoff, Alzheimer's Patient and AdvocateChip Bell, Customer Service Guru Patients as Partners takes place virtually, August 19-21, 2020. For more information please visit www.patientsaspartners.org

How to Integrate Industry Sponsored Clinical Trials Into Your Health System Feb 18, 2020

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In this podcast, you will hear a session from the 2019 Clinical Research as a Care Option (CRAACO) conference on How to Integrate Industry-Sponsored Clinical Trials Into Your Health System to Give Patients the Best Options. Points include, How to build your programsHow to become an integrated care & research organizationHow to integrate clinical research into your care systemRoswell Park and TrialScout’s strategic partnership Speakers: Irfan Khan, MD, CEO and Founder, Circuit Clinical Doug Plessinger, Chief Clinical & Scientific Development Officer, Roswell Park/GBCT The 2020 CRAACO conference will take place on April 27-28 in Raleigh, NC. Learn more here.

How Sanford Health Systems Increased Clinical Trial Participation to 10% Feb 17, 2020

Show notes

In this podcast, you will hear a case study presentation from the 2019 Clinical Research as a Care Option (CRAACO) conference on how Sanford Health Systems has increased their clinical trial participation from 3% to 10% over the last 8 years by integrating clinical care and clinical research. Points include, Creating a system for all providers to work seamlesslyEducational programs and continual training across all areas of care and specialties for trial offeringsIdentifying gaps in trial availabilityAttracting providers who are interested in clinical research for their patientsNCORP site The 2020 CRAACO conference will take place on April 27-28 in Raleigh, NC. Learn more here.

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