How To! with Charles Duhigg

Latest Episodes:

How To Take Psychedelics for Your Mental Health with Dr. Will Van Derveer Mar 17, 2026

Show notes

Stand-up comedian and philosopher Myq Kaplan has built a successful career exploring the human condition, but navigating his own underlying anxiety presents a very different challenge. He knows how to handle recreational and spiritual psychedelic trips in the jungles of Peru, but the leap to "crossing the streams" and using these substances in a formal, clinical therapeutic setting feels uncertain. On this episode: How To!'s Mike Pesca brings on Dr. Will Van Derveer, a veteran psychiatrist, co-founder of the Integrative Psychiatry Institute, and author of Psychedelic Therapy. Dr. Will Van Derveer offers Myq guidance on using medicines like ketamine and psilocybin to "shake the snow globe" of the brain's default mode network, the importance of treating the therapy like a psychological tow truck rather than a permanent ride—and why you really need to stop bothering the Sonoran Desert toads.

Executive Producer Corey Wara

Edited by Geoff Craig

Booking by Ben Astaire

Do you have a burning question or a problem you need help with? Email us at howto@mikepesca.com and we will consider your topic for the show.

For full Pesca content and updates, check out our website at https://www.mikepesca.com/⁠⁠⁠⁠⁠⁠⁠⁠ To receive ad-free content, become a Pesca Plus subscriber at ⁠⁠⁠⁠https://subscribe.mikepesca.com/ For Mike's daily takes on Substack, subscribe to The Gist List https://mikepesca.substack.com/

Follow us on Social Media:⁠⁠⁠⁠ Instagram https://www.instagram.com/pescagist/ X https://x.com/pescami YouTube https://www.youtube.com/@pescagist⁠⁠⁠⁠ TikTok https://www.tiktok.com/@pescagist

To advertise on the show, contact ⁠⁠⁠⁠ad-sales@libsyn.com⁠⁠⁠⁠ or visit ⁠⁠⁠⁠https://advertising.libsyn.com/howto

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

How To Make A How To Podcast Mar 10, 2026

Show notes

Mike Pesca has built a long career as a news analyst and podcaster, but taking over the How To! franchise presents a very different challenge: learning the ropes of the advice show genre. He knows how to dissect complex political events, but the leap to solving eccentric listener dilemmas while maximizing entertainment value feels new. On this episode: How To!'s Mike Pesca turns the microphone on himself and brings on Ian Chillag and Mike Danforth, the veteran co-hosts of NPR's How to Do Everything and producers for Wait Wait... Don't Tell Me! Ian and Mike offer Mike guidance on bypassing straightforward answers to find weirdly perpendicular solutions, the importance of providing "nutritious" conversational facts—and why you should never, under any circumstances, climb inside a refrigerator with Jesse Eisenberg. Executive Producer Corey Wara Edited by Geoff Craig Booking by Lya Yanne Do you have a burning question or a problem you need help with? Email us at howto@mikepesca.com and we will consider your topic for the show. For full Pesca content and updates, check out our website at https://www.mikepesca.com/⁠⁠⁠⁠⁠⁠⁠⁠ To receive ad-free content, become a Pesca Plus subscriber at ⁠⁠⁠⁠https://subscribe.mikepesca.com/ For Mike's daily takes on Substack, subscribe to The Gist List https://mikepesca.substack.com/ Follow us on Social Media:⁠⁠⁠⁠ Instagram https://www.instagram.com/pescagist/ X https://x.com/pescami YouTube https://www.youtube.com/@pescagist⁠⁠⁠⁠ TikTok https://www.tiktok.com/@pescagist To advertise on the show, contact ⁠⁠⁠⁠ad-sales@libsyn.com⁠⁠⁠⁠ or visit ⁠⁠⁠⁠https://advertising.libsyn.com/howto

