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Tiny microbes make a huge difference in our health. These internal ecological systems utilize communication or signaling to maintain this health, effecting immune system function. This podcast shares an important discovery in this communication that influences receptivity to cancer treatment. Listen and learn.
Dr. Kathy McCoy is a professor in the Department of Physiology and Pharmacology at the University of Calgary and the director of the International Microbiome Centre. Her research is focused on interactions between the microbiome and immune system and she shares an exciting just-published study that presents a key finding in cancer treatment. Specifically, her research asked how gut microbes play a rule in influencing or regulating the efficacy of immune checkpoint blockade therapy or cancer immunotherapy. She says that scientists have known for a few years that our microbiome is associated with immunotherapy success or lack thereof, but needed more information to make a difference in treatment.
Here's the big idea behind her findings: while researchers have known there's a microbial immune conversation, they now know that it's a three-way conversation rather than a two-way conversation.
In addition to the microbes and immune system players, metabolites sent out by microbes have a say; furthermore, this conversation gets enhanced by cancer immunotherapy.
More specifically, they found that one of these metabolites, inosine, binds to a receptor present on T-cells and causes a signal transduction cascade that makes that T-cell turn on an anti-tumor response—it makes the cytokines necessary to attack cancer cells. If a patient doesn't have this metabolite, the immunotherapy may not work as well. The hope is researchers can figure out how to encourage this metabolite in patients. Listen in for more details about this study and about its life-changing implications.
For more, see her lab website: kathymccoylab.ca.
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Episode also available on Apple Podcasts: apple.co/30PvU9C
A metabolic pathway study on an ocean floor compound led marine scientist Veronika Kivenson straight to our gut. When she found evidence that a genetic code expansion utilized for metabolism in an ocean sediment compound also appears in the human gut, she knew she needed to understand this pathway better.
Listen and learn
Veronika Kivenson recently received her Ph.D. in Marine Science from UC Santa Barbara and is now working on a post doc at Oregon State University.
She studies microorganism and how they react with their surroundings, especially their metabolism, and what they consume and produce. While studying marine sediment, she came across an interesting connection with gut metabolism. An amino acid that converts from a stop codon in order to metabolize trimethylamine appears in both places. Furthermore, trimethylamine is listed in the negative column in animal-based diet pros and cons.
Animal-based foods are a major source of trimethylamine. In our liver, it becomes trimethylamine-N-oxide, or TMAO, which causes plaque, an element of cardiovascular disease symptoms. But if a pathway in the gut can prevent that formation of TMAO, that's significant. Veronika Kivenson is looking at the potential beneficial role in the genetic code expansion pathway that consumes and prevents TMA from becoming TMAO, or part of plaque formation.
What's really interesting is that this consuming bacteria is also associated with meat consumption. The Bilophila genus bacteria, through genetic code expansion, prevents the formation of the harmful TMAO. Studies on these pathways could lead to probiotic therapies to address cardiovascular disease.
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Episode also available on Apple Podcasts: apple.co/30PvU9C
Bootsie Martinez joins the podcast today to discuss her work in criminal justice, linguistics, education, and more. She is a consultant, expert witness, college instructor, and writer with a passion for language analysis. How does her skillset fit into the legal world? She joins us to explain…
Bootsie is certified in Forensic Linguistic Analysis, has a Masters in Criminal Justice, and is currently completing a Ph.D. in Linguistics. Her areas of specialties include retail security, loss prevention, and fraudulent nursing schools. She is also the author of The Retail Manager's Guide to Crime and Loss Prevention and Sticks and Stones – and contributes to various crime-related magazine publications.
In this conversation, we dive into:
You can learn more about Bootsie and her work by clicking here!
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Episode also available on Apple Podcasts: apple.co/30PvU9C
Bootsie Martinez Important Note:
Feeling overwhelmed by all the "stuff" in your life, business, or living space? Struggling to focus, stay on task, or simply find things when you need them?
Today we speak with an organization expert who has the solutions: Andrew Mellen. As Founder and CEO of Andrew Mellen, Inc. and author of Calling Bullsh*t on Busy: A Practical Guide to Ditching the Time Management Myth and Quickly Achieving Your Goals and Unstuff Your Life!, he's helped hundreds of thousands of people and businesses reclaim time and peace of mind through various programs designed to eliminate the messiness of modern life.
Press play to learn:
Mellen explains the process people tend to go through as they change their organizational habits and retrain their minds and behaviors to sustain them. His approach is centered around how people think, feel, and interact with their "stuff." He details how he coaches people and the type of people he's helped – including those with hoarding tendencies and a desire to be extreme minimalists.
As his business continues to grow, Mellen aims to reach more people more quickly… do you want to be one of them?
If you're ready to start feeling more organized and efficient in all areas of life, visit Andrew Mellen Professional Organizer NYC | Speaker | Productivity + Decluttering Expert.
Take advantage of a 5% discount on Ekster accessories by using the code FINDINGGENIUS. Enhance your style and functionality with premium accessories. Visit bit.ly/3uiVX9R to explore latest collection.
Episode also available on Apple Podcasts: apple.co/30PvU9C
Tom Cosgrove, Aidan Charron, and Michael Karapetian join the podcast today to discuss their work with Earthday.org – an organization that takes action on various environmental issues. As an annual event, Earth Day is a historical movement where citizens of the world rise up in a united call for creativity, innovation, ambition, and bravery…
Tom is the Chief Creative and Content Officer for EarthDay.org. He offers more than 25 years of experience in the media/entertainment, digital/technology, and marketing fields. His skills include content programming, branding, strategic planning, P&L oversight, and board management.
