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Copyright: © Richard Jacobs
One of the biggest challenges for any data-centric organization is in understanding the type of data that exists and knowing how best to manage it. When document classification is done incorrectly or not done at all, a variety of possibilities emerge that threaten network security and smooth business operations. Wide permissions on documents open the door to fraudulent activity, and conflicts between the business and IT side of an organization about how to handle certain types of data can cause further problems that increase vulnerability to attacks and data breaches. This is where DocAuthority can help.
By creating an automatic inventory of all organizational data with 99.9 percent accuracy and identifying unprotected sensitive documents, consistent document classification and network security concerns are taken care of in a way that allows business processes to continue uninterrupted. As the CTO and founder of DocAuthority, Ariel Peled joins the podcast to discuss the ins and outs of the products and solutions they offer, as well as new products and initiatives on the horizon. Tune in and visit docauthority.com to learn more.
Mike Michalowicz, author, entrepreneur, investor, and business-success consultant (mikemichalowicz.com), delivers an insightful overview of the methods and practices that entrepreneurs can use to grow their businesses and build upon a solid foundation.
Mike Michalowicz doesn't believe in wasting time; in fact, there is no time to waste when you are a sought-after speaker, consultant, and prolific author of multiple books on business and entrepreneurship. Only in his third decade of life on this earth Michalowicz had already founded and sold two multi-million-dollar companies and was looking for more opportunities to dive into. Riding high on his confidence from recent successes he dove headfirst into angel investing where he proceeded to lose most of the financial security he had put away, but… like a true entrepreneur, he dusted himself off and built it all back again with new ventures and a wise plan to grow strong companies from the ground up, block by block, to success. Michalowicz has received much exposure for his line of successful books and also for his method known as the "Profit First Formula," which is a means for businesses to ensure profitability from their very next deposit forward and ongoing.
Mike is the celebrated author of Profit First, The Pumpkin Plan, Clockwork, The Toilet Paper Entrepreneur, and others. He discusses his desire to end entrepreneurial poverty, and his drive to share the secrets that can help businesspeople succeed, and build their dreams. Michalowicz's first book discussed the concept of hiding profit away, referred to as 'profit first,' which caught the attention of business leaders and publishers, and was one of his first methods that business leaders responded to positively.
Michalowicz details the stages of sales in business and how business owners can take steps that bolster their finances and ultimately their confidence to move their businesses forward, have balance in their lives, and more control of their path. He outlines the variables in business, such as productivity and efficiency, and the importance of choreographing all resources to achieve results and allow a business to run more automatically.
Michalowicz also stresses the importance of actually taking time to 'think,' to process your ideas as they come, and prioritize new avenues for growth. He cites the example of bees and their environment and how each bee understands its role in the ultimate goal of producing eggs, and compares that to efficiency and understanding in business activities that produce higher productivity. Additionally, he discusses the importance of discovering where your survivability and thrivability exist, to understand what your brand promises, and what is the one activity that makes that promise a reality. He discusses the brand, FedEx, and how their success ultimately is based upon their primary function: logistics and delivery of packages on time. Thus it is important to identify what your brand promises and always deliver it.
The business-success author underscores the importance of having people on your team who can coordinate all the resources and line them up to achieve results via fulfilling customer satisfaction, delivering on promises, innovating, and more.
Michalowicz has moved into his third million-dollar venture and is always looking for new opportunities. He is a former columnist for The Wall Street Journal, former MSNBC business makeover expert and consultant, and is a sought-after keynote speaker on innovative entrepreneurial issues. As a celebrated business author and journalist his methods and practices have become popular tools utilized by entrepreneurs everywhere. His books are go-to manuals for many successful business leaders and his book, The Toilet Paper Entrepreneur, was referred to by BusinessWeek as "the entrepreneur's cult classic."
Jason Andrew is the CEO of Limelight Health (limelighthealth.com), and a health and technology innovator and visionary. Andrew discusses Limelight Health's goal to deliver the most efficient, compelling quoting and underwriting platform for the employee benefits industry.
