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    Big Picture Science

    The surprising connections in science and technology that give you the Big Picture. Astronomer Seth Shostak and science journalist Molly Bentley are joined each week by leading researchers, techies, and journalists to provide a smart and humorous take on science. Our regular “Skeptic Check” episodes cast a critical eye on pseudoscience.

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    Copyright: © Big Picture Science 2025

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    Latest Episodes:
    Skeptic Check: After the Hereafter Aug 08, 2016
    Show notes

    There are few enduring truths, but one is that no one gets out of life alive. What’s less certain is what comes next. Does everything stop with death, or are we transported to another plane of existence? First-hand accounts of people who claim to have visited heaven are offered as proof of an afterlife. Now the author of one bestseller admits that his story was fabricated.

    We’ll look at the genre of “heaven tourism” to see if it has anything to say about the possible existence of the hereafter, and why the idea of an afterlife seriously influences how we live our lives on Earth.

    Also, a neurologist describes what is going on in the brain during near-death and other out-of-body experiences.

    It’s Skeptic Check, our monthly look at critical thinking … but don’t take our word for it!

    Guests:

    • Ben Radford – Paranormal investigator, research fellow at the Committee for Skeptical Inquiry and deputy editor of the Skeptical Inquirer, and author of the Discovery News article, “Why People Believed Boy’s ‘Visit to Heaven’ Story”

    • Greg Garrett – Professor of English at Baylor University, writer on books, culture and religion for the Huffington Post, and author of Entertaining Judgment: The Afterlife in Popular Imagination

    • Steven Novella – Professor of neurology at Yale University School of Medicine and host of the “Skeptic’s Guide to the Universe” podcast

    Originally Aired May 24, 2015

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    Raising the Minimum Age Jul 18, 2016
    Show notes

    We all try to fight it: the inexorable march of time. The fountain of youth doesn’t exist, and all those wrinkle creams can’t help. But modern science is giving us new weapons in the fight against aging. So how far are we willing to go?

    Hear when aging begins, a summary of the latest biotech research, and how a lab full of youthful worms might help humans stay healthy.

    Also, a geneticist who takes a radical approach: collect the DNA that codes for longevity and restructure our genome. He finds inspiration – and perhaps genes as well – in the bi-centenarian bowhead whale.

    But what if age really is mind over matter? A psychologist’s extraordinary thought experiment with septuagenarian men turns back the clock 20 years. Will it work on diseases such as cancer as well?

    Guests:

    • Gordon Lithgow – Geneticist, Buck Institute for Research on Aging, Novato, California
    • Manish Chamoli – Post-doctoral researcher, Buck Institute for Research on Aging
    • George Church – Professor of Genetics, Harvard Medical School, author of Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves
    • Ellen Langer – Professor of Psychology, Harvard University and author of Counterclockwise: Mindful Health and the Power of Possibility

    First released April 6, 2015.

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    Microbes: Resistance is Futile Jul 11, 2016
    Show notes

    You are what you eat. Whether you dine on kimchi, carnitas, or corn dogs determines which microbes live in your stomach. And gut microbes make up only part of your total micro biome.

    Find out how your microbes are the brains-without-brains that affect your health and even your mood. Also, why you and your cohorts are closer than you thought: new research suggests that you swap and adopt bugs from your social set.

    Plus, the philosophical questions that are arise when we realize that we have more microbial DNA than human DNA.

    And a woman who skipped soap and shampoo for a month to see what would grow on her.

    Guests:

    • Bill Miller – Physician and author of The Microcosm Within: Evolution and Extinction in the Hologenome
    • Beth Archie – Biologist at the University of Notre Dame
    • Nada Gligorov – Assistant professor of medical education at Mount Sinai Hospital
    • Julia Scott – Freelance reporter working in San Francisco. Her article, “A Wash on the Wild Side” appeared in the May 22, 2014 issue of the New York Times Magazine. of the New York Times Magazine.

    First released

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    Science Fiction True Jul 04, 2016
    Show notes

    Don’t believe everything you see on TV or the movies. Science fiction is just a guide to how our future might unfold. It can be misleading, as anyone who yearns for a flying car can tell you. And yet, sometimes fantasy becomes fact. Think of the prototype cellphones in Star Trek.

    We take a look at science that seems inspired by filmic sci-fi, for example scientists manipulating memory as in Sunshine of the Spotless Mind. And despite his famous film meltdown, Charleton Heston hasn’t stopped the Soylent company from producing what it calls the food of the future.

    Plus, why eco-disaster films have the science wrong, but not in the way you might think. And, what if our brains are simply wired to accept film as fact?

    Guests:

    • Steve Ramirez -Neuroscientist, Massachusetts Institute of Technology
    • Rob Rhinehart – CEO and founder of Soylent
    • Jason Mark – Editor of Earth Island Journal
    • Jeffrey Zacks – Cognitive Neuroscientist, Washington University, St. Louis, and author of Flicker: Your Brain on Movies


    First released December 22, 2014.

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    Skeptic Check: The Me in Measles Jun 27, 2016
    Show notes

    Wondering whether to vaccinate your children? The decision can feel like a shot in the dark if you don’t know how to evaluate risk. Find out why all of us succumb to the reasoning pitfalls of cognitive and omission bias, whether we’re saying no to vaccines or getting a tan on the beach.

    Plus, an infectious disease expert on why it may take a dangerous resurgence of preventable diseases – measles, whooping cough, polio – to remind us that vaccines save lives.

    Also, a quaint but real vaccine fear: that the 18th century smallpox vaccine, made from cowpox, could turn you into a cow!

    It’s our monthly look at critical thinking … but don’t take our word for it!

