TRACK THE VAX

Coming Soon: Track the Vax Nov 25, 2020

Following the race to the COVID-19 Vaccine. Track the Vax will be a limited-series podcast with a goal of explaining how the COVID vaccines work, understanding the mechanism behind their effectiveness, talking to those behind the safety goggles...and trying to stay out of the political fray…and get back to the science. However, like all things these days, when it comes to FDA approval, we may have to step into the political ring. As the government possibly prepares to fast-track a vaccine before phase 3 trials end and a recent vaccine trial was "paused" due to political pressure, we will offer either episodes or perhaps supplemental shows to dive into those issues (in addition to the weekly drop).

FDA Chief Vows Transparency in Vaccine Approvals Dec 01, 2020

As pharmaceutical companies move at warp speed to develop a vaccine, the U.S. agency at the center of emergency approvals is "working around the clock" to evaluate whether the limited data meets the standard for emergency approval, FDA commissioner Dr. Stephen Hahn tells our weekly podcast Track the Vax. So far, U.S.- based Moderna as well as Pfizer and BioNTech have both submitted requests for emergency FDA authorization for their respective vaccines. "We're looking at the data right now and it's too early to draw any conclusions but I can assure you our team is working night and day on this," Hahn said. "When the data analysis is ready... we'll make that available to the american people and the committee." The first immunisations using the BioNTech and Pfizer vaccine could take place in the U.K as early as this week. The FDA's Vaccines and Related Biological Products Advisory Committee is scheduled to discuss the request for emergency use authorization on December 10. Hahn told us he won't prejudge what their decision will be, but says their job is to weigh a variety of criteria as it reviews the data, including the participants included in the studies.

How Do the New COVID-19 Vaccines Work? Dec 09, 2020

The two vaccines showing most promise - and moving first through the regulatory process - are a new type of vaccine known as messenger RNA vaccines. Before COVID-19, mRNA vaccines have never been on the market, but they have been studied. To learn more about the mRNA vaccine technology we chatted with Richard Kuhn, Ph D, who holds an endowed chair at Purdue University and serves as editor-in-chief of Virology.

What Do We Really Know About Pfizer's New COVID Vax? Dec 16, 2020

The first vaccine in the U.S. has been granted Emergency Use Authorization and begun distribution and inoculation among the first group of recipients: frontline healthcare providers and assisted-living residents. Questions remain, however, about Pfizer's data and long-term studies. To learn more we chatted with Pfizer's Vice President and Chief Scientific Officer for viral Vaccines, Dr. Phil Dormitzer, who leads Pfizer's research and development into viral vaccines.

How Do We Inject Confidence Into Vaccine Hesitant Americans? Dec 22, 2020

With a 'return to normal' from the pandemic practically hinging on COVID-19 vaccines, how do you overcome those who are vaccine hesitant? How does vaccination history impact perception and what role do medical professionals have in explaining the science? To learn more we chatted with MedPage Today Editorial Board member Peter Hotez, MD, PhD, Co-Director of the Center for Vaccine Development at Texas Children's Hospital and Dean of the National School of Tropical Medicine at Baylor College of Medicine.

Why Aren't Highest-Risk People Better Represented in COVID Vaccine Trials? Dec 29, 2020

Vaccination across the nation is now underway, with healthcare workers and those living and working in long-term care facilities among the first to receive the vaccines. Long-term and nursing home residents make up about 1% of the U.S. population, but have accounted for roughly 40% of all COVID-19 deaths, while those older than 50 are more likely to die from COVID-19 than younger age groups. However, they've accounted for less than a quarter of total COVID-19 vaccine clinical trial participants. Why are they so scarcely represented in trials? To learn more, we chatted with Sharon Inouye, MD, MPH, a professor of medicine at Harvard Medical School and geriatrician at Hebrew Senior Life. She is also director of the Aging Brain Center at the Hinda and Arthur Marcus Institute for Aging Research. The episode kicks off with a discussion with 60-year old clinical trial participant Kelley Pick, to hear about her experience in a trial.

