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Copyright: © Richard Jacobs
In this podcast, Dr. Mehdi Soleymani-Goloujeh, Department of Stem Cells and Developmental Biology at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, in Iran, discusses regenerative medicine, types of extracellular vesicles and the current state of extracellular vesicles research.
Podcast Points:
Dr. Soleymani-Goloujeh discusses exosomes. Exosomes are membrane-bound extracellular vesicles (EVs), produced in the endosomal compartment of nearly all eukaryotic cells.
EVs, unlike cells, cannot replicate. Dr. Soleymani-Goloujeh talks about the roles that extracellular vesicles can play in the body, and he expounds upon issues regarding insulin and discusses how the pancreas utilizes EVs.
Dr. Soleymani-Goloujeh's work covers multiple areas. His work has included research in the area of diabetes, cell-penetrating peptides, extracellular vesicles, and stem cells, cell therapy, nanotechnology, and tissue engineering. Dr. Soleymani-Goloujeh provides an overview of the process of insulin delivery and the delivery of drugs throughout the body. He continues by discussing EV engineering and the various factors that are involved to facilitate efficient delivery.
Dr. Soleymani-Goloujeh talks in detail about multiple technologies that pertain to type 1 diabetes, discussing the important roles of exosomes, as well as signaling, and the power of nature.
For 23 years, Cali Estes, Ph.D. has been working with all types of people struggling from all kinds of addictions—from heroin or cocaine or alcohol to food or shopping or pornography.
She discusses the following:
Dr. Estes works with a wide range of individuals, from the ordinary person to the NFL athlete to some of the most popular celebrities, all of whom struggle in one way or another with some type of addiction. It is her belief that addiction cannot be resolved simply by getting a person to remove the addictive substance or behavior from their life, but by digging deeply until the root cause of addictive behaviors is uncovered; only then can an addiction truly be addressed.
She discusses why many conventional approaches to recovery don't work for a lot of people, and what's wrong about the fundamental assumptions such programs rely upon.
Dr. Estes' approach is a combination of several methods, including talk therapy, cognitive behavioral therapy techniques, life coaching, addiction coaching, motivational interviewing, and techniques that address brain damage from years' worth of substance use.
She discusses how she helps people with her Sober On-Demand program, and proprietary uses of a machine which repairs damaged receptors in the brain. Dr. Estes truly takes a holistic approach to each and every client, addressing their personal and unique needs and goals.
In her opinion, the goal isn't just to be sober or free from addiction: the goal is to be happy while sober, and happy while free from addiction.
For more information, visit https://caliestes.com/ and https://theaddictionscoach.com/.
From a business perspective, the Christian market is one of the most underserved markets in the natural health space. Eric Zielinski (commonly called Dr. Z) is a doctor of chiropractic, public health researcher, best-selling author, and producer of the Hope for Breast Cancer documentary, and he joins the podcast to discuss a number of interesting topics, such as the following:
Biblical health is about healthy living without violating Christian beliefs, and if you ask Dr. Z, he'll tell you it's being severely overlooked and undervalued by many Christians. He argues that this is in large part due to the many concerns and lack of awareness surrounding certain practices and substances becoming increasingly popular in the natural health sector, such as aromatherapy, CBD, essential oils, yoga, and energy healing.
One of the biggest problems he sees in this regard is a detrimental double standard: "This is the double standard: I don't see a lot of folks…Mormons, or Jews or Christians or Muslims concerned about opioids or concerned about chemotherapy or highly addictive, potentially damage-causing pharmaceutical drugs, so I'm trying to put things into perspective for people. Why are you so concerned about a plant…an essential oil, when you're going to take a pharmaceutical without a second thought?" he says.
He goes on to explain that the key is in educating people and raising awareness about a variety of practices and substances used in health and wellness, and modern medicine.
Press play for more.
Alejandro Reyes, Associate Professor, Microbiologist and MSc in Biological Sciences, the University of the Andes, discusses microbes and the importance of gut health.
Podcast Points:
Reyes holds a Ph.D. in Computational and Systems Biology at Washington University in San Luis, MO, United States. Reyes discusses his background and work, and his more than ten years of research studying the microbiome.
Reyes's work is focused on Applied Computational Biology, in the development of many tools that can be used for the analysis of data that is derived from current technologies of optical studies, such as genomics, transcriptomics, metabolomics, etc. for the characterization and classification of microbial communities and their interactions with the environment.
He is interested in applications that can be applied to human health outcomes. He discusses viruses and the microbiome in detail, touching on the many viruses that may not make you sick, but stay with you nonetheless, over time.
