Medical Mysteries

Mary Toft Dec 15, 2020

In 18th century England, Mary Toft defied all medical odds when she started giving birth to rabbits.

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The Bubonic Plague Pt. 2 Dec 08, 2020

When the plague broke out again in the late 19th century, scientists dissected buboes, bodies, and fleas… and found the source of the Black Death. The disease had already killed millions throughout Europe and Asia. In 1900, it reached San Francisco.

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The Bubonic Plague Pt. 1 Dec 01, 2020

It was one of the most lethal pandemics in global history. The bubonic plague’s devastating spread in 6th and 14th century Europe paved the way for how we handle outbreaks today — though patients in medieval times saw no sign of a cure.

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Brain-Eating Amoeba Nov 17, 2020

In July 2013, a 12-year-old girl from Arkansas was diagnosed with a rare and deadly brain-eating amoeba known as Naegleria fowleri. Her exposure came from a local water park, but brain-eating amoebas are lurking everywhere — including our own faucets.

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Aging Syndrome Nov 10, 2020

Progeria is a rare disorder that causes children's bodies to age and deteriorate quickly. Those with the condition have a life expectancy of 13 years. We follow the journey of one patient, Hayley Okines, who dedicated her short life to helping others battle the disease.

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Alice in Wonderland Syndrome Nov 03, 2020

For these patients, rooms shrink, bodies grow disproportionately large, and objects appear farther than they are. Many believe author Lewis Carroll had this condition, and that it inspired the classic tale for which the syndrome was named.

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Ergotism and the Salem Witch Trials Pt. 2 Oct 27, 2020

Modern day researchers are still trying to explain what happened in 17th century Salem. Many have blamed the event on mass hysteria, but one doctor points to an outbreak of a fungus called ergot — the same organism used to create LSD.

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Ergotism and the Salem Witch Trials Pt. 1 Oct 20, 2020

In 17th century Massachusetts, three young girls experienced strange symptoms –– prickling of the skin, convulsions and trance-like states. Before long, dozens were complaining of the same ailments, and accusations of witchcraft started to emerge.

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Cotard Syndrome: Real-Life Zombies Oct 13, 2020

This psychological condition, also known as "Walking Corpse Syndrome" causes people to suffer from disturbing delusions. Many feel that their bodies are void of blood or organs, while other patients are convinced they're dead and stuck in the world of the living.

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Cutaneous Horns Oct 06, 2020

The earliest description comes from a 16th century British pamphlet, featuring a Welsh widow with a four-inch-long growth protruding out of her forehead. Cutaneous horns were originally regarded as divine punishment, or a spectacle to be paraded around. In more recent decades, doctors have worked to understand the variety of decidedly less supernatural causes.

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Anthrax Sep 29, 2020

In the wake of 9/11, one man’s exposure to a rare and deadly illness sparked widespread panic in the U.S. On September 19th, Bob Stevens opened a letter containing a strange white powder. A week later, he was fighting for his life as a victim of a biological weapon. It left many wondering who was responsible… and would they be next?

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Lobotomies Pt. 2 Sep 22, 2020

With Dr. Walter Freeman’s invention in the 1940s, psychologists could perform a transorbital lobotomy from the comfort of their office… with an ice pick through the eye.

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Lobotomies Pt. 1 Sep 15, 2020

In the 1940s, Portuguese neurologist António Egas Moniz received the Nobel Prize for his groundbreaking new treatment: the prefrontal lobotomy. His procedure was adopted by hospitals all over the world—but the treatment was controversial, and came to be known as one of medicine’s greatest mistakes.

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The Girl Who Didn’t Age Sep 08, 2020

In the early 1990s, Brooke Greenberg was born with a rare condition that kept her from aging. Her condition was accompanied by inexplicable conditions that doctors couldn't connect: seizures, ulcers, tumors… And by her 16th birthday, she was still the size of a toddler.

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Alzheimer's Disease Pt. 2 Sep 01, 2020

Over 100,000 people die from Alzheimer's Disease in the United States alone. Doctors are feverishly working to try and understand the disease in hopes of finding a cure. But the human brain holds many mysteries, and the results so far haven't been promising.

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Alzheimer's Disease Pt. 1 Aug 25, 2020

In 1901, a 51-year-old woman named Auguste Deter shuffled into a German asylum. She had forgotten nearly everything about her life: where she lived, her husband's name, and how old she was. She was put into the care of revolutionary psychiatrist Alois Alzheimer.

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Typhus Pt. 2 Aug 18, 2020

During WWII, two Polish scientists raced to find a vaccine to end typhus once and for all. In Switzerland, another scientist discovered the pesticidal possibilities of a chemical called DDT.

