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    Life Sciences

    Blood Podcast

    Stay up to date on the latest research and reviews for both clinical and basic hematology with Blood podcast, published weekly in conjunction with each issue of Blood. Additionally, Blood review series podcasts feature in depth discussion with authors of recently published review articles. Subscribe and never miss a new episode.

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    Copyright: © 2023 American Society of Hematology

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    Latest Episodes:
    Hemophilia prophylaxis with fitusiran vs BPA/CFC; germline NBN variants in pediatric B-ALL; Histone demethylation and cell-intrinsic immune response in AML May 30, 2024
    Show notes

    In this week's episode we'll learn about fitusiran prophylaxis in patients with hemophilia A or B, with or without inhibitors. Next we'll hear about new findings that heterozygous germline variants in the NBN gene that are linked to increased risk of B-cell acute lymphoblastic leukemia in children. Finally, we'll explore new insights on the histone demethylase PHF8, which has been identified as a master regulator of cell-intrinsic immune responses in acute myeloid leukemia.

    Featured Articles:

    • Fitusiran prophylaxis in people with hemophilia A or B who switched from prior BPA/CFC prophylaxis: the ATLAS-PPX trial
    • Germline genetic NBN variation and predisposition to B-cell acute lymphoblastic leukemia in children
    • Epigenetic control over the cell-intrinsic immune response antagonizes self-renewal in acute myeloid leukemia
    Effects of voxelotor on cerebral blood flow in pediatric sickle cell disease; thrombosis in Vexas syndrome; response to tyrosine kinase inhibitors in ABL-class acute lymphoblastic leukemia May 23, 2024
    Show notes

    In this week's episode we’ll discuss the effects of voxelotor on cerebral blood flow in pediatric sickle cell disease, learn more about venous and arterial thrombosis in patients with Vexas syndrome, and discuss differential sensitivity to tyrosine kinase inhibitors in ABL-class acute lymphoblastic leukemia.

    Featured Articles:

    • The influence of voxelotor on cerebral blood flow and oxygen extraction in pediatric sickle cell disease
    • Venous and arterial thrombosis in patients with VEXAS syndrome
    • Tyrosine kinase inhibitor response of ABL-class acute lymphoblastic leukemia: The role of kinase type and SH3 domain
    Stamping out high-risk myeloma with D-KRd and tandem transplant; plasmin-cleaved VWF in microthrombosis; SCD plasma sensitizes iPSC-derived sensory neurons May 16, 2024
    Show notes

    In this week's podcast we'll discuss another step forward in stamping out high-risk myeloma. Then we'll hear about the plasmin-cleaved von Willebrand factor, or VWF, in microthrombosis. Finally we'll hear about new insights into the origins of sickle cell pain.

    Featured Articles:

    • Daratumumab, carfilzomib, lenalidomide, and dexamethasone with tandem transplant for high-risk newly
      diagnosed myeloma
    • Plasmin-cleaved von Willebrand factor as a biomarker for microvascular thrombosis
    • Sickle cell disease iPSC-derived sensory neurons exhibit increased excitability and sensitization to patient
      plasma
    Allogeneic transplant in first remission for post-induction molecular MRD; circulating HSPCs actively participate in human hematopoiesis; let-7 miRNAs repress HIC2 to regulate BCL11A transcription and hemoglobin switching May 09, 2024
    Show notes

    In this week's episode we’ll discuss the utility of MRD in identifying patients with NPM1 AML who benefit from allogeneic transplant in first remission, learn more about the contribution of circulating hematopoietic stem/progenitor cell subsets to human hematopoietic hemostasis, and discuss the role of Let-7 miRNAs in regulation of BCL11A transcription and hemoglobin switching.

    Featured Articles:

    • Postinduction molecular MRD identifies patients with NPM1 AML who benefit from allogeneic transplant in first remission
    • let-7 miRNAs repress HIC2 to regulate BCL11A transcription and hemoglobin switching
    • Circulating Hematopoietic Stem/Progenitor Cell subsets contribute to human hematopoietic homeostasis


    ADAMTS13 recovery in caplacizumab-treated TTP; inhibition of venetoclax-resistant BCL2 variants with sonrotoclax; genomic insights from Castleman disease in twins May 02, 2024
    Show notes

    In this week's epside we'll learn about ADAMTS recovery after caplacizumab therapy in patients with immune thrombotic thrombocytopenic purpura. Then, we'll hear about preclinical characterization of sonrotoclax, a potential second-generation BCL2 inhibitor. Finally we'll hear about new insights into the etiology of Castleman disease where researchers describe the unusual occurrence of idiopathic multicentric Castleman disease in identical twins.

