JACC This Week

Latest Episodes:

May 6, 2025 Issue Summary | JACC Apr 28, 2025

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This special electrophysiology-themed issue of JACC, summarized by Dr. Valentin Fuster, dives into cutting-edge research on atrial fibrillation, pulsed field ablation, sudden cardiac arrest in athletes, and preventive strategies in congenital heart disease. From new therapies like finerenone to breakthrough mapping techniques, this episode captures the evolving sophistication and promise of arrhythmia management in modern cardiology.

Bridging Gaps for SCD Prevention in HCM: Why Regional Validation Matters | JACC Baran Apr 22, 2025

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Hosts Mitsuaki Sawano, MD, Shun Kohsaka, MD, and Nobuhiro Ikemura, MD, welcome Masashi Amano, MD, from the National Cerebral and Cardiovascular Center in Japan, to discuss his recent article titled "Validation of Guideline Recommendation on Sudden Cardiac Death Prevention in Hypertrophic Cardiomyopathy," published in JACC: Heart Failure.Drawing from the REVEAL-HCM registry of 3,611 patients across 21 Japanese centers, the study evaluated how well U.S. and European guidelines for ICD implantation apply to Japanese patients with HCM. The findings revealed poor outcomes in end-stage HCM (EF <50%) and favorable prognosis in apical HCM, a subtype more prevalent in Japan. Dr. Amano discusses the limitations of applying international risk stratification tools in a Japanese context and emphasizes the need for regional validation.

Altshock-2 | JACC Deep Dive Apr 21, 2025

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In this in-depth analysis of the Altshock-2 trial (Study on Early Intra-aortic Balloon Pump Placement in Acute Decompensated Heart Failure Complicated by Cardiogenic Shock), Harlan M Krumholz, MD, FACC, goes deep into the study and its two related editorials. Listen here for this unique behind-the-scenes look at the review process, plus a thoughtful summary of the study and the two related editorials. All this content appears in JACC, in our special focus issue on cardiogenic shock.

April 29, 2025 Issue Summary | JACC Apr 21, 2025

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In this episode, Dr. Valentin Fuster dives into the complex and high-stakes world of cardiogenic shock, spotlighting new clinical trials, expert consensus guidance, and cutting-edge insights from machine learning. From evaluating the impact of intra-aortic balloon pumps to rethinking mechanical support strategies, the episode delivers a powerful update on one of cardiology's most urgent challenges.

The Influence of Extracorporeal Life Support on Patients in Cardiogenic Shock Assessed by Machine Learning: A Machine Learning Subanalysis From the ECLS-SHOCK Trial | JACC Apr 21, 2025

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Single-Access Technique for Impella-Assisted Balloon Aortic Valvuloplasty and High-Risk PCI in Cardiogenic Shock | JACC Apr 21, 2025

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Nonhemorrhagic Pericardial Effusion With Tamponade and Cardiogenic Shock Due to Large Coronary Artery Fistula | JACC Apr 21, 2025

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LAVA-ECMO–Supported Dual-Transcatheter Aortic and Mitral Valve-in-Valve Replacement in Cardiogenic Shock | JACC Apr 21, 2025

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A Vascular Plug for Persistent Shock Following Transcatheter Mitral Valve Replacement | JACC Apr 21, 2025

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Mixed Cardiogenic-Vasodilatory Shock: Current Insights and Future Directions | JACC Apr 21, 2025

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