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Typhus Pt. 1 Aug 11, 2020

In the sixteenth century, sporadic outbreaks of a deadly fever crippled armies and altered the political landscape of Western Europe. Centuries later, a British surgeon reshaped the world’s understanding of how disease spread—and uncovered the key to fighting typhus.

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Phantom Limb Pain Pt. 2 Aug 04, 2020

Today, doctors still work to understand what causes Phantom Limb Pain—and whether it can be cured in all cases. Innovative treatments like Mirror Therapy, and Virtual and Augmented Reality offer insights into how it can be cured.

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Phantom Limb Pain Pt. 1 Jul 28, 2020

In the mid-1500s, French surgeon Ambroise Paré realized patients who survived an amputation could still feel their missing limbs. Doctors theorized for centuries about the phenomenon, driven by one question: How do you treat a limb that doesn’t exist?

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Truman Show Syndrome Pt. 2 Jul 21, 2020

After studying the "Truman Show Delusion" for years, Doctors Joel and Ian Gold discovered an underlying condition. It's possible that societal fears over progress and technology have a lasting impact on the subconscious…

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Truman Show Syndrome Pt. 1 Jul 14, 2020

In the early 2000s, psychologist Dr. Joel Gold met several patients who believed they were the stars of their own reality shows. They each shared similar delusions of being recorded by hidden cameras, with their friends and family part of the cast and crew, and unseen producers coaxing them toward a grand prize.

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Disease Forgery Pt. 2 Jul 07, 2020

Growing up in the ‘90s, Gypsy Rose was convinced she suffered from cancer and epilepsy. But in truth, her mother Dee Dee was addicted to faking her daughter’s illnesses—a disorder in itself, known today as Munchausen’s by Proxy.

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Disease Forgery Pt. 1 Jun 30, 2020

In 1991, a 24-year-old woman checked herself into the hospital dozens of times, each with a new and perplexing illness. Her symptoms didn't match anything doctors had seen before. Then they discovered she was suffering from Munchausen's Syndrome—and was addicted to making herself sick.

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Radium Girls Pt. 2: Radium on Trial Jun 23, 2020

In 1925, five dying US Radium Dial Painters sued their employer. They claimed they were dying of radiation poisoning—but experts at the time believed radium was healthy, not toxic. So the Radium Girls took the stand to try to convince juries—and the world—of radium's dangers.

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Radium Girls Pt. 1: Women Who Glowed in the Dark Jun 16, 2020

In the 1920s, dial-painters at US Radium's New Jersey factory began getting sick. They were diagnosed with syphilis and phossy jaw, but their symptoms didn't add up. The women suspected something about their job was making them fatally ill—but they were running out of time to solve the mystery.

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Body Integrity Dysphoria Jun 09, 2020

Our body is the only one we'll ever know, for better or worse. And for those suffering from Body Integrity Dysphoria, they feel like one or more of their limbs doesn't belong. Many of them resort to drastic measures like self-amputation to achieve their ideal body. But researchers are still trying to figure out why.

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Mental Health Pt. 4: The 21st Century Jun 02, 2020

Today, one in four homeless Americans are living with a mental health condition. Many are unable to turn to shelters out of fear that it will worsen symptoms and the prison system has subsequently taken on the role of asylums. But understanding foreign cultures may hold the key to a cure.

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Mental Health Pt. 3: The 20th Century May 26, 2020

In the late 1800s, Dr. Emil Kraepelin identified schizophrenia as its own mental health condition. But this new revelation also increased the stigma surrounding the disorder. Over the course of the next century, people living with schizophrenia became a target in the eugenics movement, both in America and overseas.

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Mental Health Pt. 2: 1700s to 1900s May 19, 2020

When a young Quaker woman died in an asylum in 1790, William Tuke resolved to found a new facility focused on treatment—not incarceration. But mental health conditions were poorly understood, and many of the early expiramental treatments could be better described as torture.

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Mental Health Pt. 1: Origins May 12, 2020

Socrates was one of the greatest philosophers of all time—and he heard voices. Pheidippides invented the marathon—and experienced hallucinations. Were these symptoms of mental health conditions, or signs of divine intervention? And how could ancient Greek doctors treat their delusional patients?

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Beating the Odds: Reshma Begum May 08, 2020

Welcome to our special five-part series, Beating the Odds. Every day this week we’re telling the true tales of medical miracles that shocked the world: Today we’re discussing Reshma Begum, a seamstress in Bangladesh who was pulled out alive from the wreckage of a building…17 days after it collapsed.