Andrew's extensive background as an agent in Silicon Valley where he was engaging daily with game-changing technology motivated and inspired him to launch innovative tools for the health insurance industry. He is an experienced startup entrepreneur with a passion for solving problems in the health insurance, health education, and wellness industries.
Andrew is a recognized health insurance and health reform expert and sought-after leadership advisor in the industry who excels at bringing key individuals together to solve complex problems and innovate. Notably, Andrew served as CEO and founder of Stone Meadow Benefits & Insurance Associates, CEO and co-founder of Coverage Partners, VP business development and co-founder of PK4Tech, and as VP and managing producer of Lawson-Hawks Insurance Associates.
The healthcare and technology expert discusses the current state of operations in his industry. He states that many facilities are utilizing systems and platforms that are 20 or 30 years old and are simply antiquated, unable to keep up with the changing times and technologies. He discusses some of the problems in the industry, and underscores how communication between industry players is critical. And he explains the importance of using API data. API, which stands for application programming interface, allows a service or product to talk to other services or products. Therefore, an API allows data and functionality to be introduced or opened up to other developers and businesses, and it is a common way in which companies exchange their data and services.
Andrew discusses the stage of their production and funding, and his expectations for the future. He states they have customers using their products and more and more companies are coming forward to overhaul their outdated systems, which increases efficiency for companies and consumers alike. He discusses the ratings of various plans from dental to life to health, and how their platform allows for a better grasp of products that are available.
Limelight Health's mission and primary goal is to deliver ongoing industry innovation and provide time-efficient, current, accurate data to the industry and health community at large. Through their work with comprehensive quoting and decision support, Limelight Health is able to generate successful, fluid end-to-end integrations with the most current technologies.
Charles Martin, PhD, data scientist, machine learning AI consultant, and chief scientist at Calculation Consulting, delivers a thorough overview of the technologies that are helping companies expand their customer base and increase revenue.
Martin is an experienced professional in machine learning, deep learning, data science, and AI software development. He has a long history in the technology field and was instrumental in the development of machine learning systems for major corporations and companies such as GoDaddy, Aardvark (acquired by Google), eBay, and Blackrock. Martin assisted Demand Media in their successful mission to become the first $1B IPO since Google. His specialization in software engineering and ML experience has made him a top consultant for many companies. Additionally, Martin is a full stack developer for web, object oriented, and numerical programming. Martin earned his PhD in Theoretical Chemistry from the University of Chicago.
Martin gives an overview of his company and explains how they specialize in AI and machine learning with a keen focus on translating research into products. Calculation Consulting operates primarily in three areas, strategy, data science, and product development. In regard to strategy, the company seeks to find ways to design new products and predict revenue streams from aggregate data. Regarding data science, their team provides data solutions by applying machine learning algorithms to discover the essential patterns that can drive traffic, engagement, and sales. And in product development, Calculation Consulting builds and deploys contemporary, end-to-end, highly sophisticated, cloud-based software systems.
The technology visionary discusses some of the areas his company excels in, such as semantic search and matching. Semantic relates to 'meaning' in language. Semantic search improves search accuracy by more fully understanding a searcher's intent via the contextual meaning. By utilizing concept matching, synonyms, and natural language algorithms, a semantic search can produce a better interactive search and deliver more specific personalized results. He discusses some of the prototypes he has built in this area of the tech field. Martin expounds upon the ways that research has progressed especially thanks to Kaggle, the successful online community of data scientists and machine learners that is powered and owned by Google, Inc. Kaggle enables its many users to locate and publish data sets, to intensely explore and build models in a web-oriented data-science environment, work in connection with other data scientists, enter their work in competitions, and so forth. Martin explains how Facebook, Google, and Amazon alone have put thousands of their top engineers to work on these types of open source projects to develop the most innovative research and turn it into real tools and products.
He discusses some of the top open source tools for natural language processing, and his techniques for running them in actual production, working with queries, etc. in the real world. He explains that the process of pulling all this information together, understanding how to utilize the techniques, methods, etc. is an area of their particular expertise.