How Did COVID Vaccine Development Move at Warp Speed? Jan 05, 2021

As vaccine distribution ramps up across the U.S., and globally, skepticism remains. Many cite the speed at which vaccines have rolled out as one of their main concerns. In this episode we explore how we got here, how the biopharmaceutical industry readied for this very moment that allowed them to move at warp speed. The vice president for science and regulatory advocacy at PhRMA, Jim Mayne, PhD, joins us to explain how the science-based, public-private partnerships aided in the momentum, how the R&D ecosystem has evolved and why he believes the bio-pharmaceutical industry was not caught off guard by the pandemic.

The Distribution Debacle Jan 12, 2021

Vaccine distribution — it's been a rocky road. While millions of doses have been shipped, only about one-third have been administered. The federal government has said a lag in reporting as well as the holiday season are partly to blame. But as long lines were seen across the country and in some states a bit of chaos, what happened? Was Operation Warp Speed more about vaccine development than distribution? To examine the issues of what went wrong and what can be done to fix it, in this episode we speak with emergency physician and former Baltimore Health Commissioner Leana Wen, MD, as well as Mike Alkire, president of Premier, the giant medical supply and healthcare technology firm, and host of the "Inside Out" podcast.

COVID-19 Vaccine Policies: Ethical Concerns Jan 20, 2021

Eight COVID-19 vaccines have been approved somewhere in the world, at least for emergency use. In the U.S., only Moderna and Pfizer's two-dose mRNA vaccines are now available for distribution. But as the COVID pandemic continues to run rampant, vaccine supply everywhere remains limited. How did different countries decide who gets it and who doesn't? And what happens to the dozens of phase III clinical trials and their placebo participants who possibly qualify for vaccination with a different shot? To explore these and more ethical questions related to the COVID-19 vaccines, in this episode we speak with Arthur Caplan, PhD, director of the Division of Medical Ethics at NYU Grossman School of Medicine in New York City.

NIH Director: Collaboration Amid Chaos, and Biden's First 100 Days Jan 27, 2021

A new week, and a new administration that has taken over the pandemic response. Now that 1 million vaccine doses are administered almost daily, President Joe Biden has increased the daily vaccination goal to 1.5 million Americans. What will the COVID national strategy actually look like under a new administration, and is Biden's goal achievable? To explore those questions, and what the future of collaboration in science looks like, we chat with NIH Director Francis Collins, MD, PhD.

Can COVID Vaccination Become Mandatory? Feb 02, 2021

New viral strains continue to spread across the country, which has added to the urgency of getting as many people vaccinated as possible. With supplies of the two vaccines currently available in the U.S. falling well short of demand, mandating vaccination is likely not a realistic scenario now. But it could be in the coming months. Is it legal for states, private employers, and even airlines, to mandate a vaccine that has only been approved for emergency use? Who could be held responsible if something goes wrong after getting the shot? Carmel Shachar, JD, executive director of The Petrie-Flom Center for Health Law Policy at Harvard Law School, joins us to explore those legal questions, and more.

COVID Vaccines: Too Risky for Some People? Feb 09, 2021

Nearly 1.5 million Americans are being vaccinated every day against COVID-19. Allergic reactions have led some to question if they should get the vaccine; and scant data from clinical trials for the currently approved vaccines in vulnerable populations means we don't fully know how those with certain conditions will react. Does that mean those with certain allergies or conditions like HIV, multiple sclerosis, or cancer should pass on the shot? What about those who are pregnant? Barbara Alexander, MD, infectious disease specialist at Duke University and current president of the Infectious Diseases Society of America, joins us to explore who should get the shot. Later in the podcast, Mark Turrentine, MD, a professor at the Baylor College of Medicine and co-chair of the American College of Obstetricians and Gynecologists (ACOG) COVID-19 OB Expert Work Group, also joins to explain whether the vaccine is safe for pregnant and nursing women.

