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    Life Sciences

    Innovate and Elevate

    Join Sharon Kedar, Co-Founder of Northpond Ventures, as she has candid, in-depth conversations with top doctors, scientists, and trailblazing innovators.

    Innovate and Elevate is the podcast where the pioneering ideas and leading-edge discoveries that redefine human health are explored. Behind every revolutionary method and device is a human, or humans, daring to make the impossible possible.

    Sharon, an investor at the forefront of science-driven venture capital, talks with these change agents about how they are rewriting the rules in their fields – from human health and longevity to breakthrough diagnostics and therapeutics.

    Featured by Harvard’s Wyss Institute, this podcast delivers the sophisticated, knowledgeable, and essential insights you need to understand how innovation impacts our lives.

    Because Humanity Deserves Better.

    Sharon Kedar is Co-Founder, Partner of Northpond Ventures. She is also a human health advocate and has been invited to and spoken at notable institutions and events nationwide, including The New York Stock Exchange, The White House, ARPA-H, and Harvard University.

    “This new podcast is just what I needed- a platform to learn about health and innovation. I just listened to the first episode hosted by Sharon Kedar, a true pioneer for women. The amazing thing is that this podcast delivered with such humanity. I was glad to hear women leaders talking about real world things like women helping women, balancing our lives, advancing our careers, and prioritizing our health. It was fascinating to learn from Dr. Rexrode that women’s healthcare is often just a trial for doctors (lack of women based tests) and how frustrating that is for doctors. I loved hearing from these two top experts and can’t wait to tune into more episodes. And I plan to recommend this show to women and men! Finally, the pregnancy example really hits home and was a perfect motivator.”

    “It’s hard to find helpful and insightful content that is easy to understand. This podcast does that and should be considered on a par with Dr Andrew Huberman’s podcast.”

    “The dialogue was engaging and informative without feeling overwhelming. Both Sharon and Dr Rexrode are so knowledgeable in their fields. I can’t wait to see who the other guests will be!”

    Advertise

    Copyright: © Copyright 2024 Sharon Kedar

    • Apple Podcasts
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    Latest Episodes:
    Matters of the Heart: What Women Need to Know with Dr. Natalie Bello May 30, 2024
    Show notes

    In this episode, Sharon is joined by Dr. Natalie Bello, Director of Hypertension Research, Staff Physician and Associate Professor of Cardiology at Cedars-Sinai Medical Center.

    After learning that 80% of heart disease is preventable in medical school, Dr. Bello decided that focusing her career on helping people stay healthy, optimize their risk factors, and live long lives was an easy choice to make.

    Hypertension, also known as “The Silent Killer,” is a leading global contributor to heart disease. A common myth is that heart disease disproportionately affects men when, in fact, it is the number one killer of both men and women. This misinformation has major consequences, namely that women experiencing chest pain wait 29% longer in the emergency room to be seen by a doctor than their male counterparts.

    Dr. Bello shares that just because a woman doesn’t present their pain the same way as a man doesn’t mean that they aren’t experiencing the same pain. Being your biggest health advocate is the best way to regain your agency in heart health. Sometimes, for a woman, that may look like firmly declaring that your chest pain has brought you to the emergency room, stating your risk factors and that you must be treated for potentially having a heart attack.

    Dr. Bello recommends the tests for anyone with chest pain or interested in improving their heart health, like an EKG, troponin, stress test, or angiogram. In order to assess personal risk factors, the Pooled Cohort Equations to Prevent Heart Failure (PCP-HF) or PREVENT are most used. Dr. Bello then discusses the mechanics of hereditarily passing down heart conditions between genders and the importance of increasing the number of studies on pregnancy’s impact on the body.

    Episode Outline

    (00:55) Meet Dr. Bello

    (01:35) 80% of Heart Disease Is Preventable

    (05:14) PSA: Women Wait Longer in the ER With Chest Pain

    (12:46) Knowledge Is Power: Know Your Hereditary and Gender-Specific Risk Factors

    Connect with Sharon

    • Connect with Sharon on LinkedIn: Sharon Kedar
    • Learn more about Innovate and Elevate innovateandelevatepodcast.com
    • Subscribe to Innovate and Elevate on YouTube
    • Join the newsletter to receive the latest episodes in your inbox: Innovate and Elevate Newsletter

    Connect with Dr. Bello

    • Follow Dr. Bello on LinkedIn

    Additional Resources

    • Women and Black adults wait longer to be seen in the ER for chest pain By American Heart Association News
    • PREVENT Online Calculator
    • ASCVD Risk Estimator App
    • How Heart Palpitations Led Oprah to Discover She Was Approaching Menopause

    This podcast is produced by the women at The Wave Editing


    Mice Don’t Menstruate: Reimagining Women’s Health Using Organ Chips with Dr. Donald Ingber May 07, 2024
    Show notes

    In this episode, Sharon is joined by Dr. Donald Ingber, Founding Director at Wyss Institute for Biologically Inspired Engineering at Harvard University.

