Stay ConnectedWelcome to New Frontiers in Functional Medicine, Longevity & Epigenetics™ where I interview the best minds in functional medicine to discuss the science and research behind medicine, longevity, epigenetics, and so much more. Expect thought-provoking ideas, new research, lots of clinical pearls for practitioners, and step-change information for clinicians and patients. Join us! ~DrKF
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Join me and Dr. Colleen Cutcliffe, my brilliant friend, scientist, and the powerhouse CEO of Pendulum, for our deepest dive yet into all things Akkermansia. This free-flowing conversation will take your understanding of this extraordinary strain to a whole new level. We’ll explore Akkermansia’s pivotal role in metabolic health—think cravings, weight regulation, A1C—and why we’re deficient in the first place. Plus, we’ll discuss its connection to stress, anxiety, and even neurodegenerative diseases. We’ll also dive into the hotly debated topic of Akkermansia’s impact on MS, unpacking both sides of the controversy. And, we’ll touch on its promising influence on hormonal balance, from infertility to menopause.
As someone who's deeply invested in science, I’m personally bullish on Akkermansia and trust Pendulum’s products as part of my own foundational health stack. With groundbreaking science and fresh insights, this episode will change the way you approach your practice. ~DrKFCheck out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.
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For many struggling with depression, the message they often hear from traditional care is "just live with it" or "there’s nothing more we can do." In today’s episode, we’re challenging that narrative. I’m joined by Dr. Achina Stein and Silvia Covelli from the Healing Depression Project - a groundbreaking residential treatment and research program. Dr. Stein, a functional psychiatrist, and Silvia, who’s personally battled chronic depression, are offering a fresh approach to treatment-resistant depression. Their in-residence program, launching in March, takes a whole-person approach—integrating nutrition, lifestyle changes, trauma healing, and community support. And with research built into the program, they’re not just helping patients; they’re also paving the way to make this approach more accessible for everyone. If you’re ready to rethink depression treatment, this episode is for you. ~DrKF
Check out the show notes at https://tinyurl.com/2t55s3y3 for the full list of links and resources.
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NOW ACCEPTING APPLICATIONS The team at Healing Depression Project is thrilled to announce an upcoming 45-Day Depression Recovery Program starting on March, 2025. The program includes a 30-day in-person retreat at a deluxe and serene ranch in Austin, TX, followed by a 15-day at-home integration phase, ensuring sustainable improvement. Scholarship Opportunities Available: Participants who are invited to apply can also apply for a scholarship program. If a scholarship is awarded, it can cover up to 80% of the total investment. Schedule a call for details: https://tinyurl.com/2z3dxtv7THANK YOU TO OUR SPONSORS DIAMOND DUTCH: https://dutchtest.com/for-providers
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Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz
YouTube: https://tinyurl.com/hjpc8daz Instagram: https://www.instagram.com/drkarafitzgerald/ Facebook: https://www.facebook.com/DrKaraFitzgerald/ DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb Younger You Group Program: https://tinyurl.com/4hvusavw Younger You book: https://tinyurl.com/mr4d9tym Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfwWe’re doing a deep dive into NAD, a molecule that has received a lot of attention but still confuses many of us, clinicians included. My guest today is able to unpack the complexities of NAD in a way you’ll find extremely illuminating and useful. I’m excited to have Dr. Greg Kelly Senior Director of Product Development at Qualia, back with us, explaining how NAD is foundational for energy, longevity, and overall cellular health. Dr. Kelly brings clarity to how NAD influences mitochondrial function, DNA repair, and pretty much all of the hallmarks of aging. Yet, problematically, it declines as we age. This episode will cover different NAD compounds, how deficiency might present clinically, and how to measure NAD reliably. Have a listen and get ready to expand your understanding around this essential compound. ~DrKF
Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.