    Featured Articles:

    • ADAMTS13 recovery in acute thrombotic thrombocytopenic purpura after caplacizumab therapy
    • Sonrotoclax overcomes BCL2 G101V mutation–induced venetoclax resistance in preclinical models of
      hematologic malignancy
    • Single-cell landscape of idiopathic multicentric Castleman disease in identical twins
    Durable response after tisa-cel in adults with relapsed/refractory follicular lymphoma; high microRNA-145 plasma levels indicate decreased risk of VTE; epigenetic/immunogenetic signature in the prediction of outcomes for high-count monoclonal B lymphocytosis Apr 25, 2024
    Show notes

    In this week's episode, we’ll discuss the findings from a study assessing responses after treatment with tisagenlecleucel [LM1] in adults with relapsed/refractory follicular lymphoma, learn more about the association between high microRNA-145 plasma levels and decreased risk of future incident venous thromboembolism, and discuss how epigenetic and immunogenetic signatures can be used in the prediction of outcomes for high-count monoclonal B lymphocytosis.


    Featured Articles:

    • Durable Response After Tisagenlecleucel in Adults With Relapsed/Refractory Follicular Lymphoma: ELARA Trial Update
    • Prediction of outcomes for high-count monoclonal B lymphocytosis using an epigenetic and immunogenetic signature
    • High microRNA-145 plasma levels are associated with decreased risk of future incident venous thromboembolism: The HUNT study
    Gut microbiota exploitation by CPX-351 in AML; optimizing anti-myeloma immunity for ASCT; which pediatric ITP patients will develop lupus? Apr 18, 2024
    Show notes

    In this week's episode, we'll discuss gut microbiota exploitation by CPX-351 in acute myeloid leukemia. Then we'll learn about optimizing anti-myeloma immunity. New research shows that regulatory T cells suppress myeloma-specific immunity during autologous stem cell mobilization and transplantation. Finally we'll discuss among pediatric patients with ITP or other autoimmune cytopenias, which ones will go on to develop systemic lupus?

    Featured Articles:

    • CPX-351 exploits the gut microbiota to promote mucosal barrier function, colonization resistance, and immune homeostasis
    • Regulatory T cells suppress myeloma-specific immunity during autologous stem cell mobilization and transplantation
    • Antinuclear antibody–associated autoimmune cytopenia in childhood is a risk factor for systemic lupus erythematosus
    Jak2V617F clonal hematopoiesis promotes arterial thrombosis; Staphylococcus aureus infection in Sézary syndrome; clinical features of RAC2-related immunodeficiency Apr 13, 2024
    Show notes

    In this week's episode we’ll discuss the mechanism by which Jak2V617F clonal hematopoiesis promotes arterial thrombosis, discuss how Staphylococcus aureus induces drug resistance in cancer T cells in Sézary syndrome, and learn more about the clinical and functional features of RAC2-related immunodeficiency.

    Featured Articles:

    • Jak2V617F clonal hematopoiesis promotes arterial thrombosis via platelet activation and cross talk
    • Staphylococcus aureus induces drug resistance in cancer T cells in Sézary syndrome
    • Clinical and functional spectrum of RAC2-related immunodeficiency


    Molecular mimicry in aplastic anemia; emicizumab prophylaxis in infants with hemophilia; hydroxyurea reduces infections in SCA Apr 04, 2024
    Show notes

    In this week's episode we'll discuss molecular mimicry in aplastic anemia, novel experiments show that antigens associated with viral infections can mimic epitopes presented on hematopoietic progenitor cells. Then, we'll learn about prophylaxis with subcutaneous emicizumab in infants with hemophilia. Finally we'll see how hydroxyurea is associated with a significant reduction in infections among children with sickle cell anemia in Uganda.

    Articles featured this week:

    • Virus-reactive T cells expanded in aplastic anemia eliminate hematopoietic progenitor cells by molecular
      mimicry
    • Emicizumab prophylaxis in infants with hemophilia A (HAVEN 7): primary analysis of a phase 3b open-label
      trial
    • Hydroxyurea reduces infections in children with sickle cell anemia in Uganda
    Review Series on the Influence of the Tumor Microenvironment on the Pathogenesis of B-Cell Lymphomas Mar 28, 2024
    Show notes

    In this bonus episode of Blood Podcast, Associate Editor, Dr. Freda Stevenson is joined by Drs. Karin Tarte, Andrea Radtke, and Leandro Cerchietti to discuss the Review Series on the influence of the tumor microenvironment on the pathogenesis of B-cell lymphomas.

    Find the full review series in Blood Journal volume 143 issue 12.

    Previous 1 13 14 15 16 17 40 Next

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