Aidan is the Director of End Plastic Initiatives and has always been passionate about a clean environment and engaging in outdoor activities. He holds a degree in Biology from the University of North Carolina, Wilmington.
Michael is the Great Global Cleanup Coordinator. As an experienced sustainability expert and speaker in the environmental non-profit industry, he offers insight into the urgency of acting now to build a better world for future generations.
In this conversation, we highlight:
How can we proactively address the climate crisis and seize the opportunity for a brighter future? Click play now to find out!
You can learn more about Earth Day by visiting EarthDay.org!
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Episode also available on Apple Podcasts: apple.co/30PvU9C
Today, we are joined by the esteemed Dr. Jay Chhablani, a distinguished professor of ophthalmology and vitreoretinal surgeon at the Department of Ophthalmology, University of Pittsburgh. As the Director of Clinical Research at the UPMC Vision Institute, Dr. Chhablani stands at the forefront of cutting-edge advancements in eye care.
Embark on a fascinating exploration as Dr. Chhablani, a retina specialist and surgeon, shares his wealth of knowledge on retinal diseases, ranging from bothersome floaters to age-related macular degeneration. Delve into the intricacies of ophthalmic surgeries, including the delicate art of retinal detachment repair.
Press play to discover:
Eager to learn more? Tune in and explore more at Jay Chhablani, MD | Department of Ophthalmology | University of Pittsburgh.
Take advantage of a 5% discount on Ekster accessories by using the code FINDINGGENIUS. Enhance your style and functionality with premium accessories. Visit bit.ly/3uiVX9R to explore latest collection.
Episode also available on Apple Podcasts: apple.co/30PvU9C
Zack Abbott returns to the podcast to discuss the importance of probiotics – and how bacteria can be used for various health and wellness applications. As the CEO and Co-founder of ZBiotics and the inventor of ZBiotics' proprietary technology, Zack has used his unique background to achieve something fascinating: the production of the world's first genetically engineered probiotic.
Zack has a Ph.D. in microbiology & immunology from the University of Michigan, where he studied bacterial gene regulation in Legionella pneumophila. Now, he is on a mission to leverage bacteria for good, rather than combat them for bad…
What gives probiotics the unique ability to improve our daily lives? Join us now to find out!
In this episode, we discuss:
You can learn more about Zack's work with ZBiotics here!
Take advantage of a 5% discount on Ekster accessories by using the code FINDINGGENIUS. Enhance your style and functionality with premium accessories. Visit bit.ly/3uiVX9R to explore latest collection.
Episode also available on Apple Podcasts: apple.co/30PvU9C
Dr. Heidi B. Hammel is Vice President of Science at AURA, Inc., the organization overseeing iconic telescopes like the Hubble Space Telescope and James Webb Space Telescope (JWST).
Join us as we delve into:
Dr. Hammel shares her visionary work on the upcoming telescope, the Habitable Worlds Observatory Telescope, and its potential role in discovering evidence of extraterrestrial life. Explore the distinctions between JWST and the next-generation telescope, uncovering its unique capabilities.
Gain insights into the current status of the 30-year-old Hubble Space Telescope – how it perseveres today and its anticipated future.
Are we on the brink of being the first generation to unearth evidence of life beyond Earth? Discover the pioneering efforts of Dr. Hammel and the AURA team that could lead the way.
Press play to embark on this captivating celestial odyssey, and for more astronomical wonders, visit Home - AURA Astronomy.
Take advantage of a 5% discount on Ekster accessories by using the code FINDINGGENIUS. Enhance your style and functionality with premium accessories. Visit bit.ly/3uiVX9R to explore latest collection.
Episode also available on Apple Podcasts: apple.co/30PvU9C
This fascinating episode on health and wellness features Michael Snyder, a Professor in Stanford University School of Medicine's Department of Genetics. Michael is widely considered a leader in the field of functional genomics and proteomics – and is a major participant of the ENCODE project.
Trained as a microbiologist, Michael is dedicated to gaining a global perspective on health care. Because many aspects of our medical system are broken, he is focused on refining the fields of genomics and proteomics with cutting-edge research. How is technology changing the way we monitor our bodies? Michael sits down to explain…
Join the conversation now to find out:
You can learn more about Michael and his work by visiting his laboratory website!
Take advantage of a 5% discount on Ekster accessories by using the code FINDINGGENIUS. Enhance your style and functionality with premium accessories. Visit bit.ly/3uiVX9R to explore latest collection.
Episode also available on Apple Podcasts: apple.co/30PvU9C
Today, we connect with Dr. Gabrielle Lyon, the founder of The Institute for Muscle-Centric Medicine and a nationally recognized speaker and media contributor. As a functional medicine practitioner, Dr. Lyon is an expert in brain and thyroid health, lean body mass support, and longevity.
Dr. Lyon has always been interested in nutritional sciences.
In this episode, we cover:
You can learn more about Dr. Lyon and her work by visiting her website.
Keep an eye out for her latest book, Forever Strong: A New, Science-Based Strategy for Aging Well, releasing on October 17, 2023. Follow the presale link to secure your copy today!
Take advantage of a 5% discount on Ekster accessories by using the code FINDINGGENIUS. Enhance your style and functionality with premium accessories. Visit bit.ly/3uiVX9R to explore latest collection.
Episode also available on Apple Podcasts: apple.co/30PvU9C
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