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After my conversation with Dr. Greg Fahy in August, I realized that I had additional questions that we didn't have time to address the first time around. Importantly, since here I am studying the effects of dietary and lifestyle interventions on aging, I wanted to know his thoughts on the dietary components of the TRIMM study and beyond. Dr. Fahy shares his thoughts on my question and some others on side effects on different medication and supplement interventions, the mechanism by which he thinks the restoration of hair color occurred in some of his study participants, and how to think about (and feel motivated about!) incorporating safe exercise. This brief bonus podcast episode is just right for squeezing into your holiday schedule. Enjoy! ~DrKF
Missed the first conversation with Dr. Greg Fahy? Catch up on the original episode for key insights and context before diving into the follow-up! https://tinyurl.com/bdcwktbj Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast for the full list of links and resources. GUEST DETAILS Greg Fahy, PhD Intervene Immune: https://interveneimmune.com/who-we-are/ Email: fahy@interveneimmune.com Dr. Greg Fahy received his Ph.D. in Pharmacology and Cryobiology from the Medical College of Georgia in 1977. A world-renowned cryobiologist, Dr. Fahy is the chief science officer and co-founder of Intervene Immune, where he leads groundbreaking research on thymus regeneration and combating age-related immune decline. He designed and led the TRIIM trial, the first to demonstrate both thymus rejuvenation and the reversal of human epigenetic age. His work has been pivotal in advancing aging research, resulting in successful follow-up trials like TRIIM-XA, and further planned studies aimed at refining and expanding these innovative treatments. WORK WITH OUR TEAM At Dr. Fitzgerald’s New Frontiers Functional Medicine and Nutrition Clinic, we specialize in personalized root cause medicine, offering both in person and virtual consultations. Our team of functional medicine physicians and nutritionists is trained in the research based, Younger You Longevity Protocol and experienced in working with many conditions, including gastrointestinal, immune, cardiovascular, metabolic, brain, and many more, and in supporting those seeking optimal wellness. Ready to explore how we can help you feel your best? Visit https://tinyurl.com/yx4fjhkb to book a free15-minute Discovery Call today. Want more? CONNECT WITH DrKF Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz YouTube: https://tinyurl.com/hjpc8daz Instagram: https://www.instagram.com/drkarafitzgerald/ Facebook: https://www.facebook.com/DrKaraFitzgerald/ DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb Younger You Group Program: https://tinyurl.com/4hvusavw Younger You book: https://tinyurl.com/mr4d9tym Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfwThe brain’s ability to recover after trauma is astonishing—and often overlooked in conventional care. In this episode of New Frontiers in Functional Medicine, I sit down with Dr. David Musnick, a long-time friend and brilliant clinician, to explore how we can unlock the brain’s full potential for healing. Dr. Musnick challenges the standard of care for traumatic brain injuries and post-concussion syndrome, introducing a functional medicine approach that integrates advanced tools like Frequency-Specific Microcurrent, targeted nutritional strategies, and personalized interventions.
His insights into the stages of recovery, the importance of addressing neuroinflammation, and the role of the gut-brain connection were a true "aha" for me. We also dive into groundbreaking methods for reversing secondary brain damage, a concept that could change everything for patients and practitioners alike. This conversation is packed with actionable takeaways and hope for those navigating brain injuries, cognitive impairment, or persistent post-concussion symptoms. You don’t want to miss it.~DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast for the full list of links and resources. GUEST DETAILS David Musnick MD FMI Center for Optimal Health http://www.fmioptimal.com http://www.peakmedicine.com Clinic: (208)609-9130 David Musnick MD is a Sports Medicine and Functional Medicine MD who practices in Eagle Idaho and Bellevue WA. In 2016 he developed the first program to heal the brain after Concussion based on the Pathophysiology mechanisms that go on after a Concussion and TBI. He has healed hundreds of patients and is published on his approach in the book Integrative Neurology. In his practice he defines the brain areas that have been injured and develops a detailed approach to healing these areas. His approach integrates food choices, supplements, sleep, exercise, EMF protection, HBOT and Frequency Specific Microcurrent. He has expanded his approach to also treat Cognitive Impairment and other Neurological disorders such as MS and Parkinson’s. He sees patients in both Idaho and Washington but can see patients from other states on Telemedicine via a Peer to Peer consultation. THANK YOU TO OUR SPONSORS DIAMOND DUTCH: https://dutchtest.com/for-providers Biotics Research: https://www.bioticsresearch.com/ Integrative Therapeutics: https://tinyurl.com/4emwj48z GOLD OneSkin: https://tinyurl.com/ycxtw4zt TimeLine Nutrition:: https://tinyurl.com/bdzx2xmsQUALIA: Try Qualia NAD+ for up to 50% off! Visit https://qualialife.com/drkarafitzgerald and use code DRKARAFITZGERALD at checkout for an additional 15% off your entire purchase!
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CONNECT WITH DrKF Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz YouTube: https://tinyurl.com/hjpc8daz Instagram: https://www.instagram.com/drkarafitzgerald/ Facebook: https://www.facebook.com/DrKaraFitzgerald/ DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb Younger You Group Program: https://tinyurl.com/4hvusavw Younger You book: https://tinyurl.com/mr4d9tym Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfwFor anyone who has been paying attention, you may already know that the takeaways related to hormone replacement therapy (HRT) from the original Women’s Health Initiative (WHI) study have been completely overhauled. It’s about time! As a result, it’s not an understatement to say that we are in the midst of a total transformation in hormone replacement therapy (HRT) and it’s essential that as providers we (1) get up to speed on the nuances of the new interpretations and (2) learn how to personalize the guidance we give. Dr. Allison Smith, from Precision Analytical, is really a bright, guiding light in this new era of hormone care. She joins me in this episode of New Frontiers to start to unpack some of those important considerations and share resources for where practitioners can learn more. She explains why more detailed hormone metabolite testing can provide answers to hormonal symptoms when standard serum measures of testosterone and estrogen are “normal.” She also shines a light on the need for understanding how our patients are metabolizing hormones, especially if they are on HRT as well as to optimize their long-term cardiovascular, bone, skin, and brain health. This is indispensable listening and I’m sure you’ll enjoy this conversation as much as I did. - DrKF
Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.
