Beyond the Endpoint

It's Not Just the Scale: Supporting Sustainable Change in Obesity Treatment Oct 08, 2025

In the first of a three-part series on obesity and GLP-1 medications, our guest Jennifer Norris shares the evolving landscape of obesity treatment. The conversation addresses common misconceptions and examines how GLP-1 medications, such as Ozempic, have transformed care alongside surgery and lifestyle interventions.

Beyond the Headlines: Funding Research, Vaccines, Sleep Health, and AI in Healthcare Sep 24, 2025

The "Beyond the Headlines" series returns with summer healthcare and research news. Hosts Manesh Patel and Emily O'Brien discuss misconceptions about research funding, a Danish study on vaccine safety, the potential impacts of poor sleep, and how AI tools are transforming medical practice and training. Tags: #medicalnews #healthnews #research #clinicalresearch

Understanding Autism: Insights from Research and Practice Sep 10, 2025

Ushering in the second season of Beyond the Endpoint, Lauren Franz, MBChB, MPH, interim director of the Duke Center for Autism and Brain Development, joins Manesh Patel and Emily O'Brien for an in-depth conversation about autism research, care, and community. Franz explains what autism is as a neurodevelopmental spectrum condition and how our understanding of it has evolved significantly over the last decade. The discussion examines the intricate interplay between genetic and environmental factors that may contribute to the development of autism, and explores current intervention approaches. The hosts and guest also discuss the groundbreaking research at Duke University that employs artificial intelligence to analyze medical records for earlier detection of autism. This approach could help shorten the time between when autism can be diagnosed and when it is typically identified. Throughout the episode, Franz stresses the importance of involving the autism community in research and decision-making processes.

Playing to Advance Care: A Championship Mindset in Clinical Research Jun 04, 2025

What do championship sports teams and successful research institutions have in common? In the season finale of Beyond the Endpoint, Dr. Adrian Hernandez joins hosts Manesh Patel and Emily O’Brien to break down what clinical research institutions can learn from their counterparts on the court. From basketball dynasties to resilient mindsets, Dr. Hernandez offers a powerful playbook on building strong research systems, prioritizing patients, and why sharing “negative” results matters. Don’t miss the wrap-up to Season 1! 🔗 Access resources related to this episode https://dcri.org/blog/ep-10-playing-advance-care-championship-mindset-clinical-research

Beyond the Headlines: Protein myths. Anti-aging hype. Autism research. A new diabetes drug? May 07, 2025

In this new episode of the Beyond the Endpoint series, “Beyond the Headlines,” hosts Emily O’Brien and Manesh Patel break down what’s you should know about these trending medical topics. From hype to headlines—get clinical insight that goes deeper. Access resources related to this episode https://dcri.org/blog/ep-9-beyond-headlines 187880

Stepping Up: From Curiosity to Confidence — What to Know Before You Join a Trial Apr 23, 2025

Why do people volunteer for clinical trials — and what should they know before doing so? In this episode of Beyond The Endpoint, we explore common questions, reasons, and myths about clinical trial participation. Hosts Manesh Patel and Emily O’Brien talk with guest Krista Camuglia, a Research Practice Manager with the Duke Heart Center Clinical Research Unit, who brings unique insights thanks to her work on the frontlines of research coordination. 🎙️ Listen to "Part 1: Why Participate in Clinical Research?" https://dcri.org/blog/ep-7-stepping-why-participate-clinical-research

Stepping Up: Why Participate in Clinical Research? Apr 09, 2025

In this episode, cancer survivor Katie Ortman-Doble opens up about her journey through clinical research and why she chose to participate. Hosts Emily O’Brien and Manesh Patel, joined by Jenny Cook, talk about the life-saving potential of clinical trials and the real impact they have on patients and science. Hear Katie’s inspiring story and the reasons behind her decision to join a trial. 🔗 Access resources related to this episode https://dcri.org/blog/ep-7-stepping-why-participate-clinical-research

Bridging Science and Policy: A Conversation with Dr. Robert Califf Mar 25, 2025

In this episode of Beyond the Endpoint, former FDA commissioner Dr. Robert Califf joins hosts Manesh Patel and Emily O’Brien to discuss critical challenges shaping the future of patient care. From misinformation to regulatory science to the financialization of healthcare, Dr. Califf has unique insight into the evolving healthcare landscape and the role of data in improving patient outcomes. 🔗 Access resources related to this episode https://dcri.org/blog/ep-6-bridging-science-and-policy-conversation-dr-robert-califf