Martin explains in detail the methods of analyzation and how the technology is useful in a practical business work environment. He discusses their project phases and how they assist companies, citing specific examples of companies they have helped, to use neural networks to solve business-specific problems. Martin discusses click-thru and view prediction models, and gives examples of businesses that Calculation Consulting has assisted in their quest to learn more about customer behavior to increase revenue. Specifically, Martin details ways to increase click-thru efficiency using machine learning, and other tips to drive interest and sales.
The machine learning specialist relates how, today, there are so many problems that can be solved via machine learning technology. He discusses online traffic and clicks and the successes he has had growing companies with the technologies, some of which have seen their revenue streams expand to amazing new levels. Further, Martin discusses the reservations that some high-level managers and even CEOs may have about making the transition to the new technologies, in spite of the exponential advantages for their companies. But Martin states that while some companies are slow to move, those with the right mindset, who hunger to jump into the AI arena, are clients that he and his team at Calculation Consulting can help to reach new levels of success in business.
Jane Antony, postdoctoral researcher, Stanford Medicine, Stem Cell Biology and Regenerative Medicine, delivers an important and thorough overview of the current state of cancer research and methods that may lead to promising new discoveries.
Antony worked toward her Ph.D. through a unique joint program of the National University of Singapore and Imperial College London to bolster her study and understanding of cancer cell biology. She has been an active member of various research groups in Singapore and the UK that focus their efforts primarily on cancer biology, ovarian cancer, metastasis, signal transduction, and therapeutics. Her current work pertains to the identification of innovative therapeutic targets in invasive breast cancer illuminating differential signaling schemas in tumor heterogeneity. Antony is constantly curious, with a passion for understanding the link between metastasis and cancer stem cells.
Antony discusses her current cancer research. She states since cancer is an intrinsic disease, whatever you use to target it will impact the normal healthy tissue as well. Generally, a disease's etiology, or cause, can be classified as intrinsic, extrinsic, or idiopathic. Antony's particular interest is in regard to metastasis and how cancer spreads. Antony states that many cancers can be removed surgically and can utilize therapies that shrink the cancer cells, but if it spreads to other organs it becomes more difficult to treat. Antony gives a detailed analysis of what is currently known about DNA as it relates to cancer growth. She describes the different types of cancers, how they metastasize, and typically where they travel to, or could. Additionally, she provides an in-depth overview of the current therapies such as radiation and chemotherapy. In regard to radiation therapy, it certainly has an effect on normal cells as well, and chemotherapy, unfortunately, becomes less effective over time and multiple treatments.
Antony talks about some of her work and areas of particular interest such as tumor suppressors. Understanding how tumor suppressors are involved in the development of cancer, specifically genes that regulate Receptor Tyrosine Kinases (RTKs) can quite possibly provide some important answers. A gene of great interest is the OPCML, which is present in healthy, normal cells but is switched off in cancer, which makes treatment very difficult with lowered chances for recovery. Understanding how this gene functions in cells is a critically important issue. Targeting genes that regulate RTKs can lead to possible gene-based cancer therapies for patients.
Antony details other important developments in research, such as limiting dilution assays (LDA). LDA is designed to define an undetermined frequency of effector cells within a population. They are dose-response assays that enable detection of a positive or negative immunoresponse in each unique culture within replicates that vary in the number of actual responder cells tested. By calculating stem cell frequencies researchers can study how stem cells are evolving throughout treatment.
Antony describes her findings in regard to stem cells and various types of cancers. She states that in blood cancers, the methods are somewhat different, in that bone marrow is removed and then reinstated after treatment has flushed out the affected area. Obviously, this is a treatment advantage of liquid cancers, for solid tumor cancers cannot benefit in the same way due to their form. And she talks about an assortment of other interesting trials that are underway that may provide further answers of great benefit to science and medicine.
Antony is a postdoctoral member of the American Society for Cell Biology (ASCB), as well as a member of the EMT International Association, and an associate member of the American Association for Cancer Research. She holds a Doctor of Philosophy from the National University of Singapore, a Bachelor of Engineering from the National University of Singapore, and a Doctor of Philosophy from Imperial College of Science, Technology & Medicine.