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

How To Ghostbust The Old Fashioned Way Mar 03, 2026

Show notes

Enid Baxter Ryce has built a fascinating career as an artist and university professor, but her unique living situation presents a very different challenge: navigating life on a massive, decommissioned, and potentially haunted military base. She knows how to uncover the historical art left behind in the empty barracks, but the leap to understanding and confronting the supernatural entities that might linger there feels intimidating and out of reach. On this episode: How To!'s Mike Pesca brings on Dr. Irving Finkel, a renowned British Museum curator, Assyriologist, and author of The First Ghosts. Irving offers Enid guidance on bypassing modern skepticism to view hauntings through an ancient Mesopotamian lens, the power of using precise incantations to address spirits—and why dealing with a ghost should be treated as practically as catching a mouse in the kitchen.

Executive Producer Corey Wara

Edited by Geoff Craig

Booking by Lya Yanne

Do you have a burning question or a problem you need help with? Email us at howto@mikepesca.com and we will consider your topic for the show.

To advertise on the show, contact ⁠⁠⁠⁠ad-sales@libsyn.com⁠⁠⁠⁠ or visit ⁠⁠⁠⁠https://advertising.libsyn.com/howto

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

How to Emigrate as a Throuple Feb 24, 2026

Show notes

Dan Savage has built a legendary career giving sex and relationship advice, but as the U.S. political climate shifts, he's yearning to chase a very different dream: relocating his polyamorous family to Europe. He knows how to navigate complex relationship dynamics, but the leap to untangling international immigration law feels intimidating and technically out of reach. On this episode: How To! with Mike Pesca consults Charley Nieuwesteeg, a Dutch immigration lawyer specializing in the Dutch-American Friendship Treaty (DAFT). Charley offers Dan guidance on bypassing the bureaucratic hurdles to establish residency, navigating the logistics of "daisy-chain" migration—and why proving a romantic relationship to the Dutch government is surprisingly straightforward.

Executive Producer Corey Wara Edited by Geoff Craig Booking by Lya Yanne Do you have a burning question or a problem you need help with? Email us at howto@mikepesca.com and we will consider your topic for the show. For full Pesca content and updates, check out our website at https://www.mikepesca.com/⁠⁠⁠⁠⁠⁠⁠⁠ To receive ad-free content, become a Pesca Plus subscriber at ⁠⁠⁠⁠https://subscribe.mikepesca.com/ For Mike's daily takes on Substack, subscribe to The Gist List https://mikepesca.substack.com/ Follow us on Social Media:⁠⁠⁠⁠ Instagram https://www.instagram.com/pescagist/ X https://x.com/pescami YouTube https://www.youtube.com/@pescagist⁠⁠⁠⁠ TikTok https://www.tiktok.com/@pescagist To advertise on the show, contact ⁠⁠⁠⁠ad-sales@libsyn.com⁠⁠⁠⁠ or visit ⁠⁠⁠⁠https://advertising.libsyn.com/howto

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

How To Be a DJ, Not a Playlist with Tom Nash Feb 17, 2026

Show notes

Stewart has built a respectable career as a lawyer in Montreal, but he's yearning to chase a very different dream: becoming a club DJ. He knows how to curate a killer playlist, but the leap to commanding a live room feels intimidating and technically out of reach. On this episode: How To!'s Mike Pesca brings on Tom Nash, a former top Sydney club DJ (known as DJ Hookie) who spins using prosthetic hooks. Tom offers Stewart guidance on bypassing the technical hurdles to truly read a crowd, building a music brand from "scratch"—and why the DJ's one true job is to delight the audience. Executive Producer Corey Wara Edited by Geoff Craig Booking by Lya Yanne Do you have a burning question or a problem you need help with? Email us at howto@mikepesca.com and we will consider your topic for the show. For full Pesca content and updates, check out our website at https://www.mikepesca.com/⁠⁠⁠⁠⁠⁠⁠⁠ To receive ad-free content, become a Pesca Plus subscriber at ⁠⁠⁠⁠https://subscribe.mikepesca.com/ For Mike's daily takes on Substack, subscribe to The Gist List https://mikepesca.substack.com/ Follow us on Social Media:⁠⁠⁠⁠ Instagram https://www.instagram.com/pescagist/ X https://x.com/pescami YouTube https://www.youtube.com/@pescagist⁠⁠⁠⁠ TikTok https://www.tiktok.com/@pescagist To advertise on the show, contact ⁠⁠⁠⁠ad-sales@libsyn.com⁠⁠⁠⁠ or visit ⁠⁠⁠⁠https://advertising.libsyn.com/howto

