FoundMyFitness

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#035 Gordon Lithgow, Ph.D. on Protein Aggregation, Iron Overload & the Search for Longevity Compounds Apr 04, 2017

Show notes

Dr. Gordon Lithgow of the Buck Institute for Research on Aging tells us about worms!

This unassuming scientific model has a lot of important advantages for science: they can be frozen and subsequently thawed and retain viability, they are extremely well understood down to the precise number of cells in their body and the wiring of their nervous system, known as the connectome. Additionally, they have a short lifespan and are cheap to work with. Why would that be advantageous, you may ask?

This is where Dr. Lithgow's work on the Caenorhabditis Intervention Testing Program comes in. Short-lived organisms give Dr. Lithgow and his colleagues the opportunity to see how their biology responds to compounds in different contexts and to do so cheaply and rapidly. Think a vitamin, pharmaceutical or one of any number of other compounds may have a broad effect on longevity? Try it on Caenorhabditis first! Taking this approach allows the broad screening of compounds that might not otherwise get its chance in the limelight if science were limited to only working with rodents, for example.

In this episode, you'll discover:

(00:00) Introduction
(03:30) What is C elegans and why do researchers use it?
(06:43) Proteostasis and its involvement in aging
(10:59) Shocking worms with heat extends their lifespan
(16:40) Sauna use activates human heat-shock proteins, improving health
(19:27) Excess dietary iron accelerates protein aggregation, promoting Alzheimer's and Parkinson's diseases
(25:07) Vitamin D deficiency accelerates aging
(35:19) Using worms to search for compounds that extend life in humans

If you're interested in learning more, you can read the full show notes here.

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#034 Refined Sugar and Its Effects on Mortality, the Brain, Cancer, Hormones & More Mar 16, 2017

Show notes

If you're anything like me, having the facts straight can sometimes help you to push through the tough part of building new habits or breaking old bad ones. This podcast talks about the realities of what the science says surrounding the consumption of refined sugar.

Some of the facts may surprise you! In this episode, you'll discover:

(00:00) Introduction
(01:16) Excess sugar consumption is common and dangerous
(05:16) Sugar accelerates the aging process itself
(09:14) Refined sugar harms the brain
(11:22) High fructose corn syrup is uniquely dangerous
(14:04) How to quit sugar

If you're interested in learning more, you can read the full show notes here.

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#033 Does Saturated Fat Cause Heart Disease? Feb 10, 2017

Show notes

Today we try to answer or at least explore a big question in the world of health: does saturated fat cause heart disease?

This is not an unreasonable concern given the fact that there have been several associative studies that have found a link between saturated fat and heart disease, which is, no doubt, a fat that we find abundantly in the typical American diet since it is richly found in staples like fatty beef, pork, butter, cheese, and other dairy products.

And if you're in the United States and you're not at least a little concerned about heart disease, you may be asleep at the wheel since it's currently our leading cause of death.

In this episode, you'll discover:

(00:00) Separating the effects of sugar and saturated fat in research
(04:23) Small dense LDL are the problem
(07:48) Interactions between genetics, fats, and carbohydrates
(16:37) Getting and using your genetic data
(18:07) Dangers of cutting out saturated fats

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#032 Does Meat Consumption Cause Cancer? Jan 28, 2017

Show notes

Does meat consumption cause cancer? Or, put another way… does avoiding meat help prevent cancer?

If you aren't already savvy to the topic, this may sound more absurd than it should. Here's why: there have been many, many, many correlative studies that have found that higher meat consumption is associated with a significantly higher risk of cancer and cancer mortality.

In this episode, you'll discover:

(00:00) Introduction
(01:18) How cancer starts
(04:49) Growth factors make cancer thrive
(08:54) Applying the science to your needs
(11:33) Cycle prolonged fasting with recovery and protein

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#031 On Depression and Its Underlying Causes Jan 25, 2017

Show notes

The World Health Organization estimates that more than 350 million individuals of all ages have depression and approximately one-third of all patients with depression fail to respond to conventional antidepressant therapies like SSRI's. The good news is that today, good science is starting to illuminate the underlying biological mechanisms of depression. This new understanding may soon help the clinical world develop new and more effective treatments.

In this episode, you'll discover:

(00:00) The scope of depression and SSRI use
(03:37) How inflammation can cause depression
(09:26) But what causes inflammation?
(12:03) Treating depression with diet

Join over 300,000 people and get the latest distilled information on depression and it's underlying causes straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

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#030 Roland Griffiths, Ph.D. on Psilocybin, Psychedelic Therapies & Mystical Experiences Jan 19, 2017

Show notes

Dr. Roland R. Griffiths

Dr. Roland R. Griffiths is a clinical pharmacologist at Johns Hopkins and has been researching mood-altering compounds for over 40 years.

As an unusually prolific scientist, having published over 360-times, he's also responsible for having started the psilocybin research program at Johns Hopkins nearly 2 decades ago.

In this podcast, you'll discover:

(00:00) Introduction
(04:05) Psilocybin produces meaningful mind-altering effects
(12:52) Psilocybin can treat depression and anxiety in people with life-threatening cancer 1
(22:53) Psilocybin rewires the brain, preferentially breaking fear-based circuits
(28:11) Meditation and psychedelics quiet neural activity of the default mode network
(34:09) "The hard problem of consciousness" may not be solved by neuroscience
(40:16) Psilocybin helps people quit smoking (80 percent abstinence at six months post-treatment) 2
(47:08) The risks of psilocybin include bad trips and psychiatric problems
(01:02:00) Meditation delivers similar benefits to psilocybin without the risks
(01:07:18) Sauna use improves mood Salvinorin A
(01:10:23) Salvinorin A, ayahuasca, and other psychedelics

If you're interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/roland-griffiths

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#029 Jed Fahey, Sc.D. on Isothiocyanates, the Nrf2 Pathway, Moringa & Sulforaphane Supplementation Jan 06, 2017

Show notes

Dr. Jed Fahey is a multi-decade veteran of isothiocyanate research and is the director of the Cullman Chemoprotection Center at Johns Hopkins University.