The microbiologist discusses what he specifically studies, regarding the microbiome, detailing information on phages. Bacteriophages, commonly referred to as simply, phages, are the most plentiful organisms within the biosphere. They are an ever-present feature of prokaryotic existence. A bacteriophage, specifically speaking, is a virus that infects a bacterium.
Viruses, as we know often infect bacteria, are perhaps the most diverse components of the biosphere, genetically speaking. And the characterizing of phage diversity within the human gut is creating a buzz in the science community in regard to how we view ourselves as supra-organisms. Reyes discusses phage therapy in detail, and he talks about how phages are triggered, providing information on bacteria and how they sacrifice themselves.
Reyes continues his discussion by providing information on his thoughts regarding cell attachment. Additionally, he discusses phage population and some other studies they conducted, and he states there is so much that they still must learn about viruses, genes, and phages.
Dr. Carolyn Kurle describes how a biogeochemical tool can explain the foraging patters and locations of animals to improve ecosystem management strategies.
She explains:
Associate professor in the ecology and behavior and evolution sections at UC San Diego, Dr. Carolyn Kurle works with animal foraging data to improve wildlife management efforts. In this conversation, she explains in particular how stable isotope analysis presents ratios of light to heavy nitrogen and carbon isotopes that tell researchers where an animal has eaten and what they have eaten.
She elucidates this complex system by first explaining trophic interactions ecology—a level system from producers up to herbivores, than omnivores, and finally to top predator carnivores. The heavier isotope accumulates at each level and the resulting ratio of heavy to light gives specific-enough information to make foraging inferences.
Wildlife managers can create ecosystem management strategies by using this data to understand, for example, how essential the white bark pine needle tree is to grizzly bears. Therefore as this tree is facing disease and pest infestation with reduced numbers, managers know to plan for more effective and specific grizzly bear management.
Dr. Kurtle discusses many other examples, including those that show how troubling biomagnification issues for California Condors might be better managed by understanding which populations depend on marine life with high toxic levels.
For more, see her website at http://biology.ucsd.edu/research/faculty/ckurle
Rupert Sheldrake, PhD, biologist, and author, known for his hypothesis of morphic resonance, discusses morphogenetic fields, morphic resonance, evolutionary biology, and much more.
Podcast Points:
During his tenure at Cambridge University, Dr. Sheldrake worked in developmental biology as a Fellow of Clare College. Dr. Sheldrake discusses his background and his lifelong love of biology, starting out as a young boy—cultivated through his connections to animals and interest in plants. He discusses his thoughts on science throughout his studies at Cambridge and Harvard.
He talks about form development, and the many questions of science, detailing some of his research in cells and cell death. He provides a detailed analysis of his thoughts on morphogenetic fields. A morphogenetic field, simply defined, is a group of cells that are able to respond to separate, local biochemical signals that lead to the development of precise morphological structures, or organs.
Continuing, Dr. Sheldrake talks about plant and animal development, and modules that are organized by morphogenetic fields. Expanding his discussion, he explains how fields work, discussing electromagnetic fields and gravitational fields. As he explains, fields are spread out, in and around, a developing plant or animal, and they contain a formal structure, which is what molds or shapes the developing structures.
He cites examples that substantiate his theories, regarding fields and the wholly integrative nature of those fields. He discusses his theories on morphic resonance, and how individual organisms can draw on collective memories of the form of their ancestors.
Going further, Dr. Sheldrake explains his other thoughts on form and other hypotheses regarding memory, and the brain's memory storage abilities, detailing morphic resonance and how the evidence, he states, points to the fact that the brain actually tunes in to memory, but that memory is not actually 'stored.'
Many suffers of thyroid issues that are only offered one medicinal choice, but Dr. Shames says there are several natural supplements that provide meaningful holistic wellness. In this conversation, you'll hear:
Author Dr. Richard Shames has been in private practice for 25 years but shifted his focus after witnessing his wife's search for relief from symptoms due to irregular thyroid measures. The Synthroid prescription the endocrinologists she first saw did not ease her symptoms, but after being connected with a university research group, she found relief from holistic health treatment. They wrote the book Feeling Fat, Fuzzy, or Frazzled? to educate readers about better options to treat and balance our three hormone-producing glands: the thyroid, adrenal, and reproductive glands.
He discusses why the diabetes epidemic may have overshadowed thyroid treatment's need for fuller attention. Because the medical system is less apt to look at hormone balance from a broader perspective, often the standard T3 medicine lacks the holistic wellness available from natural thyroid medicine.
Furthermore, he explains how the thyroid, adrenal glands, and reproductive glands make for a hormone system that needs to be balanced in concert with each other. For example, women are often prescribed estrogen, which actually increases thyroid-binding agents in your bloodstream. By treating patients through a holistic wellness lens, these three hormonal-producing systems can work more effectively together.