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Beating the Odds: Michael Benson May 07, 2020

Welcome to our special five-part series, Beating the Odds. Every day this week we’re telling the true tales of medical miracles that shocked the world: Today we’re discussing Michael Benson, a cameraman who survived a helicopter crash, only to find himself stuck inside a volcano’s crater…for two days.

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Beating the Odds: José Salvador Alvarenga May 06, 2020

Welcome to our special five-part series, Beating the Odds. Every day this week we’re telling the true tales of medical miracles that shocked the world: Today we’re discussing José Salvador Alvarenga, a Salvadoran fisherman who spent over 13 months adrift at sea…and survived.

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Lou Gehrig’s Disease (ALS) Pt. 2 May 05, 2020

In 2014, the “Ice Bucket Challenge” went viral across the internet. Hundreds of thousands of people from across the globe participated in videos hoping to help bring an end to ALS.

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Beating the Odds: Beck Weathers May 04, 2020

Welcome to our special five-part series, Beating the Odds. Every day this week we’re telling the true tales of medical miracles that shocked the world: Today we’re discussing Beck Weathers, a Texas pathologist who survived the disastrous 1996 blizzard on Mount Everest...

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Beating the Odds: Anna Bågenholm May 04, 2020

Welcome to our special five-part series, Beating the Odds. Every day this week we’re telling the true tales of medical miracles that shocked the world: Today we’re discussing the story of Anna Bågenholm, whose heart stopped in 1999 after she was trapped in a labyrinth of thick ice for nearly an hour and a half…

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Lou Gehrig’s Disease (ALS) Pt. 1 Apr 28, 2020

In 1939, Lou Gehrig would play his last game with the New York Yankees. After more than 2,000 consecutive starts, his physical abilities began to decline. Nearly a century earlier, a doctor in Paris was beginning research on the disease that would one day be synonymous with Gehrig.

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NEW: Severe Allergic Reactions Apr 21, 2020

We are thrilled to bring you a brand new episode of Medical Mysteries today and for the foreseeable future. We thank you for your patience during this unprecedented time.

When 10-year-old Morgan Smith was on a Colorado camping trip with his family in 2006, everything was going fine. But when he bit into a piece of fish—everything changed.

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Panic Virus Pt. 2 Apr 14, 2020

In 2001, disgraced doctor and medical researcher Andrew Wakefield left the UK and re-settled in Austin, Texas. There, he continued spreading dangerous misinformation about the MMR (measles, mumps, rubella) vaccine and its alleged connection to autism. As measles outbreaks swept the country, the medical establishment tried to counter his influence.

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Panic Virus Pt. 1 Apr 07, 2020

In 1998, British physician Andrew Wakefiled published a paper claiming he had found a direct connection between the measles, mumps, and rubella vaccine with autism. His dangerous claims caused an entire movement of people who were no longer willing to vaccinate their children out of fear...

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Gloria Ramirez “The Toxic Lady” Mar 31, 2020

On February 19th, 1994, a young woman from Riverside, California was rushed to the emergency room after becoming unresponsive in her home. When doctors began operating on her, they noticed something strange: crystals in her blood. Within minutes the medical staff all started to collapse one by one.

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Parcast Classic: Allergic to Water Mar 24, 2020

Due to the unfortunate spread of COVID-19, Parcast has decided to halt recording for the time-being. This is a precautionary measure taken to ensure the safety of our hosts and staff. In the meantime, we're excited to share one of our classic episodes that we know you'll enjoy!

Alexandra Allen’s nightmare first began in 2009 when she was 12-years-old. After swimming in a hotel pool, she nearly went into anaphylactic shock. Following a battery of tests, doctors were shocked by what caused her reaction. The Utah native was allergic to water.

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The HIV & AIDS Epidemic Pt. 2 Mar 17, 2020

In December 1984, Indiana-native Ryan White was diagnosed with AIDS at the age of thirteen. The disease had no known treatment, no cure, and Ryan was given six months to live. The clock was ticking, and Ryan soon found himself at the center of a media storm.

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The HIV & AIDS Epidemic Pt. 1 Mar 10, 2020

In 1981, Dr. James Curran at CDC began investigating a mysterious case of an illness that seemed to be affecting gay men across the United States. As more people began to die, the stakes were raised, and Dr. Curran was on a race to see if he could find the cause.

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The Case of the Frozen Addicts Mar 03, 2020

In 1982, six heroin addicts found themselves immobilized, as if frozen. For over seven years, Dr. J. William Langston worked to save their lives...

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Hantavirus Pt. 2 Feb 25, 2020

After a 1993 outbreak, doctors thought they understood Hantavirus as a rare but preventable infection. That was until an inexplicable "cluster" appeared in Yosemite, and then spread through the American west...threatening to become an epidemic.