Can the Same Vaccines Protect Against New COVID Strains? Feb 16, 2021

As many as a dozen COVID-19 variants are knowingly circulating worldwide. Among them, B.1.1.7 and B.1.351, the highly transmissible strains that originated in the U.K. and South Africa, respectively. As more vaccines continue to push forward for emergency approval worldwide, we're still learning the effectiveness of the current vaccines against the new strains; and how the new mutations mean even those who have already had COVID-19 may not be immune from reinfection. To explore the new strains and what it means for vaccination efforts, future mutations, and herd immunity, Angela Rasmussen, PhD, a virologist with Georgetown University's Center for Global Health Science and Security, joins us on this week's episode.

What Do We Really Know About Adenovirus Vectors for Vaccines? Feb 23, 2021

As the U.S. hits the half-million death mark from COVID-19 -- a grim milestone that is equal to roughly the entire population of Atlanta and more than that of Miami -- a new weapon is being added to the COVID-19 vaccine arsenal. Johnson & Johnson is seeking emergency use authorization for what would become the U.S.'s first one-dose and non-mRNA COVID vaccine. It employs adenovirus vectors, a technology that has been used in labs for decades and was approved for the Ebola vaccine by the FDA in December 2019. It's the same technology that AstraZeneca/Oxford and Sputnik V use. Still, questions remain on how these vaccines may be different than mRNA or similar enough to other existing shots to encourage vaccine uptake. To explain how adenovirus vectors work and what to expect from the new products, Daniel Griffin, MD, PhD, chief of infectious disease at ProHEALTH Care, an Optum unit, joins us on this week's episode.

Latest COVID Vax: One and Done? Mar 02, 2021

Millions of Americans are in line to get one of now three vaccines approved by the FDA for emergency use. The latest — Johnson & Johnson's one-dose adenovirus vector — can be stored for up to three months in a fridge and is easier to transport. Johnson & Johnson is no stranger to the technology, having used it in its Ebola vaccine. Despite its rollout goals of 100 million doses by June, Rick Nettles, MD, vice president of medical affairs at J&J's Janssen division, says researchers are already looking ahead to expanding its use for children and pregnant women. He joins this week's episode.

When Can I Walk Into a Pharmacy And Get a COVID Shot? Mar 09, 2021

Vaccine distribution nationwide continues to ramp up, with nearly 2-million shots being given daily. President Biden has now said that every adult could be vaccinated by the end of May. A big promise that brings with it hope... a light at the end of the COVID-19 tunnel. But when will COVID vaccination be as simple as getting a flu shot? Many of the doses currently being given are at mass-vaccination sites. Will local and national pharmacies be able to simplify the process? The government still controls the supply and distribution of COVID-19 shots. We wanted to understand what that process looks like and when they expect to offer vaccines on-demand. Rina Shah, PharmD, group vice president, for pharmacy operations and services at Walgreens, joins us on this week's episode to answer those questions.

Why Women Experience COVID and the Vaccines Differently Than Men Mar 16, 2021

It's been one full year into the pandemic and it's clear: women are bearing the brunt of it. And it's not only because women have been forced out of the workplace at disproportionate rates — hitting the lowest level of female participation in the workplace since 1988 — or because more than 75% of those working in the healthcare sector are women. In fact, women appear hardwired to experience COVID-19 and the vaccines differently. Data from the CDC suggests side effects from the vaccines are worse in women; for example, 63 of the total 66 reported cases of anaphylaxis happened in women. Sabra Klein, PhD, a professor at the Johns Hopkins Bloomberg School of Public Health and co-director of the Center for Women's Health, Sex, and Gender Research, joins us on this week's episode to explain the biological reasons behind the data.