For more information such as recommended doctors, see the Top Docs list at http://www.thyroid-info.com/index.htm.
He also recommends seeking out a nutritional practitioner in addition to supplemental information. Dr. Shames also has a website at http://thyroidpower.com/
At Turn Biotechnologies, the team is attempting the seemingly impossible: the reversal of ageing.
On today's podcast, you'll learn the following:
"It is possible to reverse the epigenetic landscape of the cells and bring it back in time so that a cell, which by the process of aging becomes dysfunctional with time, can actually be reprogrammed or reversed in a way that it becomes more youthful and more functional, and this could have repercussions on the cell itself, but also broadly speaking, systemically in the individual," says Vittorio Sebastiano, explaining the premise of Turn Bio, a company for which he serves as both co-founder and scientific advisory board chairman.
Sebastiano expounds on a number of interesting subjects, including what causes genes to express certain types of cells and what types of environmental stimuli may disrupt this programming, leading to the creation of dysfunctional cell types (i.e. what he calls the process of ageing), various methods of epigenetic regulation, the hallmarks of cellular ageing, the important distinction between ageing and senescence, and what he sees in terms of both short-term and long-term goals with this work.
Visit https://www.turn.bio/ to learn more.
Denis Noble, CBE, Ph.D., FRS, the celebrated and outspoken British biologist, physiologist, and prolific author, discusses his incredible, noteworthy career in biology, exciting concepts in genetics, and the level of causation in biology.
Podcast Points:
British biologist, Noble has long been a major voice in modern biology. Dr. Noble was the Burdon Sanderson Chair of Cardiovascular Physiology at the University of Oxford for more than two decades. He was later named Professor Emeritus. Additionally, Dr. Noble was appointed the Co-Director of Computational Physiology.
Dr. Noble is one of the earliest researchers in systems biology and he played an integral role in the development of the first mathematical model of the human heart. His thoughts on evolutionary theory have been part of a growing movement, a sort of revolution in evolutionary biology.
Dr. Noble discusses his background and talks about what got him interested in his areas of research and study. As a self-described 'card-carrying reductionist scientist,' Dr. Noble was interested in the concept of a privileged level of causation. And as he states, it was really always about, and is about, simply molecules. He recounts some early experiments he engaged in, attempts to reproduce the rhythm of the heart, with differential equations representing the molecular event.
Which molecules are involved? This was an important question for the research. After much experimentation and study, he came to the conclusion that the cell itself is partially causing what happens. Rhythm only occurs by something that is constrained by the cell membrane. He explains the complex details of how the process works and how differential equations will not lead to answers unless the appropriate information is added into the mix.
The research scientist discusses how DNA is produced, and how cells have mechanisms for controlling errors. Cells, in short, have great control over what happens within systems. Dr. Noble goes on to discuss other important experiments, in the nervous system and other systems such as the immune system. Continuing, the Ph.D. expert talks about the genome.
He discusses the origin of diseases and the fact that we know very little about biology above the level of the genome, in contrast to what we know about molecular biology in general. But remarkably, we still don't know exactly how cells work.
One-third of our population faces some type of sleep disorder. Dr. Dholakia strives to increase awareness.
In this podcast, he explains:
Board-certified neurologist and sleep specialist Dr. Swapan Akhilesh works as a physician at the Atlanta VA Medical Center and is the medical director of the Atlanta VA sleep laboratory as a neurologist for sleep disorders.
He focuses on the whole spectrum of sleep disorders from snoring to sleep apnea to insomnia. He discusses that while obstructive sleep apnea and insomnia are the most common disorders, there are numerous other disorders worthy of study because their effects can be dangerous.
Because of the overlap of neurology and sleep, Dr. Dholakia is able to bring the science of each together for better understanding. As a neurologist for sleep disorders, he is able to explain neurological complications that lead to these disorders.
For example, the inability of some brains to decompartmentalize waking versus sleeping states causes narcolepsy. Because these lines are blurred for the brain, sleeping intrudes into wakeful times.
He also explains many of the mysteries in sleep disorders such as idiopathic hypersomnia: they don't understand why these patients are constantly sleepy and are undergoing research to try and understand this better.
Finally, Dr. Dholakia explains possible improvements into more common issues like sleep apnea treatments but also warns of the commonness of sleep disorders that can affect our health. Therefore, he's working to educate and encourage the public to seek treatment.
He advises veterans who want to learn more to seek out the VA's specialized sleep centers. The American Academy of Sleep Medicine and the American Alliance of Healthy Sleep are also good resources.
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