CRISPR Cuts

Imran House and Junyun Lai Discuss CRISPR Screening in Immuno-Oncology Jan 31, 2024

Imran House, Ph.D. and Junyun Lai Ph.D. are Senior Scientists at the biotech start-up, oNKo-Innate in Melbourne, Australia that focuses on developing immuno-oncology therapies. In this episode, they discussed what they do at oNKo-innate, their career transitions from leaving academics to entering the biotech industry, and how CRISPR is impacting cancer-immunotherapy development. They also discussed overcoming common obstacles faced when developing cytokine therapies and future outlooks on clinical trials using these kinds of therapies.

Reach out and connect with both Imran and Junyun on social media platforms:

Imran House, Ph.D.

X: @ImranHouse

Junyun Lai, Ph.D.

X: @JunyunLai

Mark DeWitt and Don Kohn Discuss Their ex vivo CRISPR-based Therapy to Cure Sickle Cell Anemia Oct 20, 2023

Dr. Mark DeWitt Ph.D., Associate Director at Mammoth Biosciences, and Dr. Don Kohn M.D., distinguished professor and Director of the UCLA Human Gene and Cell Therapy Program and CIRM grantee sat down with us to discuss their latest clinical trials to cure sickle cell anemia, how synthetic guides accelerated their journey from the bench to the clinic, and their experience in the cell and gene therapy space.

Dina Simkin Breaks Down Epilepsy Cell Modeling May 16, 2023

Dina Simkin, Professor of Neurology at Northwestern University, joins us in this episode of CRISPR Cuts. Dr. Simkin talks about her path to becoming a researcher, art, and the importance of patient and isogenic iPSC models to study genetically linked forms of epilepsies.

Sunil Sharma and Raffaella Soldi Talk CRISPR For Unbiased Drug Screening for Rare Pediatric Cancers Apr 24, 2023

Dr. Sunil Sharma and Dr. Raffaella Soldi of the Translational Genomics Research Institute chat about using CRISPR arrayed screens to identify novel drug targets for Ewing's Sarcoma, outlooks for the future of cancer therapies, and the Arizona heat.

Stephanie Cherqui Discusses Clinical Development of CRISPR Therapies for Rare Diseases Mar 20, 2023

Professor Stephanie Cherqui, UCSD, has worked on the development of cell therapies for two rare genetic diseases, cystinosis and Friedreich’s ataxia. In this interview, Dr. Cherqui chats about her experience working on rare diseases, developing a CRISPR-edited therapy for Friedreich's ataxia, navigating regulatory challenges in cell and gene therapies, and more.

Christian Groendahl On Pioneering a CRISPR-based Microbial Gene Therapy Dec 05, 2022

Tune in to hear Christian Groendahl, CEO of SNIPR Biome, talk about CRISPR editing in prokaryotes, their novel E. coli-targeting CRISPR therapy trials, and his experiences and vision leading a start up.

Bryan Dechairo Envisions an Accessible Future for CRISPR Diagnostics Sep 06, 2022

In this episode, Bryan Dechairo, CEO of Sherlock Biosciences, talks about the impact of technology advances in the field of CRISPR diagnostics, his experiences leading Sherlock Biosciences, and his team’s mission of accessibility.

Ayal Hendel Talks About CRISPR in Bubble Boy Disease Jun 07, 2022

Dr. Ayal Hendel, a genome-editing pioneer and group leader at Bar Ilan University in Israel, was one of the first researchers to use modified synthetic sgRNA to edit primary cells with CRISPR. In this episode, Dr. Hendel shares his perspectives on the recent CRISPR advancements and his work on the bubble boy disease.

Jimi Olaghere Opens up About His Sickle Cell Disease and CRISPR Trial May 05, 2022

Jimi has dealt with sickle cell disease, a genetic disorder with serious implications, his entire life. Undergoing a CRISPR gene editing trial turned his hope for a cure into reality with promising results from the early phases. Tune in to learn about Jimi's journey in this episode.