COVID Vaccine Side Effects: Is the System Working? Mar 23, 2021

It's now 100 days since the first COVID shot was given in the largest mass vaccination campaign in U.S. history. With more than 2 million shots administered daily, more vaccines are going in arms each day in America than in all of the clinical trials combined. Each vaccine's clinical trial had 30,000-40,000 participants and was required to produce data for at "least two months after completion of the full vaccination regimen to help provide adequate information to assess a vaccine's benefit-risk profile." Today, that means we are getting more and more real-world data from a larger and more diverse group than any clinical trial could ever hope to produce. And as vaccine makers continue to seek FDA authorization, the real-world data also require intense scrutiny. According to the CDC, the current vaccine safety monitoring program is one of the most intense ever. But how does it work — and is it intense enough? Aaron Kesselheim, MD, JD, MPH, professor of medicine at Harvard Medical School and Brigham and Women's Hospital in Boston, joins us on this week's episode to answer that question and explain the possible shortfalls, as well as what you should know if you need to report something.

Summer Surges: Will COVID Vaccines End the Pandemic? Apr 13, 2021

COVID surges and vaccination rates. Are the two inextricably linked? Vaccination rates continue to increase as many states have opened availability to all adults. But also increasing? COVID-19 surges, apparently resulting from a combination of eager travelers, relaxed distancing and mask mandates, and new variants that are more transmissible and perhaps more dangerous. What does that mean for vaccines and the ability to stop this pandemic? Nahid Bhadelia, MD, MALD, the medical director for Boston Medical Center Special Pathogens Unit and associate professor of infectious diseases at Boston University School of Medicine, joins "Track the Vax" host Serena Marshall on this week's episode to discuss whether we can vaccinate our way out of the pandemic.

Fair Shot? Does COVID Vaccine Availability Ensure Equity? Apr 20, 2021

The vaccine rollout so far has shown us that the process has been all but equitable for some of the most vulnerable populations. According to newly posted CDC data, more than half of all American adults have now received at least one dose of a COVID vaccine, and a third are fully vaccinated. A disproportionate number of those already vaccinated, however, are white. Black and Hispanic communities received a smaller share of the vaccine. As vaccine eligibility nationwide opens up to all adults, it's worth asking whether that will equate to equitable access. Richard Besser, MD, a pediatrician, former acting CDC Director, and the current President and CEO of the Robert Wood Johnson Foundation, the nation's largest non-profit dedicated to health, joins us on this week's episode to examine how equitable the vaccine distribution has been and where efforts need to be focused.

What's in a Name? COVID Vaccine 'Passports' vs 'Verification' Apr 27, 2021

Across the country, states are moving forward to either require or ban vaccine passports, even as nations move forward with bilateral agreements to allow travel without quarantining if you have one. As more people get vaccinated it will become the travel conundrum. Many cruise lines already say they will require proof of vaccination for crews and passengers. Sports and entertainment venues in certain states also say it will be required for entry. The federal government has maintained they won't be mandating one, but private companies are saying that a "passport" or COVID vaccine card is your ticket in. Would a vaccine passport, called by any other word, be as controversial? To find out how exactly these passports or verification cards would work, and "what's in a name," we spoke with Dakota Gruener, Executive Director for ID2020, a nonprofit group that's working on digital identification and is part of the Good Health Pass Collaborative; and Brian Castrucci, DrPH, MA, an epidemiologist and President & CEO of the de Beaumont Foundation.

Are Side Effects Why Many Pass on COVID Shots? May 04, 2021

Fever. Sore arm. Flu-like symptoms. These are the COVID-19 vaccines' side effects, which now also include possible rare blood clots in the brain, and maybe even shingles. But are the side effects worse than getting COVID? For roughly 5 million Americans, they are concerned enough to skip that second dose, according to the CDC. Even as we learn about the possibility of these side effects, others are no longer a concern. Bell's palsy, for example, which was noted during clinical trials and at the FDA meetings as something to watch, has now been determined following an analysis to be no more likely than with other viral vaccines. So which side effects do we need to be on the lookout for, and which ones will pass just as quickly as we felt them? In this episode, Dial Hewlett Jr., MD, medical director for the Westchester County, New York Department of Health and fellow with the Infectious Diseases Society of America, joins us to explain. Dr. Hewlett also previously worked at Pfizer with their global medical product evaluation team.

