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Copyright: © Richard Jacobs
"My reason for wanting to start the company was a very simple one actually, and a very personal one: my wife had cancer, she had breast cancer…misdiagnosed and then finally correctly diagnosed in 2005. She became metastatic in 2010," says Robin Bannister, Founder and Director of Research and Development at Care Oncology Clinic.
Dr. Bannister had spent his entire professional life studying different pharmaceuticals and trying to understand the ways in which old drugs could be repurposed, but now there was a new level of urgency to his work. He knew he had to act quickly. To find the drug he was looking for, he first had to reduce the list of 5,000 or so drugs to a list that was more manageable, and he did this by focusing on those that had a long history of safe use and mild side effects, particularly in cancer patients.
The basis of the treatment provided at Care Oncology Clinic takes advantage of the Warburg effect—the metabolic processes used by cancer cells to stay alive and grow. The Care Oncology protocol employs drugs which, simply put, make it exceedingly difficult for cancer cells to survive by limiting the resources they use in order to defend themselves in harsh environments—environments created not only by the standard of care for cancer, but also the body's own immune system. By tuning in to today's episode, you will learn the details of this and more, including:
Locate the Care Oncology USA website at https://careoncology.com/.
You hear a sound, and you absolutely hate it; as a result, your brain prioritizes that sound, further and more deeply ingraining it in your brain. This experience creates a very negative emotional and physiological reaction in you, and could be triggered by any number of sounds commonly encountered in modern life—the sound of someone chewing gum, tapping, dripping water…you name it. There's a name for this, and it's misophonia.
In addition to misophonia, Jennifer Conlin, Doctor of Audiology, has tinnitus, which is a condition that involves hearing a high-frequency tone that becomes chronic, causes a negative emotional response, and leads to a negative feedback loop in the brain. It might be hard to see the good in having both of these conditions, but it's what ultimately led Dr. Jennifer Conlin to not only identify her speech-language pathology specialty and foster her love of audiology but help others through a myriad of auditory problems in her role as an audiologist at Love to Hear Again Audiology in Texas.
In this episode, you will learn:
· In what ways different brands of hearing aids differ from each other
· How artificial intelligence is being implemented in hearing aids, to include language translations and fall detection
· How tinnitus and other auditory conditions can be treated
· How a person's hearing can impact their mental state, including the development of dementia, social withdrawal, depression, and chronic fatigue
Tune in and visit love2hearagain.com to learn more.
Not more than 10 years ago, the consensus among most scientists was that extracellular vesicles (EVs)—biological particles found in our urine, saliva, and throughout our bodies—were mere waste products with no role in communication between cells. Today, we know that's simply not true: EVs certainly play a role in cell communication, but the extent to which they do so is still a topic of research. We also know that they have the potential to be used for diagnostic and therapeutic purposes. For example, the identification of EVs in the blood can be diagnostic of cancer, and we know that metastatic cancer cells release EVs that are softer than other types of EVs. Additionally, EVs can be taken from fat tissue and used for therapeutic purposes.
This is just a fraction of what Joy Wolfram, Ph.D., Director of The Nanomedicine and Extracellular Vesicles Laboratory at the Mayo Clinic in Florida discusses on the podcast today. She also explains the work they are doing to synthesize nanoparticles which are capable of being modified in a way that allows them to transport therapeutic agents (e.g. cancer drugs, anti-inflammatory compounds) through the bloodstream and directly to the site of diseased tissue. By tuning in, you'll learn about all of this and more, including:
Hives, swelling of the eyes, mouth, or tongue, sneezing, wheezing, sudden vomiting, a sense of impending doom: these are just a few of the symptoms of an allergic reaction. For over 10 years, Dr. Richard Wasserman's focus has been on developing a treatment for food allergies called oral immunotherapy (OIT), a method by which a very small amount of an allergen is given to an allergic individual as a way of prompting desensitization. Over time, the amount of allergen is gradually increased until the individual is able to consume a full, meal-sized portion of the allergen. To date, IOT has been used to treat allergies to 20 different foods, including peanuts, cashews, eggs, milk, wheat, chickpeas, and sunflower seeds. In today's podcast, you will learn:
Dr. Richard Wasserman has a medical degree from the University of Texas Southwestern Medical School and completed a pediatric residency and fellowship training in bone marrow transplant recovery and immunology at Children's Hospital of Philadelphia. Tune in to hear the full conversation. Learn more about food allergy by visiting foodallergy.org.