TJ Cradick Speaks About Their HIV CRISPR Therapy in Trials Mar 31, 2022

TJ Cradick, Chief Scientific Officer at Excision Bio, discusses their CRISPR HIV therapy that recently proceeded into clinical trials in this episode and their ongoing work on other viral diseases.

Bryce Olson Relays His Experience on Personalized Therapies for Cancer Patients Mar 15, 2022

After being diagnosed with aggressive prostate cancer, Bryce Olson quickly learned the science behind it and has leveraged NGS to understand his tumor genomics and find opportunities in personalized therapies. Hear the patient perspective for the first time on our podcast through Bryce's narration of his experience and pursuit of next generation cell and gene therapies.

Neville Sanjana Discusses Ways to Enhance CRISPR-Cas13 Knockdown in Human Cells Jan 28, 2022

In this collaboration episode with NEB, we interview Dr. Neville Sanjana, a core faculty member at the New York Genome Center, about his recent publication in which chemically modified guide RNAs were used to enhance CRISPR-Cas13 knockdown in human cells.

Kiana Aran Chats About her Nature Award and New Non-Profit Nov 15, 2021

In this episode, we chat with Dr. Kiana Aran, the CSO of Cardea Bio and associate professor at Keck Graduate Institute, who recently won the Nature Research Award for Inspiring Women in Science. Dr. Aran talks about her experience being a nominee and award winner, her early days and scientific journey, and the launch of her new non-profit, Aran Nebula.

6 Women CRISPR Leaders Get Candid About Their Journeys to the Top Oct 28, 2021

We chatted with six female leaders in the CRISPR—Alison van Eenennaam, Ph.D., Kiana Aran, Christina Trojel-Hansen, Ph.D., Laura Lambert, Ph.D., Elena Miñones Moyano, Ph.D., and Samantha Maragh, Ph.D.— about their professional journeys.

Tune in to this episode for a candid and honest discussion on a broad range of topics, including their experiences as women of color, life as working moms, adjusting in male-dominated fields, experiences being part of the LGBTQIA community, and the role of mentors in professional development.

Jesse Boehm Discusses Tackling Rare Cancers Using CRISPR Jul 28, 2021

In this CRISPR Cuts episode, Dr. Jesse Boehm, the Chief Scientific Officer of the Break Through Cancer Foundation and principal investigator at the Broad Institute, talks about his work on rare cancers. He also covers how CRISPR technology is transforming cancer research.

NIH Scientists Discuss the iNDI Project for Alzheimer's Disease Modeling Jun 13, 2021

The Inducible Pluripotent Stem Cell Neurodegeneration Initiative (iNDI), an NIH effort, aims to standardize disease models for Alzheimer’s and related dementias. Hear the principal contributors, Dr. Michael E. Ward and Dr. Mark R. Cookson, scientists at the NIH, talk about the inception of the iNDI project, the challenges and opportunities, and the future of neurodegenerative research.

Joe Miano Talks About Prime Editing in Mice May 26, 2021

Prime editing is a new genome engineering tool that emerged just a couple of years back. Right from the get-go, this technology made waves as a potential alternative to CRISPR. Now, the first comparative study in mice is out. Dr. Joe Miano, Professor at the Augusta University in Georgia, talks about their collaborative work comparing traditional CRISPR-mediated homology-directed repair with prime editing in mice.

IGI Researchers Are Using CRISPR to Reduce Cyanide in Cassava Apr 28, 2021

Did you know cassava can cause cyanide poisoning if it is not processed correctly and consumed with a protein-poor diet? In this episode, we chat with IGI researchers, Jess Lyons and Michael Gomez about their work on using CRISPR to reduce cyanide in cassava and improve its food safety.

Kevin Davies Chats About His Latest Book "Editing Humanity" Mar 30, 2021

Kevin Davies, the executive editor of The CRISPR Journal, has closely watched the genetics space evolve over the last decades. His expertise and experience were the perfect foundation for his latest book "Editing Humanity: The CRISPR Revolution and the New Era of Genome Editing." In this episode, Kevin discusses his motivation for the book, along with some behind-the-scenes stories when writing this timely literature piece.