Dr. Sabrina Leslie, Associate Professor of Physics and Quantitative Life Sciences at McGill University, leads listeners on an interesting journey into the complex and important world of molecule imaging and research.
As an experienced researcher and respected university leader at McGill, Dr. Leslie founded her single-molecule imaging laboratory in 2012. The lab was instrumental in the development of novel techniques to discover and explore complex interactions and dynamics of macromolecules. Dr. Leslie has pursued doctoral studies in optical physics, has completed extensive research on biomolecules in liquids, and explored her passion for imaging in a health sciences context. She is a recipient of a Mary Fieser Postdoctoral Fellowship, and her work at Harvard led to the invention of a single-molecule imaging technology known as Convex Lens-induced Confinement (CLiC). And it was this groundbreaking work in the field that thrust her onto the international stage as a noted pioneer in single-molecule investigations with a broad range of applications. Dr. Leslie earned her Ph.D. in Optical and Atomic Physics at the University of California at Berkeley
Dr. Leslie discusses her lab's intensive work deconstructing molecular interactions to answer questions in biology and develop new drugs for medical and therapeutic applications. She talks about the importance of time scales, speed of camera, and resolution, in their work as they seek to visualize the interactions in real time. By using cameras they are able to watch molecules for a long time and deconstruct the methods of operation.
Collaborating with biochemists and cancer scientists, as well as applied mathematicians, the Leslie Lab's single-molecule investigations of protein and DNA interactions, have provided significant new information about gene regulation mechanisms. Specifically, Dr. Leslie's work has also been focused on exploring a wide range of interactions and dynamics of proteins and DNA, as well as other macromolecules, and with regard to molecular shape and environment.
The macromolecule researcher details her lab's groundbreaking work with the imaging technology known as Convex Lens-induced Confinement (CLiC). As she explains, the process works by essentially squeezing the tiny molecules into little traps so that the essence of the molecule is completely held in focus, viewable from all angles. And by utilizing fluorescent labels they are able to closely track them for observation.
She details some of their current research regarding DNA binding with a focus on applications and therapeutics, etc. As they continued their experimentation they began introducing other molecules and polymers, to fill up space and then observe how DNA probes find their target sites. As she states, they have a particular interest in the nexus between the physics and the biology, where structural elements can have an impact on the biochemical reactions. Further, she talks about some surprising discoveries regarding proteins and droplet formation simulation.
In concert with biochemists in Montreal, Dr. Leslie's team is instigating CLiC studies of non-membranous organelles (NMOs). Liquid droplets form when proteins and nucleic acids phase-separate from cellular material, similar to how oil separates from water. Importantly, there is significant evidence suggesting that misregulation of MMOs is associated with select diseases such as Alzheimer's.
Lastly, Dr. Leslie expounds upon some of the areas of research they are most excited to dig into, such as gene editing, and she gives an overview of their collaborations with pharmaceutical companies on oligonucleotide therapeutics. (Oligonucleotide therapeutics is an inventive class of biopharmaceutical products composed of short strings of synthetic nucleotides that resemble the actual building blocks for DNA.)
Rayne Steinberg, chief executive officer of Arca Funds (arcafunds.com), discusses the complex and constantly evolving digital marketplace, financial products, and ways that qualified investors can successfully navigate the vast sea of new currencies and platforms.
Steinberg is a seasoned securities structuring and risk management professional. He has played an instrumental role in many businesses, including his influential contributions as co-founder of WisdomTree. Steinberg was responsible for raising capital, building and overseeing the sales team that successfully raised $50 Billion in ETF AUM. Steinberg earned a Bachelor of Science degree from the University of Pennsylvania's prestigious Wharton School of Business.
Steinberg discusses his early journey into the business, including his time as co-founder of WisdomTree. He explains the financial products and fee structures, and how high fee was a problem that made it difficult for industries to disrupt themselves. His interest in crypto was that it was an asset class for people to invest in, but it was also a novel wrapper in which to wrap many and various financial service products. Specifically speaking, ETFs are wrappers that are comprised of multiple securities representing an overall investment strategy.