Antibiotic resistance—the ability of bacteria to survive even large doses of broad-spectrum antibiotics—is a growing problem in the modern world, one that threatens the safety of everyone on the planet. But this hasn't always been the case; not more than 20 years ago, the idea of antibiotic resistance was not really on anyone's radar, which is a testament to how quickly the problem has developed, and therefore how time-sensitive it is to develop a solution. According to Dr. Vincent A. Fischetti, head of the Fischetti Lab at Rockefeller University, as well as the results from phase 2 clinical trials which put it to the test, the solution lies in a bacteriophage enzyme called lysin.
On today's episode, Dr. Fischetti explains how bacteriophages (commonly referred to as phages) kill bacteria, and how he and his team harnessed this knowledge in a way that's led to the development of the first-ever alternative to antibiotics that's been FDA-approved to enter phase 3 clinical trials. This potential treatment for bacterial diseases in humans could very well eliminate the daunting threat of antibiotic resistance. Dr. Fischetti brings an impressive amount of fascinating information to the conversation today. By tuning in, you're bound to learn a number of things, including:
Press play for all the details.
Richard Andrews, SM, MS, President/CEO, and Mark Sampson, Chief Scientific Officer, of Azitra, a clinical-stage medical dermatology company, provide an insightful overview of their work.
Andrews has vast experience as a top executive, leading the operations, finance, and development for biotechnology firms primarily focused on novel products to combat inflammatory disease. And Dr. Sampson, recently of Botanix Pharmaceuticals, has immense experience in the development of preclinical strategies as well as clinical development plans for new, advanced antimicrobial indications. He is a seasoned and sought-after researcher.
The disease researcher, and executive, provide an overview of how Azitra strives to address serious skin diseases. Azitra combines various technologies designed to repair disease problems, and utilizes the microbiome to deliver those, thus adding to the therapeutic benefit. They talk about cancer-associated rash, and the various kinds of skin problems that they see. The dermatology experts explain the diversity in a healthy microbiome, and how there are, remarkably, up to a million different bacteria per square centimeter of skin. They explain how this network can be disrupted, which can lead to problems—dysbiosis, which is a microbial imbalance on or inside the body, impaired microbiota for example.
The researchers explain their goal to reset the balance of the skin microbiome to help protect against harmful bacteria and pathogens. And they provide a wealth of information on various cancers and the relationships to the microbiome.
In this podcast:
How the microbiome is related to skin issues
Cancer-associated rashes
Microbial imbalance
Oscar Sierra, L.Ac, a Nationally Board Certified Acupuncture Specialist (NCCAOM), Dipl. O.M., provides an overview of the current trends in modern acupuncture and many interesting facts about its beneficial aspects that you may not have known.
Sierra received a BS in Nutrition from the University of Georgia. He is certified in Reiki, and has intensely studied Chinese Medicine and Acupuncture via an apprenticeship for nearly half a decade with Chinese Medicine practitioners in Atlanta.
Sierra discusses the medical world's interpretations of what is conventional medicine versus traditional medicine. As Sierra states, he practices traditional medicine, practices that are backed by thousands of years of written history, and a track record. Whatever works that is safe and effective for the patient is what Sierra focuses on. Sierra explains how ancillary compounds work, as he discusses the benefits of vitamins, such as vitamin C, and more. Sierra talks about medicinal plants for cancer treatment. And he outlines certain chemo drugs that are based on phytochemicals, and how they are useful, how they are derived, etc.