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Announcing: How To! with Mike Pesca Feb 13, 2026

Show notes

How To! has a new host - veteran journalist and podcaster Mike Pesca, host of The Gist, Not Even Mad, and Funny You Should Mention podcasts. It's the same great Ambie Award nominated show, covering new topics, with new experts, and Mike's signature humor.

You've got questions. We find answers.

We all need advice, but it's not always clear who to ask. Each week, Mike Pesca invites a listener on the show to tackle a real problem, like protecting our elderly loved ones from scammers, emigrating as a throuple, and speaking without saying "um" - all with help from world-class experts: attorneys, doctors, entrepreneurs, authors, researchers - who actually know what they're talking about. Think of it as eavesdropping on someone else's therapy session, without the co-pay or awkward silence.

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

How To Start Writing (w/ Anna Quindlen & John Dickerson) Encore Feb 10, 2026

Show notes

You've probably heard about the importance of journaling, putting thoughts on paper to help process the daily vicissitudes of life. But it's easy to stall once you see a blank page or get self conscious about what exactly you're writing. On this episode of How To!, we bring together Anna Quindlen, bestselling novelist and author of the new book Write For Your Life, and John Dickerson, co-host of Slate's Political Gabfest, CBS News reporter, author and veteran journaler. They share their wit and wisdom on how to start writing about your personal life — and how to keep it going amid all the distractions. (And stay tuned after the credits for an exclusive sneak peek of Anna Quindlen's next novel).

If you liked this episode, check out "How To Write a Bestseller" and "How To Get Your Book Published."

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Now Is the Time to Escape Your Bad Relationship. Here's How. (Encore) Feb 03, 2026

Show notes

Dating is always tough, but during a pandemic it can feel downright impossible. "I'm incredibly lonely, and it's impossible to meet anybody my age right now," our listener Sarah said. Feeling isolated, Sarah has clung to a friends-with-benefit situation with Matthew, her friend and dance partner. But at 36, Sarah knows the relationship isn't meant to last. On this episode of How To!, we bring on Logan Ury, director of relationship science at Hinge, dating coach, and author of How to Not Die Alone: The Surprising Science That Will Help You Find Love, to help Sarah break up with Matthew and move on. And moving on, Logan says, doesn't necessarily mean just dating. What Sarah might really be missing is a community—and so she ought to search for not only a romantic partner but also friends who function as "other significant others."

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

How To Rob a Bank (Encore) Jan 27, 2026

Show notes

Joe Loya robbed over 30 banks during an 18-month span before going to jail. In this episode of How To! Charles wants to rob one bank on a Saturday afternoon, and get away scot-free. Can Joe teach Charles the tricks of the trade? Or will he shatter his dreams, and a few stereotypes along the way? Also, is it a good idea to carry a microphone while attempting a robbery?

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

How To Never Miss a Deadline (Encore) Jan 21, 2026

Show notes

Avalon is driven, creative, and… can't meet a deadline to save her life. In her defense, she's a card-carrying member of the gig economy, juggling a complicated schedule as a DJ and visual artist. Avalon's tried to organize her life using a bullet journal, but procrastination keeps getting in the way of her career pursuits. On this episode of How To!, the second in a two-part series on time management, we talk to Christopher Cox, author of The Deadline Effect: How To Work Like It's the Last Minute Before the Last Minute. He explains why concrete deadlines, the shorter the better, can actually help Avalon's creativity. And he gives all of us tips on how to set the perfect deadline—and never miss it.

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.