    Dr. Ingber’s commitment to following his passion has led him to countless medical and technological breakthroughs, including organ-chip technology. These incredible chips recreate the structure and function of human organs. Drugs can be administered through organ-chips so that blood impact can be monitored. Once more widely adopted, organ-chip testing will be able to replace animal testing. As Dr. Ingber shares, the results will surpass those of animal testing.

    The organ-chip technology already includes women’s health models and holds great promise to revolutionize this under-invested area. Because animals, namely mice, do not have menstrual cycles, their biological environments are already skewed to test any women’s health-related projects. Organ-chips are a great solution to close the data gap. Dr. Ingber shares two projects underway in partnership with the Gates Foundation: to create a cure for bacterial vaginosis and to create a non-hormonal contraceptive.

    Dr. Ingber highlights the importance of nurturing the business side of scientific breakthroughs so that innovations can reach patients. Twenty percent of Harvard’s intellectual property comes out of the Wyss Institute, and both funding and mentorship play crucial roles in that success metric.

    Episode Outline

    (00:53) Meet Dr. Donald Inbger

    (02:11) Where Art Meets Science: Inside The Brilliant Mind of Dr. Ingber

    (07:08) What Is Organ-on-a-Chip Technology?

    (13:17) Reimaging Women’s Health with Organ-Chips

    (21:11) Think Outside The Box: Bringing Innovation to Life

    Connect with Sharon

    • Connect with Sharon on LinkedIn: Sharon Kedar
    • Learn more about Innovate and Elevate innovateandelevatepodcast.com
    • Subscribe to Innovate and Elevate on YouTube
    • Join the newsletter to receive the latest episodes in your inbox: Innovate and Elevate Newsletter

    Connect with Dr. Ingber

    • Follow The Wyss Institute on LinkedIn
    • Learn more about Emulate, Inc.

    Additional Resources

    • The Wyss Institute
    • The Wyss-Northpond Research And Innovation Alliance
    • First rodent found with a human-like menstrual cycle
    • The White House Initiative on Women's Health Research

    This podcast is produced by the women at The Wave Editing.


    Dare to Dream: An Ultrasound Bra For Breast Health with Dr. Canan Dagdeviren Apr 09, 2024
    Show notes

    Dr. Canan Dagdeviren is Associate Professor of Media Arts and Sciences at the Massachusetts Institute of Technology and Director of the Conformable Decoders research group at the MIT Media Lab.

    In this episode, Dr. Dagdeviren shares the incredible story behind the lab’s wearable, conformable ultrasound breast patch that enables standardized and reproducible breast imaging. They’re developing a first-of-its-kind ultrasound technology for breast tissue scanning and imaging which offers a non-invasive method for tracking real-time dynamic changes of soft tissue. This technology is meant to be used in adjunct with current screening methods, addressing the various barriers that many women at high risk for breast cancer face when it comes to breast screening.

    Driven by her aunt's battle with breast cancer, Dr. Dagdeviren embarked on a journey to innovate breast cancer screening solutions. In our conversation, she shares the current prototype for The Conformable Ultrasound Breast Patch (CUSBr-Patch), detailing the logistics of how it works and how she envisions the patient experience.

    Beyond product innovation, Dr. Dagdeviren emphasizes the need for elevating standards in clinical trials. She outlines the commitment she and her team have made to implement a diverse patient-centric approach in their lab.

    If you are a woman at high risk for breast cancer and currently on a breast cancer screening plan, please consider applying to be a part of the Conformable Decoders’ clinical trial. You can email Dr. Dagdeviren at canand@mit.edu for more information.

    Connect with Sharon

    • Connect with Sharon on LinkedIn: Sharon Kedar
    • Learn more about Innovate and Elevate innovateandelevatepodcast.com
    • Subscribe to Innovate and Elevate on YouTube
    • Join the newsletter to receive the latest episodes in your inbox: Innovate and Elevate Newsletter

    Connect with Dr. Dagdeviren:

    • Connect with Dr. Dagdeviren on LinkedIn
    • Learn more about Conformable Decoders

    Additional Resources

    • Conformable Ultrasound Breast Patch (CUSBr-Patch) For Deep Tissue Scanning And Imaging
    • The Ultrasound Breast Patch Prototype Video
    • MIT Future Founders
    • BBC 100 Women 2023: Canan Dagdeviren


    Credits

    This podcast is produced by the women at The Wave Editing.