Beyond the Headlines: What’s trending in medical news? Mar 08, 2025

Ozempic curbing alcohol cravings, ADHD linked to shorter life expectancy, and an NBA rising star diagnosed with DVT—what does the science actually say? In this first episode of Beyond the Headlines, a new Beyond the Endpoint series, hosts Emily O’Brien and Manesh Patel break down the research behind these trending stories. Access resources related to this episode https://dcri.org/blog/ep-5-beyond-headlines

Wearables in Clinical Research: Data, Trends, and Challenges Feb 24, 2025

Smartwatches, fitness trackers, and health data—how are wearables reshaping clinical research? In this episode, Dr. Marat Fudim joins us for an insightful discussion on how wearable technology is shaping the way we monitor health and conduct research. Topics include: • Are wearables improving patient care or just tracking steps? • How do researchers use wearable data in clinical trials? •What are the biggest challenges in integrating this tech? 🎙️ Listen now and explore the possibilities of wearable health tech! 🔗 Access resources related to this episode https://dcri.org/blog/ep-4-wearables-clinical-research-data-trends-and-challenges

The Intersection of Politics and Medicine: Impacts on Clinical Practice Feb 12, 2025

In this episode of Beyond the Endpoint, Emily O’Brien and Manesh Patel sit down with Leslie Curtis, former senior FDA policy advisor, to explore the FDA’s role in balancing science, public health, and regulation, along with how political transitions influence clinical research, healthcare funding, and the approval process for new treatments. 🔗 Access resources related to this episode https://dcri.org/blog/ep-3-intersection-politics-and-medicine-impacts-clinical-practice

Bending the Curve on Hypertension Jan 27, 2025

Reducing hypertension risk isn’t just about cutting salt. This week on Beyond The Endpoint, Emily O’Brien, Manesh Patel, and Jenny Cook talk with Dr. Dhruv Kazi about the complex public health battle against hypertension. From interventions to strategies for patient and physician adherence, this episode covers scalable solutions to change the future of hypertension. 🔗 Access resources related to this episode https://dcri.org/blog/ep-2-bending-curve-rewriting-future-hypertension

Caring Through Loss: The Role of Grief in Clinical Settings Jan 12, 2025

In this episode of "Beyond the Endpoint," hosts Emily O'Brien and Manesh Patel are joined by guest host Jenny Cook to discuss grief among healthcare providers with Tony Galanos, a researcher and physician at the Duke University School of Medicine. Galanos — "Dr. G" as he's called around Duke — shares insights from his 12-year program helping other clinicians to address and process the grief that can be an inevitable part of their work. He highlights the emotional toll that healthcare work can take and the importance of acknowledging and processing grief. The episode explores the concept of the "hidden curriculum" in medical training, the practice of "the pause" after intense resuscitation efforts, and also dives into how everyone can better manage their own grief after losing a loved one. 🔗 Access resources related to this episode https://dcri.org/blog/ep-1-caring-through-loss-role-grief-clinical-settings

Inviting Our Colleagues To Participate In DCRI On Record Apr 28, 2021

Inviting Our Colleagues To Participate In DCRI On Record by Duke Clinical Research Institute

John Shepherd And Michele Nolen Apr 27, 2021

John Shepherd And Michele Nolen by Duke Clinical Research Institute

Assessing Results of Open-label, Comparative Effectiveness Trials for Cardio-metabolic Drugs Dec 09, 2019

Assessing Results of Open-label, Comparative Effectiveness Trials for Cardio-metabolic Drugs by Duke Clinical Research Institute

Duke IBD Podcast Series: IBD and Nutrition Dec 21, 2018

Duke IBD Podcast Series: IBD and Nutrition by Duke Clinical Research Institute

IBD Podcast with Dr. Jane Onken Dec 13, 2018

IBD Podcast with Dr. Jane Onken by Duke Clinical Research Institute

Patient Perspective Nutrition And Diet In Perioperative Recovery Nov 21, 2018

Patient Perspective Nutrition And Diet In Perioperative Recovery by Duke Clinical Research Institute