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Hantavirus Pt. 1 Feb 18, 2020

It’s an unexplained and deadly infection that first reared its ugly head in May 1993. At least, that’s what researchers originally thought. As doctors began to investigate the disease, they soon found that it had a much longer history and had claimed many more lives than they’d ever suspected.

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Broken Heart Syndrome Feb 11, 2020

Takotsubo Cardiomyopathy, also known as stress-induced cardiomyopathy, apical ballooning syndrome, or, more romantically, “Broken Heart Syndrome,” refers to a group of symptoms, brought on by acute emotional stress—which can cause heart failure.

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Laughing Death Pt. 2 Feb 04, 2020

For decades, researchers tried to find the cause of “The Laughing Sickness,” also known as Kuru. But it wasn't until the 1990s that researchers found the clue that turned the entire medical community on its head.

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Laughing Death Pt. 1 Jan 28, 2020

In the mid-1900s, members of the remote Fore tribe in Papua New Guinea faced extinction at the hands of the strange neurological condition that caused spontaneous barks of laughter.

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Reye Syndrome Jan 21, 2020

Beginning in 1951, Doctor Ralph Reye took note of an alarming, fatal condition that killed thousands of child patients. Mild colds and flus would become life-threatening neurological conditions that left patients dead or with severe brain damage. And the culprit was an ordinary product present in nearly every household in the developed world.

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The Fasting Girl Jan 14, 2020

In the late 1800s, Mollie Fancher was entangled with a city trolley car that dragged her violently through the streets of Brooklyn. This caused a series of inexplicable ailments that left her bedridden for the remainder of her life. But Mollie’s strangest symptom was her ability to go 14 years without eating a thing…

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The Death of President Harding Jan 07, 2020

At the time, doctors believed the 57-year-old’s symptoms could have been caused by a stroke, but there have been many other medical theories since then. Some people even believe that President Warren G. Harding was poisoned.

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Best of 2019: Fatal Familial Insomnia Pt. 2 Dec 31, 2019

Here’s one of our listeners’ most requested episodes of 2019: Once modern medicine recognized Fatal Familial Insomnia as a disease, it faced a greater challenge: finding a cure.

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Best of 2019: Fatal Familial Insomnia Pt. 1 Dec 24, 2019

Here’s one of our listeners’ most requested episodes of 2019: Don’t let the complicated name fool you—this mystery is no laughing matter: Inability to sleep. Loss of coordination. Slow, painful loss of mental faculties.

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Flesh-Eating Bacteria Dec 17, 2019

It’s a terrifying infection that liquefies skin and muscle. Though rare, doctors are still ill-equipped to fight flesh-eating bacteria, and it still continues to take lives to this day.

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Allergic to Water Dec 10, 2019

Alexandra Allen’s nightmare first began in 2009 when she was 12 years old. After swimming in a hotel pool, she nearly went into anaphylactic shock. After a battery of tests, doctors were shocked by what caused her reaction. She was allergic to water.

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Adrenoleukodystrophy Pt. 2 Dec 03, 2019

After Lorenzo Odone was diagnosed with adrenoleukodystrophy in 1984, his parents developed a treatment that saved his life. But in 1993, they faced accusations of fraud when a Hollywood movie based on Lorezno's story gave false impressions to a number of other desperate patients.

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Adrenoleukodystrophy Pt. 1 Nov 26, 2019

In a matter of months, eight-year-old Lorenzo Odone lost his hearing and sight, as well as his ability to move, swallow, and speak. Doctors told him he had five years to live at most. But his parents refused to accept this and went on a frantic search for a cure.

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Leisure Sickness Nov 19, 2019

Could being a workaholic actually have dangerous effects? Just ask the victims of Leisure Sickness—a psychological phenomenon in which individuals who are especially devoted to their work become physically ill when they try to relax.

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Anti-NMDA Receptor Encephalitis Pt. 2 Nov 12, 2019

Twenty-four-year-old journalist Susannah Cahalan’s illness continued to wreak havoc on her brain after a month-long hospital stay in 2009. With no change in her condition, one doctor would finally figure out her diagnosis using one simple test.

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Anti-NMDA Receptor Encephalitis Pt. 1 Nov 05, 2019

24-year-old journalist Susannah Cahalan began coming down with a troubling set of symptoms in 2009. She experienced hallucinations, numbness and delusions, which grew life-threatening as doctors struggled to diagnose her.

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Human Chimerism: Different DNA Oct 29, 2019

A condition in which a person possesses cells with more than one distinct genetic makeup. This can alter DNA evidence linking a mother’s relation to her child—even if she had conceived, carried, and given birth to them.