    Guests:

    • Paul Offit – Infectious disease specialist at the Children’s Hospital of Philadelphia
    • Neil deGrasse Tyson – Astrophysicist, director of the Hayden Planetarium in New York City
    • Adam Korbitz – Lawyer specializing in space law
    • Andrew Maynard – Professor of environmental health science, director, Risk Science Center, University of Michigan

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    Surviving the Anthropocene Jun 13, 2016
    Show notes

    The world is hot, and getting hotter. But higher temperatures aren’t the only impact our species is having on mother Earth. Urbanization, deforestation, and dumping millions of tons of plastic into the oceans … these are all ways in which humans are leaving their mark.

    So are we still in the Holocene, the geological epoch that started a mere 11,000 years ago at the end of the last ice age? Some say we’ve moved on to the age of man – the Anthropocene.

    It’s the dawn of an era, but can we survive this new phase in the history of our planet?

    Guests:

    • Pat Porter - Relative
    • Jonathan Amos – Science writer for the BBC in London
    • Gaia Vince – Writer, broadcaster, former editor for New Scientist, news editor of Nature, and author of Adventures in the Anthropocene: A Journey to the Heart of the Planet We Made
    • David Grinspoon – Astrobiologist, senior scientist at the Planetary Science Institute in Tucson, Arizona
    • Francisco Valero – Emeritus physicist and research scientist at the Scripps Institution of Oceanography at the University of California, San Diego


    Originally aired February 23, 2015.

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    How to Talk to Aliens Jun 06, 2016
    Show notes

    "Dear E.T. …” So far, so good. But now what? Writing is never easy, but what if your task was to craft a message to aliens living elsewhere in the universe, and your prose would represent all humankind? Got writer’s block yet?

    What to say to the aliens was the focus of a recent conference in which participants shifted their attentions away from listening for extraterrestrial signals to transmitting some. In this show, we report on the “Communicating Across the Cosmos” conference held at the SETI Institute in December 2014.

    Find out what scientists think we should say. Also, how archeology could help us craft messages to an unfamiliar culture. Plus, why journalists might be well-suited to writing the message. And, a response to Stephen Hawking’s warning that attempting to contact aliens is too dangerous.

    Guests:

    • Douglas Vakoch – Director of interstellar message composition, SETI Institute
    • Paul Wason – Archaeologist, anthropologist and vice president for the life sciences and genetics program at the Templeton Foundation
    • Al Harrison – Emeritus professor of psychology, University of California, Davis
    • Morris Jones – Journalist and space analyst in Sydney, Australia
    • Shari Wells-Jensen – Professor of English, Bowling Green State University


    First released January 12, 2015.

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    Shocking Ideas May 09, 2016
    Show notes

    Electricity is so 19th century. Most of the uses for it were established by the 1920s. So there’s nothing innovative left to do, right? That’s not the opinion of the Nobel committee that awarded its 2014 physics prize to scientists who invented the blue LED.

    Find out why this LED hue of blue was worthy of our most prestigious science prize … how some bacteria actually breathe rust … and a plan to cure disease by zapping our nervous system with electric pulses.

    Guests:

    • Siddha Pimputkar – Postdoctoral researcher in the Materials Department of the Solid State Lighting and Energy Electronics Center under Shuji Nakamura, winner of the 2014 Nobel Prize in Physics, University of California, Santa Barbara
    • Jeff Gralnick – Associate professor of microbiology at the University of Minnesota
    • Kevin Tracey – Neurosurgeon and president of the Feinstein Institute for Medical Research in New York


    First released December 2014.

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    Living Computers May 02, 2016
    Show notes

    It’s the most dramatic technical development of recent times: Teams of people working for decades to produce a slow-motion revolution we call computing. As these devices become increasingly powerful, we recall that a pioneer from the nineteenth century – Ada Lovelace, a mathematician and Lord Byron’s daughter – said they would never surpass human ability. Was she right?

    We consider the near-term future of computing as the Internet of Things is poised to link everything together, and biologists adopt the techniques of information science to program living cells.

    Plus: What’s your favorite sci-fi computer?

    Guests:

    • Walter Isaacson – President and CEO of the Aspen Institute and the author of The Innovators: How a Group of Hackers, Geniuses, and Geeks Created the Digital Revolution
    • Christopher Voigt – Bioengineer at MIT
    • Andy Ihnatko – Technology journalist
    • André Bormanis – Writer, screenwriter, Star Trek
    • John Barrett – Electronic engineer, NIMBUS Centre for Embedded Systems Research at the Cork Institute of Technology, Ireland

    First released December 7, 2014.

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    Moving Right Along Apr 18, 2016
    Show notes

    You think your life is fast-paced, but have you ever seen a bacterium swim across your countertop? You’d be surprised how fast they can move.

    Find out why modeling the swirl of hurricanes takes a roomful of mathematicians and supercomputers, and how galaxies can move away from us faster than the speed of light.

    Also, what happens when we try to stop the dance of atoms, cooling things down to the rock bottom temperature known as absolute zero.

    And why your watch doesn’t keep the same time when you’re in a jet as when you’re at the airport. It’s all due to the fact that motion is relative, says Al Einstein.

    Guests:

    • William Phillips – Nobel Prize-winning physicist at Joint Quantum Institute, a partnership between the National Institute of Standards and Technology and the University of Maryland.
    • Bob Berman – Astronomy writer and author of Zoom: How Everything Moves: From Atoms and Galaxies to Blizzards and Bees
    • Michael Smith – Meteorologist, senior vice president of AccuWeather Enterprise Solutions, and author of Warnings: The True Story of How Science Tamed the Weather


    First released August 18, 2014.

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