In this episode, you'll discover:

(00:00) Introduction
(03:44) What is sulforaphane?
(10:25) The NRF2 pathway, a master regulator of antioxidants
(14:22) Cruciferous vegetables are rich sources of sulforaphane
(20:39) Does cooking broccoli destroy sulforaphane?
(26:00) Sulforaphane supplements vary widely in quality
(36:41) Antibiotics wipe out sulforaphane-producing bacteria in the gut
(46:44) Managing Helicobacter pylori growth with a sulforaphane-rich diet
(56:15) Sulforaphane reduces inflammation, but does it extend lifespan?
(01:11:31) The therapeutic potential of sulforaphane for autism spectrum disorders, Alzheimer's disease, and schizophrenia
(01:22:44) Research challenges and clinical trials
(01:30:51) Is sulforaphane an anti-depressant?
01:34:50 - Moringin from moringa may be an alternative to sulforaphane with similar bioaction
(01:53:55) How to maximize sulforaphane conversion
(02:13:27) Testing the anticancer power of sulforaphane

If you're interested in learning more, you can read the full show notes here.

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#028 Sulforaphane and Its Effects on Cancer, Mortality, Aging, Brain and Behavior, Heart Disease & More Dec 12, 2016

Show notes

This podcast is about one of the most important biological pathways you could possibly take the time to learn about: the NRF2 pathway.

The most potent naturally-occurring inducer of this pathway, a plant compound known as sulforaphane, may be one of the most potent health-enhancing compounds at our disposal and yet... no one is keeping it out of your hands! No $1,000 per pill markup is keeping it out of your hands -- it's available to anyone willing to take the little bit of time it takes each week to produce broccoli sprouts.

Here are a few of the more salient points surrounding sulforaphane that are discussed in this podcast...

(00:00) Introduction
(03:36) Cruciferous vegetables reduce risk of death from all causes
(07:15) Mechanisms of sulforaphane's anti-cancer effects
(12:02) Sulforaphane activates NRF2, detoxifying the body
(18:53) Curciferous vegetables and cardiovascular disease
(21:57) Does sulforaphane slow aging?
(29:39) Sulforaphane improves symptoms of autism, schizophrenia, and depression
(36:18) Neurodegernative diseases and taumatic brain injury can be treated with sulphoraphane
(41:36) Concluding thoughts

If you're interested in learning more, you can read the full show notes here.

Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.found myfitness.com/newsletter

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#027 Valter Longo, Ph.D. on the Fasting-Mimicking Diet & Fasting for Longevity, Cancer & Multiple Sclerosis Sep 30, 2016

Show notes

Dr. Valter Longo

This episode of the FoundMyFitness podcast features Dr. Valter Longo, a professor of gerontology and biological sciences and director of the longevity institute at the University of Southern California.

Dr. Longo has made huge contributions to the field of aging, including the role of fasting and diet in longevity and healthspan in humans as well as metabolic fasting therapies for the treatment of human diseases.

In this podcast, Valter and I discuss...

(00:00) Introduction
(03:30) The fasting-mimicking diet makes fasting accessible to more people
(08:10) Prolonged fasting stimulates stem cell regeneration
(12:57) Does inflammation cause aging or is it the other way around?
(17:59) Using the fasting-mimicking diet in a hospital setting
(22:18) Fasting prior to chemotherapy preps cancer cells for death and protects healthy cells from damage
(36:05) Using fasting and time-restricted feeding to control weight gain
(42:08) How long do you need to fast to induce autophagy?
(45:32) A fasting-mimicking diet reversed a multiple sclerosis-like autoimmune condition in mice
(52:09) What are the cellular mechanisms that underlie the regenerative benefits of fasting?
(58:27) Are fasting-mimicking drugs, such as spermidine and resveratrol, safe and effective? What about metformin?
(01:07:03) Blocking the growth hormone/IGF-1 axis protects from cancer and diabetes in people with Laron's syndrome
(01:14:23) Exercise is essential for healthy metabolism and longevity

If you're interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/valter-longo

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#026 Ruth Patterson, Ph.D. on Time-Restricted Eating in Humans & Breast Cancer Prevention Jul 08, 2016

Show notes

Dr. Ruth Patterson

Dr. Ruth Patterson, a professor in the UC San Diego Department of Family Medicine and Public Health as well as Associate Director of Population Sciences and leader of the Cancer Prevention program at Moores Cancer Center at UC San Diego Health.

In this episode, we chat about:

(00:00) Introduction
(03:33) Lifestyle modifications that reduce breast cancer risk
(11:18) Modern life disrupts our circadian rhythm, causing us to eat at odd times
(14:31) Women who practiced time-restricted eating with a 13-hour fasting window had a 40 percent reduced recurrence of breast cancer
(23:03) A longer daily fasting window lowers hemoglobin A1C, earlier fasting reduces inflammation
(28:24) Giving your metabolism time-off allows the body to repair itself
(30:48) Does eating frequency matter while practicing time-restricted eating?
(35:04) Daily fasting improves sleep quality and increases physical activity
(38:27) Genetic risk factors for breast cancer
(40:54) Modest lifestyle changes can really lower your breast cancer risk

If you're interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/ruth-patterson

Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

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