Can We Spread COVID After Vaccination? May 11, 2021

Wear your mask. Or, don't wear your mask if you are vaccinated, as long as you are outside. But, keep masking and social distancing inside even if you are vaccinated. It's confusing to many. Vaccines have been proven to prevent serious infection, and studies that show a reduction in transmission are building, but they aren't foolproof. A recent study by Public Health England found that a single dose of either the Pfizer-BioNTech or AstraZeneca vaccine reduced household transmission by up to half. Those both require two doses to be considered "fully vaccinated." The study comes as we hear more about breakthrough COVID cases. In this episode, Colleen Kelley, MD, an associate professor of infectious diseases at Emory University School of Medicine in Atlanta and a principal investigator for the Moderna and Novavax phase III clinical trials at the Ponce de Leon Clinical Research Site, joins us to explain the risk of transmission after vaccination.

Next Up in Line for COVID Vaccines: Kids May 18, 2021

The COVID-19 vaccine rollout has now expanded to include young adolescents among those eligible to receive Pfizer's two-dose shot. This expanded authorization comes as mask mandates across the country are lifting. Adding younger teens means an additional 17-million sleeves can be rolled up to receive a shot as the U.S. pushes forward with the largest mass vaccination program in history. But, even if vaccinations mean life can go 'back to normal,' many parents are concerned over potential side effects and long-term impacts of the vaccine. Others, however, are rushing to vaccinate ahead of summer camps. Every parent wonders: when will a vaccine be available for even younger kids? Some parents have even considered enrolling their young children in clinical trials for an earlier shot at a dose. Joining us this week is Paul A. Offit, MD, director of the Vaccine Education Center and professor of pediatrics in the Division of Infectious Diseases at Children's Hospital of Philadelphia. He's also a member of the FDA's Vaccines and Related Biological Products Advisory Committee (VRBPAC), the impartial group of experts that has been responsible for giving the greenlight for emergency use authorization.

Is Herd Immunity With COVID-19 Realistic? May 25, 2021

Almost half of all Americans have now received at least one COVID-19 vaccine dose and roughly 40% are fully vaccinated, making mask mandates a thing of the past. Already, more than half a dozen states have vaccinated more than 70% of adults with at least one dose and some counties are hitting vaccine rates as high as 90% for those over 65 years of age. As we've watched deaths from COVID drop across the country, it seems we are getting closer to the goal of the pandemic response: getting a high enough percentage of people with immunity to return to "normal." While all signs seem to point to us being closer to that goal, will it also signal the end of the pandemic? After all, herd immunity is a global effort and dozens of countries haven't even vaccinated 5% of their population. Tom Frieden, MD, MPH, the former CDC Director under President Obama, and current president and CEO of Resolve to Save Lives, joins us on this week's episode to explain if we'll get there or if our goal should be something else completely.

U.S. Moves Forward on COVID as Other Parts of the World See Surges Jun 01, 2021

The U.S. has hit a new COVID-19 milestone -- not a grim one, but one of hope -- experiencing the lowest case and death counts since early on in the pandemic. Around the world, a different picture is emerging as countries like Brazil, India, and Malaysia are experiencing devastating surges and shortages of critical supplies. India recently reported seeing more COVID deaths in a single day than any other country at any time during the pandemic. Globally, more than 3.5 million people are estimated to have died from COVID-19 -- however, researchers at the Institute for Health Metrics and Evaluation at the University of Washington School of Medicine believe that number is vastly undercounted and the real death toll is likely two to three times higher. Even as 9% of the world's population have gotten vaccinated, half of those manufactured doses have gone to wealthy countries, whose supply is starting to exceed demand. Krutika Kuppalli, MD, vice chair of the global health committee at the Infectious Diseases Society of America and assistant professor of medicine in the division of infectious diseases at the Medical University of South Carolina, joins us in this week's episode to explain why the longer cases spread uncontained in any part of the world, the worse it fares for all of us.