    Co-Pilot Your Breast Health with Dr. Rachel Brem Mar 19, 2024
    Show notes

    On this episode of Innovate and Elevate, Sharon is joined by Dr. Rachel Brem. Dr. Brem is board-certified in Diagnostic Radiology. She is a Professor of Radiology, the Vice Chair of Radiology, and Director of Breast Imaging & Intervention at The George Washington University School of Medicine & Health Sciences.

    In this conversation, Dr. Brem shares how to understand your risk for breast cancer and her recommended imaging strategy for those with dense breast tissue. She also emphasizes the importance of co-creating a personalized healthcare plan with a doctor that suits your needs.

    Note that other risk factors may influence your individual situation. For a comprehensive understanding, explore additional resources at breastcancer.org/risk/risk-factors.

    Cancer in a dense breast is exponentially more difficult to detect in a mammogram, which is why Dr. Brem is a strong advocate for breast ultrasound and/or MRI. In fact, breast imaging specialists can find 25% more cancerous cells with ultrasound screening in women with dense breasts than they can with mammography.

    Dr. Brem doesn’t believe in a one-size-fits-all breast healthcare approach. Instead, she urges women to get the knowledge they need to make the right choices for their health and find a doctor that can tailor a plan for their unique needs.

    Finally, Dr. Brem shares her hope in the technologies currently in development to help detect cancer before imaging, such as liquid biopsy and breath analysis.

    Connect with Sharon

    • Connect with Sharon on LinkedIn: Sharon Kedar
    • Learn more about Innovate and Elevate innovateandelevatepodcast.com
    • Subscribe to Innovate and Elevate on YouTube
    • Join the newsletter to receive the latest episodes in your inbox: Innovate and Elevate Newsletter

    Connect with Dr. Rachel Brem

    • Connect with Dr. Rachel Brem on LinkedIn: Dr. Rachel Brem

    Additional Resources

    • No Longer Radical by Dr. Rachel Brem and Dr. Christy Teal
    • Brem Foundation to Defeat Breast Cancer
    • CheckMate by The Brem Foundation
    • Tyrer-Cuzick Risk Assessment Calculator
    • Breast Cancer Risk Assessment Tool (The Gail Model)

    Glossary

    • Prophylactic mastectomy: A prophylactic mastectomy is surgery to remove one or both breasts to lower the chances of getting breast cancer.
    • BRCA mutation: A BRCA mutation is a mutation in either of the BRCA1 and BRCA2 genes, which are tumor suppressor genes. Harmful mutations in these genes may produce a hereditary breast–ovarian cancer syndrome.
    • Liquid biopsy: A liquid biopsy is a test that checks for signs of diseases by analyzing a small sample of blood instead of taking tissue from the actual tumor.
    • Molecular breast imaging (MBI): Molecular breast imaging is a technique that uses a special camera and a radioactive substance to detect breast cancer by highlighting abnormal areas in the breast tissue


    Mammography is Essential and Quality Matters with Dr. Janet Storella Feb 27, 2024
    Show notes

    On this episode of Innovate and Elevate, Sharon is joined by Dr. Janet Storella, Medical Director of Breastlink Maryland at RadNet. Dr. Storella is a breast imaging specialist and a board-certified diagnostic radiologist with over 40 years of radiology experience.

    In this conversation, Dr. Storella shares deeper insight into the practice and art of mammography, contemporary issues in the field, spaces for improvement, and aspects of mammography where quality makes all the difference.

    There are differing opinions on when women should start annual mammography screening, but Dr. Storella emphasizes that understanding one’s risk factors is key to determining when to start screening and collaborating on a personalized plan with their doctor. She highlights how diagnostic imaging centers are working on lowering barriers to compliance, particularly through strategic partnerships like RadNet’s with Walmart.

    Dr. Storella shares that determining if a mammogram shows cancer can be extremely difficult because of the variable nature of breast tissue. She expands on her experiences using AI to interpret test results and the journey to convincing insurance companies to cover this impactful new practice. Even though mammograms are continuously critiqued by doctors and patients alike, Dr. Storella reminds us that ultimately mammograms save lives, help individuals detect cancer earlier, and are what we have available right now.