Nutrition In ERAS: " A Call For Clinical Trials" Nov 21, 2018

Nutrition In ERAS: " A Call For Clinical Trials" by Duke Clinical Research Institute

Data, Innovation & Guidelines in Gastroenterology – Deborah Fisher, MD Oct 26, 2018

Data, Innovation & Guidelines in Gastroenterology – Deborah Fisher, MD by Duke Clinical Research Institute

Sunil Rao at TCT 2018: Meeting Highlights and the #RadialFirst Journey Oct 02, 2018

Sunil Rao at TCT 2018: Meeting Highlights and the #RadialFirst Journey by Duke Clinical Research Institute

Renato Lopes at TCT 2018: SECURE-PCI and Timing for Statin Dosing Oct 02, 2018

Renato Lopes at TCT 2018: SECURE-PCI and Timing for Statin Dosing by Duke Clinical Research Institute

Jennifer Rymer at TCT 2018: Aborted TAVR Procedures and Same-Day Discharge for PCI Oct 02, 2018

Jennifer Rymer at TCT 2018: Aborted TAVR Procedures and Same-Day Discharge for PCI by Duke Clinical Research Institute

Nutrition in Surgery – The Clinician’s Perspective Aug 14, 2018

Nutrition in Surgery – The Clinician’s Perspective by Duke Clinical Research Institute

The Role of the Dietician in Perioperative Nutrition Screening and Care May 31, 2018

The Role of the Dietician in Perioperative Nutrition Screening and Care by Duke Clinical Research Institute

Perioperative Nutrition Optimization Clinics: The Future of Perioperative Care May 31, 2018

Perioperative Nutrition Optimization Clinics: The Future of Perioperative Care by Duke Clinical Research Institute

The Role of Nutrition in 'Strong for Surgery' May 31, 2018

The Role of Nutrition in 'Strong for Surgery' by Duke Clinical Research Institute

Science is the Best Medicine - EP7 May 16, 2017

What are clinical trials? Who should participate in them? And why are they important? In this episode of Science is the Best Medicine, Abhinav Sharma talks to Harvard’s Eugene Braunwald, MD, a cardiologist who’s been a firsthand witness to more than 50 years of clinical trials.

Science is the Best Medicine - EP6 May 09, 2017

Duke’s Mona Fiuzat, PhD, talks with Abhinav Sharma about how scientific discoveries are translated to usable treatments and how the U.S. Food and Drug Administration really works.

Science is the Best Medicine - EP5 May 09, 2017

Cardiologist Joseph Hill, MD, PhD, editor-in-chief of Circulation, discusses what it’s like to run a peer-reviewed journal and how medical discoveries are disseminated in the age of information overload.

Science is the Best Medicine - EP4 May 02, 2017

Medicare, Obamacare, rising costs, and preexisting conditions: The controversy over health care in the United States rages on in Congress and online. In this episode Mark McClellan, director of the Margolis Center for Health Policy and former U.S. Food and Drug Administration commissioner, discusses the complexities of healthcare policy.

Science is the Best Medicine - EP3 May 02, 2017

Robert Lefkowitz, MD, won the Nobel Prize for Chemistry in 2012 for his groundbreaking work on the proteins known as receptors. That research has since influenced the development of a wide variety of drugs including antihistamines, ulcer drugs, and beta blockers. In this episode of the podcast, he discusses his research, his family, and the path that brought him to Duke.

Science is the Best Medicine - EP2 Apr 07, 2017

Every year, more than two million people in the United States get infections that are resistant to antibiotics and at least 23,000 people die as a result, according to the Centers for Disease Control. These so-called "superbugs" represent one of the major public health threats facing the world today. In this episode, Ephraim Tsalik, MD, PhD, discusses the rise of superbugs and how researchers are trying to find new ways to fight them.

Science is the Best Medicine - EP1 Apr 07, 2017

Chronic kidney disease (CKD) is among the most common diseases in the United States, affecting approximately 14 percent of the adult population. The disease, which often goes unnoticed until its advanced stages, can increase the risk of heart attack, stroke, or other serious medical conditions. In this episode of Science is the Best Medicine, Abhinav Sharma, MD, talks with DCRI Co-Chief Fellow John Stanifer, MD, Msc, about his work with CKD research in East Africa and rural North Carolina.

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