Michael Friend Advocates For Diversity in CRISPR Feb 23, 2021

In this episode, Michael Friend, CEO of Minority Coalition for Precision Medicine, discusses the lack of diversity in genome editing field and covers potential solutions for ensuring an inclusive future, particularly for black scientists.

CRISPR Forecast 2021 with Paul Dabrowski and Robert Deans Jan 12, 2021

In this episode, Paul Dabrowski, CEO of Synthego, and Robert Deans, CSO of Synthego, discuss the CRISPR silver linings of 2020 and predict the directions and milestones for gene editing in 2021.

CRISPR Office Hours with Hamid Ghanadaan May 20, 2020

The COVID-19 pandemic is a unique situation for lab scientists, many of whose work has come to a standstill. Hamid Ghanadaan, CEO of Linus, discusses the impact of COVID-19 on science and the next steps for scientists, based on their survey of >1000 scientists.

Ryan Pawell Talks About Indee Labs’ CRISPR Delivery Technology for Affordable Immunotherapies May 07, 2020

The mission of Indee Labs, a Berkeley biotech, is to deliver CRISPR reagents into cells using microfluidics for developing affordable cell and gene therapies in the future. We interviewed Ryan Pawell, Founder and CEO of Indee Labs, about the concept of using microfluidics for CRISPR delivery, their mission and ongoing projects, and the convergence of engineering and biology for building scalable platforms.

Making of a CRISPR Film: Behind the Scenes with Producers of Human Nature Apr 22, 2020

What is the process to make a science film? In this episode, Sarah Goodwin and Elliot Kirschner, producers of Human Nature, a documentary on CRISPR, offer glimpses into making of the film.

Leading St. Jude's Genome Engineering Capabilities: A Chat with Shondra Miller Jan 28, 2020

Shondra Miller shares her experience of starting a shared genome engineering resource at the St. Jude Children's Research Hospital. Learn more about her research projects and her views on the past, present, and future of the genome editing field in this podcast episode.

The Potential of CRISPR Editing in Stem Cells: An Interview with Bill Skarnes Nov 13, 2019

Dr. Bill Skarnes, Professor at The Jackson Laboratory, chats about how CRISPR edited stem cells are becoming a gold standard to study gene function and disease modeling.

CRISPR in Fungi: An Interview with Rebecca Shapiro Sep 04, 2019

Rebecca Shapiro, Assistant Professor at the University of Guelph, talks about CRISPR genome editing in fungal pathogens to understand their disease-causing mechanism. Her lab also works on gene drives in fungi for studying large scale genetic interactions and developing ways for treating fungal biofilms.

Paul Dabrowski Gets Candid About the Past, Present, and Future of Synthego Aug 07, 2019

In this interview, Paul Dabrowski, CEO of Synthego, talks about how Synthego got started, his mantra behind leading the company, and future directions. He also offers insights into Synthego’s unique capabilities⁠—the powerful combination of engineering and biology that enable scaling.

Dana Foss is Solving the CRISPR Delivery Problem to Advance Therapeutics May 22, 2019

CRISPR has great potential in therapeutics, but CRISPR delivery in vivo remains a challenge. Researcher Dana Foss discusses her lab’s novel approach for specific delivery of CRISPR components in cells and tissues.

SHERLOCK Founders Crack the Case of CRISPR Diagnostics May 08, 2019

CRISPR is going beyond gene editing into a new area: diagnostics. Omar Abudayyeh and Jonathan Gootenberg, co-founders of SHERLOCK Biosciences, talk about the present advances and future of CRISPR diagnostics.

Kiana Aran Chats About Her New Biosensor: CRISPR-Chip Apr 18, 2019

Kiana Aran, a biomedical engineering expert, talks about her research on CRISPR-Chip, a new biosensor that combines CRISPR & electronics to detect specific genes in genomic DNA.

How the Innovative Genomics Institute is Helping People Understand CRISPR Mar 19, 2019

Megan Hochstrasser, Science Communications Manager at the Innovative Genomics Institute, talks about the importance of CRISPR science communication and the ongoing efforts at IGI to help people understand this genome engineering tool.