    Finally, Dr. Storella explains the technical factors that contribute to high-quality breast imaging and why an uncomfortable mammogram is a positive sign of adequate compression. She also highlights the rigorous standards that mammography technologists are required to meet, reinforcing her message that breast cancer screening is an advanced and highly artful skill.

    Connect with Dr. Storella

    • Connect with Dr. Storella on LinkedIn: Dr. Janet Storella

    Connect with Sharon

    • Connect with Sharon on LinkedIn: Sharon Kedar
    • Learn more about Innovate and Elevate innovateandelevatepodcast.com
    • Subscribe to Innovate and Elevate on YouTube
    • Join the newsletter to receive the latest episodes in your inbox: Innovate and Elevate Newsletter

    Additional Resources

    • American Cancer Society - Survival Rate for Breast Cancer
    • MammogramNow™ at Walmart
    • DeepHealth, a RadNet AI subsidiary
    • Dr. Storella Named 2023 Top Doctor
    • Tyrer-Cuzick Risk Assessment Calculator
    • Breast Cancer Risk Assessment Tool (The Gail Model)
    • The Brem Foundations Risk Calculator, CheckMate

    Dedication

    This episode of Innovate and Elevate is dedicated to the late Megan Ford, who passed away in 2021 following a breast cancer recurrence. A trailblazer in her own right, Megan’s passion was helping people grow and succeed in their careers. It’s time for all of us to innovate and elevate.

    Support Innovate and Elevate

    Did you love this episode? Let us know by rating and reviewing the show on Apple Podcasts. It’s easy - click this link, scroll to the bottom of the page, and select “Write a Review.” Let us know what you liked best about the episode. While you’re at it, consider following Innovate and Elevate. Follow now!

    Credits

    This podcast is produced by the women at The Wave Editing.


    Treat Your Body As If You Were Pregnant with Dr. Kathryn Rexrode, Chief of Women’s Health at BWH Jan 31, 2024
    Show notes

    On this episode of Innovate and Elevate, Sharon is joined by Dr. Kathyrn Rexrode, Chief of the Division of Women’s Health in the Department of Medicine at Brigham and Women’s Hospital and Professor of Medicine at Harvard Medical School.

    In their conversation, Dr. Rexrode discusses the progression in her career from experiencing imposter syndrome to stepping into her confidence and authority as a physician, professor, and woman in leadership. She also highlights how rejecting a scarcity mindset and supporting other women professionally has helped bolster her self-confidence. In Dr. Rexrode’s words, “The more we support one another, the more collective success we’ll have.”

    Dr. Rexrode describes her nonlinear 26-year path to becoming a full professor at Harvard Medical School. For anyone wanting to start a family and become a full-time professor, or generally devote themselves to climbing the career ladder, Dr. Rexrode emphasizes that there isn’t a one-size-fits-all approach. Sharon and Dr. Rexrode share how they navigate motherhood and career growth, which often requires a willingness to redefine what success looks like on an individual level.

    Finally, Dr. Rexrode brings listeners back to the early days of her career and the shocking realities that sparked her passion for improving healthcare standards for women. She continues that mission today, encouraging everyone to treat their body with the same respect, care, and attention they would if they were pregnant.

    Guest Bio

    Dr. Kathryn Rexrode serves as Chief of the Division of Women’s Health in the Department of Medicine at Brigham and Women’s Hospital and is a Professor of Medicine at Harvard Medical School. She is a board-certified general internist with a predominantly women’s health practice as a primary care physician at the BWH Gretchen S. and Edward A. Fish Center for Women’s Health.

    Connect with Dr. Rexrode

    • Connect with Dr. Rexrode on LinkedIn: Dr. Kathryn Rexrode

    Connect with Sharon

    • Connect with Sharon on LinkedIn: Sharon Kedar
    • Subscribe to Innovate and Elevate on YouTube.
    • Learn more about Innovate and Elevate innovateandelevatepodcast.com
    • Join the newsletter to receive the latest episodes in your inbox: Innovate and Elevate Newsletter

    Additional Resources

    • Women ≠ Tiny Men | Brigham Magazine

    Support Innovate and Elevate

    Did you love this episode? Let us know by rating and reviewing the show on Apple Podcasts. It’s easy - click this link, scroll to the bottom of the page, and select “Write a Review.” Let us know what you liked best about the episode. While you’re at it, consider following Innovate and Elevate. Follow now!

    Credits

    This podcast is produced by the women at The Wave Editing.


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