Covid Boosters: Will We or Won’t We? Jun 08, 2021

It has now been 6 months since the first wave of Americans received their first shot of a COVID-19 vaccine. Proving just how effective the vaccines are in the U.S., we've seen the virus spread down to levels not seen since the start of the pandemic. But one thing we still don't know: how long immunity will last. As Pfizer and Moderna move forward for full FDA licensure, executives at both companies have cited the need for a likely booster. Pfizer CEO Albert Bourla, DVM, PhD, predicted the need for a booster to be "somewhere between 6 and 12 months" after first being vaccinated. Explaining the key role variants will play in the decision, Moderna CEO Stéphane Bancel predicted it could be as soon as September for those at highest risk of severe infection. NIAID director Anthony Fauci, MD, told a Senate subcommittee that he would expect the need for a booster, but declined to put a timeline on his prediction. "I don't anticipate that the durability of the vaccine protection is going to be infinite," Fauci said. Researchers within his institute at the NIH recently began looking into, not just if boosters are necessary but also how to possibly mix vaccines and the impacts on protection. On this week's episode, William Schaffner, MD, professor of Preventive Medicine and Infectious Diseases at Vanderbilt University Medical Center in Nashville, joins us to help break down what the science tells us now, and what to expect.

S02-1: Could More Mask Mandates Stop the Delta Surge? Sep 28, 2021

Wearing a masking to protect yourself and others against the spread of the coronavirus has become something of a political, social, and emotional fireball. Should the vaccinated continue to wear them? Is a mask really necessary outdoors? So many questions remain, but the answers are hard to come by as health agencies, local officials, and even health experts seem to continually change their recommendations. On this week's episode, Monica Gandhi, MD, MPH, associate chief in the Division of HIV, Infectious Diseases, and Global Medicine at the University of California San Francisco, joins us to help break down what the science shows about masks and their ability to protect us.

S02-2: Requiring the COVID Vaccine: The Legal Battle Ahead Oct 05, 2021

Mandating the COVID-19 vaccine has been called presidential overreach, un-American, even unprecedented, despite a long history of requiring vaccines to prevent other illnesses. In August, President Joe Biden mandated employees at all companies with more than 100 employees get vaccinated or undergo routine testing. And now, beginning in early November, federal agencies can enforce that same mandate on federal employees. Mass firings have occurred; but more often than not, employees chose to get the shot over losing their job. On this week's episode, Lawrence Gostin, JD, professor of global health law at Georgetown University, author of the new book "Global Health Security," and director of the World Health Organization Collaborating Center for National and Global Health Law, joins us to discuss where we may see legal challenges and if those challenges have a sound footing.

S02-3: Merck's COVID Pill Has Been Called a 'Game Changer' -- Is It? Oct 12, 2021

You get sick with COVID-19. Instead of quarantining and hoping you don't get worse, or heading into the hospital, you can simply call your doctor, get a prescription, and take it at home. Seems too good to be true. But is it the future of COVID-19 treatment? Merck is hoping their new antiviral will do just that. The company officially submitted an application Monday to the FDA for emergency use authorization, for what would be the first pill to treat COVID-19. This pill, molnupiravir, has been called everything from a "game changer" to "blockbuster." The approval could come in a matter of weeks. But is it all it's been talked up to be? On this week's episode, William Schaffner, MD, a professor of preventive medicine and infectious diseases at Vanderbilt University in Nashville, helps explain what the new pill means in the fight against COVID-19, and what to watch for as it moves toward emergency use.

S02-4: COVID Booster? But I Only Just Got Vaccinated! Oct 19, 2021

Three different vaccines to protect against COVID-19 have been either approved or authorized for emergency use in the U.S. And now the conversation has turned to booster doses for all three. Booster shots are nothing new. After all, a flu "booster" is what is encouraged each and every year. When it comes to COVID-19, however, the back and forth and disconnect between the different government agencies may have left some confusion about who does and doesn't need a booster. After all, COVID vaccine studies show that even after a few months, efficacy is still higher than the original goal for the vaccine. On this week's episode, Ellie Murray, ScD, assistant professor of epidemiology at Boston University School of Public Health, joins us to help answer the question, do I really need another shot?

