JACC This Week

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Sodium Zirconium Cyclosilicate for Management of Hyperkalemia During Spironolactone Optimization in Patients with Heart Failure | JACC Mar 10, 2025

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In this episode, Dr. Valentin Fuster discusses a study on sodium zirconium cyclosilicate (SZC) for managing hyperkalemia in heart failure patients on mineralocorticoid receptor antagonists (MRAs) like spironolactone. While SZC effectively reduced hyperkalemia and allowed higher spironolactone doses, concerns over worsening heart failure events highlight the complex balance between treatment benefits and risks.

Clinical Effect of Genetic Testing in Inherited Cardiovascular Diseases : A 14-Year Retrospective Study | JACC Mar 10, 2025

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In this episode, Dr. Valentin Fuster discusses a 14-year study on the clinical impact of genetic testing for inherited cardiovascular diseases, conducted by Dr. Steffany Grondin at the Montreal Heart Institute. The study found that genetic testing helped diagnose 24% of patients, refine clinical management, and improve variant interpretation, while also highlighting the need for more research and better access to genetic expertise in healthcare.

Efficacy of Acoramidis on All-Cause Mortality and Cardiovascular Hospitalization in Transthyretin Amyloid Cardiomyopathy | JACC Mar 10, 2025

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In this episode, Dr. Valentin Fuster highlights a groundbreaking study on acoramides, a novel treatment for transthyretin amyloid cardiomyopathy (ATTR), which shows significant reductions in mortality and cardiovascular hospitalizations compared to a placebo. Experts discuss the clinical implications, comparing acoramides to the previously approved tafamidis, noting exciting advancements in treatments for a once-untreatable disease.

Association between cigarette smoking and subclinical markers of cardiovascular harm | JACC Mar 10, 2025

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In this episode, Dr. Valentin Fuster discusses a groundbreaking study on the link between cigarette smoking and subclinical cardiovascular harm, focusing on markers of inflammation, thrombosis, and atherosclerosis. The research, based on data from over 182,000 participants across 22 cohorts, reveals how smoking intensity and duration impact early cardiovascular damage and highlights the potential of these biomarkers in shaping future public health strategies and regulatory policies.

Best Practices for Imaging of Transcatheter Valve Failure: An Update from the Heart Valve Collaboratory | JACC Mar 10, 2025

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In this podcast highlights the growing concern over transcatheter valve failure following transcatheter aortic valve replacement (TAVR), emphasizing the need for standardized imaging protocols and frequent follow-ups. Experts discuss best practices for monitoring and managing these patients, urging collaborative international efforts to validate new imaging techniques and improve patient outcomes.

Clinical Considerations for Q1 Competitive Sports Participation for Athletes With Cardiovascular Abnormalities | JACC Mar 10, 2025

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In this episode, Dr. Valentin Fuster dives into a groundbreaking scientific statement from the American Heart Association and American College of Cardiology, providing updated clinical considerations for competitive athletes with cardiovascular abnormalities. The statement, which integrates 40 years of research, focuses on preventing sudden cardiac death and improving shared decision-making strategies for athletes facing heart conditions, offering expert guidance across 11 key task forces.

Diagnostic Performance and Clinical Impact of Photon-Counting Detector CT in CAD | JACC Baran Mar 04, 2025

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In this week's JACC Baran (Episode 4), hosts Mitsuaki Sawano, MD, JACC Executive Associate Editor, and Shun Kohsaka, MD, FACC, JACC Regional Editor welcome Koshiro Sakai, MD, to discuss the 2025 revised ACS guidelines and Photon-Counting CT (PCD-CT). A retrospective cohort study of 7,500 cases suggested an association between PCD-CT and enhanced diagnostic accuracy, with potential implications for reducing unnecessary invasive catheterization procedures. The episode also highlights global research perspectives and the importance of clear scientific communication.

Transcatheter vs Surgical Aortic Valve Replacement in Lower-Risk Patients: An Updated Meta-Analysis of Randomized Controlled Trials | JACC Mar 03, 2025

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In this episode, Dr. Valentin Fuster summarizes the March 11, 2025 issue of the JACC, which features groundbreaking research on transcatheter aortic valve replacement (TAVR) and its expanding applications. The podcast delves into the latest studies on TAVR's impact on heart failure patients, the need for better patient selection, and how new findings are shaping the future of aortic stenosis treatment.

Transcatheter Aortic Valve Replacement Beyond Severe Aortic Stenosis: JACC State-of-the-Art Review | JACC Mar 03, 2025

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Advancing Transcatheter Aortic Valve Replacement: Expanding Evidence, Refining Strategies | JACC: Inside This Issue Mar 03, 2025

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The field of transcatheter aortic valve replacement (TAVR) continues to evolve, with new research expanding its indications and refining its application. This JACC special issue brings together cutting-edge studies, meta-analyses, and expert perspectives on key topics shaping the future of TAVR. Highlights include pivotal trials assessing TAVR in low-risk patients, a growing focus on moderate aortic stenosis and heart failure, and novel insights into reintervention strategies. The issue also presents comprehensive analyses on asymptomatic severe aortic stenosis, valve durability, and patient selection for next-generation TAVR applications. As TAVR increasingly moves beyond its initial role in high-risk patients, the studies featured here provide essential data to guide clinical decision-making, optimize outcomes, and address the challenges of valve longevity, structural durability, and patient-centric approaches. We hope this collection informs and inspires continued innovation in structural heart disease management.

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