Steinberg explains his company's model and intentions. Arca Funds applies to sound, institutional-grade asset management processes to the future-forward crypto and blockchain-investing arena. Arca Funds' primary focus is on stable regulation and security, compliance, as well as custody and risk management. Steinberg discusses how our current system has largely been centralized, with individuals giving their trust to authorities to maintain their transactions, etc. Thus, the new model of crypto represents a reconfiguration of that system, as its approach is one of decentralization. He gives an example of how in the new digital ecosystem, individuals are the custodians of their own passcodes, and so forth, placing a higher level of responsibility upon the individual. As Steinberg states, with the new freedom in the digital market comes new risks as well, and Arca Funds was designed specifically to help individuals bridge the gap between the old and new, to find their footing in these rapidly expanding digital markets. The Arca Funds platform allows for safe experimentation as users gain experience in the markets.
Steinberg outlines many of their products. Arca launched a series of quality funds designed to offer greater diversified and compliant exposure to the expanding crypto asset class. And down the road, they plan to develop unique tokenized products that will significantly disrupt and replace the aging landscape of centralized, expensive financial service products that are not easily converted into cash. And as there is the risk in the markets, Steinberg states that their platform is only available for high net worth individuals and qualified buyers, as is defined by regulators. He explains the intricate details of their various products' structures, and who they would be attractive for, and why. And he details how Arca Funds is able to assist in the qualifying of asset products that come into the marketplace. From Bitcoin to Ethereum, regarding hedge funds, and so much more, Steinberg's Arca Funds evaluates the many opportunities and provides real, sound information on them. And as the products are not just security products but are also technology products, Arca Funds' team utilizes a thorough process to get to know the products, and the technology, as the digital market is quite complex for the average user. As such, Arca Funds' returns typically better the averages.
The Arca team systematically and thoroughly combines their many decades of institutional asset management experience; a broad history of successful, relevant business creation; and the technical expertise to create real value for the individuals they service.
Michael A. Grandner, PhD, Arizona College of Medicine, provides an overview of the many aspects of sleep, how it impacts functioning, and the ways we can improve the quality of our sleep.
Dr. Grandner is an experienced researcher, noted speaker, and respected colleague at many prestigious institutions. He serves as the director of the Sleep and Health Research Program at the University of Arizona, and as director of the Behavioral Sleep Medicine Clinic at the Banner-University Medical Center. Additionally, Dr. Grandner is an assistant professor in the departments of psychiatry and medicine in the UA College of Medicine, assistant professor of psychology in the UA College of Science, as well as an assistant professor of nutritional sciences in the College of Agriculture and Life Sciences. He is certified in behavioral sleep medicine by the American Board of Sleep Medicine.
Dr. Grandner discusses the connections between sleep and health and how it plays an important role in many and various areas of functioning. He states that a lot of their research focuses on finding ways to help with sleep improvement. He looks at quality and quantity of sleep, timing, when people are sleeping, and why. He gives details on the range of ways they study sleep in their laboratory. He talks about the various types of emerging technologies that can assist them with measuring the aspects of sleep. As sleep exists deep in the brain, it is impossible to perfectly measure sleep, thus Dr. Grandner states that they must measure around it, guessing at other measures such as movement and brain wave activity, etc.
Achieving healthy sleep is crucial for great overall health, cardiovascular health, and is also an important factor in obesity, diabetes, and psychological well being. And as such, when we don't get enough of it, or the quality level is low, functioning can be impacted in many ways. Interestingly, Dr. Grandner points out that many people actually degrade their own opportunity to achieve quality sleep by reinforcing periods of insomnia. As he states, the best thing to do when you're in bed and can't sleep is to get up. Lying in bed and trying to fight it only reinforces the state, essentially teaching your brain that bedtime is a time for brain activity and thought. Thus getting out of bed and taking on some sort of activity till you feel ready to sleep could prove helpful.