Dr. Allison Smith, ND, Lead Clinical Educator at Precision Analytical
Email ="email" target="_blank">drsmith@dutchtest.com
Dr. Allison Smith completed her N.D. at the National University of Natural Medicine in Portland, Oregon, and has worked in private practice focusing on primary care, women’s health and dermatologic laser therapy. Over the last 10 years, she has consulted with providers on thousands of cases in the context of hormone testing and brought awareness of testing to providers in clinical practice through consulting, webinars, case presentations, and articles. She now leads an esteemed lineup of clinical educators at Precision Analytical, home of the DUTCH test.Precision Analytical, Home of the DUTCH Test https://dutchtest.com/
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Talking with Dr. Julie Faitg was a powerful reminder of just how much we’re discovering about mitochondria and aging. When you pair an elite mitochondrial scientist with a breakthrough nutrient like Urolithin A, the insights go beyond what you’d expect. Julie gives us this incredible look into how we can actually change the course of aging at the cellular level. This conversation made me rethink what we know about supporting long-term health and resilience, and I think it will do the same for you. It’s one of those big-picture, eye-opening conversations that I can’t wait for you to hear. ~DrKF
CHECK OUT THE SHOW NOTES AT https://www.drkarafitzgerald.com/fxmed-podcast/ for a full list of links and resources. GUEST DETAILS Dr. Julie Faitg, PhD Email: jfaitg@timeline.com Dr. Julie Faitg is a leading expert in mitochondrial research, with over nine years of experience focusing on muscle and brain biology, and recently expanding her expertise to include skin health. Holding a PhD in Translational and Clinical Research from the Wellcome Trust Centre for Mitochondrial Research, she collaborates with renowned scientists worldwide, including Nobel laureate Eric Kandel and mitochondrial experts. Currently, Dr. Faitg serves as the Senior Translational Scientist and Regulatory Affairs Lead at Timeline, where she makes significant contributions to research and development across various organ systems in the field of mitochondrial biology.Timeline: https://tinyurl.com/4x832df9 SPECIAL OFFER: Timeline is offering a 10% discount on all of their products to New Frontiers listeners. Head over to https://tinyurl.com/4x832df9 and use code KaraSkin at checkout.
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It’s not overstating it to say that I have cited Dr. Artemis Simopoulos’ work in virtually every lecture I have ever given that included the topic of omega-3 fatty acids. She is an incredible human being, indomitable NIH researcher, and absolute legend in her field. In our conversation on New Frontiers, Dr. Simopoulos reviews those essential truths about the evolution of our dietary intake of omega-3 vs. omega-6 fatty acids, the increase in ultra-processed food consumption, and how these play into our health landscape today. She also pulls on some particularly interesting threads around genetic variability in our ability to metabolize fatty acids and the implications of this for inflammatory conditions (of course, almost all chronic diseases have an inflammatory component). This is especially relevant for “rapid metabolizer” populations that tend to over-produce prostaglandins and leukotrienes, compared to resolvins, when exposed to a standard American diet. I know her insights will inform how you personalize your recommendations. - DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources. GUEST DETAILS Artemis P. Simopoulos, M.D., President, The Center for Genetics Nutrition and Health https://tinyurl.com/4x2zahxk Artemis P. Simopoulos, M.D., the author of The Healthiest Diet for You: Scientific Aspects (her latest book), is the Founder and President of the Center for Genetics, Nutrition and Health, a nonprofit educational organization in Washington, D.C. since 1990. A graduate of Bar- nard College, Columbia University, with a major in Chemistry, and a graduate of the Boston University School of Medicine, she is a physician and endocrinologist whose research at the National Institutes of Health (NIH) was on the nutritional aspects of genetic and endocrine disorders; evolutionary aspects of diet and fatty acids; and the importance of a balanced ratio of omega-6/omega-3 fatty acids in health and disease and in growth and development. Dr. Simopoulos is a world authority on essential fatty acids and was nutritional adviser to the Office of Consumer Affairs at the White House. She is the author of The Omega Diet; The Healing Diet and has completed a Chapter for the Encyclopedia of UN- ESCO on “Omega-3, Omega-6, Omega-9 Fatty Acids: Sources, Metabolism and Supplements.” She is currently Consulting Editor to Lifestyle Genomics. Dr. Simopoulos has edited over 60 books and journal supplements in addition to publishing over 370 scientific papers. She has received many awards, has been Visiting Professor and Keynote Speaker worldwide.