S02-5: Should Doctors Peddling COVID Disinformation Lose Their License? Oct 26, 2021

Should doctors who spread disinformation lose their medical licenses? Phony cures and/or resistance to public health messaging is nothing new, and during the COVID-19 pandemic, we've seen it all -- from patients suing their doctors or hospital systems to allow for use of the deworming medication ivermectin to treat COVID-19, to healthcare providers echoing conspiracy theories that the virus is a hoax. The Federation of State Medical Boards put out a statement in early August saying that they support disciplinary action, including suspension or revocation of medical licenses, for those who "generate and spread COVID-19 vaccine misinformation or disinformation." When we inquired if any such actions had been taken and what the numbers looked like, we were told they are currently surveying their member boards to find out just how widespread of an issue this has become. On this week's episode, Eve Bloomgarden, MD, of Northwestern University Feinberg School of Medicine in Chicago, who is a member of No License for Disinformation, a non-partisan grassroots coalition taking on disinformation by healthcare providers, joins us to explain how they plan to push for action against those who spread false information.

S02-6: What Do We Know About the Rare COVID-19 Vaccine Complications? Nov 02, 2021

Side effects from the COVID-19 vaccines -- such as soreness and fever -- are quite common, but the more serious complications are among the top reasons why many may still be hesitant to get vaccinated. Now that hundreds of millions of people have gotten the shots, the FDA and CDC -- through their Vaccine Adverse Event Reporting System (VAERS) -- are getting a clearer picture of how frequently more serious side effects occur. On this week's episode, Peter Marks, MD, director of the FDA's Center for Biologics Evaluation and Research, joins us to offer insights into the data on adverse events and the questions that still remain.

S02-7: COVID Vax Now Widely Available for Young Kids -- Will Parents Consent? Nov 09, 2021

Twenty-eight million American children ages 5 to 11 are now eligible for a COVID-19 vaccine. Within hours of the emergency use authorization, vaccine distribution mechanisms kicked into high gear, allowing for kids to roll up their sleeves without having to go too far. Vaccines are now being distributed in pediatrician offices, pharmacies, and schools, as a strategy to eliminate any logistical barriers that kids may face in getting vaccinated. But many parents, who are the key decision makers, remain skeptical that kids need the shot. After all, COVID cases among children have been more mild, with fewer hospitalizations and deaths compared with adults. An October poll by the Kaiser Family Foundation found that 30% of parents of kids in this newly authorized age group will "definitely not" vaccinate them. So what does this mean for classrooms and masking? And what does the science say when it comes to the need to vaccinate kids? On this week's episode, Paul Offit, MD, the director of the Vaccine Education Center at Children's Hospital of Philadelphia, and a member of the FDA's Vaccines and Related Biological Products Advisory Committee, joins us to discuss how vaccinating kids may be the key to returning to a "new normal."

S02-8: How Do We Handle Compassion Fatigue Toward the Unvaccinated? Nov 16, 2021

As COVID-19 vaccines become available to more age groups, will fatigue from the pandemic subside? Or will it create a greater disconnect between the healthcare workers struggling to provide consistent and compassionate care, and the people sick with COVID who need treatment due to resistance to protective health measures? Oftentimes, it can feel like you're doing all the right things -- getting vaccinated, wearing masks, social distancing -- while others are opting out, which can lead to compassion fatigue, a mental health condition that differs from burnout, and is hitting those on the front lines the hardest. On this week's episode, Jessica Gold, MD, MS, of the department of psychiatry at Washington University School of Medicine in St. Louis, joins us to explain how healthcare professionals can move past the fatigue and care for themselves.

S02-9: What Do We Know About Breakthrough Cases, and How Can We Prevent Them? Nov 23, 2021

While the CDC initially recommended COVID-19 booster shots for a limited swath of Americans, last week they updated their guidance to allow all adults 18 and up to receive a booster. Data have pointed to breakthroughs among the earliest vaccine recipients, as well as older individuals and those with pre-existing conditions. On this week's episode, Katelyn Jetelina, PhD, MPH, an epidemiologist at the University of Texas School of Public Health in Dallas, walks us through what to watch for when it comes to breakthroughs, as more Americans travel this holiday season than since the start of the pandemic.