Sierra talks about common treatments they use at his facility in Atlanta. Additionally, he discusses the importance of attending to our basic three, which he describes as: adequate and balanced activity (physical, mental, emotional, spiritual), sleep and downtime, and our diet (not just what we eat but how we eat it). Herbs are great, but they cannot be the complete solution if the 'basic three' are not being cared for.
Sierra goes on to discuss many accounts of cancer patients, and other disease sufferers who have taken a more natural path to healing and have seen dramatic improvements. Sierra's approach to healing is based on the patient rather than the disease. It's a holistic, natural, patient-centered approach to medicine that focuses on prevention.
In this podcast:
How medicinal plants are used for cancer treatment
The current trends in modern acupuncture
The 3 basic areas we need to focus on to form a foundation for good health
Howard Hindin, DDS, of The Hindin Center (hindincenter.com), discusses airway preservation and other myofunctional dentistry issues that affect people.
Dr. Hindin is a graduate of the prestigious New York University College of Dentistry. He is trained in all areas of general dentistry, including surgery and endodontia. Additionally, Dr. Hindin assists people with cosmetic dentistry issues, and many types of oral and dental problems, including temporo mandibular joint disorders, and cranio facial pain.
Dr. Hindin discusses the typical treatments for patients, but he stresses that treatment must be personalized. He discusses airway issues and identifies some of the cardinal signs of airway problems, such as mouth-breathing. He provides valuable information on how nasal breathing can be restored. Dr. Hindin explains invasive and non-invasive treatments. And he discusses oral appliances which can be tried first, to see if improvement in nasal breathing can be achieved.
The Hindin Center dental expert talks about bad habits, and how light can be a factor in delayed production of melatonin, which makes sleep more difficult. Dr. Hindin recounts some experiments with rats that demonstrated how food affects body systems. Continuing, Dr. Hindin provides an overview of human processes and what would be considered an ideal example of functioning for the day, discussing eating, sleeping, bowel movements, and more. Dr. Hindin talks about hidden airway problems that many people are not aware they may have at all. And Dr. Hindin talks about reflux, cardiovascular issues, and other potential signs of airway sleep problems.
In this podcast you'll learn…
Some of the signs of airway sleep problems
The importance of melatonin production
Why it's important to have a regular body cycle throughout the day
Monica M. Laronda, PhD, Assistant Professor of Pediatrics (Endocrinology), provides an overview of her research work in endocrinology, reproductive biology, and 3D printed ovaries.
Laronda is passionate about research and she has a keen interest in the reproductive biology and endocrinology that forms the foundation for the the development of treatments to protect or restore hormone function and fertility. Laronda received her PhD from Northwestern University and her Postdoctoral Fellow work was done at Northwestern University's Feinberg School of Medicine (Obstetrics Gynecology).
Laronda talks about their main patient focus: childhood cancer survivors whose treatment or disease may have rendered them infertile later in life. She talks about bioprosthetic ovaries and the uses of 3D printing. As she explains, their early work has shown success in mice, and she discusses what that means for future research. The PhD explains how egg cells work, and the natural decline that happens over time, as well as how disease can affect them. She discusses the complexity of the ovary, and her lab's research in which they investigated biochemical differences, etc. to assist in the development of the best bioprosthetics. She discusses transplanted tissue and how long it can last once transplanted.
The endocrinology expert explains their scaffolding models and her team's hopes for further study. And Laronda provides information on the micro-environment, scaffolding proteins, etc. that play a role in cellular functions.
In this podcast you'll learn:
How 3D printing is helping to advance bioprosthetic development
The importance of primordial follicles
How disease can impact fertility
Mackenzie Wells has always had an interest in the science behind flavors and aromas, which led her to take a job right out of high school in the coffee roasting business. Over the past four years, she's refined her skills and knowledge set in the world of coffee roasting and become quite the expert. She joins the podcast today to discuss the details of the roasting process, different coffee roasting techniques, three primary heat sources used in roasting, three methods of coffee decaffeination, how a coffee bean's flavor profile is affected by the location in which it's grown, the rising popularity of barrel-aged coffees, what it means to say that a coffee bean is of a "single origin" and so much more. In this episode, you will learn:
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