Improving Targeted Delivery to Enhance Personalized Medicine Feb 26, 2019

Andre Watson, CEO of Ligandal, talks about how his company is improving the payload delivery of gene therapy, making it more accurate and efficient, to make new gene therapy a reality for the public.

Alex Philippidis Reviews Trends in Biopharma & Biotech Market Feb 07, 2019

Biotech and biopharma companies are in a phase of accelerated growth. Alex Philippidis, a science journalist at Genetic Engineering & Biotechnology News discusses the changing face of big pharma, biotech, and CRISPR gene editing industries, as they raise more money and the world changes around them.

Avery Posey Discusses CAR T Cell Cancer Therapies Jan 24, 2019

Dr. Avery Posey is leading the charge on CAR T cell therapy research to bring this technology to cancer patients as soon as possible. Learn how CAR T works, what stage it’s in now, and how it will help revolutionize the treatment of cancer.

Trevor Martin Discusses How CRISPR is Changing Diagnostics Jan 10, 2019

Trevor Martin, CEO of Mammoth Biosciences, talks about the science behind CRISPR diagnostics, and what Mammoth is doing to bring it to consumers in the next decade.

CRISPR for Curious Minds Dec 13, 2018

In this Holiday-special mash-up episode, CRISPR Cuts teams up with Curiosity podcast to discuss the ins and outs of CRISPR. Gear up, it's going to be a fun ride!

Andrew Porterfield Discusses CRISPR in the Grocery Store Nov 21, 2018

Andrew Porterfield is a scientific marketing consultant, science journalist, and all around science communicator. We caught up with Andrew to discuss the latest news about how CRISPR is impacting the agriculture industry and how the various regulatory decisions related to this technology may shape its use and adoption in different parts of the world.

Alison Van Eenennaam Edits Cattle Using CRISPR Nov 09, 2018

Alison Van Eenennaam is a geneticist at UC Davis, primarily interested in using CRISPR and other DNA-based biotechnologies in cattle production and agricultural systems. Learn about her exciting projects, ranging from "All Boys" cattle to hornless dairy cows, and the technical difficulties of working with large mammals in this episode.

CRISPR in Gene Drives: Experts Opine Oct 23, 2018

Gene drives have frequently been in the news in the past few years. In this episode, we discuss what exactly gene drives are, their applications, and how scientists are ensuring that they are used responsibly. Tune in to hear what researchers Anna Buchman from UCSD and Kevin Esvelt from MIT had to say.

Knockout Cell Pools Are Simplifying CRISPR Experiments Oct 03, 2018

Dr. Ania Wronski, Product Manager for the Engineered Cells portfolio at Synthego, discusses how their new engineered cells products are enabling CRISPR access to researchers worldwide. Learn about the different ways in which researchers use knockout cell pools & their advantages over RNAi.

CRISPR Edited Animals & Their Applications Sep 18, 2018

What do you think of when you hear the term "transgenic animal"? The hippogriff from Harry Potter? A mouse model to study diabetes? Kevin and Minu discuss what transgenic animals are, how they are used in research, and how CRISPR has changed the transgenic game. After listening, head over to The Bench blog to read more about CRISPR and transgenic animals.

Carl Zimmer Discusses Heredity, Genomics, and CRISPR Sep 05, 2018

It's not every day you get to meet one of your idols! Minu and Kevin caught up with Carl Zimmer, an award-winning New York Times columnist and science journalist. Minu chatted with Zimmer and got a rare behind-the-scenes glimpse into his latest book "She Has Her Mother's Laugh" and discussed his views on CRISPR and genomics.

Reed Kelso Strives to Enable CRISPR Access For All Scientists Aug 24, 2018

Reed Kelso, Head of Cell Engineering Research and Applications at Synthego, is a bio-wizard. In this episode, Kevin & Minu catch up with Reed about his role at Synthego and the day-to-day operations at the fast paced start-up. Reed talks about the revolutionary engineered cells products that he and his team recently launched & the hard work behind this amazing achievement. He also speculates about the future applications of CRISPR; his bets are on CRISPR making a massive splash in agriculture!

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