FoundMyFitness

Latest Episodes:

#024 Ray Cronise on Cold Thermogenesis, Intermittent Fasting, Weight Loss & Healthspan May 03, 2016

Show notes

Ray Cronise

Ray Cronise is a former NASA material scientist and cofounder of zero gravity, a company that offers weightless parabolic flights to consumers and researchers. The interesting thing about this interview, isn't strictly raised professional background, however, but instead his propensity towards aggressive self-experimentation.

In this episode, Ray and I discuss...

(00:00) Introduction
(03:40) Ray's 23-day (and counting) water fast
(05:13) Using fasting and cold stress to lose weight
(10:44) Meeting nutritional needs over the long-term
(17:22) We are simultaneously overnourished and malnourished
(23:31) Inflammation may be the best predictor of aging
(29:03) What is metabolism and how do we measure it?
(40:22) Meal timing to optimize health
(01:12:04) Cold stress promotes wellness
(01:27:19) Similarities between cold stress and exercise
(01:42:27) Exercise and cold stress delay neurodegeneration
(01:45:13) Cold stress increases fat oxidation
(01:51:52) Anecdotes and fun facts about melatonin

If you're interested in learning more, you can read the full show notes here.

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#023 Dominic D'Agostino, Ph.D. on Modified Atkins Diet, Ketosis, Supplemental Ketones and More Mar 23, 2016

Show notes

Dr. Dominic D'Agostino

This podcast is with Dr. Dominic D'Agostino, an assistant professor at the University of South Florida in Tampa and all-around expert on ketosis.

In this podcast we discuss:

(00:00) Introduction
(03:46) Ketosis has abundant therapeutic potential
(10:20) What to eat to maintain nutritional ketosis
(19:58) Does a high-fat diet harm the gut?
(29:14) Adaptations to a ketogenic diet expand mitochondrial capacity
(38:45) How the brain uses ketones
(46:36) Ketones improve Alzheimer's symptoms (unless you have an APOE4 allele)
(57:17) Are ketone supplements a "magic pill?"
(01:07:32) Why cancer cells may need sugar
(01:23:51) Metformin is more than a diabetes drug
(01:30:33) The body creates sugars while in ketosis
(01:36:21) Restricting glutamine to slow cancer growth
(01:43:24) Ketone supplements taste awful, but likely improve health

If you're interested in learning more, you can read the full show notes here.

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#022 Peter Attia, M.D. on Macronutrient Thresholds for Longevity & Performance, Cancer & More Mar 13, 2016

Show notes

Dr. Peter Attia

Peter is the founder of Attia Medical, a medical practice with offices in San Diego and New York City, focusing on the applied science of longevity and optimal performance.

In addition to being a medical doctor, Dr. Attia has done research on the role of regulatory T cells in cancer regression and other immune-based therapies for cancer. Regulatory T cells have also been, in the past, referred to as suppressor T cells because of their role in actually attenuating or reducing the inflammatory response.

Dr. Attia and I share interests in all things related to longevity and healthspan, which includes the role of diet, nutrition, sleep, exercise, and stress. Dr. Attia is a medical doctor and specializes in implementing these strategies in clinical practice. You can learn more about that at his website www.attiamedical.com.

In this episode, we discuss...

(00:00) Introduction
(05:39) The difficulty of identifying longevity compounds
(08:41) The mTOR and IGF-1 growth/longevity pathways
(19:11) Preventing cell and tissue damage to live longer
(22:28) Dr. Attia's ideal diet for prolonging lifespan
(25:45) Measuring gut microbes is challenging
(35:34) Alzheimer's disease risk is more lifestyle than genetics
(42:05) Environmental triggers of Alzheimer's disease
(55:49) What prolonged fasting teaches us about metabolism
(53:36) Healing brain injury and concussion with metabolism

If you're interested in learning more, you can read the full show notes here.

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#021 How Cryotherapy Affects the Brain, the Immune System, Metabolism, and Athletic Performance Feb 12, 2016

Show notes

Dr. Rhonda Patrick explains how cold shock is a type of hormesis, which is a description of a type of stress that, in the right doses, is enough to shock the body and kick off adaptive processes and response mechanisms that are hardwired into our genes, and, once on, are able to create a resilience that actually exceeds what was needed to counter the initial stimuli.

In this episode, you'll discover:

(00:00) Introduction
(03:09) Cold exposure is good stress for the brain
(15:42) Cryotherapy reduces inflammation
(23:12) Cold exposure, weight loss, and thermogenesis
(30:45) Cold exposure increases antioxidant capacity and
(33:42) How to use cold exposure to enhance athletic performance and recovery
(52:44) Whole-body cryotherapy vs cold water immersion

If you're interested in learning more, you can read the full show notes here.

Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

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#020 Rich Roll on Self-Transformation, Environmental Impact of Food, and the Plant-Based Diet Jan 23, 2016

Show notes

Rich Roll

This podcast features Rich Roll. Rich is an author, a podcaster ("Rich Roll Podcast" on iTunes), as well as founder and first person to complete the EPIC5 Challenge. The EPIC5 challenge involves completing 5 Full Iron Distance triathlons on 5 Hawaiian islands in under a week. Rich has also been a repeated top finisher in the Ultraman World Championships in Hawaii, which is a three-day, 515km (320 mile) annual endurance race held on the Big Island of Hawaii.

You can read about Rich's journey to Ultraman competitor in his book, "Finding Ultra: Rejecting Middle Age, Becoming One of the World's Fittest Men, and Discovering Myself."

If you're interested in learning more, you can read the full show notes here.

Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

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#019 Dr. Darya and Kevin Rose Talk Meditation Retreats, Diet, Seasonal Eating, and More Dec 25, 2015

Show notes

In this episode, Dr. Rhonda Patrick chats with Dr. Darya and Kevin Rose.