S02-10: Does a Past COVID Infection Protect Just as Well as Vaccines? Nov 30, 2021

COVID booster shots are now recommended for millions of Americans, prompting questions on why immunity acquired from the vaccines is waning so soon. Anthony Fauci, MD, director of the National Institute of Allergy and Infectious Diseases, has hinted that periodic booster shots against COVID are likely here to stay, and may redefine what it means to be "fully vaccinated." While natural immunity from previous COVID infection is of scientific interest, it's also a political talking point that some have seized on to sidestep vaccination. What does the science show when it comes to the duration of natural immunity? And how does natural immunity compare to vaccine-acquired immunity? On this week's episode, Bob Wachter, MD, of the University of California San Francisco, answers questions about immunity and how to stay protected.

S02-11: Psychological Barriers May Lead to COVID Vaccine Refusal Dec 07, 2021

wo years into the COVID-19 pandemic -- and 1 year after vaccines first became available -- there are still those who are opting out of getting vaccinated. Deep distrust in government and science are among the reasons that some are continuing to hold out on the shots. But experts suggest that there are psychological barriers that may have nothing to do with mistrust. To understand all of the factors at play, we need to first recognize how the mind processes the act of making a decision -- whether it is to opt in or out. On this week's episode, Gretchen Chapman, PhD, department head of social and decision sciences at Carnegie Mellon University in Pittsburgh, joins us to help us understand the psychology behind COVID vaccine refusal.

S02-12: What to Expect When We're Expecting More Omicron Cases Dec 14, 2021

Omicron has reached the U.S., and widespread vaccination may not be enough to keep the new variant from spreading. The variant is expected to outpace Delta in the coming weeks, with more than 30 states having now reported a case. On this week's episode, Abraar Karan, MD, MPH, an infectious disease physician at Stanford University, joins us to explain all we know -- and still don't -- when it comes to this new variant.

S02-13: Under the Microscope: How Sequencing Plays Pandemic Detective Dec 21, 2021

The longer the COVID-19 epidemic persists the more likely we are to see more super-spreader events, even among those vaccinated, and possibly by variants not yet identified. Health experts have already worked to help prevent and treat COVID – but say there's more we need to do to track individual cases and community spread. On this week's episode, John Connor, MD, an associate professor and researcher at the National Emerging Infectious Diseases Laboratories at Boston University, joins us to explain how they track the introduction of COVID and remnants of COVID infections over time.

S02-14: How Do We Treat Long COVID? Dec 28, 2021

Millions of Americans are experiencing chronic, lingering, and debilitating symptoms months after recovering from COVID-19. The symptoms of so-called long COVID range from breathing problems to memory impairment, making it difficult for clinicians to pinpoint the syndrome and who may be at highest risk. The NIH has directed $1 billion toward studying the syndrome, and some hospitals, including pediatric hospitals, have opened centers to research and care for patients experiencing long COVID. On this week's episode, Jonathan Whiteson, MD, medical director of cardiac and pulmonary rehab at NYU Langone Medical Center in New York City, and spokesperson for the American Academy of Physical Medicine and Rehabilitation, joins us to explain how long COVID is being detected and treated, and the new guidance for physicians.

S02-15: COVID-19 Vaccines: What Does the Future Hold? Jan 04, 2022

We did it all. We social distanced, masked, got vaccinated, masked some more, and got boosted. But still, with Omicron -- a much more contagious variant spreading like wildfire -- infections are at an all-time high. There remain more than 100 different vaccines in human trials and development for COVID-19, from protein subunits to inactivated coronavirus vaccines, as well as another 70-plus in animal trials. So, is boosting with our existing authorized vaccines going to be our "new normal?" Or, are there new vaccines still in development that would allow us to truly be "one and done." On this week's episode, Dial Hewlett Jr., MD, the medical director for Westchester County, New York, and deputy to the commissioner for the Westchester County Department of Health, joins us to explain what future vaccines are coming down the pike and where research will lead us.

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