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Leishmaniasis Pt. 2: The Deadly Parasite Oct 22, 2019

It wasn’t until Doug Preston and his team returned from their expedition in Honduras in 2015 that tragedy struck. What they had contracted in the ruins was a horrifying, sometimes lethal and incurable disease of leishmaniasis, a tropical parasitic disease.

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Leishmaniasis Pt. 1: The Deadly Parasite Oct 15, 2019

Explorers set out on an expedition into the wilderness of Honduras in 2015. They were seeking a lost city, but returned with far more than they bargained for.

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Encephalitis Lethargica Pt. 2: Under the Rug Oct 08, 2019

A sleeping sickness that swept its way across the globe after World War I vanishes almost as abruptly as it arrived.

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Encephalitis Lethargica Pt. 1: The Great War Oct 01, 2019

Swelling of the brain. Involuntary movements. Extreme exhaustion. A little-known and poorly understood disease swept its way across in the globe in the aftermath of World War I. But as the number of diagnoses swelled, so did the confusion. Agreeing on the symptoms was hard enough, how could anyone hope to find a cure?

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Graves’ Disease: George & Barbara Bush Sep 24, 2019

In 1991, President George H.W. Bush was hospitalized with an erratic heartbeat. For three tense days, the nation watched with bated breath, planning for the worst - until the doctor came back with a surprising diagnosis.

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Fatal Familial Insomnia Pt. 2: Dreaming of a Cure Sep 17, 2019

Once modern medicine recognized Fatal Familial Insomnia as a disease, it faced a greater challenge of finding a cure. With research ongoing, the answer may lie in similar medical mysteries which have plagued humanity for centuries.

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Fatal Familial Insomnia Pt. 1: The Sleepless Family Sep 10, 2019

Inability to sleep. Loss of coordination. Slow, painful loss of mental faculties. These are the symptoms of a mysterious disease, passed on through generations of one family. For centuries, they believed they were cursed, until the modern era brought them a diagnosis.

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Myasthenia Gravis Sep 03, 2019

Drooping eyelids. Difficulty swallowing. Weak arms. None of these symptoms by themselves seem particularly deadly. Nor do they seem like they could all be symptoms of the same illness. But they are. And the illness does kill - suddenly, and without warning. A diagnosis evaded doctors for centuries. With such a mysterious background, it seemed that a treatment for the disease was impossible.

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Hiccup Girl Pt. 2 Aug 27, 2019

With conventional medicine proving unable to cure her case of intractable hiccups, Jennifer Mee turned to unorthodox methods to get them under control. However, in 2013, the hiccups turned out to be the least of Jennifer's problems.

Parcasters - Which UFO sighting kicked off the alien craze? It wasn’t Roswell! Subscribe to Extraterrestrial today to learn about the close encounter that started it all, the Mount Rainier flying saucer sighting. Search for Extraterrestrial on Spotify to listen now!

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Hiccup Girl Pt. 1 Aug 20, 2019

In 2007, 15-year-old Jennifer Mee began to hiccup. Seven weeks later, she still hadn't stopped. As doctors struggled to cure Jennifer's condition, she began to wonder if she'd have them for the rest of her life.

Parcasters - Two men, one account. The Pascagoula abduction is one of the most credible in U.S. history, but where do you stand? Follow the case this week on Extraterrestrial, available on Spotify or wherever you listen to podcasts.

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The Elephant Man Pt. 2 Aug 13, 2019

Around 1886, after two years on the freak show circuit, Joseph Merrick was once again in the care of the London Hospital’s top surgeon, Frederick Treves. But even Britain’s best medical minds were unsure if they could explain Joseph’s disorder before it was too late.

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The Elephant Man Pt. 1 Aug 06, 2019

In 1867 in Leicester, England, five-year-old Joseph Merrick began developing strange symptoms - overgrown limbs, massive facial tumors, and rough, loose flaps of skin. His condition baffled doctors, terrified the public, and eventually launched him to nationwide fame as “The Elephant Man.”

Parcasters - Thank you so much for listening to our new show!

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Welcome to Medical Mysteries! Jul 19, 2019

Parcast's Original Show, Medical Mysteries brings high-stakes story-telling and intrepid investigation to the hospital, in a medical procedural for the podcast space. Every week, we follow desperate patients battling mysterious symptoms--from the bizarre to the terrifying--as determined doctors race against the clock for a diagnosis. Medical Mysteries premieres Tuesday August 6th. New episodes available every Tuesday on Spotify, or wherever you listen to podcasts. Subscribe today!

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