Dr. Darya Rose, PhD is a neuroscientist, author of "Foodist: Using Real Food and Real Science to Lose Weight Without Dieting," and creator of Summer Tomato, which was featured in TIME magazine's list of the web's 50 best websites in 2011.

Kevin you may know from TV, the investing world, or any of a wide variety of things he's well known for (founding digg.com, just for starters). More recently, Kevin hosts a podcast where he's had guests ranging from titans of industry like Elon Musk to notables like his buddy Tim Ferriss, multi-time New York Times best selling author, investor, self-experimenter and fellow podcaster.

In this episode, we discuss...

(00:00) Introduction
(03:23) Darya Rose talks about her 10-day silent retreat
(11:32) Mindfulness can be achieved during daily activities
(16:10) Kevin's self-experimentation with a ketogenic diet
(23:59) Rhonda's interviews with Dr. Valter Longo and Ray Cronise on fasting
(29:13) Tumeric increases the body's detoxification enzymes
(33:17) Darya's career from PhD student to health advocate
(39:32) The benefits of eating seasonally
(45:12) Technology that promotes mindfulness and productivity

If you're interested in learning more, you can read the full show notes here.

Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

#018 Dr. Pierre Capel on the Power of the Mind & the Science of Wim Hof Nov 06, 2015

Show notes

Dr. Pierre Capel

Dr. Pierre Capel is a professor emeritus in experimental immunology at the Utrecht University in the Netherlands where he researched a wide range of topics from genetic modification to cancer immunotherapy.

Pierre also works with Wim Hof, otherwise known as the iceman (guest on the last podcast) who is especially well-known for some of his amazing physical feats, like staying in a tub with direct contact to ice for over an hour and fifty three minutes.

Pierre explains some of the science behind how Wim is able to withstand cold temperatures for prolonged periods of time. The explanation comes down to what the 2014 PNAS study on Wim's technique showed: that reductions in carbon dioxide temporarily increased blood pH. The missing piece to the puzzle that Pierre brings in is the simple fact that pain receptors that are critical to feeling cold temperatures actually rely on what are known as "acid sensing ion channels", which have been shown in other studies to become inactive within the pH ranges Wim and his trainees are able to increase their blood to.

In this episode, we discuss...

(00:00) Introduction
(05:45) Harmful chronic stress vs beneficial eustress
(09:18) Exercise improves a person's ability to deal with chronic stress
(12:55) Meditation causes a measurable change in DNA expression
(15:51) Loneliness caused 60% increase in tumor incidence in rats
(19:02) Loneliness causes an increase in transcription factor NF-kB
(23:32) How mood affects the immune system through cortisol and circadian rhythm
(26:50) Immune responses activated in the gut can cause depression
(30:25) How meditation affects the brain and relieves chronic stress
(40:02) Dr. Capel talks about his meditation practice and why he does it
(44:42) How Wim Hof endures freezing temperatures for hours
(58:16) Mice exposed to severe cold stress experienced beneficial brain reconfiguration
(01:08:05) The close relationship between love and smell

If you're interested in learning more, you can read the full show notes here.

Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

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#017 Wim Hof (the Iceman) on Defeating Extreme Cold & Attenuating the Immune Response Oct 22, 2015

Show notes

Wim Hof

Wim Hof, also known as "the Iceman", holds the world record for the longest ice bath (1 hour and 53 minutes and 12 seconds), just to name one of his many impressive feats. Dr. Patrick and Wim talk a bit about Wim's back story that culminated in him trying out cold water immersion, the relatively recent 2014 scientific publication of the "Wim Hof Method" which includes cold exposure during training, exposure to bacterial endotoxin, Wim's breathing techniques, and meditation.

In this episode, we discuss...

(00:00) Introduction
(02:08) Wim Hof tells the story of how he fell in love with the cold
(08:35) Activating the sympathetic nervous system to lower inflammation
(14:37) Hyperventilation changes blood pH enough to inactivate pain receptors
(16:24) Just four days of breathing exercises decreased inflammation
(28:06) How much of the effects of meditation are due to breathing technique?
(36:45) Cold exposure increases norepinephrine two- to three-fold
(44:05) Treating depression with cold therapy

If you're interested in learning more, you can read the full show notes here.

Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

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#016 PRESENTATION: Rhonda Speaks at the Orthomolecular Congress in Bussum, Netherlands Oct 15, 2015

Show notes

Dr. Rhonda Patrick delivers the keynote lecture at the Orthomolecular Medicine Congress in Bussum, Netherlands (MBOG Congres 2015).

In this talk, you'll learn about:

(00:00) Introduction
(04:52) Micronutrient inadequacies and triage theory
(10:42) Role of DNA damage in cancer and aging
(21:10) Vitamin D, serotonin, and the development of autism
(41:39) Omega-3s also regulate serotonin

If you're interested in learning more, you can read the full show notes here.

Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

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#015 Buffering the Negative Effects of Chronic Stress with Meditation Sep 25, 2015

Show notes

In this podcast, I discuss some of the mechanisms by which chronic stress (and rumination) affect health and aging and how meditation can reduce rumination and buffer stress.

In this episode, you'll discover:

(00:00) Introduction
(02:41) Eustress such as exercise vs distress such as fear
(06:15) Effects of stress on the brain
(07:30) Effects of stress on the gut and microbiome
(10:21) Stress accelerates biological aging
(15:04) Meditation reduces rumination and promotes empathy
(19:53) Effects of meditation in the brain
(24:28) Meditation slows biological aging and lengthens telomeres

If you're interested in learning more, you can read the full show notes here.

Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

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