Dr. Grandner outlines some of the research and interesting studies his team is involved with currently as well as other studies on the horizon. Current research focuses on the ways sleep and sleep-related behaviors could be connected to cardiovascular disease, obesity, diabetes, neurocognitive functioning, mental health, and even longevity. Their projects have been funded by the National Collegiate Athletics Association (NCAA), the National Institute on Minority Health and Health Disparities (NIMHD), the National Heart, Lung, and Blood Institute (NHLBI), the National Institute for Environmental Health Sciences (NIEHS), and the American Heart Association (AHA).
Their community-based studies consider a vast swath of issues from social environment, access to care, stress, diet, and exercise, as well as aspects of cardiometabolic functioning, to look at the ways sleep is related to each. Dr. Grandner seeks to develop new tools to help people gauge the kind of sleep they are getting and how to improve it. In regard to sleep, Dr. Grandner states, it is not something that you can command. We need to give ourselves the right environment, mentally and physically, that will allow sleep to happen. He discusses the quality versus the quantity, and the ways to evaluate that, as well as the importance of regular sleep patterns.
Dr. Grandner discusses the internal body clocks that govern function, and the various types of personalities and genes that play a role in sleep schedules. He discusses the sleep-wake system versus the circadian system, which relates to the biological process that displays an endogenous, entrainable oscillation of approximately 24 hours. He explains how hormone shifts and rhythms can be changed, shifted, and blunted, and how light can help with making adjustments, in regard to the winter blues, seasonal affective disorder, etc.
Dr. Grandner has published over 100 articles and chapters on myriad issues relating to sleep and health. His significant work in the field has been cited over 2,500 times. Dr. Grandner is associate editor of the recognized journal, Sleep Health, and he serves on the editorial boards of various other journals: SLEEP, Journal of Clinical Sleep Medicine, Sleep Medicine, and others. He is a sought-after speaker on the connection between sleep and good health and as such has been invited often to the National Institutes of Health, and has presented for the US Congress.
It's true: we're wired to eat, but what should we be eating? Is there a one-for-all holy grail of diets that we just haven't found yet, or is an "appropriate" diet something that varies from person to person? How much should we be exercising, and does stress really contribute to weight gain? The answers you get will probably depend on who you're asking. Today's podcast focuses on Robb Wolf's opinion on these and a variety of other topics.
As one of the world's leading experts in paleo nutrition, author of two books on The New York Times Best Seller list (The Paleo Solution: The Original Human Diet and Wired to Eat), and former research biochemist, it's safe to say his opinions carry a lot of weight. Tune in for an intriguing and eye-opening conversation that touches on the role of diet, lifestyle, genetics, epigenetics, socialization, and the gut microbiome in overall health and quality of life.
Visit robbwolf.com to join his newsletter and access a plethojump-start materials that'll help jump start your journey to health.
Here is the article: https://jamanetwork.com/journals/jama/article-abstract/2679460
Talk of the need for a renewable, clean energy source is everywhere these days, but until now, aluminum hasn't really been a player in the discussion. Why not? Josiah Nelson asked the same question when a mistake in the lab led him to observe an unexpected reaction between water and aluminum that'd been stripped of its outermost layer. The result? An intense bubbling created by the oxidation of water, leaving nothing behind but hydrogen and aluminum oxide.
He soon realized he'd stumbled upon something that could change the world: a 100% renewable way to make hydrogen and electricity with efficiencies comparable to fossil fuels at about one-fifth of the cost of non-renewable and unclean hydrogen-generating processes. That's not all: this process of hydrogen generation is scalable and reliable enough for industrial manufacturing.
It didn't take long for him to join forces with Tirthak Saha in the founding of Trolysis, a company devoted to bringing this technology to market and ultimately powering the world. With the demand for hydrogen hovering somewhere around 90 billion metric tons per year in the US alone, Nelson's claim to have found the holy grail for renewable energy enthusiasts might just be legitimate. Both Nelson and Saha offer an exciting and engaging discussion about the Trolysis technology, the underlying chemistry at play, and the three main problems with other methods of hydrogen regeneration. Hit play and learn more at trolysis.com.
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