THANK YOU TO OUR SPONSORS DIAMOND Integrative Therapeutics: https://tinyurl.com/4emwj48z Biotics Research: https://www.bioticsresearch.com/ Integrative Therapeutics: https://tinyurl.com/4emwj48z GOLD OneSkin: https://tinyurl.com/ycxtw4zt TimeLine Nutrition:: https://tinyurl.com/bdzx2xms MIDROLL QUALIA: Try Qualia Senolytic at http://qualialife.com/Kara15 with code KARA15 for 15% off. DUTCH -- Learn more about DUTCH Testing https://tinyurl.com/2y24st67 CONNECT WITH DrKF: Want more? Join our newsletter here: https://tinyurl.com/mrx7ykbr YouTube: https://tinyurl.com/hjpc8daz Instagram: https://www.instagram.com/drkarafitzgerald/The centrality of gut health in total body health and aging means it’s a key topic for us to keep revisiting and updating our knowledge on. For instance, how confident do you feel about interpreting analytical indices such as phyla distribution, dysbiosis index, diversity score, as well as the myriad bacterial populations that can be resident in the GI tract? Join me and Dr. Julia Malkowski as we dive into advanced stool testing and how the insights gleaned from the GI360 test can tell us a lot about our patients’ health and lifestyle (ever wondered how the carnivore diet, long-term use of GLP-1 agonists, or chronic stress impact the gut?). We also explore keystone bacterial species and their impact on systemic health, what is better than fiber for increasing microbiome diversity, different testing methods including the impressive MALDI-TOF Mass Spectrometry Technology and a ton of clinical pearls on tackling those report findings in clinical practice. There is something for everyone in this excellent conversation with Dr. Julia Malkowski, from the newly-minted to the seasoned functional medicine practitioner, and health-savvy consumers too. Tune in, grab your GI360 Sample Report and get ready to take notes! ~DrKF
Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.
Julia Malkowski, ND, DC, BSc
Dr. Malkowski began her career in Functional Medicine upon seeing excellent results restoring the health of her infant son. She went on to complete her bachelor's degree in biomedical science, Doctorate in Chiropractic and Doctorate in Naturopathic Medicine, while raising her healthy family. She remains committed to optimal health on a personal and professional level as Staff Doctor of Clinical Education at Doctor’s Data, Inc., and maintains her own private functional medicine practice Docere Health outside Chicago, IL.Doctor’s Data, Inc. https://doctorsdata.com/GI360-stool
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It's important to me to include a variety of voices in the sphere of aging and longevity, and Matt Kaeberlein PhD is certainly one that I appreciate for his tempered and rational arguments. I value his insights and his work with other scientists who are tussling with the challenging questions and research interpretations in this field. We are at this extraordinary inflexion point where scientists are debating the very definition of aging itself, which has important implications for how we then measure and study it. Dr. Kaeberlein shares his thoughts on this as well as the latest on longevity interventions such as rapamycin, metformin, intermittent fasting, and caloric restriction. Find out why he thinks we'll always hit a wall with moving the needle on lifespan, and why healthspan is such an important target. I think you will find this conversation illuminating and useful. An additional note for any of my listeners/readers who have been tracking the various discussions around the utility of epigenetic clocks and other measures of aging: I personally very much believe in epigenetics, even as the field continues to evolve. The foundation of this traces back to my beginnings in this field, working under my mentor Richard Lord PhD, who taught me that as scientists and clinicians we have no choice but to embrace uncertainty. No laboratory tests are as precise as many of us would like to think they are - microbiome, organic acid, nutrient testing, those foundational tools of functional medicine that we are very comfortable using, included. This applies to standard labs too - I recently received a notification from one of the two biggest labs in the US stating that, due to a change in the testing instrument used, values for red cell indices (the oldest tests on the planet!) would be altered compared to prior results. As clinicians we have to grapple with uncomfortable uncertainty in medicine every single day - from that reality we still have to move forward and make the best clinical decisions we can. Epigenetic age testing is simply another tool in the mix that can add value to understanding a patient's picture, and we can use it even as we interpret it with a similar acknowledgement of uncertainty. If you would like to add your thoughts to this discussion, please share below. - DrKF
Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.
Matt Kaeberlein, PhD, CEO, Optispan ="https://tinyurl.com/2r89rvdd" target="_blank">https://tinyurl.com/2r89rvdd
Email ="email" target="_blank">Matt@optispan.life
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